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The electronic structure characteristics of bilayer graphyne, bilayer graphdiyne, and bilayer graphtriyne were systematically studied using molecular orbital (MO) analysis, density of states (DOS), and interaction region indicator (IRI) methods. The delocalization characteristics of the out-of-plane and in-plane π electrons (i.e., πout and πin electrons) of these materials were analyzed using the localized orbital locator (LOL). In addition, their responses to external magnetic fields were investigated through anisotropic induced current density (AICD) and isoscalar chemical shielding surfaces (ICSSs) to compare the induced ring currents and magnetic shielding effects, further exploring the aromaticity of the three bilayer materials. The research results indicate that as the number of alkyne groups increases, the aromaticity of the bilayer graphyne structure gradually weakens. Finally, their photophysical properties were studied through TD-DFT calculations. The results show that they exhibit strong localized excitation characteristics. [ABSTRACT FROM AUTHOR]

Depending on high permeability, high Curie temperature, and low eddy current loss noise, nanocrystalline alloys, as the innermost layer, exhibit great potential in the construction of cylindrical magnetic shielding systems with a high shielding coefficient and low magnetic noise. This study compares a magnetic noise of 1 Hz, simulated by the finite element method (FEM), of a cylindrical nanocrystalline magnetic shield with different structural parameters based on the measured initial permeability of commercial Fe-based nanocrystalline (1K107). The simulated results demonstrate that the magnetic noise is irrelevant to the pump and probe hole diameter. The magnetic noise of a nanocrystalline cylinder with a fixed length gradually increases with the rise in aspect ratio. The radial and axial magnetic noise of a nanocrystalline cylinder with a fixed diameter can reach optimal values when the aspect ratio is 1.3 and 1.4, respectively. The layer thickness of a nanocrystalline cylinder is negatively correlated to magnetic noise. Additionally, by comparing the 1 Hz magnetic noise of a cylindrical nanocrystalline magnetic shield with varying initial permeability, it can be concluded that an increase in loss factor results in an increase in magnetic noise. These results are useful for the design of a high-performance passive magnetic shield with low magnetic noise. [ABSTRACT FROM AUTHOR]

In this paper, a method to predict near-field magnetic shielding effectiveness (NSE) of ferrite sheets is proposed by measuring their relative permeability. The NSE prediction for ferrite sheets is developed using eight regression models based on higher-order terms of permeability, extracted through Minitab's regression analysis using data from the measured NSE and relative permeabilities of the ferrite sheets. To analyze the accuracy of the predicted NSE in comparison to the measured NSE, the mean square error (MSE) was computed. As a result, the extracted regression models enable fast and accurate NSE predictions for ferrite sheets up to 100 MHz, achieving an MSE of less than 1.0, in contrast to numerical simulation methods that require several hours. [ABSTRACT FROM AUTHOR]

In wireless power transfer systems, the relative positional misalignment between transmitting and receiving coils significantly impacts the system's mutual inductance characteristics, thereby constraining the system's output power stability and transmission efficiency optimization potential. Hence, accurate formulas for calculating mutual inductance are crucial for optimizing coil structures and achieving mutual inductance stability. This study focuses on the mutual inductance characteristics of rectangular coils under positional misalignment conditions in a dual-sided electromagnetic shielding environment. Initially, the research deduces the incident magnetic flux density induced by the current in rectangular coils through the dual Fourier transform and magnetic vector potential method. Subsequently, Maxwell's equations and boundary conditions are employed to analytically examine the induced eddy currents within the shielding layer, allowing for the calculation of reflected magnetic flux density. Based on these analyses, the study derives a formula for mutual inductance using the magnetic flux density method. A prototype was built for experimental verification. The experiment results show that the maximum error between the measured mutual inductance and the calculated result is less than 3.8%, which verifies the feasibility and the accuracy of the proposed calculation method. Simulations and empirical validation demonstrate the superior accuracy and practicality of the proposed formula. This research not only offers an innovative technological pathway for enhancing the stability and efficiency of wireless power transfer systems but also provides a solid theoretical foundation and guiding framework for coil design and optimization. [ABSTRACT FROM AUTHOR]

Since the fiber optic gyroscope (FOG) is rigidly strapped down to the earth's crust, there are various errors that affect the universal time (UT1) measurements. In this paper, the errors caused by various physical factors and mechanisms are analyzed in detail, with precession and nutation errors being taken into account, and modeling of the observation equations based on precession and nutation error correction is proposed. The mapping relationship with UT1 is established based on this observation equation; after the corresponding error correction and VLBI calibration, the high-accuracy solution of UT1 is finally completed. Through 14-day measurement experiments under a room temperature environment without any vibration isolation and magnetic shielding devices, the error variation of UT1 solution compared with the earth orientation parameter (EOP) 14 C04 data is calculated at less than 3.57 ms, with UT1 solution accuracy improved by 56% compared with the traditional method. These results indicate that this work facilitates the study of giant FOG error modeling and correction, advancing our understanding of errors in giant FOG measurements and improving the accuracy of UT1 solution. [ABSTRACT FROM AUTHOR]

A novel screening platform based on an Fe3O4@C@PDA-Ni2+@COX-2 ligand fishing combination with high-performance liquid chromatography–mass spectrometry was first designed, synthesized, and employed to screen and identify COX-2 inhibitors from Panax notoginseng leaves. The obtained magnetic nanoparticles exhibit outstanding preconcentration ability that allows for controlling the enzyme orientation to avoid enzyme active site blocking, conformational changes, or denaturing during immobilization. The as-prepared Fe3O4@C@PDA-Ni2+@COX-2 composite was carefully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectrometry (FT-IR), Xray powder diffraction (XRD), thermal gravimetric analyzer (TGA), vibrating sample magnetometer (VSM), and Zeta potential analysis. The analytical parameters influencing the magnetic solid-phase fishing efficiency were optimized by univariate and multivariate methods (Box–Behnken design) by testing a positive control and celecoxib with active and inactive COX-2. Under the optimized ligand fishing conditions, twelve potential COX-2 inhibitors were screened and characterized in Panax notoginseng leaves. The results indicate that the proposed method provides a simple, feasible, selective, and effective platform for the efficient screening and identification of active compounds from Chinese herbal medicine. It has guiding significance for the synthesis and development of novel anti-inflammatory drugs, and provides a reference for the efficient discovery of anti-inflammatory drugs or lead compounds from the complex system of Chinese herbal medicine. [ABSTRACT FROM AUTHOR]

A demagnetization study was conducted on a magnetically shielded room (MSR) at Fraunhofer IPM, designed for applications such as magnetoencephalography (MEG) and material testing. With a composite of two layers of mu-metal and an intermediate aluminum layer, the MSR must provide a residual field under 5 nT for the successful operation of optically pumped magnetometers (OPMs). The degaussing process, employing six individual coils, reached the necessary residual magnetic field within the central 1 m3 volume in under four minutes. Due to the low-frequency shielding factor of 100, the obtained average residual field is shown to be limited by environmental residual field changes after degaussing and not by the degaussing procedure. [ABSTRACT FROM AUTHOR]

