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1. Induction of anti-leukemic cytotoxic T lymphocytes by fusion of patient-derived dendritic cells with autologous myeloblasts

Author

Gong, Jianlin, Koido, Shigeo, Kato, Yoko, Tanaka, Yasuhiro, Chen, Dongshu, Jonas, Anna, Galinsky, Ilene, DeAngelo, Daniel, Avigan, David, Kufe, Donald, and Stone, Richard

Subjects
*DENDRITIC cells, *LEUCOCYTES, *IMMUNE system, *LYMPHOCYTES, *IMMUNOTHERAPY, *T cells
Abstract

Presentation of AML antigens by dendritic cells (DC) could potentially induce a T cell-mediated anti-leukemic immune response. In the present study, we generated DC from adherent (AD-DC) and non-adherent (NAD-DC) myeloblasts obtained from bone marrows of AML patients. Both cell populations displayed morphological, phenotypic and functional properties of DC. The functions of NAD-DC were compared to AD-DC that had been fused with autologous AML blasts (FC/AML). The FC/AML induced greater T cell proliferation and CTL activity against autologous AML blasts (9/10 cases) as compared to NAD-DC. FC/AML may thus represent a promising strategy for DC-based immunotherapy of patients with AML. [Copyright &y& Elsevier]

Published
2004
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