5,191 results
Search Results
2. Validation of the INDDEX24 mobile app v. a pen-and-paper 24-hour dietary recall using the weighed food record as a benchmark in Burkina Faso
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Rogers, Beatrice, Somé, Jérome W, Bakun, Peter, Adams, Katherine P, Bell, Winnie, Carroll, David Alexander, Wafa, Sarah, and Coates, Jennie
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Nutrition ,Clinical Research ,Oral and gastrointestinal ,Stroke ,Cardiovascular ,Metabolic and endocrine ,Humans ,Female ,Adolescent ,Young Adult ,Adult ,Middle Aged ,Mobile Applications ,Benchmarking ,Cross-Sectional Studies ,Burkina Faso ,Diet ,Energy Intake ,Surveys and Questionnaires ,Micronutrients ,Nutrition Assessment ,Diet Records ,Reproducibility of Results ,Dietary recall ,Survey methods ,Tablet-based data collection ,Accuracy ,Cost-effectiveness ,Animal Production ,Food Sciences ,Nutrition & Dietetics ,Animal production ,Food sciences ,Nutrition and dietetics - Abstract
Effective nutrition policies require timely, accurate individual dietary consumption data; collection of such information has been hampered by cost and complexity of dietary surveys and lag in producing results. The objective of this work was to assess accuracy and cost-effectiveness of a streamlined, tablet-based dietary data collection platform for 24-hour individual dietary recalls (24HR) administered using INDDEX24 platform v. a pen-and-paper interview(PAPI) questionnaire, with weighed food record (WFR) as a benchmark. This cross-sectional comparative study included women 18-49 years old from rural Burkina Faso (n 116 INDDEX24; n 115 PAPI). A WFR was conducted; the following day, a 24HR was administered by different interviewers. Food consumption data were converted into nutrient intakes. Validity of 24HR estimates of nutrient and food group consumption was based on comparison with WFR using equivalence tests (group level) and percentages of participants within ranges of percentage error (individual level). Both modalities performed comparably estimating consumption of macro- and micronutrients, food groups and quantities (modalities' divergence from WFR not significantly different). Accuracy of both modalities was acceptable (equivalence to WFR significant at P < 0·05) at group level for macronutrients, less so for micronutrients and individual-level consumption (percentage within ±20 % for WFR, 17-45 % for macronutrients, 5-17 % for micronutrients). INDDEX24 was more cost-effective than PAPI based on superior accuracy of a composite nutrient intake measure (but not gram amount or item count) due to lower time and personnel costs. INDDEX24 for 24HR dietary surveys linked to dietary reference data shows comparable accuracy to PAPI at lower cost.
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- 2022
3. Position paper of the EACVI and EANM on artificial intelligence applications in multimodality cardiovascular imaging using SPECT/CT, PET/CT, and cardiac CT
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Slart, Riemer H. J. A., Williams, Michelle C., Juarez-Orozco, Luis Eduardo, Rischpler, Christoph, Dweck, Marc R., Glaudemans, Andor W. J. M., Gimelli, Alessia, Georgoulias, Panagiotis, Gheysens, Olivier, Gaemperli, Oliver, Habib, Gilbert, Hustinx, Roland, Cosyns, Bernard, Verberne, Hein J., Hyafil, Fabien, Erba, Paola A., Lubberink, Mark, Slomka, Piotr, Išgum, Ivana, Visvikis, Dimitris, Kolossváry, Márton, and Saraste, Antti
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- 2021
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4. Current perspectives on Coronavirus 2019 (COVID‐19) and cardiovascular disease: A white paper by the JAHA editors
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Gupta, Ajay K, Jneid, Hani, Addison, Daniel, Ardehali, Hossein, Boehme, Amelia K, Borgaonkar, Sanket, Boulestreau, Romain, Clerkin, Kevin, Delarche, Nicolas, DeVon, Holli A, Grumbach, Isabella M, Gutierrez, Jose, Jones, Daniel A, Kapil, Vikas, Maniero, Carmela, Mentias, Amgad, Miller, Pamela S, Ng, Sher May, Parekh, Jai D, Sanchez, Reynaldo H, Sawicki, Konrad Teodor, Riele, Anneline SJM te, Remme, Carol Ann, and London, Barry
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Cardiovascular ,Infectious Diseases ,Emerging Infectious Diseases ,Infection ,Good Health and Well Being ,Betacoronavirus ,COVID-19 ,Cardiovascular Diseases ,Comorbidity ,Coronavirus Infections ,Global Health ,Humans ,Incidence ,Pandemics ,Pneumonia ,Viral ,SARS-CoV-2 ,cardiovascular disease ,cardiovascular risk factors ,coronavirus disease 2019 ,management ,treatment ,COVID‐19 ,SARS‐CoV‐2 ,Cardiorespiratory Medicine and Haematology - Abstract
Coronavirus Disease 2019 (COVID-19) has infected more than 3.0 million people worldwide and killed more than 200,000 as of April 27, 2020. In this White Paper, we address the cardiovascular co-morbidities of COVID-19 infection; the diagnosis and treatment of standard cardiovascular conditions during the pandemic; and the diagnosis and treatment of the cardiovascular consequences of COVID-19 infection. In addition, we will also address various issues related to the safety of healthcare workers and the ethical issues related to patient care in this pandemic.
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- 2020
5. Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: an Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
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Anker, Stefan D, Butler, Javed, Khan, Muhammad Shahzeb, Abraham, William T, Bauersachs, Johann, Bocchi, Edimar, Bozkurt, Biykem, Braunwald, Eugene, Chopra, Vijay K, Cleland, John G, Ezekowitz, Justin, Filippatos, Gerasimos, Friede, Tim, Hernandez, Adrian F, Lam, Carolyn SP, Lindenfeld, JoAnn, McMurray, John JV, Mehra, Mandeep, Metra, Marco, Packer, Milton, Pieske, Burkert, Pocock, Stuart J, Ponikowski, Piotr, Rosano, Giuseppe MC, Teerlink, John R, Tsutsui, Hiroyuki, Van Veldhuisen, Dirk J, Verma, Subodh, Voors, Adriaan A, Wittes, Janet, Zannad, Faiez, Zhang, Jian, Seferovic, Petar, and Coats, Andrew JS
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Clinical Research ,Patient Safety ,Clinical Trials and Supportive Activities ,Cardiovascular ,Heart Disease ,Prevention ,Good Health and Well Being ,Betacoronavirus ,COVID-19 ,Clinical Trials as Topic ,Coronavirus Infections ,Europe ,Heart Failure ,Humans ,Informed Consent ,Pandemics ,Patient Selection ,Pneumonia ,Viral ,Research Design ,SARS-CoV-2 ,Heart failure ,Clinical trials ,Coronavirus ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology - Abstract
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has important implications for the safety of participants in clinical trials and the research staff caring for them and, consequently, for the trials themselves. Patients with heart failure may be at greater risk of infection with COVID-19 and the consequences might also be more serious, but they are also at risk of adverse outcomes if their clinical care is compromised. As physicians and clinical trialists, it is our responsibility to ensure safe and effective care is delivered to trial participants without affecting the integrity of the trial. The social contract with our patients demands no less. Many regulatory authorities from different world regions have issued guidance statements regarding the conduct of clinical trials during this COVID-19 crisis. However, international trials may benefit from expert guidance from a global panel of experts to supplement local advice and regulations, thereby enhancing the safety of participants and the integrity of the trial. Accordingly, the Heart Failure Association of the European Society of Cardiology on 21 and 22 March 2020 conducted web-based meetings with expert clinical trialists in Europe, North America, South America, Australia, and Asia. The main objectives of this Expert Position Paper are to highlight the challenges that this pandemic poses for the conduct of clinical trials in heart failure and to offer advice on how they might be overcome, with some practical examples. While this panel of experts are focused on heart failure clinical trials, these discussions and recommendations may apply to clinical trials in other therapeutic areas.
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- 2020
6. The effects of 16-weeks of prebiotic supplementation and aerobic exercise training on inflammatory markers, oxidative stress, uremic toxins, and the microbiota in pre-dialysis kidney patients: a randomized controlled trial-protocol paper
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Headley, Samuel A, Chapman, Donna J, Germain, Michael J, Evans, Elizabeth E, Hutchinson, Jasmin, Madsen, Karen L, Ikizler, Talat Alp, Miele, Emily M, Kirton, Kristyn, O’Neill, Elizabeth, Cornelius, Allen, Martin, Brian, Nindl, Bradley, and Vaziri, Nosratola D
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Biomedical and Clinical Sciences ,Clinical Sciences ,Cardiovascular ,Prevention ,Clinical Trials and Supportive Activities ,Clinical Research ,Kidney Disease ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Renal and urogenital ,Adult ,Aged ,Amylose ,Analysis of Variance ,Biomarkers ,Double-Blind Method ,Exercise ,Gastrointestinal Microbiome ,Humans ,Inflammation ,Kidney Failure ,Chronic ,Middle Aged ,Oxidative Stress ,Resistant Starch ,Zea mays ,Resistant starch ,Inflammatory markers ,Oxidative stress ,Uremic toxins ,Urology & Nephrology ,Clinical sciences ,Health services and systems ,Nursing - Abstract
BackgroundChronic kidney disease (CKD) is characterized by dysbiosis, elevated levels of uremic toxins, systemic inflammation, and increased markers of oxidative stress. These factors lead to an increased risk of cardiovascular disease (CVD) which is common among CKD patients. Supplementation with high amylose maize resistant starch type 2 (RS-2) can change the composition of the gut microbiota, and reduce markers of inflammation and oxidative stress in patients with end-stage renal disease. However, the impact of RS-2 supplementation has not been extensively studied in CKD patients not on dialysis. Aerobic exercise training lowers certain markers of inflammation in CKD patients. Whether combining aerobic training along with RS-2 supplementation has an additive effect on the aforementioned biomarkers in predialysis CKD patients has not been previously investigated.MethodsThe study is being conducted as a 16-week, double-blind, placebo controlled, parallel arm, randomized controlled trial. Sixty stage 3-4 CKD patients (ages of 30-75 years) are being randomized to one of four groups: RS-2 & usual care, RS-2 & aerobic exercise, placebo (cornstarch) & usual care and placebo & exercise. Patients attend four testing sessions: Two baseline (BL) sessions with follow up visits 8 (wk8) and 16 weeks (wk16) later. Fasting blood samples, resting brachial and central blood pressures, and arterial stiffness are collected at BL, wk8 and wk16. A stool sample is collected for analysis of microbial composition and peak oxygen uptake is assessed at BL and wk16. Blood samples will be assayed for p-cresyl sulphate and indoxyl sulphate, c-reactive protein, tumor necrosis factor α, interleukin 6, interleukin 10, monocyte chemoattractant protein 1, malondialdehyde, 8-isoprostanes F2a, endothelin-1 and nitrate/nitrite. Following BL, subjects are randomized to their group. Individuals randomized to conditions involving exercise will attend three supervised moderate intensity (55-65% peak oxygen uptake) aerobic training sessions (treadmills, bikes or elliptical machine) per week for 16 weeks.DiscussionThis study has the potential to yield information about the effect of RS-2 supplementation on key biomarkers believed to impact upon the development of CVD in patients with CKD. We are examining whether there is an additive effect of exercise training and RS-2 supplementation on these key variables.Trial registrationClinicaltrials.gov Trial registration# NCT03689569 . 9/28/2018, retrospectively registered.
