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Synthesis and application of layered nanomaterials are known as emerging field in nanotechnology. Inorganic layered nanomaterials with nanometer scale, high aspect ratios, and large-surface area generate various scientific and technological interests in several potential areas of application such as separation technology, medical sciences, chromatography drug delivery, and catalysis. In this research, naproxen was opted as a unique model of the drug to intercalate into three-dimensional layered double hydroxide (LDH) nanostructures by calcination–reconstruction method. The designed-naproxen nanostructures were synthesized and used as novel drug nanocarriers. The synthesized nanomaterial characteristics were confirmed by FTIR, XRD, and SEM. The results of antibacterial activity indicated that homemade nanostructure can inhibit bacterial growth. Furthermore, MTT assay analysis showed that synthesized-nanostructure in physiological concentration has not cytotoxicity on C2C12 myoblast cells in vitro. Subsequent to intercalation with naproxen according to calcination–reconstruction method, the basal spacing of LDH increased to 2.62 nm from primary 0.77 nm in diameter, which confirms successful intercalation of naproxen into inserted layer of LDH by bridging interaction. Also, in-vitro drug release tests in PBS (pH 7.4) showed constant release profile for naproxen. Consequently, due to the facile and low-cost fabrication of three-dimensional LDH nanostructure, it can be considered as a potential alternative for traditional and high cost drug delivery. [ABSTRACT FROM AUTHOR]

Background: Magnetic nanocomposites with a core–shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier. Methods: Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results: The results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect. Conclusion: The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that Fe3O4@LDH multicore-shell nanostructure may have potential application for constant drug delivery. [ABSTRACT FROM AUTHOR]