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The crop model based on physiology and ecology has been widely applied to the simulation of regional potential productivity. By determining the appropriate spatial resolution of meteorological data required for model simulation for different regions, we can reduce the difficulty of acquiring model input data, thereby improving the regional computing efficiency of the model and increasing the model applications. In this study, we investigated the appropriate spatial resolution of meteorological data needed for the regional potential productivity simulation of the WheatGrow model by scale effect index and verify the feasibility of using the landform to obtain the appropriate spatial resolution of meteorological data required by the potential productivity simulation for the winter wheat region of China. The research results indicated that the spatial variation of landforms in the winter wheat region of China is significantly correlated to the spatial variation of multi-year meteorological data. Based on the scale effect index, we can obtain a spatial distribution of appropriate spatial resolution for the meteorological data required for the regional potential productivity simulation of the WheatGrow model for the winter wheat region of China. Moreover, although we can use the spatial heterogeneity of landforms to guide the selection of appropriate spatial resolution for the meteorological data, in the regions where the spatial heterogeneity of the landform is relatively weak or relatively strong over a small range, the method of using a single heterogeneity index derived from semi-variogram cannot well reflect the scale effect of simulation results and needs further improvement. [ABSTRACT FROM AUTHOR]