1. Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway.
- Author
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Chen YH, Zhang RG, Xue F, Wang HN, Chen YC, Hu GT, Peng Y, Peng ZW, and Tan QR
- Subjects
- Animals, Antidepressive Agents pharmacology, Antidepressive Agents therapeutic use, Behavior, Animal drug effects, Butadienes pharmacology, Cell Proliferation drug effects, Cell Survival drug effects, Cells, Cultured, Depression drug therapy, Depression pathology, Disease Models, Animal, Male, Neural Stem Cells cytology, Neural Stem Cells physiology, Nitriles pharmacology, Rats, Brain-Derived Neurotrophic Factor metabolism, Depression therapy, Hippocampus cytology, MAP Kinase Signaling System drug effects, Neural Stem Cells drug effects, Quetiapine Fumarate pharmacology, Quetiapine Fumarate therapeutic use, Transcranial Magnetic Stimulation
- Abstract
Quetiapine (QUE) and repetitive transcranial magnetic stimulation (rTMS) have been considered to be possible monotherapies for depression or adjunctive therapies for the treatment of the resistant depression, but the underlying mechanisms remain unclear. The present study aimed to assess the effects of combined QUE and rTMS treatment on depressive-like behaviors, hippocampal proliferation, and the in vivo and in vitro expressions of phosphorylated extracellular signal-regulated protein kinase (pERK1/2) and brain-derived neurotrophic factor (BDNF) in male Sprague-Dawley rats. The administration of QUE and rTMS was determined not only to reverse the depressive-like behaviors of rats exposed to chronic unpredictable stress (CUS) but also to restore the protein expressions of pERK1/2 and BDNF and cell proliferation in the hippocampus. Additionally, QUE and rTMS promoted the proliferation and increased the expression of pERK1/2 and BDNF in hippocampal-derived neural stem cells (NSCs), and these effects were abolished by U0126. Taken together, these results suggest that the antidepressive-like effects of QUE and rTMS might be related to the activation of the BDNF/ERK signaling pathway and the up-regulation of cell proliferation in the hippocampus., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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