1. Relationship between non-specific activity of macrophages and immune responses to <em>Listeria monocytogenes</em>.
- Author
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Yoshikai, Y., Miake, S., Matsumoto, T., Nomoto, K., and Takeya, K.
- Subjects
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MACROPHAGES , *RETICULO-endothelial system , *CONNECTIVE tissue cells , *ANTIGEN presenting cells , *LISTERIA monocytogenes , *LISTERIA , *MONOCLONAL antibodies , *LABORATORY mice - Abstract
Delayed footpad reactions and acquired cellular resistance to Listeria monocytogenes were studied in mice whose mononuclear phagocyte system (MPS) had been blocked or stimulated. Colloidal carbon was used for the blockade of MPS and Corynebacterium parrum used for the stimulation. Strong delayed footpad reactions. On the other hand, the i.v. rejection of 3 × 101; listeria induced an appreciable level mice, while in MPS-stimulated mice, i.v. injection with even 4 × 103; listeria could not induce such strong delayed footpad reaction. On the other hand, the i.v. injection of 3 × 10¹ listeria induced an appreciable level of delayed footpad reaction only in MPS-blocked mice. Acquired cellular resistance was depressed by MPS stimulation, whereas it was augmented by MPS blockade. These results suggested that non-specific activity of MPS modulates subsequent immune responses after inoculation of listeria. [ABSTRACT FROM AUTHOR]
- Published
- 1980