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- 2020
7. Fatigue Behavior Study of the Biodegradable Cardiovascular Stent
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Ameddah, Hacene, Lounansa, Salim, Mazouz, Hammoudi, Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, di Mare, Francesca, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, Bouraoui, Tarak, editor, Benameur, Tarek, editor, Mezlini, Salah, editor, Bouraoui, Chokri, editor, Znaidi, Amna, editor, Masmoudi, Neila, editor, and Ben Moussa, Naoufel, editor
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- 2022
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8. Integrating Biocybernetic Adaptation in Virtual Reality Training Concentration and Calmness in Target Shooting
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Muñoz, John E., Pope, Alan T., Velez, Luis E., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Holzinger, Andreas, editor, Pope, Alan, editor, and Plácido da Silva, Hugo, editor
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- 2019
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9. The most influential papers in mitral valve surgery; a bibliometric analysis
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Allen, N., O’Sullivan, K., and Jones, J. M.
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- 2020
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10. Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques [INVITED PAPER]
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Li, Jiawen and Chen, Zhongping
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Fluid Mechanics and Thermal Engineering ,Engineering ,Biomedical Engineering ,Bioengineering ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Biomedical Imaging ,Heart Disease ,Atherosclerosis ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,IVUS ,Optical coherence tomography ,cardiology ,integraged IVUS/OCT ,intravascular OCT ,intravascular imaging ,multi-modality imaging ,ultrasound ,vulnerable plaques - Abstract
Heart attack is mainly caused by the rupture of a vulnerable plaque. IVUS-OCT is a novel medical imaging modality that provides opportunities for accurate assessment of vulnerable plaques in vivo in patients. IVUS provides deep penetration to image the whole necrotic core while OCT enables accurate measurement of the fibrous cap of a plaque owing to its high resolution. In this paper, the authors describe the fundamentals, the technical designs and the applications of IVUS-OCT technology. Results from cadaver specimens are summarized, which indicated the complementary nature of OCT and IVUS for assessment of vulnerable plaques, plaque composition, and stent-tissue interactions. Furthermore, previously reported in vivo animal experiments are reviewed to assess the clinical adaptability of IVUS-OCT. Future directions for this technology are also discussed in this review.
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- 2015
11. Electronic cigarettes and health with special focus on cardiovascular effects: position paper of the European Association of Preventive Cardiology (EAPC)
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Pedro Marques-Vidal, Konstantinos C. Koskinas, Jean-Claude Barthélémy, Maryam Kavousi, Delphine De Smedt, Vassilios S. Vassiliou, Charlotta Pisinger, Monica Tiberi, Maja-Lisa Løchen, Demosthenes B. Panagiotakos, and Eva Prescott
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medicine.medical_specialty ,Epidemiology ,Disease ,tobacco ,law.invention ,SDG 3 - Good Health and Well-being ,law ,heart rate ,medicine ,Electronic cigarette ,Risk factor ,Intensive care medicine ,VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801 ,business.industry ,cardiovascular ,blood pressure ,Preventive cardiology ,Premature death ,myocardial infarction ,Position paper ,VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 ,Cardiology and Cardiovascular Medicine ,business ,Tobacco product - Abstract
This is a pre-copyedited, author-produced version of an article accepted for publication in European Journal of Preventive Cardiology following peer review. The version of record Kavousi, Pisinger, Barthelemy, Smedt, Koskinas, Marques-Vidal, Panagiotakos, Prescott, Tiberi, Vassiliou, Løchen. Electronic cigarettes and health with special focus on cardiovascular effects: position paper of the European Association of Preventive Cardiology (EAPC). European Journal of Preventive Cardiology (EJPC). 2020:2047487320941993, is available online at: https://doi.org/10.1177/2047487320941993. Background - Tobacco use is the single largest preventable risk factor for premature death of non-communicable diseases and the second leading cause of cardiovascular disease. In response to the harmful effects of tobacco smoking, the use of electronic cigarettes (e-cigarettes) has emerged and gained significant popularity over the past 15 years. E-cigarettes are promoted as safe alternatives for traditional tobacco smoking and are often suggested as a way to reduce or quit smoking. However, evidence suggests they are not harmless. Discussion - The rapid evolution of the e-cigarette market has outpaced the legislator’s regulatory capacity, leading to mixed regulations. The increasing use of e-cigarettes in adolescents and young individuals is of concern. While the long-term direct cardiovascular effects of e-cigarettes remain largely unknown, the existing evidence suggests that the e-cigarette should not be regarded as a cardiovascular safe product. The contribution of e-cigarette use to reducing conventional cigarette use and smoking cessation is complex, and the impact of e-cigarette use on long-term cessation lacks sufficient evidence. Conclusion - This position paper describes the evidence regarding the prevalence of e-cigarette smoking, uptake of e-cigarettes in the young, related legislations, cardiovascular effects of e-cigarettes and the impact of e-cigarettes on smoking cessation. Knowledge gaps in the field are also highlighted. The recommendations from the population science and public health section of the European Association of Preventive Cardiology are presented.
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- 2020
12. Position paper of the EACVI and EANM on artificial intelligence applications in multimodality cardiovascular imaging using SPECT/CT, PET/CT, and cardiac CT
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Oliver Gaemperli, Paola Anna Erba, Antti Saraste, Michelle C. Williams, Alessia Gimelli, Piotr J. Slomka, Christoph Rischpler, Roland Hustinx, Marc R. Dweck, Hein J. Verberne, Andor W. J. M. Glaudemans, Bernard Cosyns, Márton Kolossváry, Panagiotis Georgoulias, Luis Eduardo Juarez-Orozco, Ivana Išgum, Gilbert Habib, Mark Lubberink, Riemer H. J. A. Slart, Olivier Gheysens, Dimitris Visvikis, Fabien Hyafil, Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Translational Immunology Groningen (TRIGR), Cardiovascular Centre (CVC), IvI Research (FNWI), UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de médecine nucléaire, Clinical sciences, Cardio-vascular diseases, Cardiology, Slart, R, Williams, M, Juarez-Orozco, L, Rischpler, C, Dweck, M, Glaudemans, A, Gimelli, A, Georgoulias, P, Gheysens, O, Gaemperli, O, Habib, G, Hustinx, R, Cosyns, B, Verberne, H, Hyafil, F, Erba, P, Lubberink, M, Slomka, P, Isgum, I, Visvikis, D, Kolossvary, M, Saraste, A, University Medical Center Groningen [Groningen] (UMCG), University of Twente, University of Edinburgh, Utrecht University [Utrecht], University of Groningen [Groningen], Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Fondazione Toscana Gabriele Monasterio, University Hospital of Larissa, Cliniques Universitaires Saint-Luc [Bruxelles], Université Catholique de Louvain = Catholic University of Louvain (UCL), Hirslanden Medical Center, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Timone [CHU - APHM] (TIMONE), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), GIGA [Université Liège], Université de Liège, Universitair Ziekenhuis [Brussels, Belgium], University of Amsterdam [Amsterdam] (UvA), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Pisa - Università di Pisa, Uppsala University, Uppsala University Hospital, Cedars-Sinai Medical Center, Laboratoire de Traitement de l'Information Medicale (LaTIM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Semmelweis University [Budapest], University of Turku, Turku University Hospital (TYKS), Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences, Biomedical Engineering and Physics, ACS - Atherosclerosis & ischemic syndromes, ANS - Brain Imaging, and ACS - Heart failure & arrhythmias
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medicine.medical_specialty ,Medizin ,030204 cardiovascular system & hematology ,Guidelines ,Cardiovascular ,Multimodality imaging ,030218 nuclear medicine & medical imaging ,Multimodality ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Artificial Intelligence ,Positron Emission Tomography Computed Tomography ,Machine learning ,medicine ,Humans ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Position paper ,Deep learning ,Positron-Emission Tomography ,Tomography, Emission-Computed, Single-Photon ,Tomography, X-Ray Computed ,Nuclear Medicine ,Tomography ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,PET-CT ,medicine.diagnostic_test ,business.industry ,Coronary computed tomography angiography ,General Medicine ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,X-Ray Computed ,Functional imaging ,Positron emission tomography ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Radiologi och bildbehandling ,Applications of artificial intelligence ,Emission-Computed ,Cardiology and Cardiovascular Medicine ,business ,Emission computed tomography ,Radiology, Nuclear Medicine and Medical Imaging ,Single-Photon - Abstract
In daily clinical practice, clinicians integrate available data to ascertain the diagnostic and prognostic probability of a disease or clinical outcome for their patients. For patients with suspected or known cardiovascular disease, several anatomical and functional imaging techniques are commonly performed to aid this endeavor, including coronary computed tomography angiography (CCTA) and nuclear cardiology imaging. Continuous improvement in positron emission tomography (PET), single-photon emission computed tomography (SPECT), and CT hardware and software has resulted in improved diagnostic performance and wide implementation of these imaging techniques in daily clinical practice. However, the human ability to interpret, quantify, and integrate these data sets is limited. The identification of novel markers and application of machine learning (ML) algorithms, including deep learning (DL) to cardiovascular imaging techniques will further improve diagnosis and prognostication for patients with cardiovascular diseases. The goal of this position paper of the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI) is to provide an overview of the general concepts behind modern machine learning-based artificial intelligence, highlights currently prefered methods, practices, and computational models, and proposes new strategies to support the clinical application of ML in the field of cardiovascular imaging using nuclear cardiology (hybrid) and CT techniques.
