Search

In nanotechnology, compounds containing metal materials are used in pharmaceutical sciences. The main purpose of this research was to introduce a novel method to control the amount of zeolite imidazolate framework (ZIF) in water by forming a protective layer such as layered double hydroxide (LDH). Firstly, ZIF was synthesised as the nucleus of the nanocomposite, and then LDH was formed by in situ synthesis as a protective layer. Scanning electron microscope, Fourier‐transform infrared spectroscopy, X‐Ray Diffraction, and Brunauer, Emmett and Teller techniques were used to determine (ZIF‐8@LDH chemical structure and morphology. Our findings revealed that the ZIF‐8@LDH‐MTX complex could interact with carboxyl groups and trivalent cations by creating a bifurcation bridge, clarity, and high thermal stability. The antibacterial test indicated that ZIF‐8@LDH was able to inhibit pathogenic growth. 2,5‐Diphenyl‐2H‐Tetrazolium Bromide assay results showed that ZIF‐8@LDH alone had no notable cytotoxic effect on Michigan Cancer Foundation‐7 (MCF‐7) cancer cells. However, the cytotoxicity rate was significantly increased in treated MCF‐7 cells with ZIF‐8@LDH‐MTX compared to that of treated cells with methotrexate alone, which can be reasoned by the protection of drug structure and increasing its permeability. The drug release profile was constant at pH = 7.4. All findings indicated that the ZIF‐8@LDH complex could be considered a newly proposed solution for effective anti‐cancer drug delivery. [ABSTRACT FROM AUTHOR]

Breast cancer is a public health problem globally and is the most frequent cancer world wide. Currently, anti-inflammatory and anti-cancer drugs are of prime interest in treating some cancers especially breast cancer and have become an exciting challenge for researchers. The use of layered structures consisting of anions and cations called layered double hydroxides (LDHs) has attracted the attention of many researchers in the field of biomedical and pharmaceuticals. LDHs-nanostructures can be used as drug carriers, especially anti-inflammatory and anti-cancer drugs to treat cancers. Thus, the LDHs should have a number of physicochemical properties to act as a desirable drug carrier. Among the primary factors to increase the efficiency of LDHs are their surface characteristics and size, number and type of ions, rapid clearance from the body after drug release, and non-toxicity. All of these properties make LDHs nano-carriers for carrying anti-inflammatory and anti-cancer drugs to treat a variety of cancers. Therefore, we focus on reviewing the nature of LDH nano-carriers and evaluating the desirable properties for drug delivery, drug loading methods into LDH and anti-inflammatory drug delivery methods, their potential applications in biomedical and their toxicity and antimicrobial effects in breast cancer. [ABSTRACT FROM AUTHOR]