In the field of wireless power transmission (WPT) for electric vehicles, the challenge of magnetic shielding technology is particularly prominent. Achieving effective magnetic shielding often comes at the cost of transmission efficiency, creating a significant technical bottleneck. As a result, research into improving transmission efficiency while minimizing magnetic leakage has become a primary focus in the industry. This is seen as critical for driving the sustainable development of the electric vehicle sector. In response to this challenge, this paper presents the construction of an active magnetic shield using an isotropic coil configuration, which not only optimizes system efficiency but also significantly reduces magnetic leakage in WPT systems. The paper begins by introducing the concept of an active magnetically shielded isotropic coil structure for wireless power transmission. Next, it details the design methodology and operational principles of the structure, followed by the derivation of the mathematical model and equivalent circuit. The effectiveness of the magnetic shielding mechanism is examined from a theoretical standpoint, and the influence of coil parameters on both shielding performance and transmission efficiency is analyzed. Finally, based on the optimized coil parameters, the design of the wireless charging system incorporating the magnetic shielding structure is completed. This includes relevant theoretical calculations, simulation analyses, and experimental validation to confirm the feasibility of the design. The results demonstrate that the active magnetically shielded isotropic coil significantly reduces magnetic leakage, lowering it by approximately 95.68% compared to traditional coils, while achieving a transmission efficiency of 95.68% in experiments. [ABSTRACT FROM AUTHOR]

Energy loss in shielding soft magnetic materials at low frequencies (1–100 Hz) can cause fluctuations in the material's magnetic field, and the resulting magnetic noise can interfere with the measurement accuracy and basic precision physics of biomagnetic signals. This places higher demands on the credibility and accuracy of loss separation predictions. The current statistical loss theory (STL) method tends to ignore the high impact of the excitation dependence of quasi-static loss in the low-frequency band on the prediction accuracy. STL simultaneously fits and predicts multiple unknown quantities, causing its results to occasionally fall into the value boundary, and the credibility is low in the low-frequency band and with less data. This paper proposes a progressive loss decomposition (PLD) method. Through multi-step progressive predictions, the hysteresis loss simulation coefficients are first determined. The experimental data of the test ring verifies the credibility of PLD's prediction of the two hysteresis coefficients, improving the inapplicability of the STL method. In addition, we use the proposed method to obtain the prediction results of the low-frequency characteristics of the loss of a variety of typical soft magnetic materials, providing a reference for analyzing the loss characteristics of materials. [ABSTRACT FROM AUTHOR]

Magnetic-shielding technologies play a crucial role in the field of ultra-sensitive physical measurement, medical imaging, quantum sensing, etc. With the increasing demand for the accuracy of magnetic measurement, the performance requirements of magnetic-shielding devices are also higher, such as the extremely weak magnetic field, gradient, and low-frequency noise. However, the conventional method to improve the shielding performance by adding layers of materials is restricted by complex construction and inherent materials noise. This paper provides a comprehensive review about the enhancement of magnetic shielding in three aspects, including low-noise materials, magnetization control, and active compensation. The generation theorem and theoretical calculation of materials magnetic noise is summarized first, focusing on the development of spinel ferrites, amorphous, and nanocrystalline. Next, the principles and applications of two magnetization control methods, degaussing and magnetic shaking, are introduced. In the review of the active magnetic compensation system, the forward and inverse design methods of coil and the calculation method of the coupling effect under the ferromagnetic boundary of magnetic shield are explained in detail, and their applications, especially in magnetocardiography (MCG) and magnetoencephalogram (MEG), are also mainly described. In conclusion, the unresolved challenges of different enhancement methods in materials preparation, optimization of practical implementation, and future applications are proposed, which provide comprehensive and instructive references for corresponding research. [ABSTRACT FROM AUTHOR]

The present study investigated the 1H Nuclear Magnetic Resonance (NMR) spectra of hydrogen-rich water (HRW) produced using the EVObooster device. The analyzed HRW has pH = 7.1 ± 0.11, oxidation–reduction potential (ORP) of (−450 ± 11) mV, and a dissolved hydrogen concentration of 1.2 ppm. The control sample was tap water filtered by patented technology. A 600 NMR spectrometer was used to measure NMR spectra. Isotropic 1H nuclear magnetic shielding constants of the most stable clusters (H2O)n with n from 3 to 28 have been calculated by employing the gauge-including-atomic-orbital (GIAO) method at the MPW1PW91/6-311+G(2d,p) density function level of theory (DFT). The HRW chemical shift is downfield (higher chemical shifts) due to increased hydrogen bonding. More extensive formations were formed in HRW than in control filtered tap water. The exchange of protons between water molecules is rapid in HRW, and the 1H NMR spectra are in fast exchange mode. Therefore, we averaged the calculated chemical shifts of the investigated water clusters. As the size of the clusters increases, the number of hydrogen bonds increases, which leads to an increase in the chemical shift. The dependence is an exponential saturation that occurs at about N = 10. The modeled clusters in HRW are structurally stabilized, suggesting well-ordered hydrogen bonds. In the article, different processes are described for the transport of water molecules and clusters. These processes are with aquaporins, fusion pores, gap-junction channels, and WAT FOUR model. The exponential trend of saturation shows the dynamics of water molecules in clusters. In our research, the chemical shift of 4.257 ppm indicates stable water clusters of 4–5 water molecules. The pentagonal rings in dodecahedron cage H3O+(H2O)20 allow for an optimal arrangement of hydrogen bonds that minimizes the potential energy. [ABSTRACT FROM AUTHOR]

A wearable microgrid that centralizes and distributes harvested energy across different body regions can optimize power utilization and reduce overall battery weight. This setup underscores the importance of developing cable-free wireless power transfer (WPT) systems for mobile and portable devices to eliminate the risks posed by wired connections, especially in dynamic and hazardous environments. We introduce a thin, stretchable, and safe hand band capable of watt-level wireless charging through the widely adopted Qi protocol operating at 130 kHz. The implementation of non-adhesive fabric encapsulation serves to protect the 50-μm-thin spiral copper antenna from mechanical strain, ensuring an overall hand band stretchability of 50%. We also create a stretchable "Ferrofabric", characterized by a magnetic permeability of 11.3 and a tensile modulus of 75.3 kPa, that provides magnetic shielding for the antenna without compromising wearability. The "Ferrofabric" improves the coil inductance but induces core loss in AC application. By fully understanding and managing loss mechanisms such as the skin effect, proximity effect, core loss, and joule heating, we achieve a wireless charging efficiency of 71% and power delivery of 3.81 W in the kHz frequency range. Our WPT hand band is unobstructive to hand motion and can charge a handheld smartphone as fast as a desktop charger or power a battery-free chest-laminated e-tattoo sensor, with well-managed thermal and electromagnetic safety. Through a holistic electromagnetic, structural, and thermal design, our device culminates in a safe, rugged, and versatile solution for wearable WPT systems. [ABSTRACT FROM AUTHOR]

