6 results on '"Rosa, Paulo"'
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2. Development and Evaluation of an Antimicrobial Formulation Containing Rosmarinus officinalis.
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Macedo, Lucas Malvezzi de, Santos, Érica Mendes dos, Ataide, Janaína Artem, Silva, Gabriela Trindade de Souza e, Guarnieri, João Paulo de Oliveira, Lancellotti, Marcelo, Jozala, Angela Faustino, Rosa, Paulo Cesar Pires, and Mazzola, Priscila Gava
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ROSEMARY ,TANNINS ,ESCHERICHIA coli ,SCIENTIFIC literature ,PHENOLS - Abstract
Rosmarinus officinalis belongs to the Lamiaceae family, and its constituents show antioxidant, anti-inflammatory, antidepressant, antinociceptive, and antibacterial properties. The aim of this study was to develop a topical formulation with R. officinalis extract that had antimicrobial and antioxidant activity. Maceration, infusion, Soxhlet, and ultrasound were used to produce rosemary extracts, which were submitted to antioxidant, compound quantification, cell viability, and antimicrobial assays. Infusion and Soxhlet showed better results in the DPPH assay. During compound quantification, infusion showed promising metabolite extraction in phenolic compounds and tannins, although maceration was able to extract more flavonoids. The infusion and ultrasound extracts affected more strains of skin bacteria in the disk diffusion assays. In the minimum inhibitory concentration assay, the infusion extract showed results against S. aureus, S. oralis, and P. aeruginosa, while ultrasound showed effects against those three bacteria and E. coli. The infusion extract was chosen to be incorporated into a green emulsion. The infusion extract promoted lower spreadability and appropriated the texture, and the blank formulation showed high levels of acceptance among the volunteers. According to the results, the rosemary extract showed promising antioxidant and antimicrobial activity, and the developed formulations containing this extract were stable for over 90 days and had acceptable characteristics, suggesting its potential use as a phytocosmetic. This paper reports the first attempt to produce an oil-in-water emulsion using only natural excipients and rosemary extract, which is a promising novelty, as similar products cannot be found on the market or in the scientific literature. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
3. Secado, toxicidad y potencial antimicrobiano del aceite esencial Curcuma longa L
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Sales, Everton Holanda, Everton, Gustavo Oliveira, Rosa, Paulo Victor Serra, Conceição, Carlos Eduardo Pereira, Pinheiro, Feliciana Santos, Chagas, Simone Nunes Leal, Batista, Christyann Lima Campos, Soares, Liane Batista da Cruz, Carvalho, Ana Maria Almeida Silva, Silva, Igor Santos da, Araújo Neto, Ari Pereira de, and Mouchrek Filho, Victor Elias
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Curcuma ,Toxicity ,Rhizomes ,Antimicrobial ,Rizomas ,Toxicidad ,Toxicidade ,Antimicrobiano - Abstract
This study aimed to dry the rhizomes of Curcuma longa L. applying mathematical modeling, determined the antimicrobial activity and toxicity of the essential oil (EO) obtained after the drying process applied. The collected plant material was submitted to convective drying kiln at 45 °C. Mathematical models were applied to represent the drying process and statistical analysis performed using the statistica software 10. The EOs were obtained through the hydrodistillation technique and antimicrobial activity by the Disc Diffusion and Dilution Method in Broth against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella sp. For the toxicity test, the Artemia salina bioassay was applied. Through the results obtained it was possible to determine that Logarithm's mathematical model was the one that best fit the experimental data. The EO showed bactericidal activity against all microorganisms tested. The toxicity test proved the toxicity of EO with a LC50 greater than 250 mg/L. The results obtained prove the potential required for the application of EO of C. longa rhizomes