1. A host-dye complex for sensitive fluorescence detection and clearing of spermine in cells.
- Author
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Duan, Yi-Meng, Tian, Han-Wen, Li, Hua-Bin, Wang, Kun-Peng, Chen, Shaojin, Guo, Dong-Sheng, and Hu, Zhi-Qiang
- Subjects
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SPERMINE , *FLUORESCENCE , *FLUORESCENCE quenching , *BIOLOGICAL systems , *HOST-guest chemistry - Abstract
Spermine is an important biomarker for cancer diagnosis and treatment since it is dysregulated and overexpressed in tumors. Herein, a supramolecular reporter pair PPDD@SC4AD is exploited by complexing amphiphilic sulfonatocalix[4]arene (SC4AD) with pyrido[1,2- a ]pyrido[1′,2′:3,4]imidazo-[2,1-c]-6,7-dihydropyrazinium dibromide (PPDD). The reporter pair can detect spermine in biological systems. By detecting and depleting spermine, it realizes spermine imaging and induces apoptosis of tumor cells. SC4AD exhibits a high binding affinity and a strong complexation-induced fluorescence quenching effect. When complexing with spermine overexpressed in tumor cells, SC4AD can significantly release the fluorescence of PPDD. Moreover, spermine is efficiently encapsulated by calixarene to deplete spermine and induce apoptosis of tumor cells. The amphiphilicity of SC4AD can drive the self-assembly of PPDD@SC4AD to guarantee an efficient enhanced permeability and retention effect in vivo. PPDD@SC4AD may inspire the development of new integrated approaches of diagnosis and treatment. [Display omitted] • A host-dye reporter pair PPDD@SC4AD was used for spermine imaging and induced apoptosis in tumor cells. • PPDD@SC4AD can release the fluorescence of PPDD when complexing with overexpressed spermine in tumor cells. • The amphiphilicity of SC4AD can drive the self-assembly of PPDD@SC4AD to ensure EPR effect in vivo. • PPDD@SC4AD may provide a new idea for the development of new integrated methods of diagnosis and treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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