Search

This paper presents a predictive framework for the statistical personalization of ventricular fibers. To this end, the relationship between subject-specific geometry of the left (LV) and right ventricles (RV) and fiber orientation is learned statistically from a training sample of ex vivo diffusion tensor imaging datasets. More specifically, the axes in the shape space which correlate most with the myocardial fiber orientations are extracted and used for prediction in new subjects. With this approach and unlike existing fiber models, inter-subject variability is taken into account to generate latent shape predictors that are statistically optimal to estimate fiber orientation at each individual myocardial location. The proposed predictive model was applied to the task of personalizing fibers in 10 canine subjects. The results indicate that the ventricular shapes are good predictors of fiber orientation, with an improvement of 11.4% in accuracy over the average fiber model. [ABSTRACT FROM AUTHOR]

Myocardial fiber orientation plays a critical role in the electrical activation and subsequent contraction of the heart. To increase the clinical potential of electrophysiological (EP) simulation for the study of cardiac phenomena and the planning of interventions, accurate personalization of the fibers is a necessary yet challenging task. Due to the difficulties associated with the in vivo imaging of cardiac fiber structure, researchers have developed alternative techniques to personalize fibers. Thus far, cardiac simulation was performed mainly based on rule-based fiber models. More recently, there has been a significant interest in data-driven and statistically derived fiber models. In particular, our predictive method in [1] allows us to estimate the unknown subject-specific fiber orientation based on the more easily available shape information. The aim of this work is to estimate the effect of using such statistical predictive models for the estimation of cardiac electrical activation times and patterns. To this end, we perform EP simulations based on a database of ten canine ex vivo diffusion tensor imaging (DTI) datasets that include normal and failing cases. To assess the strength of the fiber models under varying conditions, we consider both sinus rhythm and biventricular pacing simulations. The results show that 1) the statistically derived fibers improve the estimation of the local activation times by an average of 53.7% over traditional rule-based models, and that 2) the obtained electrical activations are consistently similar to those of the DTI-based fibers. [ABSTRACT FROM PUBLISHER]