This study experimentally analyzed the impact of air gaps between a magnetic sheet and a test board with a microstrip line, which is used to measure the near-field magnetic shielding effectiveness (NSE) of magnetic sheets made of metallic powder. To conduct the measurements, a material fixture equipped with a microstrip line to generate the near magnetic field, a rectangular loop probe, and an automatic probe positioning system capable of moving the loop probe along three axes were designed and fabricated. In addition, to systematically vary the thickness of the gaps, three paper spacers with a thickness of 0.11 mm per paper were used, and a 1.0 mm thick acrylic sheet, along with a specially designed material fixture, was used to press down the magnetic sheets during measurement. The magnetic shielding properties were measured and compared under various air gap conditions using a near-field magnetic loop probe. The effect of the gaps on the shielding performance of the magnetic sheets was quantitatively evaluated for three different magnetic sheets. The experimental results showed that as the gap thickness increased, NSE tended to improve up to a frequency around 1 GHz, while in the higher frequency range of a few GHz, NSE tended to decrease. The physical background of this phenomenon was explained using an equivalent magnetic circuit represented by reluctances for the structure, where the magnetic sheet is placed above the microstrip line with an air gap. This model helps to elucidate how the presence of the air gap affects the near-field magnetic shielding performance. [ABSTRACT FROM AUTHOR]

In this paper, to address the low transmission efficiency problem caused by large magnetic leakage and insufficient antideviation performance, an integrated symmetrical coil (ISC) structure is proposed. The ISC structure eliminates the need for an external active shielding coil to counteract the leaked magnetic field, and enhances anti-offset performance by utilizing an integrated coil. Additionally, a deep learning-based method for optimizing the coil structure is employed to determine the optimal parameters. The theoretical simulation is validated using Maxwell software, and based on this, the design and parameters of the ferrite structure are adjusted to improve the magnetic shielding effect and transmission efficiency of the coil. Subsequently, a 2 kW prototype experiment is conducted to validate the findings. Results indicate that when the ISC structure is offset by 200 mm in the X-direction, the research demonstrates that the coupling coefficient fluctuation remains below 5%, achieving a transmission efficiency of up to 96.37%. Furthermore, the magnetic leakage is significantly reduced to below 27 µT at 800 mm on both sides of the door in the X-direction. [ABSTRACT FROM AUTHOR]

13C and 1H NMR spectra were observed as the function of density in 1,2-13C-enriched ethane and ethylene for the pure gaseous compounds and their binary mixtures with xenon and carbon dioxide gases as the solvents. All the chemical shifts and indirect spin–spin couplings were linearly dependent on the solvent density. The appropriate NMR parameters (σ and nJ) in isolated 13C2H6 and 13C2H4 molecules and the coefficients responsible for the binary molecular interactions were determined and compared with previous similar measurements and selected calculated shielding data. The newly obtained 13C shielding values in the isolated ethane and ethylene molecules suggest visible secondary isotope effects due to the additional carbon-13 atom. All the investigated shielding parameters depend on intermolecular interactions, and the dependence of 13C shielding is much more marked. In contrast, the indirect spin–spin couplings in 13C2H6 and 13C2H4 molecules are almost independent of solvent molecules. Their nJ values determined in liquids over sixty years ago are generally consistent with the same nJ parameters in isolated 13C2H6 and 13C2H4 molecules. [ABSTRACT FROM AUTHOR]

Caffeine is an alkaloid with a purine structure and has been well known for centuries due to its presence in popular drinks—tea and coffee. However, the structural and spectroscopic parameters of this compound, as well as its chemical and biological activities, are still not fully known. In this study, for the first time, we report on the measured oxygen-17 NMR spectra of this stimulant. To support the assignment of our experimental NMR data, extensive quantum chemical calculations of NMR parameters, including nuclear magnetic shielding constants and indirect spin–spin coupling constants, were performed. In a theoretical study, using nine efficient density functionals (B3LYP, BLYP, BP86, CAM-B3LYP, LC-BLYP, M06, PBE0, TPSSh, wB97x), and in combination with a large and flexible correlation-consistent aug-cc-pVTZ basis set, the structure and NMR parameters were predicted for a free molecule of caffeine and in chloroform, DMSO and water. A polarized continuum model (PCM) was used to include a solvent effect. As a result, an optimal methodology was developed for predicting reliable NMR data, suitable for studies of known, as well as newly discovered, purines and similar alkaloids. The results of the current work could be used in future basic and applied studies, including NMR identification and intermolecular interactions of caffeine in various raw materials, like plants and food, as well as in the structural and spectroscopic characterization of new compounds with similar structures. [ABSTRACT FROM AUTHOR]

We report direct measurements of the magnetic field screening at the limits of the Meissner phase for two superconducting niobium (Nb) samples. The samples are processed with two different surface treatments that have been developed for superconducting radio-frequency (SRF) cavity applications—a "baseline" treatment and an oxygen-doping ("O-doping") treatment. The measurements show: (1) that the screening length is significantly longer in the "O-doping" sample compared to the "baseline" sample; (2) that the screening length near the limits of the Meissner phase increases with applied field; (3) the evolution of the screening profile as the material transitions from the Meissner phase to the mixed phase; and (4) a demonstration of the absence of any screening profile for the highest applied field, indicative of the full flux entering the sample. Measurements are performed utilizing the β -detected nuclear magnetic resonance (β -NMR) technique that allows depth resolved studies of the local magnetic field within the first 100 nm of the surface. The study takes advantage of the β -SRF beamline, a new facility at TRIUMF, Canada, where field levels up to 200 mT are available parallel to the sample surface to replicate radio frequency fields near the Meissner breakdown limits of Nb. [ABSTRACT FROM AUTHOR]

Magnetoencephalography (MEG) systems are advanced neuroimaging tools used to measure the magnetic fields produced by neuronal activity in the human brain. However, they require significant amounts of liquid helium to keep the superconducting quantum interference device (SQUID) sensors in a stable superconducting state. Additionally, MEG systems must be installed in a magnetically shielded room to minimize interference from external magnetic fields. We have developed an advanced MEG system that incorporates a superconducting magnetic shield and a zero-boil-off system. This system overcomes the typical limitations of traditional MEG systems, such as the frequent need for liquid helium refills and the spatial constraints imposed by magnetically shielded rooms. To validate the system, we conducted an evaluation using signal source estimation. This involved a phantom with 50 current sources of known location and magnitude under active zero-boil-off conditions. Our evaluations focused on the precision of the magnetic field distribution and the quantification of estimation errors. We achieved a consistent magnetic field distribution that matched the source current, maintaining an estimation error margin within 3.5 mm, regardless of the frequency of the signal source current. These findings affirm the practicality and efficacy of the system. [ABSTRACT FROM AUTHOR]