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- 2021
13. Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis
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Elena Osto, Marie-Luce Bochaton-Piallat, Arno Schmidt-Trucksäss, Lina Badimon, Johannes Waltenberger, Christian Weber, Gemma Vilahur, Stefano Taddei, Yvonne Alexander, Paul C. Evans, Michael Shechter, Francesco Cosentino, Dirk J. Duncker, David G. Harrison, Danijela Trifunovic, Magnus Bäck, Fiona L. Wilkinson, Giuseppe Danilo Norata, Rosa Suades, Maria Dorobantu, Imo E. Hoefer, Victor Aboyans, Tomasz J. Guzik, Paul Morris, Marco De Carlo, Manchester Metropolitan University, Manchester, UK, University hospital of Zurich [Zurich], University of Basel (Unibas), Tel Aviv University (TAU), University of Belgrade [Belgrade], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Service de cardiologie [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Department of Cardiology, Karolinska University Hospital, Karolinska Institutet [Stockholm], University of Barcelona, Karolinska Institutet at Karolinska University Hospital, Azienda Ospedaliero-Universitaria Pisana [Pisa, Italy], University of Bucarest, Vanderbilt University School of Medicine [Nashville], Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), University Medical Center [Utrecht], INSIGNEO Institute for in Silico Medicine, University of Sheffield [Sheffield], Karolinska Institute and University Hospital, University of Pisa - Università di Pisa, Universitat Autònoma de Barcelona (UAB), Munich Cluster for systems neurology [Munich] (SyNergy), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Ludwig-Maximilians-Universität München (LMU), Université de Genève = University of Geneva (UNIGE), Grelier, Elisabeth, Tel Aviv University [Tel Aviv], Collegium Medicum, Jagiellonian University, University Medical Centre Utrecht, Department of Clinical and Experimental Medicine, University of Pisa, Department of Medicine, Autonomous University of Barcelona, Badalona, Spain., Technische Universität München [München] (TUM)-Ludwig-Maximilians-Universität München (LMU), Faculty of Medicine, University of Geneva, University of Zurich, Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)
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Physiology ,Diagnostic Techniques, Cardiovascular ,Disease ,030204 cardiovascular system & hematology ,2737 Physiology (medical) ,0302 clinical medicine ,540 Chemistry ,Cardiovascular ,Endothelial function ,Endothelial dysfunction ,IN-VIVO ,10038 Institute of Clinical Chemistry ,Observer Variation ,0303 health sciences ,cardiovascular ,FLOW-MEDIATED DILATION ,Position Paper from European Society of Cardiology Working Group ,CROSS-SECTIONAL RELATIONS ,Prognosis ,Thrombosis ,3. Good health ,Vasodilation ,Phenotype ,medicine.anatomical_structure ,Cardiovascular Diseases ,Cardiology ,NOX ISOFORM EXPRESSION ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Consensus ,Endothelium ,610 Medicine & health ,Risk Assessment ,2705 Cardiology and Cardiovascular Medicine ,Microcirculation ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Predictive Value of Tests ,BRACHIAL-ARTERY ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Humans ,NITRIC-OXIDE SYNTHASE ,SUPEROXIDE-PRODUCTION ,Pathological ,030304 developmental biology ,MESENCHYMAL TRANSITION ,business.industry ,Endothelial Cells ,Reproducibility of Results ,DIABETES-MELLITUS ,1314 Physiology ,medicine.disease ,Heart Disease Risk Factors ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,RISK-FACTORS ,Position paper ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Endothelium, Vascular ,Differential diagnosis ,business - Abstract
Endothelial cells (ECs) are sentinels of cardiovascular health. Their function is reduced by the presence of cardiovascular risk factors, and is regained once pathological stimuli are removed. In this European Society for Cardiology Position Paper, we describe endothelial dysfunction as a spectrum of phenotypic states and advocate further studies to determine the role of EC subtypes in cardiovascular disease. We conclude that there is no single ideal method for measurement of endothelial function. Techniques to measure coronary epicardial and micro-vascular function are well established but they are invasive, time-consuming, and expensive. Flow-mediated dilatation (FMD) of the brachial arteries provides a non-invasive alternative but is technically challenging and requires extensive training and standardization. We, therefore, propose that a consensus methodology for FMD is universally adopted to minimize technical variation between studies, and that reference FMD values are established for different populations of healthy individuals and patient groups. Newer techniques to measure endothelial function that are relatively easy to perform, such as finger plethysmography and the retinal flicker test, have the potential for increased clinical use provided a consensus is achieved on the measurement protocol used. We recommend further clinical studies to establish reference values for these techniques and to assess their ability to improve cardiovascular risk stratification. We advocate future studies to determine whether integration of endothelial function measurements with patient-specific epigenetic data and other biomarkers can enhance the stratification of patients for differential diagnosis, disease progression, and responses to therapy.
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- 2021
14. ESC working group on e-cardiology position paper: use of commercially available wearable technology for heart rate and activity tracking in primary and secondary cardiovascular prevention-in collaboration with the European Heart Rhythm Association, European Association of Preventive Cardiology, Association of Cardiovascular Nursing and Allied Professionals, Patient Forum, and the Digital Health Committee
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Joost Lumens, Paul McGreavy, Natasja M.S. de Groot, Magnus T. Jensen, Ines Frederix, Mark J. Schuuring, Emma Svennberg, David Duncker, Arno Schmidt-Trucksäss, Philippe H Kolh, Polychronis Dilaveris, Marco Di Rienzo, Ruben Casado-Arroyo, Hareld M. C. Kemps, Iana Simova, Axel Verstrael, Roderick W Treskes, Lis Neubeck, Martin R. Cowie, Mamas A. Mamas, Pyotr G. Platonov, Gianfranco Parati, Enrico G. Caiani, Cardiology, ACS - Heart failure & arrhythmias, and Amsterdam Cardiovascular Sciences
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Activity tracking ,Telemonitoring ,business.industry ,Wearables ,Prevention ,030204 cardiovascular system & hematology ,medicine.disease ,Cardiovascular ,Digital health ,Heart Rhythm ,Preventive cardiology ,03 medical and health sciences ,0302 clinical medicine ,Heart rate ,Position paper ,Medicine ,030212 general & internal medicine ,Medical emergency ,business ,Innovation ,Cardiovascular nursing ,Wearable technology - Abstract
Commercially available health technologies such as smartphones and smartwatches, activity trackers and eHealth applications, commonly referred to as wearables, are increasingly available and used both in the leisure and healthcare sector for pulse and fitness/activity tracking. The aim of the Position Paper is to identify specific barriers and knowledge gaps for the use of wearables, in particular for heart rate (HR) and activity tracking, in clinical cardiovascular healthcare to support their implementation into clinical care. The widespread use of HR and fitness tracking technologies provides unparalleled opportunities for capturing physiological information from large populations in the community, which has previously only been available in patient populations in the setting of healthcare provision. The availability of low-cost and high-volume physiological data from the community also provides unique challenges. While the number of patients meeting healthcare providers with data from wearables is rapidly growing, there are at present no clinical guidelines on how and when to use data from wearables in primary and secondary prevention. Technical aspects of HR tracking especially during activity need to be further validated. How to analyse, translate, and interpret large datasets of information into clinically applicable recommendations needs further consideration. While the current users of wearable technologies tend to be young, healthy and in the higher sociodemographic strata, wearables could potentially have a greater utility in the elderly and higher-risk population. Wearables may also provide a benefit through increased health awareness, democratization of health data and patient engagement. Use of continuous monitoring may provide opportunities for detection of risk factors and disease development earlier in the causal pathway, which may provide novel applications in both prevention and clinical research. However, wearables may also have potential adverse consequences due to unintended modification of behaviour, uncertain use and interpretation of large physiological data, a possible increase in social inequality due to differential access and technological literacy, challenges with regulatory bodies and privacy issues. In the present position paper, current applications as well as specific barriers and gaps in knowledge are identified and discussed in order to support the implementation of wearable technologies from gadget-ology into clinical cardiology.
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- 2021
15. The most influential papers in mitral valve surgery; a bibliometric analysis
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J. M. Jones, K. O'Sullivan, and N. Allen
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Bibliometric analysis ,Percutaneous ,Percutaneous surgery ,Mitral Valve Annuloplasty ,medicine.medical_treatment ,lcsh:Surgery ,Review ,030204 cardiovascular system & hematology ,Valve surgery ,Cardiovascular ,lcsh:RD78.3-87.3 ,03 medical and health sciences ,0302 clinical medicine ,Mitral valve ,medicine ,Humans ,Minimally Invasive Surgical Procedures ,Mitral Valve Stenosis ,Robotic surgery ,Minimally invasive ,Heart Valve Prosthesis Implantation ,Mitral valve repair ,business.industry ,General surgery ,Mitral repair ,Mitral valve replacement ,Mitral Valve Insufficiency ,General Medicine ,lcsh:RD1-811 ,Cardiac surgery ,medicine.anatomical_structure ,Treatment Outcome ,Cardiothoracic surgery ,Bibliometrics ,lcsh:Anesthesiology ,030220 oncology & carcinogenesis ,Heart Valve Prosthesis ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Abstract
This study is an analysis of the 100 most cited articles in mitral valve surgery. A bibliometric analysis is a tool to evaluate research performance in a given field. It uses the number of times a publication is cited by others as a proxy marker of its impact. The most cited paper Carpentier et al. discusses mitral valve repair in terms of restoring the geometry of the entire valve rather than simply narrowing the annulus (Carpentier, J Thorac Cardiovasc Surg 86:23–37, 1983). The first successful mitral valve repair was performed by Elliot Cutler at Brigham and Women’s Hospital in 1923 (Cohn et al., Ann Cardiothorac Surg 4:315, 2015). More recently percutaneous and minimally invasive techniques that were originally designed as an option for high risk patients are being trialled in other patient groups (Hajar, Heart Views 19:160–3, 2018). Comparison of percutaneous method with open repair represents an expanding area of research (Hajar, Heart Views 19:160–3, 2018). This study will analyse the top 100 cited papers relevant to mitral valve surgery, identifying the most influential papers that guide current management, the institutions that produce them and the authors involved.
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- 2020
16. Differences in citation frequency of clinical and basic science papers in cardiovascular research
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Opthof, Tobias
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- 2011
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17. New Cancer Study Results from University Hospital Center Described (Interventional Cardiology In Cancer Patients: a Position Paper From the Portuguese Cardiovascular Intervention Association and the Portuguese Cardio-oncology Study Group of the...).
- Abstract
A recent study from the University Hospital Center in Lisbon, Portugal, highlights the importance of addressing coronary and structural heart disease in cancer patients. While there has been increased awareness of cardiotoxicity in cancer patients, the focus has primarily been on myocardial systolic dysfunction and heart failure. Limited evidence and guidelines exist for dealing with coronary and structural heart disease in this population. To address this gap, the Portuguese Association of Cardiovascular Intervention and the Cardio-Oncology Study Group of the Portuguese Society of Cardiology have collaborated to produce a position paper on cardiac intervention in cancer patients, with a focus on percutaneous techniques. The paper provides a brief review of available evidence and practical considerations based on the authors' experience in the field. [Extracted from the article]
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- 2024
18. Studies in the Area of Hypertension Reported from McGill University Health Centre Research Institute (Mechanisms of Vascular Inflammation and Potential Therapeutic Targets: A Position Paper From the ESH Working Group on Small Arteries).
