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21 results on '"de Vogel,Stefan"'

1. Abstract 13154: Cardiovascular Risk in Users of Mirabegron Relative to Users of Antimuscarinic Treatments for Overactive Bladder: Findings From a Non-interventional, Real-world Data Safety Study

Author

Hoffman, Veena, Hallas, Jesper, Linder, Marie, Margulis, Andrea, Suehs, Brandon T, Arana, Alejandro, Enger, Cheryl, Horter, Libby, Odsbu, Ingvild, Olesen, Morten, Perez Gutthann, Susana, Xu, Yihua, Kristiansen, Nina S, Appenteng, Kwame, de Vogel, Stefan, and Seeger, John D

Published
2020
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6. Dietary folate and APC mutations in sporadic colorectal cancer

Author

de Vogel, Stefan, van Engeland, Manon, Luchtenborg, Margreet, de Bruine, Adriaan P., Roemen, Guido M.J.M., Lentjes, Marjolein H.F.M., Goldbohm, R. Alexandra, van den Brandt, Piet A., de Goeij, Anton F.P.M., and Weijenberg, Matty P.

Subjects
Colorectal cancer -- Genetic aspects, Colorectal cancer -- Research, Folic acid -- Research, Food/cooking/nutrition
Abstract

Folate deficiency has been associated with colorectal cancer risk and may be involved in colorectal carcinogenesis through increased chromosome instability, gene mutations, and aberrant DNA methylation. Within the Netherlands Cohort Study on diet and cancer, we investigated the associations between dietary folate intake and colorectal cancer risk with ([APC.sup.+]) and without ([APC.sup.-]) truncating APC mutations, accounting for hMLH1 expression and K-ras mutations. In total, 528 cases and 4200 subcohort members were available for data analyses of the study cohort (n = 120,852) from a follow-up period between 2.3 and 7.3 y after baseline. Adjusted gender-specific incidence rate ratios (RR) over tertiles of folate intake were calculated in case-cohort analyses for colon and rectal cancer. Although relatively high folate intake was not associated with overall colorectal cancer risk, it reduced the risk of APC colon tumors in men (RR 0.58, 95% CI 0.32-1.05, [P.sub.trend] 0.06 for the highest vs. lowest tertile of folate intake). In contrast, it was positively associated with [APC.sub.+] colon tumors in men (highest vs. lowest tertile: RR 2.77, 95% Cl 1.29-5.95, [P.sub.trend] = 0.008) and was even stronger when the lack of hMLH1 expression and K-ras mutations were excluded (RR 3.99, 95% Cl 1.43-11.14, [P.sub.trend] = 0.007). Such positive associations were not observed among women; nor was folate intake associated with rectal cancer when APC mutation status was taken into account. Relatively high folate consumption reduced the risk of [APC.sup.-] colon tumors, but folate intake was positively associated with [APC.sup.+] colon tumors among men. These opposite results may indicate that folate enhances colorectal carcinogenesis through a distinct APC mutated pathway.

Published
2006

8. Evaluating the Effectiveness of an Additional Risk Minimization Measure to Reduce the Risk of Prescribing Mirabegron to Patients with Severe Uncontrolled Hypertension in Four European Countries

Author

Heintjes, Edith, primary, Bezemer, Irene D, additional, Prieto-Alhambra, Daniel, additional, Smits, Elisabeth, additional, Booth, Helen P, additional, Dedman, Daniel, additional, He, Ying, additional, Hoti, Fabian, additional, Vehkala, Minna, additional, de Vogel, Stefan, additional, Robinson, Noah Jamie, additional, Appenteng, Kwame, additional, and Penning-van Beest, Fernie JA, additional

Published
2020
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12. Evaluating the Effectiveness of an Additional Risk Minimization Measure to Reduce the Risk of Prescribing Mirabegron to Patients with Severe Uncontrolled Hypertension in Four European Countries