Simple Summary: The effects of magnetic fields on health and disease have been subject to considerable research interest for the past few decades but still remain relatively poorly understood. Therefore, the identification of molecular and cellular pathways affected is of considerable importance. This study investigated the effects of very low magnetic field (LMF) exposure in a cellular model of prostate cancer (PCa), the second most common cancer diagnosed in men. Extracellular vesicles (EVs) are lipid structures released from and taken up by cells and play crucial roles in cell communication and in processes such as cancer spread via their protein and nucleic acid cargoes. Short-term (4 h) LMF exposure significantly altered the release profiles and protein content of EVs from PCa cells to a more pro-cancerous profile. We then investigated changes in several key micro-RNAs, which are regulators of cancer behaviour and indicators of cancer aggressiveness and metastasis. LMF exposure caused significant upregulation of three key oncogenic miRNAs (miR-155, miR-21, and miR-210) and significant downregulation of two key tumour-suppressive miRNAs (miR-126 and miR-200c) in the PCa cells. These changes were also associated with a significant increase in the cancer cells' invasion capability, which is a key indicator of cancer aggressiveness. We further verified the metastatic ability of the cancer cells caused by the LMF exposure by assessing two metastasis-related proteins, matrix metalloproteinases MMP2 and MMP9, which both were significantly increased. We compared these findings with normal prostate cells, which showed fewer changes in response to LMF exposure. Our findings suggest that LMF exposure may promote a more aggressive cancer phenotype by modulating key molecular and cellular pathways, highlighting the potential therapeutic implications of magnetic field modulation in cancer treatment. Prostate cancer is the second most common neoplasia and fifth-leading cause of cancer death in men worldwide. Electromagnetic and magnetic fields have been classified as possible human carcinogens, but current understanding of molecular and cellular pathways involved is very limited. Effects due to extremely low magnetic/hypomagnetic fields (LMF) are furthermore poorly understood. Extracellular vesicles (EVs) are crucial mediators of cellular communication with multifaceted roles in cancer progression, including via transport and uptake of various protein and microRNA (miRNA) EV-cargoes. miRNAs regulate gene expression and are implicated in cancer-related processes such as proliferation, metastasis, and chemoresistance. This study investigated the effects of LMF exposure (20 nT) by magnetic shielding on the prostate cancer cell line PC3 compared to the prostate epithelial cell line PNT2 under short-term (4 h) conditions. We examined EV profiles following a 4 h LMF exposure alongside associated functional enrichment KEGG and GO pathways for the EV proteomes. The 4 h LMF exposure significantly reduced cellular EV release and modified PC3 EV cargoes to a more inflammatory and metastatic profile, with 16 Disease Pathways and 95 Human Phenotypes associated specifically with the LMF-treated PC3 EV proteomes. These included cancerous, metabolic, blood, skin, cardiac and skeletal Disease Pathways, as well as pain and developmental disorders. In the normal PNT2 cells, less EV protein cargo was observed following LMF exposure compared with cells not exposed to LMF, and fewer associated functional enrichment pathways were identified. This pointed to some differences in various cellular functions, ageing, defence responses, oxidative stress, and disease phenotypes, including respiratory, digestive, immune, and developmental pathways. Furthermore, we analysed alterations in matrix metalloproteinases (MMPs) and miRNAs linked to metastasis, as this is crucial in cancer aggressiveness. The 4 h LMF exposure caused a significant increase in MMP2 and MMP9, as well as in onco-miRs miR-155, miR-210, miR-21, but a significant reduction in tumour-suppressor miRs (miR-200c and miR-126) in the metastatic PC3 cells, compared with normal PNT2 cells. In addition, 4 h LMF exposure significantly induced cellular invasion of PC3 cells. Overall, our findings suggest that changes in magnetic field exposures modulate EV-mediated and miR-regulatory processes in PCa metastasis, providing a basis for exploring novel therapeutic strategies. [ABSTRACT FROM AUTHOR]

Tropomyosin kinase receptor B (TrkB) has been explored as a therapeutic target for neurological and psychiatric disorders. However, the development of TrkB agonists was hindered by our poor understanding of the TrkB agonist binding location and affinity (both affect the regulation of disorder types). This motivated us to develop a combined computational and experimental approach to study TrkB binders. First, we developed a docking method to simulate the binding affinity of TrkB and binders identified by our magnetic drug screening platform from Gotu kola extracts. The Fred Docking scores from the docking computation showed strong agreement with the experimental results. Subsequently, using this screening platform, we identified a list of compounds from the NIH clinical collection library and applied the same docking studies. From the Fred Docking scores, we selected two compounds for TrkB activation tests. Interestingly, the ability of the compounds to increase dendritic arborization in hippocampal neurons matched well with the computational results. Finally, we performed a detailed binding analysis of the top candidates and compared them with the best-characterized TrkB agonist, 7,8-dyhydroxyflavon. The screening platform directly identifies TrkB binders, and the computational approach allows for the quick selection of top candidates with potential biological activities based on the docking scores. [ABSTRACT FROM AUTHOR]

Decades of research have shown that magnetocardiography (MCG) has the potential to improve cardiac care decisions. However, sensor and system limitations have prevented its widespread adoption in clinical practice. We report an MCG system built around an array of scalar, optically pumped magnetometers (OPMs) that effectively rejects ambient magnetic interference without magnetic shielding. We successfully used this system, in conjunction with custom hardware and noise rejection algorithms, to record magneto-cardiograms and functional magnetic field maps from 30 volunteers in a regular downtown office environment. This demonstrates the technical feasibility of deploying our device architecture at the point-of-care, a key step in making MCG usable in real-world settings. [ABSTRACT FROM AUTHOR]

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare autosomal-dominant disorder caused by a heterozygous germline mutation in the fumarate hydratase (FH) gene. HLRCC is clinically characterized by the development of three tumors: uterine leiomyomata, cutaneous leiomyomata, and renal cell carcinoma (RCC). HLRCC-associated RCC is aggressive and diagnosed at a much earlier age than sporadic RCC. It is essential for carriers of HLRCC to undergo annual renal screening by magnetic resonance imaging to detect early stage RCCs. Metastatic HLRCC-associated RCC must be treated by systemic therapy; however, it is unclear which medicines are most effective in treating this cancer owing to its low incidence rate. Immune checkpoint inhibitor (ICI) combinations or ICIs plus tyrosine kinase inhibitors are administered as systemic therapy for clear cell RCC. Here, we report a patient with HLRCC-associated RCC treated with sequential therapy, including ipilimumab plus nivolumab combination and cabozantinib, after diagnosis of HLRCC-associated RCC using FoundationOne Liquid CDx and single-site analysis. We also investigated familial FH mutations and describe a new family pedigree for HLRCC. [ABSTRACT FROM AUTHOR]

