1. Discovery of highly potent agents against influenza A virus
- Author
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Zhao, Xin, Li, Chufang, Zeng, Shaogao, and Hu, Wenhui
- Subjects
- *
INFLUENZA A virus , *AMANTADINE , *VIRUS inhibitors , *STRUCTURE-activity relationships , *EXTRACELLULAR matrix proteins , *SCIENTIFIC discoveries - Abstract
Abstract: We previously reported several new M2 inhibitors as active as amantadine against influenza A virus and validated by three types of in vitro assays. Herein, we further modified one of the most potent hits in a viral inhibition assay and conducted structure–activity relationship studies on this scaffold. As a result, compound 8e was identified to be the most potent inhibitor against wild-type influenza A virus, being nearly 240-fold more active than amantadine. [Copyright &y& Elsevier]
- Published
- 2011
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