as antimicrobial, and is still non-toxic to non-target organisms. Este estudio tuvo como objetivo secar los rizomas de Curcuma longa L. aplicando el modelado matemático, determinó la actividad antimicrobiana y la toxicidad del aceite esencial (AE) obtenido tras el proceso de secado aplicado. El material vegetal recogido se sometió a un horno de secado convectivo a 45 °C. Se aplicaron modelos matemáticos para representar el proceso de secado y el análisis estadístico realizado utilizando el software estadístico 10. Los AE se obtuvieron a través de la técnica de hidrodestulación y la actividad antimicrobiana mediante el Método de Difusión de Discos y Dilución en Caldo contra Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa y Salmonella sp. Para la prueba de toxicidad, se aplicó el bioensayo de Artemia salina. A través de los resultados obtenidos fue posible determinar que el modelo matemático del logaritmo era el que mejor se ajustaba a los datos experimentales. La AE mostró actividad bactericida contra todos los microorganismos analizados. El ensayo de toxicidad demostró toxicidad AE con un CL50 superior a 250 mg/L. Los resultados obtenidos demuestran el potencial necesario para la aplicación de AE de los rizomas de C. longa como antimicrobianos, y siguen siendo no tóxicos contra organismos no objetivo. Este estudo teve por objetivo realizar a secagem dos rizomas de Curcuma longa L. aplicando modelagem matemática, determinou a atividade antimicrobiana e a toxicidade do óleo essencial (OE) obtido após o processo de secagem aplicado. O material vegetal coletado foi submetido a estufa convectiva de secagem a temperatura 45 °C. Modelos matemáticos foram aplicados para representar o processo de secagem e análise estatística realizada utilizando o software statistica 10. Os OE's foram obtidos através da técnica de hidrodestilação e a atividade antimicrobiana pelo Método de Difusão de Disco e Diluição em Caldo frente a Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa e Salmonella sp. Para o teste de toxicidade, foi aplicado o bioensaio de Artemia salina. Através dos resultados obtidos foi possível determinar que o modelo matemático de Logarithm foi o que melhor se encaixava nos dados experimentais. O OE apresentou atividade bactericida frente a todos os microrganismos testados. O ensaio de toxicidade comprovou a toxicidade do OE com uma CL50 superior a 250 mg/L. Os resultados obtidos comprovam o potencial necessário para a aplicação do OE dos rizomas de C. longa como antimicrobiano, sendo ainda não tóxico frente a organismos não-alvo.
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- 2020
4. Actividad bactericida de aceite esencial y extracto hidroalcohólico de hojas de eucalipto globulus
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Rosa, Paulo Victor Serra, Everton, Gustavo Oliveira, Pereira, Ana Patrícia Matos, Fonseca, Danielly, Cunha, Jean Carlos Rodrigues da, Mendonça, Iago Pereira, Lima, Ericka Cristina Silva, Souza, Lauriane dos Santos, Souza, Laurilene dos Santos, Dias, Andressa Almeida Santana, Mouchrek Filho, Victor Elias, and Arruda, Mariana Oliveira
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Toxicity ,Extrato hidroalcóolico ,Aceite essencial ,Óleo essencial ,Antimicrobial ,Toxicidad ,Toxicidade ,Eucalyptus globulus ,Antimicrobiano ,Essential oil ,Extracto hidroalcohólico ,Hydroalcoholic extract - Abstract
The study aimed to evaluate the toxicity, total phenolics and antimicrobial activity using essential oil (OE) and hydroalcoholic extract (EH) of Eucalyptus globulus leaves against pathogenic microorganisms of clinical importance. The HE was prepared using the cold maceration method and the EO was extracted by hydrodistillation at 100°C for 3h. The toxicity assay was performed using the Artemia salina Leach bioassay. For antimicrobial activity, the Disc Diffusion technique was used against the bacteria Escherichia coli and Staphylococcus aureus. The toxicity LC50 obtained for EO was 595.2 mg L-1 and for HE it was 574.18 mg L-1 both classified as nontoxic. Regarding antimicrobial activity, EO presented inhibition halos for S. aureus and E. coli of 15 mm, while HE presented