We report high throughput computational screening for magnetic ground state order in 2D materials. The workflow is based on spin spiral calculations and yields the magnetic order in terms of a two-dimensional ordering vector Q. We then include spin-orbit coupling to extract the easy and hard axes for collinear structures and the orientation of spiral planes in non-collinear structures. Finally, for all predicted ferromagnets we compute the Dzyaloshinskii-Moriya interactions and determine whether or not these are strong enough to overcome the magnetic anisotropy and stabilise a chiral spin spiral ground state. We find 58 ferromagnets, 21 collinear anti-ferromagnets, and 85 non-collinear ground states of which 15 are chiral spin spirals driven by Dzyaloshinskii-Moriya interactions. The results show that non-collinear order is in fact as common as collinear order in these materials and emphasise the need for detailed investigation of the magnetic ground state when reporting magnetic properties of new materials. [ABSTRACT FROM AUTHOR]

Cobalt bismuth nano-ferrite (Co/Bi) with the chemical formula CoBi0.02Fe1.98O4 was produced using a simple flash auto-combustion method at three different temperatures: as-prepared, 600°C, and 800°C. A single-phase spinel structure was confirmed using X-ray diffraction, and the nano-scale morphology was examined using AFM (atomic force microscopy). Magnetic measurements demonstrated that increasing the annealing temperature increased the saturation magnetization Ms by 1.3 times. However, the coercivity Hc changed from semi-hard ferrite (as-prepared sample) to soft ferrite (Co/Bi nano-ferrite at 800°C) and reduced 10.7 times that of as-prepared nanoparticles. Therefore, the 800°C Co/Bi nano-ferrite with a low coercive field is recommended for transformers, recording heads, inductor cores, magnetic shielding, and microwave devices. The as-prepared sample and that at 600°C displayed super-high microwave frequency (SHF) in the X band in high-frequency applications calculated from magnetic measurement. The 800°C sample also has an extremely high microwave frequency in the Ku band, which is utilized in radar and satellite communications. Antimicrobial characterization showed that raising the annealing temperature increased the effectiveness of the samples against tested microorganisms. Thus, the samples under investigation are highly suggested for ultra-high microwave frequency applications and biological antibacterial nanomaterials. [ABSTRACT FROM AUTHOR]

Background: After initial COVID-19, immune dysregulation may persist and drive post-acute sequelae of COVID-19 (PASC). We described longitudinal trajectories of cytokines in adults up to 6 months following SARS-CoV-2 infection and explored early predictors of PASC. Methods: RECoVERED is a prospective cohort of individuals with laboratory-confirmed SARS-CoV-2 infection between May 2020 and June 2021 in Amsterdam, the Netherlands. Serum was collected at weeks 4, 12 and 24 of follow-up. Monthly symptom questionnaires were completed from month 2 after COVID-19 onset onwards; lung diffusion capacity (DLCO) was tested at 6 months. Cytokine concentrations were analysed by human magnetic Luminex screening assay. We used a linear mixed-effects model to study log-concentrations of cytokines over time, assessing their association with socio-demographic and clinical characteristics that were included in the model as fixed effects. Results: 186/349 (53%) participants had ≥2 serum samples and were included in current analyses. Of these, 101/186 (54%: 45/101[45%] female, median age 55 years [IQR = 45–64]) reported PASC at 12 and 24 weeks after COVID-19 onset. We included 37 reference samples (17/37[46%] female, median age 49 years [IQR = 40–56]). In a multivariate model, PASC was associated with raised CRP and abnormal diffusion capacity with raised IL10, IL17, IL6, IP10 and TNFα at 24 weeks. Early (0–4 week) IL-1β and BMI at COVID-19 onset were predictive of PASC at 24 weeks. Conclusions: Our findings indicate that immune dysregulation plays an important role in PASC pathogenesis, especially among individuals with reduced pulmonary function. Early IL-1β shows promise as a predictor of PASC. [ABSTRACT FROM AUTHOR]

In the wireless power transfer (WPT) system of electric vehicles, reducing magnetic leakage and minimizing the use of magnetic shielding materials while maintaining transmission efficiency are difficult problems. To this end, a single-hole compensated passive magnetic shielding structure is proposed in this paper, with the system’s magnetic leakage reduced and transmission efficiency improved through metal shielding and passive shielding. First, the magnetic shielding principles and design concepts of the magnetic core, aluminum plate, and passive shielding coils are analyzed. The single-hole compensated passive magnetic shielding structure is proposed, and then a mathematical model of the structure is derived. Second, an optimization method is proposed, using Matlab and Ansys Maxwell software to reduce the volume of metallic materials while keeping magnetic leakage within a safe range. Finally, a WPT device based on the proposed structure is constructed according to the optimized magnetic shielding and coil parameters, and the effectiveness of the structure is validated through simulation and experimentation. The results demonstrate that when the system output power is 4 kW, leakage is reduced by 62.7% compared to the single-hole unshielded coil structure using the same materials with the proposed structure. Compared to the all-aluminum plate and all-magnetic core structure, not only is leakage reduced by 1.2%, but there is also a reduction of 40.4% in magnetic core usage and 30.1% in aluminum plate usage. Moreover, the transmission efficiency reaches 93.49%. [ABSTRACT FROM AUTHOR]

In the design of wireless power transfer (WPT) systems for electric vehicles, minimizing magnetic leakage while maintaining high transmission efficiency is a challenging problem. To this end, a novel structure featuring dual transmitting coils and a ring-series magnetic shielding coil (RMSDT) is proposed to reduce magnetic leakage during system charging, thereby enhancing system safety performance. Additionally, the Particle Swarm Optimization (PSO) algorithm is employed to optimize system parameters, aiming to achieve high transmission efficiency while maintaining low magnetic leakage. To validate the effectiveness of the proposed design, a shielded WPT system for electric vehicles has been developed. Its performance is verified through a combination of experiments and simulations. The results demonstrate that the PSO algorithm significantly enhances transmission efficiency compared to traditional optimization methods. At an output power of 3.7 kW, the peak transmission efficiency exceeds 95%, representing an improvement of 4.63% compared to the conventional for-loop algorithm. Furthermore, the leakage magnetic field of the RMSDT structure in the target region is only 16.08 µT, which is effectively reduced by 41.8% compared to the conventional WPT structure and sacrifices only 0.21% transmission efficiency. In summary, this paper can provide some references to the safety and efficiency of electric vehicle WPT. [ABSTRACT FROM AUTHOR]

The present study derives the Hartree-Fock equations for multi-electron systems by solving the Hartree-Fock equations via algebraic approximation, or Hartree-Fock-Ruthan (H-F-R), utilizing the electron density functions (r1, r2). a method using Slater-type atomic orbitals to determine the relationship between the orbitals and the examined atomic properties of the determined atomic numbers. The radial density distribution function D(r1) for one electron, and the anticipated values of one-particle 〈r_1^n 〈 for two-electrons in orbital (2S2) are the features examined in this investigation. Also, the selected atoms have atomic numbers between 4 and 15. The outcome demonstrated that as the atomic number (Z) climbed, so did the maximum values of D (r1) and the expected value. Additionally, the nuclear magnetic shielding constant [ (σ] _d) increased as Z increased, the equations have been programmed in Mathematics 2001i and all calculations have been calculated in atomic units. [ABSTRACT FROM AUTHOR]

