Search

Your search keyword '"Manfred T. Reetz"' showing total 1 results
Start Over Author "Manfred T. Reetz" Search Limiters Peer Reviewed Topic chirality

Refine your results

1 results on '"Manfred T. Reetz"'

1. Directed evolution and axial chirality: optimization of the enantioselectivity of Pseudomonas aeruginosa lipase towards the kinetic resolution of a racemic allene.

Author

José Daniel Carballeira, Patrik Krumlinde, Marco Bocola, Andreas Vogel, Manfred T. Reetz, and Jan-E. Bäckvall

Subjects
*CHIRALITY, *PSEUDOMONAS aeruginosa, *LIPASES, *ALLENE
Abstract

Directed evolution of Pseudomonas aeruginosa lipase by the use of combinatorial active site saturation test (CAST) criteria provided a highly enantioselective mutant (Leu162Phe) for kinetic resolution of an axially chiral allene, p-nitrophenyl 4-cyclohexyl-2-methylbuta-2,3-dienoate (E = 111); the high enantioselectivity of the Leu162Phe mutant was rationalized by π–π stacking. [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results