1. Association of cardiovascular emerging risk factors with acute coronary syndrome and stroke: A case-control study.
- Author
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Martínez Linares, José Manuel, Guisado Barrilao, Rafael, Ocaña Peinado, Francisco Manuel, and Salgado Parreño, Francisco Javier
- Subjects
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ACUTE coronary syndrome , *AGE distribution , *ANALYSIS of variance , *BLOOD testing , *C-reactive protein , *CARDIOVASCULAR diseases risk factors , *CHI-squared test , *CONFIDENCE intervals , *DIABETES , *HYPERTENSION , *INTERVIEWING , *MATHEMATICAL statistics , *MULTIVARIATE analysis , *NONPARAMETRIC statistics , *PEPTIDE hormones , *RESEARCH funding , *STATISTICAL sampling , *SEX distribution , *STATISTICAL hypothesis testing , *STATISTICS , *T-test (Statistics) , *HOMOCYSTEINE , *LOGISTIC regression analysis , *JUDGMENT sampling , *STATISTICAL power analysis , *MULTIPLE regression analysis , *PARAMETERS (Statistics) , *BODY mass index , *CASE-control method , *RECEIVER operating characteristic curves , *ODDS ratio , *KRUSKAL-Wallis Test , *DISEASE risk factors ,STROKE risk factors - Abstract
In this study, we estimated the risk of acute coronary syndrome and stroke associated with several emerging cardiovascular risk factors. This was a case-control study, where an age - and sex-matched acute coronary syndrome group and stroke group were compared with controls. Demographic and clinical data were collected through patient interviews, and blood samples were taken for analysis. In the bivariate analysis, all cardiovascular risk factors analyzed showed as predictors of acute coronary syndrome and stroke, except total cholesterol and smoking. In the multivariate logistic regression model for acute coronary syndrome, hypertension and body mass index, N-terminal section brain natriuretic peptide and pregnancy-associated plasma protein-A were independent predictors. For stroke, the predictors were hypertension, diabetes mellitus, body mass index, and N-terminal section brain natriuretic peptide. Controlling for age, sex, and classical cardiovascular risk factors, N-terminal section brain natriuretic peptide and pregnancy-associated plasma protein-A were independent emerging cardiovascular risk factors for acute coronary syndrome, but pregnancy-associated plasma protein-A was not for stroke. High levels of cardiovascular risk factors in individuals with no episodes of cardiovascular disease requires the implementation of prevention programs, given that at least half of them are modifiable. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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