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New research from McGill University Health Centre Research Institute explores the role of inflammatory responses in small vessels in the development of cardiovascular diseases, including hypertension. The study identifies various complex molecular processes that contribute to microvascular damage, such as oxidative stress, inflammasome activation, immune-mediated responses, and protein misfolding. The researchers suggest that monoclonal antibodies targeting inflammatory cytokines and epigenetic drugs show promise in reducing microvascular inflammation and associated cardiovascular diseases. This comprehensive report provides insights into the mechanisms underlying microvascular inflammation and offers potential therapeutic strategies for vascular injury in cardiovascular disease. [Extracted from the article]
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- 2024
19. Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardioloy working Groups on Artherosclerosis and Vascular Biology, Aorta and Perirpheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis
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Alexander, Y, Osto, E, Schmidt-Trucksass, A, Shechter, M, Trifunovic, D, Duncker, DJ, Aboyans, V, Back, M, Badimon, L, Cosentino, F, De Carlo, M, Dorobantu, M, Harrison, DG, Guzik, TJ, Hoefer, I, Morris, PD, Norata, GD, Suades, R, Taddei, S, Vilahur, G, Waltenberger, J, Weber, C, Wilkinson, F, Bochaton-Piallat, ML, and Evans, PC
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Endothelial function ,Cardiovascular - Abstract
Endothelial cells (ECs) are sentinels of cardiovascular health. Their function is reduced by the presence of cardiovascular risk factors, and is regained once pathological stimuli are removed. In this European Society for Cardiology Position Paper, we describe endothelial dysfunction as a spectrum of phenotypic states and advocate further studies to determine the role of EC subtypes in cardiovascular disease. We conclude that there is no single ideal method for measurement of endothelial function. Techniques to measure coronary epicardial and micro-vascular are well established but they are invasive, time-consuming, and expensive. Flow-mediated dilatation (FMD) of the brachial arteries provides a non-invasive alternative but is technically challenging and requires extensive training and standardization. We, therefore, propose that a consensus methodology for FMD is universally adopted to minimize technical variation between studies, and that reference FMD values are established for different populations of healthy individuals and patient groups. Newer techniques to measure endothelial function that are relatively easy to perform, such as finger plethysmography and the retinal flicker test, have the potential for increased clinical use provided a consensus is achieved on the measurement protocol used. We recommend further clinical studies to establish reference values for these techniques and to assess their ability to improve cardiovascular risk stratification. We advocate future studies to determine whether integration of endothelial function measurements with patient-specific epigenetic data and other biomarkers can enhance the stratification of patients for differential diagnosis, disease progression, and responses to therapy.
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- 2021
20. Jagiellonian University Researcher Describes Research in Antihyperlipidemic Agents (Position Paper of the Polish Expert Group on the Use of Pitavastatin in the Treatment of Lipid Disorders in Poland Endorsed by the Polish Lipid Association).
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A recent research paper from Jagiellonian University discusses the use of antihyperlipidemic agents, specifically focusing on the drug pitavastatin, in the treatment of lipid disorders. The paper emphasizes the importance of measuring LDL-C levels to determine cardiovascular risk and the target for lipid-lowering therapy. It also highlights the need for better control of LDL-C levels and addresses concerns about side effects. The researchers conclude that pitavastatin is a viable therapeutic option for patients at high risk of diabetes or with existing diabetes, as well as those at cardiovascular risk. The paper provides valuable insights into the use of pitavastatin in the treatment of lipid disorders. [Extracted from the article]
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- 2023
21. The effects of 16-weeks of prebiotic supplementation and aerobic exercise training on inflammatory markers, oxidative stress, uremic toxins, and the microbiota in pre-dialysis kidney patients: a randomized controlled trial-protocol paper
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Elizabeth E. Evans, Kristyn Kirton, Bradley C. Nindl, Talat Alp Ikizler, Donna J. Chapman, Nosratola D. Vaziri, Elizabeth O'Neill, Michael J. Germain, Samuel Headley, Brian J. Martin, Emily M. Miele, Allen Cornelius, Karen Madsen, and Jasmin C. Hutchinson
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0301 basic medicine ,Nephrology ,Kidney Disease ,medicine.medical_treatment ,030232 urology & nephrology ,Inflammatory markers ,Cardiovascular ,lcsh:RC870-923 ,law.invention ,Kidney Failure ,Study Protocol ,0302 clinical medicine ,Randomized controlled trial ,law ,Chronic ,Resistant starch ,VO2 max ,Middle Aged ,Urology & Nephrology ,6.1 Pharmaceuticals ,Adult ,medicine.medical_specialty ,Clinical Trials and Supportive Activities ,Clinical Sciences ,Renal and urogenital ,Uremic toxins ,Placebo ,Zea mays ,03 medical and health sciences ,Double-Blind Method ,Clinical Research ,Internal medicine ,medicine ,Aerobic exercise ,Humans ,Exercise ,Dialysis ,Aged ,Inflammation ,Analysis of Variance ,business.industry ,Prevention ,Evaluation of treatments and therapeutic interventions ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,Gastrointestinal Microbiome ,Oxidative Stress ,030104 developmental biology ,Oxidative stress ,Arterial stiffness ,Kidney Failure, Chronic ,Amylose ,business ,Biomarkers ,Kidney disease - Abstract
Background Chronic kidney disease (CKD) is characterized by dysbiosis, elevated levels of uremic toxins, systemic inflammation, and increased markers of oxidative stress. These factors lead to an increased risk of cardiovascular disease (CVD) which is common among CKD patients. Supplementation with high amylose maize resistant starch type 2 (RS-2) can change the composition of the gut microbiota, and reduce markers of inflammation and oxidative stress in patients with end-stage renal disease. However, the impact of RS-2 supplementation has not been extensively studied in CKD patients not on dialysis. Aerobic exercise training lowers certain markers of inflammation in CKD patients. Whether combining aerobic training along with RS-2 supplementation has an additive effect on the aforementioned biomarkers in predialysis CKD patients has not been previously investigated. Methods The study is being conducted as a 16-week, double-blind, placebo controlled, parallel arm, randomized controlled trial. Sixty stage 3–4 CKD patients (ages of 30–75 years) are being randomized to one of four groups: RS-2 & usual care, RS-2 & aerobic exercise, placebo (cornstarch) & usual care and placebo & exercise. Patients attend four testing sessions: Two baseline (BL) sessions with follow up visits 8 (wk8) and 16 weeks (wk16) later. Fasting blood samples, resting brachial and central blood pressures, and arterial stiffness are collected at BL, wk8 and wk16. A stool sample is collected for analysis of microbial composition and peak oxygen uptake is assessed at BL and wk16. Blood samples will be assayed for p-cresyl sulphate and indoxyl sulphate, c-reactive protein, tumor necrosis factor α, interleukin 6, interleukin 10, monocyte chemoattractant protein 1, malondialdehyde, 8-isoprostanes F2a, endothelin-1 and nitrate/nitrite. Following BL, subjects are randomized to their group. Individuals randomized to conditions involving exercise will attend three supervised moderate intensity (55–65% peak oxygen uptake) aerobic training sessions (treadmills, bikes or elliptical machine) per week for 16 weeks. Discussion This study has the potential to yield information about the effect of RS-2 supplementation on key biomarkers believed to impact upon the development of CVD in patients with CKD. We are examining whether there is an additive effect of exercise training and RS-2 supplementation on these key variables. Trial registration Clinicaltrials.gov Trial registration#NCT03689569. 9/28/2018, retrospectively registered.
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- 2020
22. Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology
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Dominik Lautsch, Nilesh J. Samani, Guenter Breithardt, Dan Atar, Matthias Endres, Peter G. M. Mol, Hakima Hannachi, Maria Borentain, Anders Svensson, Andrew Zalewski, Paulus Kirchhof, Chantal Le Floch, Uwe Fraass, Salim Janmohamed, Jackson Neville Colin, Huseyin Naci, Martin J Landray, Jan G.P. Tijssen, Joerg Kreuzer, Tim Friede, Cathrine Thorstensen, Martin van Eickels, Victoria Vandzhura, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), and Cardiology
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Technology Assessment, Biomedical ,MONOCLONAL-ANTIBODY ,030204 cardiovascular system & hematology ,Cardiovascular ,PLACEBO-CONTROLLED TRIAL ,DOUBLE-BLIND ,0302 clinical medicine ,Clinical trials ,Cost of Illness ,Drug Discovery ,Medicine ,030212 general & internal medicine ,Precision Medicine ,Health technology assessment ,Drug Approval ,New therapies ,Societies, Medical ,Pharmaceutical industry ,Clinical Trials as Topic ,Cardiovascular disease burden ,Data Collection ,Therapies, Investigational ,Health technology ,C-REACTIVE PROTEIN ,Europe ,KEY DATA ELEMENTS ,Drug development ,Cardiovascular Diseases ,Costs and Cost Analysis ,Cardiology ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Drug Industry ,Interprofessional Relations ,HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA ,03 medical and health sciences ,Internal medicine ,Humans ,CORONARY-HEART-DISEASE ,ASSOCIATION TASK-FORCE ,business.industry ,SUBTILISIN/KEXIN TYPE 9 ,Information technology ,Personalized medicine ,Clinical trial ,HIGH-RISK ,Cardiovascular agent ,Position paper ,business - Abstract
Aims Cardiovascular disease is the most common cause of mortality and morbidity in the world, but the pharmaceutical industry's willingness to invest in this field has declined because of the many challenges involved with bringing new cardiovascular drugs to market, including late-stage failures, escalating regulatory requirements, bureaucracy of the clinical trial business enterprise, and limited patient access after approval. This contrasts with the remaining burden of cardiovascular disease in Europe and in the world. Thus, clinical cardiovascular research needs to adapt to address the impact of these challenges in order to ensure development of new cardiovascular medicines.Methods and results The present paper is the outcome of a two-day workshop held by the Cardiovascular Round Table of the European Society of Cardiology. We propose strategies to improve development of effective new cardiovascular therapies. These can include (i) the use of biomarkers to describe patients who will benefit from new therapies more precisely, achieving better human target validation; (ii) targeted, mechanism-based approaches to drug development for defined populations; (iii) the use of information technology to simplify data collection and follow-up in clinical trials; (iv) streamlining adverse event collection and reducing monitoring; (v) extended patent protection or limited rapid approval of new agents to motivate investment in early phase development; and (vi) collecting data needed for health technology assessment continuously throughout the drug development process (before and after approval) to minimize delays in patient access. Collaboration across industry, academia, regulators, and payers will be necessary to enact change and to unlock the existing potential for cardiovascular clinical drug development.Conclusions A coordinated effort involving academia, regulators, industry, and payors will help to foster better and more effective conduct of clinical cardiovascular trials, supporting earlier availability of innovative therapies and better management of cardiovascular diseases.