Aim. Development of the method for designing electromagnetic hybrid active-passive shield, consisting from active and multy-circuit passive parts, which is characterized by increased effectiveness of reducing the industrial frequency magnetic field created by twocircuit overhead power lines in residential buildings. Methodology. The designing problem of electromagnetic hybrid active-passive shield including robust system of active shielding and multy-circuit passive shield of initial magnetic field comes down to a solution of the multy-criteria two-player zero-sum antagonistic game. The game payoff vector calculated based on the finite element calculations system COMSOL Muliphysics. The game solution calculated based on the particles multyswarm optimization algorithms. Results. During the design of the electromagnetic hybrid active-passive shield the coordinates of the spatial arrangement of 11 circuits passive shield and the coordinates of the spatial location of one compensation winding, as well as the current and phase in this winding of the active shielding system are calculated. The results of theoretical and experimental studies of hybrid active and multy-circuit passive shield by magnetic field in residential building from two-circuit power transmission line with a «Barrel» type arrangement of wires presented. Originality. For the first time the method for designing hybrid active and multycircuit passive shield, consisting from active and multy-circuit passive parts, which is characterized by increased effectiveness of reducing the magnetic field of industrial frequency created by two-circuit overhead power lines in residential buildings is developed. Practical value. Based on results of calculated study the shielding efficiency of the initial magnetic field what is confirmed by experimental studies determined that shielding factors whith only multy-circuit passive shield is more 1.2 units, whith only active shield is more 4 units and with electromagnetic hybrid active-passive shield is more 6.2 units. It is shown the possibility to reduce the level of magnetic field induction in residential building from two-circuit power transmission line with a «Barrel» type arrangement of wires by means of electromagnetic hybrid active shielding with single compensating winding and multy-circuit passive shielding with 11 circuit passive shield to 0.5 μT level safe for the population. References 51, figures 17. [ABSTRACT FROM AUTHOR]

Preclinical disease models are important for the advancement of therapeutics towards human clinical trials. One of the difficult tasks of developing a well-characterized model is having a reliable modality with which to trend the progression of disease. Acute rejection is one of the most devastating complications that can occur following organ transplantation. Specifically in cardiac transplantation, approximately 12% of patients will experience at least one episode of moderate or severe acute rejection in the first year. Currently, the gold standard for monitoring rejection in the clinical setting is to perform serial endomyocardial biopsies for direct histological assessment. However, this is difficult to reproduce in a porcine model of acute rejection in cardiac transplantation where the heart is heterotopically transplanted in an abdominal position. Cardiac magnetic resonance imaging is arising as an alternative for serial screening for acute rejection in cardiac transplantation. This is an exploratory study to create and define a standardized cardiac magnetic resonance screening protocol for characterizing changes associated with the presence of acute rejection in this preclinical model of disease. Results demonstrate that increases in T1 mapping, T2 mapping, left ventricular mass, and in late gadolinium enhancement are significantly correlated with presence of acute rejection. [ABSTRACT FROM AUTHOR]

The origin of nuclear magnetic shielding in diamagnetic molecules is discussed, pointing out various contributions to the shielding from electrons and the effects of intra- and intermolecular interactions. In NMR practice, chemical shifts are determined first as the measure of shielding in observed samples. The descriptions of shielding and chemical shifts are not fully consistent. Gas phase studies permit the withdrawal of intermolecular contributions from shielding and obtaining the magnetic shielding data in isolated molecules. The shielding determination in molecules is possible using at least three methods delivering the reference shielding standards for selected nuclei. The known shielding of one magnetic nucleus can be transferred to other nuclei if the appropriate nuclear magnetic moments are available with satisfactory accuracy. It is possible to determine the nuclear magnetic dipole moments using the most advanced ab initio shielding calculations jointly with the NMR frequencies measurements for small-sized isolated molecules. Helium-3 gas is postulated as all the molecules' primary and universal reference standard of shielding. It can be easily applied using common deuterium lock solvents as the secondary reference standards. The measurements of absolute shielding are available for everyone with the use of standard NMR spectrometers. [ABSTRACT FROM AUTHOR]

Fermi National Accelerator Laboratory (FNAL) and Lawrence Berkeley National Laboratory (LBNL) are building a new High Field Vertical Magnet Test Facility (HFVMTF) for testing superconducting cables in high magnetic field. The background magnetic field of 15 T in the HFVMTF will be produced by a magnet provided by LBNL. The HFVMTF is jointly funded by the US DOE Offices of Science, High Energy Physics (HEP), and Fusion Energy Sciences (FES), and will serve as a superconducting cable test facility in high magnetic fields and a wide range of temperatures for HEP and FES communities. This facility will also be used to test high-field superconducting magnet models and demonstrators, including hybrid magnets, produced by the US Magnet Development Program (MDP). The paper describes the status of the facility, including construction, cryostat designs, top and lambda plates, and systems for powering, and quench protection and monitoring.

This document is an author correction to a previous article published in Nature Communications titled "Magnetic field screening in hydride superconductors." The correction challenges the claims made in the original article regarding the evidence for superconductivity in sulfur hydride and lanthanum hydride. The correction argues that the data presented in the original article were obtained through nonlinear transformations, rendering the conclusions invalid. The author calls for the release of the measured data to establish a clear relation between the published data and the actual measurements. Further discussion and implications of the magnetization data are provided in additional references. [Extracted from the article]

This paper proposes a reactive shield structure to reduce the leakage magnetic field of a wireless power transfer (WPT) system with a dipole coil structure. The reactive shield resonates at a frequency lower than that of the WPT system and operates in an inductive region where the reactance is positive. Therefore, the magnetic field generated by the shield coil is 180° different in phase from that generated by the transmitting coil, resulting in an effective reduction in the leakage magnetic field. The methodology for designing the reactive shield for the dipole coil structure is mathematically analyzed, and the current and magnetic field phases are compared. Its effectiveness has been validated through simulations and experiments. Specifically, the proposed method is validated through a 50 W class WPT experiment, which showed that the proposed shielding structure achieves efficiency reductions ranging from 0.3% to 1.5% and has a leakage magnetic field reduction effect of up to 67% compared to the comparison groups. [ABSTRACT FROM AUTHOR]