Author

Heintjes,Edith, Bezemer,Irene D, Prieto-Alhambra,Daniel, Smits,Elisabeth, Booth,Helen P, Dedman,Daniel, He,Ying, Hoti,Fabian, Vehkala,Minna, de Vogel,Stefan, Robinson,Noah Jamie, Appenteng,Kwame, Penning-van Beest,Fernie JA, Heintjes,Edith, Bezemer,Irene D, Prieto-Alhambra,Daniel, Smits,Elisabeth, Booth,Helen P, Dedman,Daniel, He,Ying, Hoti,Fabian, Vehkala,Minna, de Vogel,Stefan, Robinson,Noah Jamie, Appenteng,Kwame, and Penning-van Beest,Fernie JA

Abstract

Edith M Heintjes,1 Irene D Bezemer,1 Daniel Prieto-Alhambra,2,3 Elisabeth Smits,1 Helen P Booth,4 Daniel Dedman,4 Ying He,3 Fabian Hoti,5 Minna Vehkala,5 Stefan de Vogel,6 Noah Jamie Robinson,6 Kwame Appenteng,7 Fernie JA Penning-van Beest1 1PHARMO Institute for Drug Outcomes Research, Utrecht, the Netherlands; 2Idiap Jordi Gol Primary Care Research Institute and CIBERFes, Universitat Autonoma de Barcelona and Instituto de Salud Carlos III, Barcelona, Catalonia, Spain; 3Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford, England, UK; 4Clinical Practice Research Datalink (CPRD), London, UK; 5Statfinn - EPID Research, Espoo, Finland; 6Astellas Pharma Europe B.V., Leiden, Netherlands; 7Astellas Pharma Global Development, Inc., Northbrook, IL, USACorrespondence: Edith M HeintjesPHARMO Institute for Drug Outcomes Research, Van Deventerlaan 30-40, Utrecht, AE 3528, the NetherlandsTel +31 30 7440 800Email pharmo@pharmo.nlBackground: Mirabegron, indicated for the treatment of overactive bladder, is contraindicated in patients with severe uncontrolled hypertension (systolic blood pressure ≥ 180 mm Hg and/or diastolic blood pressure ≥ 110 mm Hg). In September 2015, a Direct Healthcare Professional Communication (DHPC) letter was disseminated as an additional risk minimisation measure.Purpose: To assess the effectiveness of the DHPC in reducing the proportions of patients with severe or non-severe uncontrolled hypertension at mirabegron initiation.Methods: An observational multi-database cohort study was undertaken using routinely collected healthcare data (December 2012–December 2016) from the PHARMO Database Network (Netherlands), SIDIAP database (Spain), CPRD (United Kingdom, UK) and national healthcare registers and electronic medical records from Finland. DHPC effectiveness was evaluated using interrupted time series analyses comparing trends and changes in monthly proportions of severe or non-severe uncontrolled hypertensive m

Published
2020

13. Physical activity and risk of prostate and bladder cancer in China: The South and East China case-control study on prostate and bladder cancer

Author

Reulen, Raoul C., de Vogel, Stefan, Zhong, Weide, Zhong, Zhaohui, Xie, Li-Ping, Hu, Zhiquan, Deng, Yilan, Yang, Kai, Liang, Yuxiang, Zeng, Xing, Wong, Yong Chuan, Tam, Po-Chor, Hemelt, Marjolein, Zeegers, Maurice P., RS: CAPHRI - R5 - Optimising Patient Care, and Complexe Genetica