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- 2015
23. Measuring psoriatic disease in clinical practice. An expert opinion position paper
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Ignazio Olivieri, Ennio Lubrano, Antonio Spadaro, Federica Ricceri, Giampiero Girolomoni, Francesca Prignano, Fabrizio Cantini, Piercarlo Sarzi-Puttini, Raffaele Scarpa, Fabiola Atzeni, Alessandra Narcisi, Antonio Costanzo, Lubrano, Ennio, Cantini, Fabrizio, Costanzo, Antonio, Girolomoni, Giampiero, Prignano, Francesca, Olivieri, Ignazio, Scarpa, Raffaele, Spadaro, Antonio, Atzeni, Fabiola, Narcisi, Alessandra, Ricceri, Federica, and Sarzi Puttini, Piercarlo
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medicine.medical_specialty ,Population ,Immunology ,Cardiovascular ,Comorbidities ,Metabolic syndrome ,Outcome measures ,Psoriasis ,Psoriatic arthritis ,Disease ,Outcome measure ,Liver disease ,Quality of life (healthcare) ,Risk Factors ,Cardiovascular Disease ,medicine ,Humans ,Immunology and Allergy ,Obesity ,Intensive care medicine ,education ,Cardiovascular Diseases ,Metabolic Syndrome ,Quality of Life ,Psoriasi ,education.field_of_study ,business.industry ,Metabolic Syndrome X ,Risk Factor ,Medicine (all) ,Psoriatic arthriti ,medicine.disease ,Physical therapy ,Position paper ,Comorbiditie ,business ,Human - Abstract
Psoriasis is a common, immune-mediated chronic inflammatory disease with a primary involvement of skin and joints, affecting approximately 2% of the population worldwide. Up to one third of patients with psoriasis are diagnosed with psoriatic arthritis (PsA). Psoriasis and PsA are heterogeneous diseases whose severity depends on a number of clinical factors, such as areas affected and pattern of involvement, and are associated with a range of comorbid diseases and risk factors, including obesity, metabolic syndrome, cardiovascular disease and liver disease. Thus measuring the severity of psoriatic disease needs to take into account the multidimensional aspects of the disease. Subjective measures including the impairment in quality of life or in daily living activities as well as the presence of cardio-metabolic comorbidities, are important for the outcome and add further levels of complexity that, to a certain extent, need to be assessed. Because of the wide range of comorbid conditions associated with psoriasis, comprehensive screening and treatment must be implemented for a most effective managing of psoriasis patients. A joint dermatologist–rheumatologist roundtable discussion was convened to share evidence on the real-life use of methods for measuring psoriasis severity comprehensively. Our objective was to provide an expert position on which clinical variables are to be taken into account when considering patients affected by psoriasis and/or PsA globally and on the assessment tools more suitable for measuring disease activity and/or severity in clinical practice.
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- 2015
24. University of Foggia Researcher Details Research in Telemedicine (The Italian Society of Cardiology and Working Group on Telecardiology and Informatics 2023 updated position paper on telemedicine and artificial intelligence in cardiovascular...).
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Keywords: Artificial Intelligence; Cardiology; Cardiovascular; Cardiovascular Diseases and Conditions; Cardiovascular Research; Emerging Technologies; Health Information Technology; Health and Medicine; Machine Learning; Telecardiology; Telemedicine EN Artificial Intelligence Cardiology Cardiovascular Cardiovascular Diseases and Conditions Cardiovascular Research Emerging Technologies Health Information Technology Health and Medicine Machine Learning Telecardiology Telemedicine 1176 1176 1 09/04/23 20230908 NES 230908 2023 SEP 4 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Letter on the CDC & FDA -- Investigators publish new report on telemedicine. For more information on this research see: The Italian Society of Cardiology and Working Group on Telecardiology and Informatics 2023 updated position paper on telemedicine and artificial intelligence in cardiovascular disease. [Extracted from the article]
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- 2023
25. How to Write and Review an Artificial Intelligence Paper
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Weikert, Thomas, Leiner, Tim, Schoepf, U. Joseph, Series Editor, De Cecco, Carlo N., editor, van Assen, Marly, editor, and Leiner, Tim, editor
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- 2022
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26. Extracellular vesicles in diagnostics and therapy of the ischaemic heart : Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology
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Sluijter, Joost, Davidson, Sean, Boulanger, Chantal, Buzás, Edit, De Kleijn, Dominique, Engel, Felix, Giricz, Zoltán, Hausenloy, Derek, Kishore, Raj, Lecour, Sandrine, Leor, Jonathan, Madonna, Rosalinda, Perrino, Cinzia, Prunier, Fabrice, Sahoo, Susmita, Schiffelers, Ray, Schulz, Rainer, Van Laake, Linda Wilhelmina, Ytrehus, Kirsti, Ferdinandy, Peter, University Medical Center [Utrecht], Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Experimental Cardiology Laboratory (ECL), Unirversity Medical Center, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Cardiovascular Research Center, Massachusetts General Hospital [Boston], Semmelweis University [Budapest], Sluijter, Joost Petrus Gerardu, Davidson, Sean Michael, Boulanger, Chantal M, Buzás, Edit Iren, de Kleijn, Dominique Paschalis Victor, Engel, Felix Benedikt, Giricz, Zoltán, Hausenloy, Derek J, Kishore, Raj, Lecour, Sandrine, Leor, Jonathan, Madonna, Rosalinda, Perrino, Cinzia, Prunier, Fabrice, Sahoo, Susmita, Schiffelers, Ray Michel, Schulz, Rainer, Van Laake, Linda Wilhelmina, Ytrehus, Kirsti, and Ferdinandy, Péter
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Consensus ,Physiology ,[SDV]Life Sciences [q-bio] ,Diagnostic Techniques, Cardiovascular ,Cardiology ,Cell- and Tissue-Based Therapy ,Myocardial Ischemia ,Reviews ,Heart failure ,Preconditioning ,exosomes ,Cardioprotection ,Remote conditioning ,Cell Fractionation ,Cardiovascular ,Exosomes ,Ischaemia ,Co-morbiditie ,Postconditioning ,Microvesicle ,Cell-Derived Microparticles ,Predictive Value of Tests ,Physiology (medical) ,Animals ,Humans ,Co-morbidities ,Extracellular vesicles ,Microvesicles ,Regenerative medicine ,Reperfusion ,Biomarkers ,Exosome ,Diagnostic Techniques ,Editor's Choice ,Extracellular vesicle ,Cardiology and Cardiovascular Medicine - Abstract
International audience; Extracellular vesicles (EVs)-particularly exosomes and microvesicles (MVs)-are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction. They also appear to mediate some of the paracrine effects of cells, and have therefore been proposed as a potential alternative to cell-based regenerative therapies. Moreover, EVs of different sources may be useful biomarkers of cardiovascular disease identities. However, the methods used for the detection and isolation of EVs have several limitations and vary widely between studies, leading to uncertainties regarding the exact population of EVs studied and how to interpret the data. The number of publications in the exosome and MV field has been increasing exponentially in recent years and, therefore, in this ESC Working Group Position Paper, the overall objective is to provide a set of recommendations for the analysis and translational application of EVs focussing on the diagnosis and therapy of the ischaemic heart. This should help to ensure that the data from emerging studies are robust and repeatable, and optimize the pathway towards the diagnostic and therapeutic use of EVs in clinical studies for patient benefit.
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- 2018
27. Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques [INVITED PAPER]
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Jiawen Li and Zhongping Chen
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lcsh:Applied optics. Photonics ,genetic structures ,Acoustics and Ultrasonics ,Necrotic core ,intravascular imaging ,030204 cardiovascular system & hematology ,Cardiovascular ,medicine.disease_cause ,01 natural sciences ,0302 clinical medicine ,Intravascular ultrasound ,intravascular OCT ,screening and diagnosis ,medicine.diagnostic_test ,ultrasound ,Plaque composition ,Fibrous cap ,Atomic and Molecular Physics, and Optics ,3. Good health ,Detection ,Heart Disease ,surgical procedures, operative ,medicine.anatomical_structure ,lcsh:R855-855.5 ,cardiology ,integraged IVUS/OCT ,cardiovascular system ,Biomedical Imaging ,Radiology ,4.2 Evaluation of markers and technologies ,medicine.medical_specialty ,lcsh:Medical technology ,Biomedical Engineering ,Bioengineering ,Article ,010309 optics ,Biomaterials ,03 medical and health sciences ,Optical coherence tomography ,0103 physical sciences ,Medical imaging ,medicine ,In patient ,cardiovascular diseases ,Heart Disease - Coronary Heart Disease ,IVUS ,business.industry ,lcsh:TA1501-1820 ,multi-modality imaging ,Atherosclerosis ,equipment and supplies ,Vulnerable plaque ,vulnerable plaques ,business - Abstract
Heart attack is mainly caused by the rupture of a vulnerable plaque. IVUS-OCT is a novel medical imaging modality that provides opportunities for accurate assessment of vulnerable plaques in vivo in patients. IVUS provides deep penetration to image the whole necrotic core while OCT enables accurate measurement of the fibrous cap of a plaque owing to its high resolution. In this paper, the authors describe the fundamentals, the technical designs and the applications of IVUS-OCT technology. Results from cadaver specimens are summarized, which indicated the complementary nature of OCT and IVUS for assessment of vulnerable plaques, plaque composition, and stent-tissue interactions. Furthermore, previously reported in vivo animal experiments are reviewed to assess the clinical adaptability of IVUS-OCT. Future directions for this technology are also discussed in this review.
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- 2015
28. Australian Catholic University Researcher Publishes New Data on Cardiovascular Nursing (Beyond Validation: Getting Wearable Activity Trackers into Cardiovascular Care - A Discussion Paper).
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CARDIOVASCULAR nurses ,RESEARCH personnel ,REPORTERS & reporting - Abstract
A researcher from Australian Catholic University has published a discussion paper on the integration of wearable activity trackers into cardiovascular disease care. The paper highlights the lack of systematic, evidence-based implementation approaches for incorporating these trackers into clinical settings. The researcher emphasizes the need for collaboration between clinicians, patients, implementation scientists, researchers, and health and technology partners to bridge this gap and ensure effective translation of wearable activity trackers into cardiovascular care. The paper concludes that stakeholder collaboration and the use of proven implementation science methodologies are crucial in meeting the increasing demand for these trackers from patients and clinicians. [Extracted from the article]
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- 2024
29. Research from University Hospital Essen Has Provided New Data on Angiology (Hybrid coronary revascularization: position paper of the European Society of Cardiology Working Group on Cardiovascular Surgery and European Association of Percutaneous...).
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- 2024
30. Findings from University of Perugia Advance Knowledge in Muscular Atrophy [Position paper on essential strategies for healthy aging: focus on preventing sarcopenia and cardiovascular diseases from the 38th National Congress of the Italian...].
