1. A spatially localized DNA linear classifier for cancer diagnosis.
- Author
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Yang L, Tang Q, Zhang M, Tian Y, Chen X, Xu R, Ma Q, Guo P, Zhang C, and Han D
- Subjects
- Humans, MicroRNAs genetics, MicroRNAs metabolism, Computers, Molecular, Algorithms, Computational Biology methods, Neoplasms genetics, Neoplasms diagnosis, Neoplasms classification, DNA genetics
- Abstract
Molecular computing is an emerging paradigm that plays an essential role in data storage, bio-computation, and clinical diagnosis with the future trends of more efficient computing scheme, higher modularity with scaled-up circuity and stronger tolerance of corrupted inputs in a complex environment. Towards these goals, we construct a spatially localized, DNA integrated circuits-based classifier (DNA IC-CLA) that can perform neuromorphic architecture-based computation at a molecular level for medical diagnosis. The DNA-based classifier employs a two-dimensional DNA origami as the framework and localized processing modules as the in-frame computing core to execute arithmetic operations (e.g. multiplication, addition, subtraction) for efficient linear classification of complex patterns of miRNA inputs. We demonstrate that the DNA IC-CLA enables accurate cancer diagnosis in a faster (about 3 h) and more effective manner in synthetic and clinical samples compared to those of the traditional freely diffusible DNA circuits. We believe that this all-in-one DNA-based classifier can exhibit more applications in biocomputing in cells and medical diagnostics., (© 2024. The Author(s).)
- Published
- 2024
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