Subjects
Male, lcsh:Medicine, Geographical Locations, Mathematical and Statistical Techniques, Risk Factors, Medicine and Health Sciences, Public and Occupational Health, lcsh:Science, Aged, 80 and over, Prostate Cancer, Prostate Diseases, MEN, Middle Aged, Bladder Cancer, Oncology, Research Design, Physical Sciences, Female, Anatomy, Statistics (Mathematics), Research Article, China, Asia, CARCINOMA, Urology, Research and Analysis Methods, LUNG-CANCER, Exocrine Glands, Diagnostic Medicine, Cancer Detection and Diagnosis, Humans, COHORT, VALIDITY, Statistical Methods, METAANALYSIS, Aged, lcsh:R, Prostatic Neoplasms, Cancers and Neoplasms, Biology and Life Sciences, Physical Activity, Genitourinary Tract Tumors, Urinary Bladder Neoplasms, TAIWAN, Case-Control Studies, People and Places, Prostate Gland, lcsh:Q, Mathematics, Meta-Analysis
Abstract

Background Recent meta-analyses have suggested a modest protective effect of high levels of physical activity on developing both prostate and bladder cancer, but significant heterogeneity between studies included in these meta-analyses existed. To our knowledge, few Chinese studies investigated the association between physical activity and prostate cancer and none between physical activity and bladder cancer. Given the inconsistencies between previous studies and because studies on the relation between physical activity and prostate and bladder cancer in China are scarce, it remains elusive whether there is a relationship between physical activity and prostate and bladder cancer within the Chinese population. Methods We investigated the association between physical activity and risk of developing prostate and bladder cancer within a hospital-based case-control study in the East and South of China among 260 and 438 incident prostate and bladder cancer cases, respectively, and 427 controls. A questionnaire was administered to measure physical activity as metabolic equivalents (METs). Random effects logistic regression was used to calculate odds ratios (ORs) of prostate and bladder cancer for different levels of physical activity and for the specific activities of walking and cycling. Results Increasing overall physical activity was associated with a significant reduction in prostate cancer risk (P-trend = 0.04) with the highest activity tertile level showing a nearly 50% reduction in prostate cancer risk (OR = 0.53, 95% CI: 0.28-0.98). Overall physical activity was not significantly associated with risk of bladder cancer (Ptrend = 0.61), neither were vigorous (P-trend = 0.60) or moderate levels of physical activity (P-trend = 0.21). Walking and cycling were not significantly associated with either prostate (P-trend > = 0.62) or bladder cancer risk (P-trend > = 0.25). Conclusions The findings of this largest ever case-control study in China investigating the relationship between physical activity and prostate and bladder cancer suggest that overall physical activity is associated with a decreased risk of prostate cancer, but not with bladder cancer.

Published
2017

14. Circulating Folate and Vitamin B12 and Risk of Prostate Cancer: A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls

Author

Price, Alison J, Travis, Ruth C, Appleby, Paul N, Albanes, Demetrius, Barricarte Gurrea, Aurelio, Bjørge, Tone, Bueno-de-Mesquita, H Bas, Chen, Chu, Donovan, Jenny, Gislefoss, Randi, Goodman, Gary, Gunter, Marc, Hamdy, Freddie C, Johansson, Mattias, King, Irena B, Kühn, Tilman, Männistö, Satu, Martin, Richard M, Meyer, Klaus, Neal, David E, Neuhouser, Marian L, Nygård, Ottar, Stattin, Par, Tell, Grethe S, Trichopoulou, Antonia, Tumino, Rosario, Ueland, Per Magne, Ulvik, Arve, de Vogel, Stefan, Vollset, Stein Emil, Weinstein, Stephanie J, Key, Timothy J, Allen, Naomi E, and Endogenous Hormones, Nutritional Biomarkers, and Prostate Cancer