Development of the method of designing a combined electromagnetic shield, consisting of active and passive parts, to improve the effectiveness of reduction of industrial frequency magnetic field created by two-circuit overhead power lines in residential buildings. Methodology. The problem of design of combined electromagnetic shield including robust system of active shielding and electromagnetic passive shield of initial magnetic field solved based on of the multi-criteria two-player antagonistic game. The game payoff vector calculated based on the finite element calculations system COMSOL Muliphysics. The game solution calculated based on the particles multiswarm optimization algorithms. During the design of combined electromagnetic shields spatial location coordinates of shielding winding, the currents and phases in the shielding winding of active shielding, geometric dimensions and thickness of the electromagnetic passive shield are calculated. Results. The results of theoretical and experimental studies of combined electromagnetic passive and active shielding of magnetic field in residential building from power transmission line with a «Barrel» type arrangement of wires presented. Originality. For the first time the method of designing a combined electromagnetic shield, consisting of active and passive parts, for more effective reduction of the magnetic field of industrial frequency created by two-circuit overhead power lines in residential buildings is developed. Practical value. Based on results of calculated and experimental study the shielding efficiency of the initial magnetic field determined that shielding factors whith only electromagnetic passive shield is more 2 units, whith only active shield is more 4 units and with combined electromagnetic passive and active shield is more 10 units. It is shown the possibility to reduce the level of magnetic field induction in residential building from power transmission line with a «Barrel» type arrangement of wires by means of a combined electromagnetic passive and active shielding with single compensating winding to 0.5 μT level safe for the population. [ABSTRACT FROM AUTHOR]

The magnetic shielding device, made of high-permeability soft magnetic material, is sensitive to external influences and requires a protective steel enclosure. A steel enclosure, being strongly ferrimagnetic, can alter the surrounding magnetic field distribution, thus impacting the shielding effectiveness. This study proposes a novel analytical approach to quantify this effect, which has not been previously researched. The method develops a simplified finite element simulation model based on the structural symmetry of the steel enclosure. By using this model, this study analyzes the impact of steel structures with varying heights, widths, and remanent magnetization values. The validity of the method is confirmed through experimental tests on steel buildings. The findings offer insights into the optimal placement of magnetic shielding systems and provide theoretical guidance for designing large-scale magnetic shielding devices. [ABSTRACT FROM AUTHOR]

Magnetic Scanning Microscopy (MSM) emerged with the aim of allowing the visualization of magnetic fields of a sample or material through scanning and proved particularly useful for geology, biomedicine, characterization of magnetic materials, and in the steel industry. In this regard, the reading system of an MSM was modified using a μ-metal magnetic shielding structure to analyze remanent fields. The MSM was adapted to perform readings using two different types of sensors. The sensitive area of the sensors was evaluated, and the HQ-0811 (AKM—Asahi KaseiTM Microdevices) and STJ-010 (Micro MagneticsTM) sensors were chosen, with the HQ-0811 standardized on Printed Circuit Boards (PCBs) to facilitate handling and increase the system's robustness. In the shielded chamber, two piezoelectric ANC-150 stepper motors (Attocube Systems) were used, arranged planarly, to allow the movement of the analyzed samples under the mounted sensors. To acquire data from the sensors, the Precision Current Source Model 6220 and the Nanovoltmeter Model 2182A (both from Keithley) were used, along with Keithley's Delta-Mode integrated system. To analyze the system's effectiveness, three distinct samples were analyzed for calibration, and a MATLAB program was written to analyze the images and extract the material's magnetization. Additionally, a rock sample from the Parnaíba Basin was mapped to demonstrate the system's capabilities. [ABSTRACT FROM AUTHOR]

Fluorescent‐magneto nanoemitters have gained considerable attention for their applications in mechanical controlling‐assisted optical signaling. However, the incompatibility between magnetic and fluorescent components often leads to functional limitations in traditional magneto@fluorescence nanostructure. Herein, we introduce a new compact‐discrete spatial arrangement on a "fluorescence@magneto" core–shell nanostructure consisting of a close‐packed aggregation‐induced emission luminogen (AIEgen) core and a discrete magnetic shell. This structural design effectively eliminates the optical and magnetic interferences between the dual components by facilitating AIEgens loading in core region and reducing the magnetic feeding amount through effective exposure of the magnetic units. Thereby, the resulting magneto‐AIEgen nanoparticle (MANP) demonstrates "win‐win" performances: (i) high fluorescent intensity contributed by AIEgens stacking‐enhanced photoluminescence and reduced photons loss from the meager magnetic shell; (ii) marked magnetic activity due to magneto extraposition‐minimized magnetic shielding. Accordingly, the dual functions‐retained MANP provides a proof of concept for construction of an immunochromatographic sensing platform, where it enables bright fluorescent labeling after magnetically enriching and separating procalcitonin and lipoarabinomannan in clinical human serum and urine, respectively, for the clinical diagnosis of bacterial infections‐caused inflammation and tuberculosis. This study not only inspires the rational design of magnetic‐fluorescent nanoemitter but also highlights promising potential in magneto‐assisted point‐of‐care test and biomedicine applications. [ABSTRACT FROM AUTHOR]

The current electric vehicles (EVs) market is experiencing significant expansion, underscoring the need to address challenges associated with the limited driving range of EVs. A primary focus in this context is the improvement of the wireless charging process. To contribute to this research area, this study introduces a circular spiral coil design that incorporates transceiver coils. First, an in-depth analysis is conducted using Ansys Maxwell software to assess the effectiveness of the proposed solution through the magnetic field distribution, inductance properties, and mutual inductance between receiver and transmitter coils. In the next step, a direct shielding technique is applied, integrating a ferrite core bar to reduce power leakage and enhance power transmission efficiency. The ferrite magnetic shielding guides magnetic field lines, resulting in a significant reduction in flux leakage and improved power transmission. Lastly, a magnetic resonance series (SS) compensation wireless system is developed to achieve high coupling efficiency and superior performance. The system's effectiveness is evaluated through co-simulation using Ansys Simplorer software. The results confirm the effectiveness of the proposed solution, showing its ability to transmit 3.6 kilowatts with a success rate approaching 99%. This contribution significantly advances the development of wireless charging systems for electric vehicles, addressing concerns and promoting global adoption. [ABSTRACT FROM AUTHOR]

Considering the magnetic shielding requirements of both geomagnetic field and 50 Hz power-line frequency in the complex working conditions of the power grid, an electromagnetic shielding system combining active and passive modes is proposed in this article. A three-dimensional Helmholtz coil with a magnetic shielding barrel nested inside is established by the COMSOL simulation tool, and the magnetic shielding efficiency of the system is analyzed. Comparing different materials, the simulation results indicate that permalloy alloy exhibits better shielding performance than pure iron and nickel materials. Additionally, the overall shielding efficiency of the shielding barrel increases linearly with the number of multiple layers. Under the combined active and passive electromagnetic shielding conditions, the system achieves a shielding efficiency of SE = 113.98 dB, demonstrating excellent performance in shielding both AC and DC interference magnetic fields. This study provides theoretical guidance for the construction of magnetic shielding systems in electromagnetic interference environment. [ABSTRACT FROM AUTHOR]