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NEUROLOGICAL disorders ,MUSCULAR atrophy ,MUSCULOSKELETAL system diseases ,CARDIOVASCULAR diseases ,OLDER people - Abstract
A recent study from the University of Perugia highlights the importance of addressing the health needs of Italy's aging population, particularly in preventing sarcopenia and cardiovascular diseases. The research challenges the idea that functional decline is inevitable with age and emphasizes the role of genetic, environmental, and lifestyle factors in health outcomes. Sarcopenia, a prevalent condition associated with frailty, significantly impacts physical function and mortality rates, necessitating behavioral interventions. The study emphasizes the importance of tailored interventions, enhanced screening, lifelong healthy habits, research and innovation, community support systems, and adaptable policies to address the challenges posed by an aging population. [Extracted from the article]
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- 2024
31. Managing Incidental Findings on Thoracic CT: Mediastinal and Cardiovascular Findings. A White Paper of the ACR Incidental Findings Committee.
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Munden, Reginald F., Carter, Brett W., Chiles, Caroline, MacMahon, Heber, Black, William C., Ko, Jane P., McAdams, H. Page, Rossi, Santiago E., Leung, Ann N., Boiselle, Phillip M., Kent, Michael S., Brown, Kathleen, Dyer, Debra S., Hartman, Thomas E., Goodman, Eric M., Naidich, David P., Kazerooni, Ella A., Berland, Lincoln L., and Pandharipande, Pari V.
- Abstract
The ACR Incidental Findings Committee presents recommendations for managing incidentally detected mediastinal and cardiovascular findings found on CT. The Chest Subcommittee was composed of thoracic radiologists who developed the provided guidance. These recommendations represent a combination of current published evidence and expert opinion and were finalized by informal iterative consensus. The recommendations address the most commonly encountered mediastinal and cardiovascular incidental findings and are not intended to be a comprehensive review of all incidental findings associated with these compartments. Our goal is to improve the quality of care by providing guidance on how to manage incidentally detected thoracic findings. [ABSTRACT FROM AUTHOR]
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- 2018
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32. Study Data from University College London (UCL) Update Knowledge of Heart Disease (Circadian Rhythms In Ischaemic Heart Disease: Key Aspects for Preclinical and Translational Research: Position Paper of the Esc Working Group On Cellular Biology...).
- Abstract
Keywords for this news article include: London, United Kingdom, Europe, Angiology, Cardiology, Cardiovascular, Cardiovascular Diseases and Conditions, Cardiovascular Research, Cell Biology, Circadian Rhythms, Health and Medicine, Heart Disease, Heart Disorders and Diseases, Ischemia, Risk and Prevention, Vascular Diseases and Conditions, University College London (UCL). Keywords: London; United Kingdom; Europe; Angiology; Cardiology; Cardiovascular; Cardiovascular Diseases and Conditions; Cardiovascular Research; Cell Biology; Circadian Rhythms; Health and Medicine; Heart Disease; Heart Disorders and Diseases; Ischemia; Risk and Prevention; Vascular Diseases and Conditions EN London United Kingdom Europe Angiology Cardiology Cardiovascular Cardiovascular Diseases and Conditions Cardiovascular Research Cell Biology Circadian Rhythms Health and Medicine Heart Disease Heart Disorders and Diseases Ischemia Risk and Prevention Vascular Diseases and Conditions 879 879 1 06/19/23 20230619 NES 230619 2023 JUN 19 (NewsRx) -- By a News Reporter-Staff News Editor at Heart Disease Weekly -- Current study results on Heart Disorders and Diseases - Heart Disease have been published. London, United Kingdom, Europe, Angiology, Cardiology, Cardiovascular, Cardiovascular Diseases and Conditions, Cardiovascular Research, Cell Biology, Circadian Rhythms, Health and Medicine, Heart Disease, Heart Disorders and Diseases, Ischemia, Risk and Prevention, Vascular Diseases and Conditions. [Extracted from the article]
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- 2023
33. Measuring psoriatic disease in clinical practice. An expert opinion position paper.
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Lubrano, Ennio, Cantini, Fabrizio, Costanzo, Antonio, Girolomoni, Giampiero, Prignano, Francesca, Olivieri, Ignazio, Scarpa, Raffaele, Spadaro, Antonio, Atzeni, Fabiola, Narcisi, Alessandra, Ricceri, Federica, and Sarzi-Puttini, Piercarlo
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PSORIASIS treatment , *QUALITY of life , *DERMATOLOGISTS , *RHEUMATOLOGISTS , *PSORIASIS , *HEALTH outcome assessment , *PATIENTS - Abstract
Psoriasis is a common, immune-mediated chronic inflammatory disease with a primary involvement of skin and joints, affecting approximately 2% of the population worldwide. Up to one third of patients with psoriasis are diagnosed with psoriatic arthritis (PsA). Psoriasis and PsA are heterogeneous diseases whose severity depends on a number of clinical factors, such as areas affected and pattern of involvement, and are associated with a range of comorbid diseases and risk factors, including obesity, metabolic syndrome, cardiovascular disease and liver disease. Thus measuring the severity of psoriatic disease needs to take into account the multidimensional aspects of the disease. Subjective measures including the impairment in quality of life or in daily living activities as well as the presence of cardio-metabolic comorbidities, are important for the outcome and add further levels of complexity that, to a certain extent, need to be assessed. Because of the wide range of comorbid conditions associated with psoriasis, comprehensive screening and treatment must be implemented for a most effective managing of psoriasis patients. A joint dermatologist–rheumatologist roundtable discussion was convened to share evidence on the real-life use of methods for measuring psoriasis severity comprehensively. Our objective was to provide an expert position on which clinical variables are to be taken into account when considering patients affected by psoriasis and/or PsA globally and on the assessment tools more suitable for measuring disease activity and/or severity in clinical practice. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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34. New Rheumatic Diseases and Conditions Findings from University of Bari Described [Italian Recommendations for the Assessment of Cardiovascular Risk In Rheumatoid Arthritis: a Position Paper of the Cardiovascular Obesity and Rheumatic Disease...].
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RHEUMATISM ,RHEUMATOID arthritis ,CARDIOVASCULAR diseases risk factors ,NUTRITION disorders ,RISK assessment - Abstract
A recent study conducted by the University of Bari in Italy focuses on the cardiovascular risk assessment in patients with rheumatoid arthritis (RA). The study aims to provide Italian rheumatologists with a simple and efficient method for assessing cardiovascular risk in their daily practice. The research suggests that RA patients should have their cardiovascular profile monitored using the Italian 'Progetto Cuore' chart, following the current European League Against Rheumatism (EULAR) recommendations for cardiovascular risk management. The study concludes that a standardized approach to cardiovascular risk profiling can help identify patients who may benefit from intensive preventive strategies to improve their cardiovascular outcomes. [Extracted from the article]
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- 2024
35. Cohort mortality study of Swedish pulp and paper mill workers—non malignant diseases.
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Andersson, Eva, Persson, Bodil, Geisson, Ing-Liss Bryn, Magnuson, Anders, Torén, Kjell, Wingren, Gun, and Westberg, Håkan
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WOOD pulp industry workers ,INDUSTRIAL hygiene ,MYOCARDIAL infarction ,CORONARY disease ,MORTALITY - Abstract
The article examines mortality among pulp and paper mill workers according to the mail mill pulping process, department, and gender. It states that death from acute myocardial infarction was increased, which was probably related to a combination of different occupational exposures such as dust, sulfur compounds, shift work and noise. It is concluded that the study supports earlier indications of fatal cardiovascular effects among pulp and paper mill workers.
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- 2007
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36. Differences in citation frequency of clinical and basic science papers in cardiovascular research
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Tobias Opthof, Cardiology, and Faculteit der Geneeskunde
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Biomedical Research ,Basic science ,Citation indicators ,Cardiovascular research ,Cardiology ,Biomedical Engineering ,Clinical science ,Citation profiles ,Bibliometrics ,Citation frequency ,Cardiovascular ,CWTS ,Medicine ,Humans ,Social science ,Citation ,Quality assessment ,business.industry ,Peer esteem ,Human physiology ,Data science ,Computer Science Applications ,Editorial ,Historical citation data ,Hirsch index ,Periodicals as Topic ,business - Abstract
In this article, a critical analysis is performed on differences in citation frequency of basic and clinical cardiovascular papers. It appears that the latter papers are cited at about 40% higher frequency. The differences between the largest number of citations of the most cited papers are even larger. It is also demonstrated that the groups of clinical and basic cardiovascular papers are also heterogeneous concerning citation frequency. It is concluded that none of the existing citation indicators appreciates these differences. At this moment these indicators should not be used for quality assessment of individual scientists and scientific niches with small numbers of scientists.
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- 2011
37. A systematic mapping study for ensemble classification methods in cardiovascular disease.
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Hosni, Mohamed, Carrillo de Gea, Juan M., Idri, Ali, El Bajta, Manal, Fernández Alemán, José Luis, García-Mateos, Ginés, and Abnane, Ibtissam
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CARDIOVASCULAR diseases ,PLURALITY voting ,CLASSIFICATION ,MACHINE learning ,DIGITAL libraries - Abstract
Ensemble methods overcome the limitations of single machine learning techniques by combining different techniques, and are employed in the quest to achieve a high level of accuracy. This approach has been investigated in various fields, one of them being that of bioinformatics. One of the most frequent applications of ensemble techniques involves research into cardiovascular diseases, which are considered the leading cause of death worldwide. The purpose of this research work is to identify the papers that investigate ensemble classification techniques applied to cardiology diseases, and to analyse them according to nine aspects: their publication venues, the medical tasks tackled, the empirical and research types adopted, the types of ensembles proposed, the single techniques used to construct the ensembles, the validation frameworks adopted to evaluate the proposed ensembles, the tools used to build the ensembles, and the optimization methods employed for the single techniques. This paper reports the carrying out of a systematic mapping study. An extensive automatic search in four digital libraries: IEEE Xplore, ACM Digital Library, PubMed, and Scopus, followed by a study selection process, resulted in the identification of 351 papers that were used to address our mapping questions. This study found that the papers selected had been published in a large number of different resources. The medical task addressed most frequently by the selected studies was diagnosis. In addition, the experiment-based empirical type and evaluation-based research type were the most dominant approaches adopted by the selected studies. Homogeneous ensembles were the ensemble type that was developed most often in literature, while decision trees, artificial neural networks and Bayesian classifiers were the single techniques used most frequently to develop ensemble classification methods. The weighted majority and majority voting rules were adopted to obtain the final decision of the ensembles developed. With regard to evaluation frameworks, the datasets obtained from the UCI and PhysioBank repositories were those used most often to evaluate the ensemble methods, while the k-fold cross-validation method was the most frequently-employed validation technique. Several tools with which to build ensemble classifiers were identified, and the type of software adopted with the greatest frequency was open source. Finally, only a few researchers took into account the optimization of the parameter settings of either single or meta ensemble classifiers. This mapping study attempts to provide a greater insight into the application of ensemble classification methods in cardiovascular diseases. The majority of the selected papers reported positive feedback as regards the ability of ensemble methods to perform better than single methods. Further analysis is required to aggregate the evidence reported in literature. [ABSTRACT FROM AUTHOR]
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- 2021
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38. Effects of red wine on cardiovascular diseases.
