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WOS: 000526738800001, The essential oil of Ducrosia ismaelis Asch. (Apiaceae) that grows wild in Saudi Arabia was investigated utilizing gas chromatography (GC), and gas chromatography-mass spectrometry. Fifty constituents were characterized, representing 96.1% of the total oil. the D. ismaelis essential oil (DIED) was distinguished by a high composition of oxygenated monoterpenes (51.6%). Decanal (40.6%), alpha-pinene (15.1%) and dodecanal (13.7%) were the fundamental components. Additionally, DIED was evaluated for its cytotoxic, antibacterial, antifungal and antioxidant activities. DIED revealed a great cytotoxic effectiveness against the tested cancer cell lines with IC50 values between 66.2 and 137.3 mu g/mL particularly against MCF-7 cancer cells. Furthermore, the induction of apoptosis against MCF-7 cells has been asserted using staining assay (annexin VFITC and/or propidium iodide (PI) dyes) and flow cytometry technique. the DIED possessed a strong antimicrobial activity against Gram-positive bacterial and fungal strains with MIC-values between 0.07 and 0.31 mg/ml. the values of MBC or MFC were almost once higher than those of MIC's. Moreover, the beta-carotene-bleaching and DPPH free radical-scavenging tests showed that DIED had a moderate activity (68%) as an antioxidant agent in decolouring of the beta-carotene at 1.0 mg/mL and a moderate radical scavenging for DPPH (66 and 72%) at 0.50 and 1.0 mg/mL., King Saud University, Riyadh, Saudi ArabiaDeanship of Scientific Research at King Saud University [RSP-2019/119], The authors extend theirappreciation to Researchers Supporting Project number (RSP-2019/119), King Saud University, Riyadh, Saudi Arabia for funding this work.