halos of 22 mm for S. aureus and E. coli of 17 mm. EO and HE showed antimicrobial activity and atoxicity, being important parameters to point out the products as a therapeutic alternative, encouraging their potential for application. El estudio tuvo como objetivo evaluar la toxicidad, el total de fenólicos y la actividad antimicrobiana utilizando aceite esencial (AE) y extracto hidroalcohólico (EH) de hojas de Eucalyptus globulus contra microorganismos patógenos de importancia clínica. El EH se preparó utilizando el método de maceración en frío y el AE fue extraído por hidrodestilación a 100 ºC durante 3h. El ensayo de toxicidad se realizó utilizando el bioensayo de Artemia salina. Para la actividad antimicrobiana, la técnica de difusión de discos se utilizó contra las bacterias Escherichia coli y Staphylococcus aureus. La toxicidad LC50 obtenida para AE fue de 595,2 mg de L-1 y para EH fue de 574,18 mg L-1 ambos clasificados como no tóxicos. En cuanto a la actividad antimicrobiana, AE presentó halos de inhibición para S. aureus y 15 mm E. coli, mientras que EH presentó halos de 22 mm para S. aureus y E. coli de 17 mm. AE y EH mostraron actividad antimicrobiana y atoxicidad, siendo parámetros importantes para señalar los productos como una alternativa terapéutica, fomentando su potencial de aplicación. O estudo teve por objetivo avaliar a toxicidade, fenólicos totais e atividade antimicrobiana usando óleo essencial (OE) e extrato hidroalcóolico (EH) das folhas do Eucalyptus globulus frente a microrganismos patogênicos de importância clínica. O EH foi preparado usando o método de maceração a frio e o OE foi extraído por hidrodestilação a 100°C por 3h. O ensaio de toxicidade foi realizado através do bioensaio Artemia salina Leach. Para atividade antimicrobiana utilizou-se a técnica de Difusão de Disco frente as bactérias Escherichia coli e Staphylococcus aureus. Os ensaios foram realizados em triplicata. A CL50 de toxicidade obtida para o OE foi de 595,2 mg L-1 e para o EH foi de 574,18 mg L-1 ambos classificados como atóxicos. Em relação a atividade antimicrobiana, o OE apresentou halos de inibição para S. aureus e E. coli de 15 mm, enquanto o EH apresentou halos de 22 mm para S. aureus e E. coli de 17 mm. O OE e o EH apresentaram atividade antimicrobiana e atoxicidade, sendo parâmetros importantes para apontar os produtos como uma alternativa terapêutica, incentivando seu potencial de aplicação.
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- 2020
5. Chemical characterization, toxicity, antioxidant and antimicrobial activity of the essential oils of Hymenaea courbaril L. and Syzygium cumini (L.) Skeels.
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Oliveira Everton, Gustavo, Patrícia Matos Pereira, Ana, Victor Serra Rosa, Paulo, Silva Costa Mafra, Nilton, Sérgio Santos Júnior, Paulo, Silva Souza, Franscristhiany, de Jesus Silva Mendonça, Caritas, Carvalho Silva, Fernando, Roberto Barros Gomes, Paulo, and Elias Mouchrek Filho, Victor
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ESSENTIAL oils ,SYZYGIUM - Abstract
Copyright of Revista Ciência e Natura is the property of Revista Ciencia e Natura and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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6. Drying kinetics of Bixa orellana Labil (annatto) leaves and the influence of temperature on the physicochemical and biological properties of its essential oil.
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Oliveira Everton, Gustavo, Holanda Sales, Everton, Costa Mafra, Nilton Silva, Jemima Araújo, Rebecca, Sérgio Santos Júnior, Paulo, Serra Rosa, Paulo Victor, Matos Pereira, Ana Patrícia, Silva Souza, Franscristhiany, Silva Mendonca, Caritas de Jesus, Carvalho Silva, Fernando, Barros Gomes, Paulo Roberto, and Mouchrek Filho, Victor Elias
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LEAF temperature ,ESSENTIAL oils ,DRYING ,TOXICITY testing ,ANALYTICAL mechanics ,MATHEMATICAL models ,ARTEMIA - Abstract
Copyright of Revista Colombiana de Ciencias Químico-Farmacéuticas is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
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