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2. Projecting the impact of an ebola virus outbreak on endangered mountain gorillas.

Author

Zimmerman, Dawn M, Hardgrove, Emily, Sullivan, Sara, Mitchell, Stephanie, Kambale, Eddy, Nziza, Julius, Ssebide, Benard, Shalukoma, Chantal, Cranfield, Mike, Pandit, Pranav S, Troth, Sean P, Callicrate, Taylor, Miller, Philip, Gilardi, Kirsten, and Lacy, Robert C

Subjects
Animals, Hominidae, Gorilla gorilla, Humans, Hemorrhagic Fever, Ebola, Disease Outbreaks, Ebolavirus, Vaccine Related, Prevention, Emerging Infectious Diseases, Infectious Diseases, Biodefense, Infection, Good Health and Well Being
Abstract

Ebola virus is highly lethal for great apes. Estimated mortality rates up to 98% have reduced the global gorilla population by approximately one-third. As mountain gorillas (Gorilla beringei beringei) are endangered, with just over 1000 individuals remaining in the world, an outbreak could decimate the population. Simulation modeling was used to evaluate the potential impact of an Ebola virus outbreak on the mountain gorilla population of the Virunga Massif. Findings indicate that estimated contact rates among gorilla groups are high enough to allow rapid spread of Ebola, with less than 20% of the population projected to survive at 100 days post-infection of just one gorilla. Despite increasing survival with vaccination, no modeled vaccination strategy prevented widespread infection. However, the model projected that survival rates greater than 50% could be achieved by vaccinating at least half the habituated gorillas within 3 weeks of the first infectious individual.

Published
2023

3. Endemicity of Yaws and Seroprevalence of Treponema pallidum Antibodies in Nonhuman Primates, Kenya

Author

Zimmerman, Dawn M., Hardgrove, Emily H., von Fricken, Michael E., Kamau, Joseph, Chai, Daniel, Mutura, Samson, Kivali, Velma, Hussein, Fatima, Ambala, Peris, Surmat, Andrea, Maina, Joseph G., and Knauf, Sascha

Subjects
Primates, Disease eradication, Infection, Antibodies, Health, Public health, Health
Abstract

Yaws is a disease caused by the bacterium Treponema pallidum subsp. pertenue, which is believed to be an exclusively human pathogen (1). However, this bacterium has recently been identified in [...]

Published
2019
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4. A Novel Coronavirus and a Broad Range of Viruses in Kenyan Cave Bats

Author

Kamau, Joseph, primary, Ergunay, Koray, additional, Webala, Paul W., additional, Justi, Silvia A., additional, Bourke, Brian P., additional, Kamau, Maureen W., additional, Hassell, James, additional, Chege, Mary N., additional, Mwaura, David K., additional, Simiyu, Cynthia, additional, Kibiwot, Sospeter, additional, Onyuok, Samson, additional, Caicedo-Quiroga, Laura, additional, Li, Tao, additional, Zimmerman, Dawn M., additional, and Linton, Yvonne-Marie, additional

Published
2022
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5. Strengthening global health security by improving disease surveillance in remote rural areas of low-income and middle-income countries

Author

Worsley-Tonks, Katherine E L, primary, Bender, Jeff B, additional, Deem, Sharon L, additional, Ferguson, Adam W, additional, Fèvre, Eric M, additional, Martins, Dino J, additional, Muloi, Dishon M, additional, Murray, Suzan, additional, Mutinda, Mathew, additional, Ogada, Darcy, additional, Omondi, George P, additional, Prasad, Shailendra, additional, Wild, Hannah, additional, Zimmerman, Dawn M, additional, and Hassell, James M, additional

Published
2022
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14. In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor-γ Agonist Rosiglitazone

Author

Yue, Tian-li, primary, Chen, Jun, additional, Bao, Weike, additional, Narayanan, Padma K., additional, Bril, Antoine, additional, Jiang, Wen, additional, Lysko, Paul G., additional, Gu, Juan-Li, additional, Boyce, Rogely, additional, Zimmerman, Dawn M., additional, Hart, Timothy K., additional, Buckingham, Robin E., additional, and Ohlstein, Eliot H., additional

Published
2001
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17. Safety and Immunogenicity of the Mycobacterium tuberculosis?lysA?panCDVaccine in Domestic Cats Infected with Feline Immunodeficiency Virus

Author

Zimmerman, Dawn M., Waters, W. Ray, Lyashchenko, Konstantin P., Nonnecke, Brian J., Armstrong, Douglas L., Jacobs, William R., Larsen, Michelle H., Egan, Erin, and Dean, Gregg A.

Abstract

ABSTRACTFeline immunodeficiency virus (FIV)-positive and FIV-negative cats (n= 4/group) received 2 × 106CFU Mycobacterium tuberculosis?lysA?panCDintramuscularly. Vaccination elicited antibody responses, albeit at lower levels in FIV-positive cats than in FIV-negative cats. Delayed-type hypersensitivity responses were minimal in both groups. No adverse reactions were found.

Published
2009
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18. Safety and immunogenicity of the Mycobacterium tuberculosis DeltalysA DeltapanCD vaccine in domestic cats infected with feline immunodeficiency virus.

Author

Zimmerman DM, Waters WR, Lyashchenko KP, Nonnecke BJ, Armstrong DL, Jacobs WR Jr, Larsen MH, Egan E, and Dean GA

Subjects
Animals, Antibodies, Bacterial blood, Cats, Hypersensitivity, Delayed, Feline Acquired Immunodeficiency Syndrome immunology, Tuberculosis Vaccines adverse effects, Tuberculosis Vaccines immunology
Abstract

Feline immunodeficiency virus (FIV)-positive and FIV-negative cats (n=4/group) received 2 x 10(6) CFU Mycobacterium tuberculosis DeltalysA DeltapanCD intramuscularly. Vaccination elicited antibody responses, albeit at lower levels in FIV-positive cats than in FIV-negative cats. Delayed-type hypersensitivity responses were minimal in both groups. No adverse reactions were found.

Published
2009
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