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Ramian, Jan, Bator, Piotr, Razik, Michał, Rozwadowska, Patrycja, Rybak, Jakub, Magiera, Barbara, Magiera, Karol, and Razik, Wiktor
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RED wines ,CARDIOVASCULAR diseases ,RESVERATROL ,IN vitro studies ,WINES - Abstract
Introduction and purpose: The purpose of this scientific paper is to review the current knowledge of the effects of red wine on human health, particularly with regard to cardiovascular disease. State of Knowledge: Since the 1990s, red wine has gained its status as a health-promoting alcohol through the French Paradox - when drunk in moderate amounts, it protects against cardiovascular disease. The authors have collected scientific papers on the health effects of alcohol, red wine and resveratrol-a polyphenol that is the main component with healthpromoting effects of wine. On their basis, they analyzed the assumptions of the positive effects of wine reaching inconclusive conclusions. Summary: Despite the fact that both ethanol and resveratrol have a positive effect in in vitro studies, in population studies their effect is much less significant, either because the negative behavioral-health effects in the case of ethanol are omitted or the actual effective doses of resveratrol are omitted. [ABSTRACT FROM AUTHOR]
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- 2024
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39. Integrated Analysis of Genomic and Genome-Wide Association Studies Identified Candidate Genes for Nutrigenetic Studies in Flavonoids and Vascular Health: Path to Precision Nutrition for (Poly)phenols.
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Ruskovska, Tatjana, Postolov, Filip, and Milenkovic, Dragan
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Flavonoids exert vasculoprotective effects in humans, but interindividual variability in their action has also been reported. This study aims to identify genes that are associated with vascular health effects of flavonoids and whose polymorphisms could explain interindividual variability in response to their intake. Applying the predetermined literature search criteria, we identified five human intervention studies reporting positive effects of flavonoids on vascular function together with global genomic changes analyzed using microarray methods. Genes involved in vascular dysfunction were identified from genome-wide association studies (GWAS). By extracting data from the eligible human intervention studies, we obtained 5807 differentially expressed genes (DEGs). The number of identified upstream regulators (URs) varied across the studies, from 227 to 1407. The search of the GWAS Catalog revealed 493 genes associated with vascular dysfunction. An integrative analysis of transcriptomic data with GWAS genes identified 106 candidate DEGs and 42 candidate URs, while subsequent functional analyses and a search of the literature identified 20 top priority candidate genes: ALDH2, APOE, CAPZA1, CYP11B2, GNA13, IL6, IRF5, LDLR, LPL, LSP1, MKNK1, MMP3, MTHFR, MYO6, NCR3, PPARG, SARM1, TCF20, TCF7L2, and TNF. In conclusion, this integrated analysis identifies important genes to design future nutrigenetic studies for development of precision nutrition for polyphenols. [ABSTRACT FROM AUTHOR]
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- 2024
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40. Call for papers theme issue on generative and multimodal artificial intelligence AI in digital cardiovascular medicine.
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ARTIFICIAL intelligence ,LANGUAGE models ,TECHNOLOGICAL innovations - Published
- 2023
41. Researchers at Icahn School of Medicine at Mount Sinai Report New Data on Obesity, Fitness and Wellness (Geographic Mapping of Gender Disparities In Authorship of Cardiovascular Literature).
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AUTHORSHIP in literature ,GENDER inequality ,RESEARCH personnel ,OBESITY ,WOMEN authors - Abstract
A study conducted by researchers at the Icahn School of Medicine at Mount Sinai in New York City examined gender disparities in authorship of cardiovascular literature. The study found that women in cardiology face significant disparities in publications, which hinder their career advancement. The researchers analyzed papers published in four major cardiovascular journals from 2010 to 2019 and found that only 20.6% of authors were women, with 47.7% of papers having no women authors. The study calls for action to promote women in cardiology and provide them with equitable opportunities. [Extracted from the article]
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- 2024
42. New Cardiovascular Diseases and Conditions Findings from University Hospital Leuven Outlined (Peripheral Blood Rna Biomarkers for Cardiovascular Disease From Bench To Bedside: a Position Paper From the Eu-cardiorna Cost Action Ca17129).
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VASOMOTOR conditioning ,CARDIOVASCULAR diseases ,UNIVERSITY hospitals ,BIOMARKERS ,RNA ,HEART failure - Published
- 2023
43. Heart sound classification based on improved mel-frequency spectral coefficients and deep residual learning.
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Feng Li, Zheng Zhang, Lingling Wang, and Wei Liu
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HEART sounds ,DEEP learning ,CLASSIFICATION ,DIAGNOSIS ,EARLY diagnosis - Abstract
Heart sound classification plays a critical role in the early diagnosis of cardiovascular diseases. Although there have been many advances in heart sound classification in the last few years, most of them are still based on conventional segmented features and shallow structure-based classifiers. Therefore, we propose a new heart sound classification method based on improved mel-frequency cepstrum coefficient features and deep residual learning. Firstly, the heart sound signal is preprocessed, and its improved features are computed. Then, these features are used as input features of the neural network. The pathological information in the heart sound signal is further extracted by the deep residual network. Finally, the heart sound signal is classified into different categories according to the features learned by the neural network. This paper presents comprehensive analyses of different network parameters and network connection strategies. The proposed method achieves an accuracy of 94.43% on the dataset in this paper. [ABSTRACT FROM AUTHOR]
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- 2022
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44. Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology.
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Jackson, Neville, Atar, Dan, Borentain, Maria, Breithardt, Günter, van Eickels, Martin, Endres, Matthias, Fraass, Uwe, Friede, Tim, Hannachi, Hakima, Janmohamed, Salim, Kreuzer13, Jörg, Landray, Martin, Lautsch, Dominik, Le Floch, Chantal, Mol, Peter, Naci, Huseyin, Samani, Nilesh J., Svensson, Anders, Thorstensen, Cathrine, and Tijssen, Jan
- Abstract
Aims Cardiovascular disease is the most common cause of mortality and morbidity in the world, but the pharmaceutical industry's willingness to invest in this field has declined because of the many challenges involved with bringing new cardiovascular drugs to market, including late-stage failures, escalating regulatory requirements, bureaucracy of the clinical trial business enterprise, and limited patient access after approval. This contrasts with the remaining burden of cardiovascular disease in Europe and in the world. Thus, clinical cardiovascular research needs to adapt to address the impact of these challenges in order to ensure development of new cardiovascular medicines. Methods and results The present paper is the outcome of a two-day workshop held by the Cardiovascular Round Table of the European Society of Cardiology. We propose strategies to improve development of effective new cardiovascular therapies. These can include (i) the use of biomarkersto describe patients who will benefit from new therapies more precisely, achieving better human target validation; (ii) targeted, mechanism-based approaches to drug development for defined populations; (iii) the use of information technology to simplify data collection and follow-up in clinical trials; (iv) streamlining adverse event collection and reducing monitoring; (v) extended patent protection or limited rapid approval of new agents to motivate investment in early phase development; and (vi) collecting data needed for health technology assessment continuously throughout the drug development process (before and after approval) to minimize delays in patient access. Collaboration across industry, academia, regulators, and payers will be necessary to enact change and to unlock the existing potential for cardiovascular clinical drug development. Conclusions A coordinated effort involving academia, regulators, industry, and payors will help to foster better and more effective conduct of clinical cardiovascular trials, supporting earlier availability of innovative therapies and better management of cardiovascular diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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45. Prenatal nicotine exposure was associated with long‐term impact on the cardiovascular system and regulation—Review.
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CARDIOVASCULAR system ,NICOTINE ,BLOOD pressure ,DYSAUTONOMIA - Abstract
Aim: The aim of this structured review was to discuss knowledge of nicotine use during pregnancy and long‐term effects on children's cardiovascular function. Methods: PubMed and MEDLINE were searched for original papers that covered various forms of nicotine exposure during pregnancy and this identified 314 papers published in English from inception of the databases to 1 March 2021. The research focus was prenatal exposure that had long‐term effects on the cardiovascular system. The search was expanded from the reference list of the selected papers, which identified another 17 papers. Results: The 34 original papers that were included covered 172,696 subjects from foetuses to 19 years of age. Cardiovascular autonomic dysfunction was discussed in 12 of the papers and 16 studies reported on blood pressure. The remaining studies covered structural or functional changes in arterial wall or heart. There were convincing data on autonomic dysfunction and increased blood pressure. Some data were conflicting and problems with misclassification of exposure were evident. Conclusion: Prenatal nicotine exposure was associated with long‐term developmental changes in the cardiovascular system and regulation. There were no safe periods, doses or nicotine products during pregnancy and women should abstain when planning a pregnancy. [ABSTRACT FROM AUTHOR]
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- 2021
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46. When Heart Beats Differently in Depression: Review of Nonlinear Heart Rate Variability Measures.
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Čukić, Milena, Savić, Danka, and Sidorova, Julia
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ONLINE information services ,SYSTEMATIC reviews ,MENTAL depression ,HEART beat ,MEDLINE - Abstract
Background: Disturbed heart dynamics in depression seriously increases mortality risk. Heart rate variability (HRV) is a rich source of information for studying this dynamics. This paper is a meta-analytic review with methodological commentary of the application of nonlinear analysis of HRV and its possibility to address cardiovascular diseases in depression. Objective: This paper aimed to appeal for the introduction of cardiological screening to patients with depression, because it is still far from established practice. The other (main) objective of the paper was to show that nonlinear methods in HRV analysis give better results than standard ones. Methods: We systematically searched on the web for papers on nonlinear analyses of HRV in depression, in line with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 framework recommendations. We scrutinized the chosen publications and performed random-effects meta-analysis, using the esci module in jamovi software where standardized effect sizes (ESs) are corrected to yield the proof of the practical utility of their results. Results: In all, 26 publications on the connection of nonlinear HRV measures and depression meeting our inclusion criteria were selected, examining a total of 1537 patients diagnosed with depression and 1041 healthy controls (N=2578). The overall ES (unbiased) was 1.03 (95% CI 0.703-1.35; diamond ratio 3.60). We performed 3 more meta-analytic comparisons, demonstrating the overall effectiveness of 3 groups of nonlinear analysis: detrended fluctuation analysis (overall ES 0.364, 95% CI 0.237-0.491), entropy-based measures (overall ES 1.05, 95% CI 0.572-1.52), and all other nonlinear measures (overall ES 0.702, 95% CI 0.422-0.982). The effectiveness of the applied methods of electrocardiogram analysis was compared and discussed in the light of detection and prevention of depression-related cardiovascular risk. Conclusions: We compared the ESs of nonlinear and conventional time and spectral methods (found in the literature) and demonstrated that those of the former are larger, which recommends their use for the early screening of cardiovascular abnormalities in patients with depression to prevent possible deleterious events. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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47. Oral Health and Cardiac Rehabilitation: A Scoping Review.
