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Background: The purpose of the present study was to analyze the risk multi-factors of postoperative cardiac arrhythmia for elderly patients with esophageal or cardiac carcinoma. Methods: A total of 756 operations for elderly patients (>65 years of age) with esophageal or cardiac carcinoma were performed in our department from January 1997 to December 2006. These included 197 cases (26.1%) of various types of cardiac arrhythmia after operation. Logistic regression was adopted to analyze the risk multi-factors of postoperative cardiac arrhythmia. Results: It showed that complications of other diseases before operation, selection of operation method, duration of anesthesia and operation, postoperative pain, anoxia, hypovolemia, acid-alkali disequilibrium, and electrolyte imbalance might be the risk factors of postoperative cardiac arrhythmia in elderly patients with esophageal or cardiac carcinoma, whereas minimally invasive endoscopic operation might be a protective factor. Conclusions: In order to decrease the risk factors leading to postoperative cardiac arrhythmia for elderly patients with esophageal or cardiac carcinoma, it was necessary to completely evaluate the functions of heart and lung, improve the nutrition and metabolism of heart muscle, conduct effective breathing exercises, and correct the existing cardiac arrhythmia of such patients before operation, and perform the minimally invasive operation, shorten operation duration, relieve pain efficiently during the perioperative period, and correct hypovolemia and acid-alkali disequilibrium and electrolyte imbalance. [ABSTRACT FROM AUTHOR]