Abstract

BACKGROUND: Folate and vitamin B12 are essential for maintaining DNA integrity and may influence prostate cancer (PCa) risk, but the association with clinically relevant, advanced stage, and high-grade disease is unclear. OBJECTIVE: To investigate the associations between circulating folate and vitamin B12 concentrations and risk of PCa overall and by disease stage and grade. DESIGN, SETTING, AND PARTICIPANTS: A study was performed with a nested case-control design based on individual participant data from six cohort studies including 6875 cases and 8104 controls; blood collection from 1981 to 2008, and an average follow-up of 8.9 yr (standard deviation 7.3). Odds ratios (ORs) of incident PCa by study-specific fifths of circulating folate and vitamin B12 were calculated using multivariable adjusted conditional logistic regression. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Incident PCa and subtype by stage and grade. RESULTS AND LIMITATIONS: Higher folate and vitamin B12 concentrations were associated with a small increase in risk of PCa (ORs for the top vs bottom fifths were 1.13 [95% confidence interval (CI), 1.02-1.26], ptrend=0.018, for folate and 1.12 [95% CI, 1.01-1.25], ptrend=0.017, for vitamin B12), with no evidence of heterogeneity between studies. The association with folate varied by tumour grade (pheterogeneity0.05). Use of single blood-sample measurements of folate and B12 concentrations is a limitation. CONCLUSIONS: The association between higher folate concentration and risk of high-grade disease, not evident for low-grade disease, suggests a possible role for folate in the progression of clinically relevant PCa and warrants further investigation. PATIENT SUMMARY: Folate, a vitamin obtained from foods and supplements, is important for maintaining cell health. In this study, however, men with higher blood folate levels were at greater risk of high-grade (more aggressive) prostate cancer compared with men with lower folate levels. Further research is needed to investigate the possible role of folate in the progression of this disease.

Published
2016

16. Biomarkers related to one-carbon metabolism as potential risk factors for distal colorectal adenomas

Author

de Vogel, Stefan, Schneede, Jörn, Ueland, Per Magne, Vollset, Stein Emil, Meyer, Klaus, Fredriksen, Åse, Midttun, Øivind, Bjørge, Tone, Kampman, Ellen, Bretthauer, Michael, Hoff, Geir, de Vogel, Stefan, Schneede, Jörn, Ueland, Per Magne, Vollset, Stein Emil, Meyer, Klaus, Fredriksen, Åse, Midttun, Øivind, Bjørge, Tone, Kampman, Ellen, Bretthauer, Michael, and Hoff, Geir

Abstract

BACKGROUND: Efficient one-carbon metabolism, which requires adequate supply of methyl group donors and B-vitamins, may protect against colorectal carcinogenesis. However, plasma folate and vitamins B2 and B12 have inconsistently been associated with colorectal cancer risk, and there have been no previous studies relating plasma concentrations of methionine, choline, and betaine to this outcome. METHODS: This study comprised 10,601 individuals, 50 to 64 years of age, participating in the Norwegian Colorectal Cancer Prevention (NORCCAP) screening study. Using logistic regression analyses, we crosssectionally investigated associations between distal colorectal adenoma occurrence-potential precursor lesions of colorectal carcinomas-and plasma concentrations of methyl group donors and B-vitamins, and polymorphisms of genes related to one-carbon metabolism. RESULTS: Screening revealed 1,809 subjects (17.1%) with at least one adenoma. The occurrence of high-risk adenomas (observed in 421 subjects) was inversely associated with plasma concentrations of methionine (highest versus lowest quartile: odds ratio (OR) = 0.61; 95% confidence interval (CI) = 0.45-0.83), betaine: OR = 0.74; 95% CI = 0.54-1.02, the vitamin B2 form flavin-mononucleotide (FMN): OR = 0.65; 95% CI = 0.49-0.88, and the vitamin B6 form pyridoxal 5'-phosphate (PLP): OR = 0.69; 95% CI = 0.51-0.95, but not with folate, choline, vitamin B12 concentrations, or with the studied polymorphisms. High methionine concentration in combination with high vitamin B2 or B6 concentrations was associated with lower occurrence of high-risk adenomas compared with these factors individually. CONCLUSIONS: High plasma concentrations of methionine and betaine, and vitamins B2 and B6 may reduce risk of developing colorectal adenomas. IMPACT: In addition to B-vitamins, methyl group donors such as methionine and betaine may play a role in colorectal carcinogenesis.