- Author
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Ab Malik, N., Mohamad Yatim, S., Li, LSW, and Abdullah Ramaiah, AR
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CARDIAC rehabilitation ,ORAL health ,HEALTH behavior ,HEALTH literacy - Abstract
This scoping review aimed to gain an insight into the oral health status, behaviour, knowledge, and risk among cardiovascular patients, as well as to explore challenges and to make a recommendation concerning oral health and cardiovascular patients. It focused on four key areas, namely oral health status, behaviour, knowledge, and associated risk factors. Relevant studies were searched using a combination of keywords and related search terms. Four available databases were used; EBSCOhost, Scopus, Proquest, and Pubmed to identify the relevant studies. A total of 789 papers were screened and duplicated papers were removed, 28 papers were retrieved for full-text review. It was found that most cardiovascular patients have poor oral health, while their oral health behaviour and knowledge were at a fair level. There are a limited number of studies assessing oral health conditions during cardiac rehabilitation. In general, protocol and guidelines about the importance of oral health care for cardiovascular patients are still lacking. Having good oral health has potential impacts in reducing the risk of CVD. Future research is warranted with potential intervention approaches to improve oral health conditions among cardiovascular patients, thus reducing the risk of CVD. [ABSTRACT FROM AUTHOR]
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- 2022
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48. Fetal ventricular strain in uncomplicated and selective growth‐restricted monochorionic diamniotic twin pregnancies and cardiovascular response in pre‐twin–twin transfusion syndrome
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A. Agarwal, Ramesha Papanna, Kenneth J. Moise, Anthony Johnson, Cynthia S. Bell, Roopali Donepudi, Christoph Wohlmuth, I. E. Averiss, Blair Stevens, and Helena M. Gardiner
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selective intrauterine growth restriction ,sIUGR ,Twins ,Intrauterine growth restriction ,0302 clinical medicine ,Obstetrics and gynaecology ,Pregnancy ,Single-Blind Method ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Twin Pregnancy ,ventricular strain ,Fetal Growth Retardation ,030219 obstetrics & reproductive medicine ,Radiological and Ultrasound Technology ,Obstetrics ,cardiovascular ,Obstetrics and Gynecology ,Gestational age ,Fetofetal Transfusion ,General Medicine ,Original Papers ,Fetal Weight ,Multilevel Analysis ,Regression Analysis ,Female ,Ductus venosus ,Adult ,medicine.medical_specialty ,Heart Ventricles ,Gestational Age ,Ultrasonography, Prenatal ,03 medical and health sciences ,Fetal Heart ,Fetus ,twin–twin transfusion syndrome ,medicine ,Humans ,Placental Circulation ,Radiology, Nuclear Medicine and imaging ,monochorionic ,Original Paper ,business.industry ,Reproducibility of Results ,medicine.disease ,TTTS ,Reproductive Medicine ,Pregnancy, Twin ,business - Abstract
Objectives Our primary aim was to confirm whether intertwin discordance in ventricular strain and ductus venosus (DV) time intervals predicts twin–twin transfusion syndrome (TTTS). Secondary aims were to create gestational‐age ranges for ventricular strain in uncomplicated monochorionic diamniotic (MCDA) twin pregnancies without selective intrauterine growth restriction (sIUGR) and to characterize the relationship of ventricular strain with gestational age in MCDA twin pregnancies with sIUGR that did not develop TTTS. Methods In the period 2015–2018, we enrolled 150 MCDA twin pregnancies consecutively into this prospective, blinded study of global longitudinal left and right ventricular strain. With the observer blinded to twin pairing and pregnancy outcome, videoclips of the four‐chamber view, which had been recorded during ultrasound surveillance in the usual window for development of TTTS (16–26 completed gestational weeks), underwent offline measurement of strain. Uncomplicated MCDA twin pregnancies, without sIUGR, were used to test the association between strain, gestational age and estimated fetal weight using mixed‐effects multilevel regression. Inter‐rater reliability was tested in 208 strain measurements in 31 fetuses from pregnancies which did not develop TTTS and within‐fetus variation was assessed in 16 such fetuses, in which multiple four‐chamber views were taken on the same day. The effect of sIUGR on strain in otherwise uncomplicated MCDA twin pregnancy was analyzed. MCDA twin pregnancies were defined as ‘pre‐TTTS’ when, having been referred for TTTS evaluation, they did not satisfy Quintero staging criteria, but subsequently developed TTTS requiring laser treatment. MCDA pregnancies which did not develop TTTS comprised the ‘non‐TTTS’ group. Cardiovascular parameters measured in these cases included tissue Doppler parameters and DV early filling time as a percentage of the cardiac cycle (DVeT%). Intertwin strain and DVeT% discordance was compared between non‐TTTS and pre‐TTTS cases, matched for gestational age. Results Paired strain data were available for intertwin comparison in 127/150 MCDA twin pregnancies, comprising 14 pre‐TTTS and 113 non‐TTTS pregnancies, after exclusions. Scans were collected at a median frame rate of 97 (range, 28–220) Hz. Laser therapy was performed at a median gestational age of 20.6 (range, 17.2–26.6) weeks. There were no group differences in right (RV) or left (LV) ventricular strain discordance between 68/113 non‐TTTS and 13/14 pre‐TTTS MCDA twin pregnancies 3.6% was found in eight of 13 pre‐TTTS pregnancies. In non‐TTTS pregnancies, the estimated variability in ventricular strain within each twin during the day was high (RV, 19.7; LV, 12.9). However, within each pair (intertwin variation), variability was low (RV, 5.5; LV, 2.9). Interclass correlation reflecting the proportion of total variability represented by the variability between twin pairs was low (RV, 0.22; LV, 0.18). Both RV (P
- Published
- 2020
49. Design Considerations and Flow Characteristics for Couette-Type Blood-Shear Devices.
- Author
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Chen, Xingbang, Avital, Eldad J., Imran, Shahid, Abbas, Muhammad Mujtaba, Hinkle, Patrick, and Alexander, Theodosios
- Subjects
SHEAR flow ,PROSTHETICS ,UNSTEADY flow ,LAMINAR flow ,TURBULENT flow - Abstract
Cardiovascular prosthetic devices, stents, prosthetic valves, heart-assist pumps, etc., operate in a wide regime of flows characterized by fluid dynamic flow structures, laminar and turbulent flows, unsteady flow patterns, vortices, and other flow disturbances. These flow disturbances cause shear stress, hemolysis, platelet activation, thrombosis, and other types of blood trauma, leading to neointimal hyperplasia, neoatherosclerosis, pannus overgrowth, etc. Couette-type blood-shearing devices are used to simulate and then clinically measure blood trauma, after which the results can be used to assist in the design of the cardiovascular prosthetic devices. However, previous designs for such blood-shearing devices do not cover the whole range of flow shear, Reynolds numbers, and Taylor numbers characteristic of all types of implanted cardiovascular prosthetic devices, limiting the general applicability of clinical data obtained by tests using different blood-shearing devices. This paper presents the key fluid dynamic parameters that must be met. Based on this, Couette device geometric parameters such as diameter, gap, flow rate, shear stress, and temperature are carefully selected to ensure that the device's Reynolds numbers, Taylor number, operating temperature, and shear stress in the gap fully represent the flow characteristics across the operating range of all types of cardiovascular prosthetic devices. The outcome is that the numerical data obtained from the presented device can be related to all such prosthetic devices and all flow conditions, making the results obtained with such shearing devices widely applicable across the field. Numerical simulations illustrate that the types of flow patterns generated in the blood-shearing device meet the above criteria. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
50. Statins to mitigate cardiotoxicity in cancer patients treated with anthracyclines and/or trastuzumab: a systematic review and meta-analysis
- Author
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Jacqueline B Vo, Anju Nohria, Aarti Asnani, Stefania Papatheodorou, Yawen Gao, Ann H. Partridge, Arielle Abovich, and Mary Obasi
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Anthracycline ,Epidemiology ,Cancer survivors ,Clinical Trials and Supportive Activities ,Oncology and Carcinogenesis ,Cardiovascular ,law.invention ,Randomized controlled trial ,Clinical Research ,Trastuzumab ,law ,Neoplasms ,Internal medicine ,medicine ,Humans ,Anthracyclines ,Cancer ,Original Paper ,Cardiotoxicity ,business.industry ,Prevention ,Statins ,Correction ,Publication bias ,Meta-analysis ,Relative risk ,Public Health and Health Services ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,medicine.drug ,Cohort study - Abstract
Purpose Cardiotoxicity affects 5–16% of cancer patients who receive anthracyclines and/or trastuzumab. Limited research has examined interventions to mitigate cardiotoxicity. We examined the role of statins in mitigating cardiotoxicity by performing a systematic review and meta-analysis of published studies. Methods A literature search was conducted using PubMed, Embase, Web of Science, ClinicalTrials.gov, and Cochrane Central. A random-effect model was used to assess summary relative risks (RR), weighted mean differences (WMD), and corresponding 95% confidence intervals. Testing for heterogeneity between the studies was performed using Cochran’s Q test and the I2 test. Results Two randomized controlled trials (RCTs) with a total of 117 patients and four observational cohort studies with a total of 813 patients contributed to the analysis. Pooled results indicate significant mitigation of cardiotoxicity after anthracycline and/or trastuzumab exposure among statin users in cohort studies [RR = 0.46, 95% CI (0.27–0.78), p = 0.004, $${ }I^{2}$$ I 2 = 0.0%] and a non-significant decrease in cardiotoxicity risk among statin users in RCTs [RR = 0.49, 95% CI (0.17–1.45), p = 0.20, $$I^{2}$$ I 2 = 5.6%]. Those who used statins were also significantly more likely to maintain left ventricular ejection fraction compared to baseline after anthracycline and/or trastuzumab therapy in both cohort studies [weighted mean difference (WMD) = 6.14%, 95% CI (2.75–9.52), p $$I^{2}$$ I 2 = 74.7%] and RCTs [WMD = 6.25%, 95% CI (0.82–11.68, p = 0.024, $$I^{2}$$ I 2 = 80.9%]. We were unable to explore publication bias due to the small number of studies. Conclusion This meta-analysis suggests that there is an association between statin use and decreased risk of cardiotoxicity after anthracycline and/or trastuzumab exposure. Larger well-conducted RCTs are needed to determine whether statins decrease risk of cardiotoxicity from anthracyclines and/or trastuzumab. Trial Registration Number and Date of Registration PROSPERO: CRD42020140352 on 7/6/2020.
- Published
- 2021
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