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2 results on '"multitarget metabolic systems"'

1. Metabolism as a New Avenue for Hepatocellular Carcinoma Therapy.

Author

Gnocchi, Davide, Sabbà, Carlo, Massimi, Mara, and Mazzocca, Antonio

Subjects
*HEPATOCELLULAR carcinoma, *CHRONIC active hepatitis, *PROTEIN kinase inhibitors, *METABOLIC disorders, *THERAPEUTICS
Abstract

Hepatocellular carcinoma is today the sixth leading cause of cancer-related death worldwide, despite the decreased incidence of chronic hepatitis infections. This is due to the increased diffusion of metabolic diseases such as the metabolic syndrome, diabetes, obesity, and nonalcoholic steatohepatitis (NASH). The current protein kinase inhibitor therapies in HCC are very aggressive and not curative. From this perspective, a shift in strategy toward metabolic therapies may represent a promising option. Here, we review current knowledge on metabolic dysregulation in HCC and therapeutic approaches targeting metabolic pathways. We also propose a multi-target metabolic approach as a possible new option in HCC pharmacology. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Metabolism as a New Avenue for Hepatocellular Carcinoma Therapy

Author

Davide Gnocchi, Carlo Sabbà, Mara Massimi, and Antonio Mazzocca

Subjects
Inorganic Chemistry, hepatocellular carcinoma (HCC), metabolism, therapeutic approaches, multitarget metabolic systems, Organic Chemistry, General Medicine, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Catalysis, Computer Science Applications
Abstract

Hepatocellular carcinoma is today the sixth leading cause of cancer-related death worldwide, despite the decreased incidence of chronic hepatitis infections. This is due to the increased diffusion of metabolic diseases such as the metabolic syndrome, diabetes, obesity, and nonalcoholic steatohepatitis (NASH). The current protein kinase inhibitor therapies in HCC are very aggressive and not curative. From this perspective, a shift in strategy toward metabolic therapies may represent a promising option. Here, we review current knowledge on metabolic dysregulation in HCC and therapeutic approaches targeting metabolic pathways. We also propose a multi-target metabolic approach as a possible new option in HCC pharmacology.

Published
2023
Full Text
View/download PDF

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