Published
2011
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18. Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet–gene interactions and promoter CpG island hypermethylation in colorectal cancer

Author

de Vogel, Stefan, primary, Wouters, Kim A. D., additional, Gottschalk, Ralph W. H., additional, van Schooten, Frederik J., additional, de Goeij, Anton F. P. M., additional, de Bruïne, Adriaan P., additional, Goldbohm, R. Alexandra, additional, van den Brandt, Piet A., additional, van Engeland, Manon, additional, and Weijenberg, Matty P., additional

Published
2010
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19. Genetic Variants of Methyl Metabolizing Enzymes and Epigenetic Regulators: Associations with Promoter CpG Island Hypermethylation in Colorectal Cancer

Author

de Vogel, Stefan, primary, Wouters, Kim A.D., additional, Gottschalk, Ralph W.H., additional, van Schooten, Frederik J., additional, de Goeij, Anton F.P.M., additional, de Bruïne, Adriaan P., additional, Goldbohm, Royle A., additional, van den Brandt, Piet A., additional, Weijenberg, Matty P., additional, and van Engeland, Manon, additional

Published
2009
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20. Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.

Author

Vogel, Stefan, Wouters, Kim, Gottschalk, Ralph, Schooten, Frederik, Goeij, Anton, Bruïne, Adriaan, Goldbohm, R., den Brandt, Piet, Engeland, Manon, Weijenberg, Matty, de Vogel, Stefan, Wouters, Kim A D, Gottschalk, Ralph W H, van Schooten, Frederik J, de Goeij, Anton F P M, de Bruïne, Adriaan P, Goldbohm, R Alexandra, van den Brandt, Piet A, van Engeland, Manon, and Weijenberg, Matty P

Abstract

Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). Among 609 CRC cases and 1,663 subcohort members of the Netherlands Cohort Study on diet and cancer (n = 120,852), we estimated CRC risk according to methyl donor intake across genotypes of folate metabolizing enzymes and methyltransferases.Although diet-gene interactions were not statistically significant, methionine intake was inversely associated with CRC among subjects having both common rs2424913 and rs406193 DNMT3B C > T genotypes (highest versus lowest tertile: RR = 0.44; p (trend) = 0.05). Likewise, vitamin B2 was modestly inversely associated among individuals with the MTHFR c.665CC (rs1801133) genotype (RR = 0.66; p (trend) = 0.08), but with a significant reduced risk when ≤ 1 rare allele occurred in the combination of folate metabolizing enzymes MTHFR, MTRR and MTR (RR = 0.30; p (trend) = 0.005). Folate or vitamin B6 were neither inversely associated with CRC nor was methyl donor intake associated with the CpG island methylator phenotype (CIMP).Despite the absence of heterogeneity across genotypes, might an effect of methyl donors on CRC be more pronounced among individuals carrying common variants of folate metabolizing enzymes or DNA methyltransferases. Combining genotypes may assist to reveal diet associations with CRC, possibly because rare variants of related genes may collectively affect specific metabolic pathways or enzymatic functions. [ABSTRACT FROM AUTHOR]

Published
2011
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21. Alcohol Consumption and Mutations or Promoter Hypermethylation of the von Hippel-Lindau Gene in Renal Cell Carcinoma.

Author

Schouten, Leo J., van Dijk, Boukje A.C., Oosterwijk, Egbert, van Engeland, Manon, Huisbergen-van de Kaa, Christina A., Kiemeney, Lambertus A.L.M., Goldbohm, Royle Alexandra, Kester, Arnold, de Vogel, Stefan, Schalken4, Jack A., and van den Brandt, Piet A.

Abstract

The article investigates whether alcohol is associated with genetic changes of the von Hippel-Lindau gene in renal cell cancer. According to the authors, results showed that alcohol intake from beer, wine and liquor is associated with decreased risks for renal cell cancer, but in a statistically insignificant way.

Published
2008
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