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Background: Multiple system atrophy (MSA) is a neurodegenerative disease that progresses rapidly and has a poor prognosis. This study aimed to assess the value of video oculomotor evaluation (VOE) in the differential diagnosis of MSA and Parkinson's disease (PD). Methods: In total, 28 patients with MSA, 31 patients with PD, and 30 age‐ and sex‐matched healthy controls (HC) were screened and included in this study. The evaluation consisted of a gaze‐holding test, smooth pursuit eye movement (SPEM), random saccade, and optokinetic nystagmus (OKN). Results: The MSA and PD groups had more abnormalities and decreased SPEM gain than the HC group (64.29%, 35.48%, 10%, p <.001). The SPEM gain in the MSA group was significantly lower than that in the PD group at specific frequencies. Patients with MSA and PD showed prolonged latencies in all saccade directions compared with those with HC. However, the two diseases had no significant differences in the saccade parameters. The OKN gain gradually decreased from the HC to the PD and the MSA groups (p <.05). Compared with the PD group, the gain in the MSA group was further decreased in the OKN test at 30°/s (Left, p =.010; Right p =.016). Receiver operating characteristic curves showed that the combination of oculomotor parameters with age and course of disease could aid in the differential diagnosis of patients with MSA and PD, with a sensitivity of 89.29% and a specificity of 70.97%. Conclusions: The combination of oculomotor parameters and clinical data may aid in the differential diagnosis of MSA and PD. Furthermore, VOE is vital in the identification of neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Background and Purpose: Inflammatory reaction plays a critical role in the pathogenesis of late delayed radiation‐induced brain injury (RBI). Low vitamin D levels are closely associated with various immuno‐inflammatory diseases, but the relationship with late delayed RBI remains unknown. Here, we aimed to determine the association of serum vitamin D levels with clinical parameters in late delayed RBI patients with nasopharyngeal carcinoma. Methods: 25‐Hydroxyvitamin D3 levels and clinical and cerebrospinal fluid parameters were evaluated in 21 patients with RBI and compared with 90 age‐, sex‐, and season‐matched healthy controls. Results: 25‐(OH)D3 levels were lower in patients with RBI compared to controls (40.39 ± 22.11 vs. 64.54 ± 19.89 nmol/L, p <.001), especially for aged ≥60 years (vs. <60 years, p =.038), females (vs. males, p =.012), short latency (<5 years) (vs. ≥5 years, p =.015), and severe impairment (LENT/SOMA score ≥3) (vs. LENT/SOMA score <3, p =.010). Serum 25‐(OH)D3 levels were associated with age (r = −.464, p =.015), Latency of RBI (r =.416, p =.031) and LENT/SOMA Scale (r = −.488, p =.010). Conclusions: Our data showed that serum 25‐(OH)D3 levels were reduced in late delayed RBI patients with nasopharyngeal carcinoma. [ABSTRACT FROM AUTHOR]

Solitary fibrous tumor (SFT) is a rare spindle cell soft tissue tumor which is rarely encountered in the clinical setting and imaging findings are nonspecific, mainly occurring in the tissue structure of the serosa. However, there is very little report on SFT originating in the kidney in the medical literature. We report a case of SFT with liver metastasis in an adult female and discuss the pathological features as it appears in our case. [ABSTRACT FROM AUTHOR]