Lithium salts continue to find pharmaceutical applications, particularly as psychiatric medications. As with any active pharmaceutical ingredient, structural polymorphism is an important concern for lithium-based medications that can influence solubility and other physicochemical properties. Here we report a 13C, 1H, and 7Li magic-angle spinning solid-state nuclear magnetic resonance (MAS SSNMR) study of two 1:1 polymorphic ionic cocrystals of lithium 4-methoxybenzoate and L-proline (L4MPRO(α) and L4MPRO(β)). One-dimensional 13C cross-polarization MAS and two-dimensional heteronuclear correlation NMR spectra hint at differential mobilities of the proline and benzoate moieties for the two polymorphs. Five key resonances differ in 13C chemical shift by more than 1 ppm between the two polymorphs, clearly distinguishing between them. Gauge-including projector-augmented-wave density functional theory calculations of 13C and 1H magnetic shielding constants correlate strongly with the experimental chemical shifts for both polymorphs. R2 and root-mean-square deviation metrics are shown to be insufficient in the case of 13C, but sufficient in the case of 1H, for differentiating between the polymorphs. 7Li satellite-transition MAS NMR of both polymorphs are identical, as are the computed lithium magnetic shielding constants, demonstrating the insensitivity of 7Li NMR to polymorphism in these samples. This work highlights the utility of solid-state NMR spectroscopy for examining ionic salt cocrystals and also highlights some caveats in this regard. [ABSTRACT FROM AUTHOR]

Inertial sensors that measure the acceleration of ultracold atoms promise unrivalled accuracy compared to classical equivalents. However, atomic systems are sensitive to various perturbations, including magnetic fields, which can introduce measurement inaccuracies. To address this challenge, we have designed, manufactured, and validated a magnetic field stabilisation system for a quantum sensor based on atom interferometry. We solve for the magnetic field generated by surface currents in-between a pair of bi-rectangular coils and approximate the surface current using discrete wires. The wires are wound by-hand onto machined panels which are retrofitted onto the existing mounting structure of the sensor without interfering with any experimental components. Along the central 60mm of the y-axis, which aligns with the trajectory of the atoms during interferometry, the coils are measured to generate an independent uniform axial magnetic field with a strength of Bz=22.81±0.01 μT/A [mean±2σstd. error] and an independent linear axial field gradient of strength dBz/dy=10.6±0.1 μT/Am. The uniform Bz field is measured to deviate by a maximum value of 1.3% in the same region, which is a factor of three times more uniform than the previously-used on-sensor rectangular Bz compensation set.

Insulation failure significantly contributes to the unpredictable shutdown of power equipment. Compared to the partial discharge and high-frequency (HF) injection methods, the HF common-mode (CM) leakage current method offers a non-intrusive and highly sensitive alternative. However, the detection of HF CM currents is susceptible to interference from differential-mode (DM) currents, which exhibit high-amplitude and multifrequency components during normal operation. To address this challenge, this paper proposes a double-ring current sensor based on the principle of magnetic shielding for inverter-fed machine winding insulation monitoring. The inner ring harnesses the magnetic aggregation effect to isolate the DM current magnetic field, whereas the outer ring serves as the magnetic core of the Rogowski current sensor, enabling HF CM current monitoring. First, the magnetic field distributions of the CM and DM currents were analyzed. Then, a correlation between the sensor parameters and signal-to-noise ratio of the target HF CM current was established. Finally, an experimental study was conducted on a 3-kW PMSM for verification. The results indicate that the proposed double-ring HF CM sensor can effectively mitigate DM current interference. Compared to a single-ring sensor, a reduction of approximately 40% in the DM component was achieved, which significantly enhanced the precision of online insulation monitoring.

Compact and robust optical clocks are significant in scientific research and engineering. Here, we present a physical system for a strontium atomic optical clock with dimensions of 465 mm × 588 mm × 415 mm and a weight of 66.6 kg. To date, this is one of the most compact physical systems ever reported. The application of the magnetic shielding box in this physical system allowed the effect of external magnetic field fluctuation on cold atoms to be negligible. The physical system passed rigorous environmental tests and remained operational. A wavelength meter integrated in this physical system could monitor the wavelengths of the incident laser, and it could automatically calibrate the wavelengths of all lasers using a microcomputer. This compact and robust physical system could be a hardware basis for demonstrating a portable optical clock or even a space optical clock. [ABSTRACT FROM AUTHOR]

The relatively fragile low-temperature stability of cryogen-free superconducting magnetic resonance imaging (MRI) magnets requires the careful management of exogenous heat sources. A strongly shielded gradient magnetic field is important for the optimal operation of cryogen-free MRI systems. In this study, we present an enhanced shielding method incorporating a regionalized stray field constraining strategy. By optimizing the constraint parameters, we could develop engineering-feasible gradient coil schemes without increasing system complexity but with the stray field intensity reduced by half. In real measurement in an integrated MRI system, the developed gradient assembly demonstrated good performance and supported to output images of excellent quality. Our findings suggested that the proposed method could potentially form a useful design paradigm for cryogen-free MRI magnets. [ABSTRACT FROM AUTHOR]

Thin and flexible materials that can provide efficient electromagnetic interference (EMI) shielding are urgently needed, particularly those that can be rapidly processed and withstand harsh environments. Cobalt‐based metallic glasses stand out as prime candidates due to their excellent soft magnetic properties, satisfactory shielding features, and mechanical properties. Herein, a recently developed technique is used to fabricate metallic glass microfibers from Co66Fe4Mo2Si16B12 alloy. The produced microfibers are characterized for their size and uniformity by scanning electron microscopy and their amorphous structure is confirmed by X‐ray diffraction (XRD) and differential scanning calorimetry (DSC). The cobalt‐based metallic glass microfibers show an EMI shielding factor that reaches five in the static regime and obtains an up to 25‐fold increase of the attenuation constant in the Ku frequency band. This performance originates from the combination of soft magnetic properties and excellent electrical conductivity. In addition, the flexible microfibers exhibit excellent hardness and elasticity making them suitable for EMI shielding of complex geometries. Their hardness and elastic modulus are measured by nanoindentation to be 11.31 ± 0.60 GPa, and 110.54 ± 11.24 GPa, respectively. [ABSTRACT FROM AUTHOR]

Recent spaceflights involving nonprofessional people have opened the doors to the suborbital space tourism business. However, they have also drawn public attention to the safety and hazards associated with space travel. Unfortunately, space travel involves a myriad of health risks for people, ranging from DNA damage caused by radiation exposure to the hemodynamic changes that occur when living in microgravity. In fact, the primary pathogenetic role is attributed to cosmic radiation, since deep space lacks the protective benefit of Earth's magnetic shielding. The second risk factor for space-induced pathologies is microgravity, which may affect organ function and cause a different distribution of fluid inside the human body. Both cosmic radiation and microgravity may lead to the alteration of cellular homeostasis and molecular changes in cell function. These, in turn, might have a direct impact on heart function and structure. The aim of this review is to draw attention to the fact that spaceflights constitute a novel frontier in biomedical research. We summarize the most important clinical and experimental evidence regarding the cardiovascular effects of cosmic radiation and microgravity. Finally, we highlight that unraveling the mechanisms underlying how space radiation and microgravity affect the cardiovascular system is crucial for identifying potential countermeasures and developing effective therapeutic strategies. [ABSTRACT FROM AUTHOR]