1. Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti.
- Author
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De Vita, Daniela, Frezza, Claudio, Sciubba, Fabio, Toniolo, Chiara, Badiali, Camilla, Petrucci, Rita, Bortolami, Martina, Di Matteo, Paola, Rocco, Daniele, Stringaro, Annarita, Colone, Marisa, Maxia, Andrea, Petrucci, Maria Teresa, Serafini, Mauro, and Foddai, Sebastiano
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PHYTOCHEMICALS , *INDOLE alkaloids , *B cells , *EXTRACTS , *CELL proliferation , *CELL lines - Abstract
Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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