1. Clinical Features and Diagnosis of Anterior Segment Inflammation Related to in Immunocompetent African, Asian, and Caucasian Patients.
- Author
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Leleu, Igor, Jhanji, Vishal, Touhami, Sara, Westcott, Mark, Angi, Martina, Titah, Cherif, Rousseau, Antoine, Hamard, Pascale, Brasnu, Emmanuelle, Manicom, Thomas, Blumen-Ohana, Esther, Rozenberg, Flore, Vauloup-Fellous, Christelle, Deback, Claire, Labetoulle, Marc, Sahel, Jose-Alain, Bodaghi, Bahram, Merabet, Lilia, Kobal, Alfred, and Brignole-Baudouin, Françoise
- Subjects
IRIDOCYCLITIS ,DIAGNOSIS ,CAUCASIAN race ,ETHNIC groups ,CYTOMEGALOVIRUSES - Abstract
Objective: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin.Material and Methods: Multicenter retrospective study of 38 patients with at least one test, either HCMV-positive PCR or GWc.Results: Features of Posner-Schlossman syndrome were observed in 50% of the eyes, Fuchs heterochromic iridocyclitis in 13% of the eyes, chronic nonspecific anterior uveitis in 21% of the eyes, and corneal endotheliitis in 18% of the eyes. PCR and GWc were positive for HCMV in 50% and 96.2% of the eyes, respectively. Glaucoma was diagnosed in 50% of eyes. Treatment was oral valganciclovir in about half of the patients. Other treatments were intravenous ganciclovir and/or ganciclovir topical ointment and/or intravitreal ganciclovir.Conclusions: No obvious association of specific clinical features with individual ethnicity could be identified. We found a high rate of glaucoma in all ethnic groups. There was a delay in diagnosis and specific treatment of HCMV in most patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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