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Air pollution and particulate matter in urban areas have been associated with increased mortality from cardiovascular and respiratory diseases and increased cancer risk. Carcinogenic effects of particulate matter have been related to the contents of specific compounds, such as polycyclic aromatic hydrocarbons. The latter may form bulky DNA adducts, that may be considered as candidate markers of cancer risk. We have recently shown that traffic-exposed workers and the general population in Florence have divergent levels of DNA adducts, possibly related to different levels of exposure to genotoxic agents from vehicle emissions. In the current study, in a series of 214 Florence City healthy adults enrolled in a prospective study in the period 1993–1998 (152 residents / 62 traffic-exposed workers), we investigated the correlation between individual levels of DNA bulky adducts and PM10 exposure scores based on daily environmental measures provided by the local Environmental Protection Agency for the whole study period, by two types of urban monitoring stations (high- and low-traffic). We found that PM10 cumulative scores from high-traffic stations over the last 1–2 weeks prior to blood drawing significantly correlated (r =0.58, p =0.02) with DNA adduct levels among non-smoking traffic-exposed workers (but not among residents with no occupational exposure to vehicle emissions). A multivariate regression analysis adjusted for possible confounders confirmed these findings. PM10 scores from low-traffic stations did not show any correlation. These results show that DNA adduct levels in non-smoking workers reflect the average levels of exposure to PM10 in high-traffic urban areas experienced over a time period of 1–2 weeks. Since DNA adduct levels have been found predictive of lung cancer risk, our findings provide clues relevant to the reduction of genotoxic damage and possibly cancer risk among traffic-exposed urban workers. [Copyright &y& Elsevier]

The benzo[ a ]pyrene temporal trend was investigated in 11 towns where at least five annual means were available. The overall number of stations was 22, of which 12 were traffic-oriented, 6 background and 4 industrial. The trend was generally declining at traffic-oriented sites and roughly stable at background sites. The annual means in 2004 still exceeded the forthcoming European target value of 1 ng/m 3 in two towns (up to 1.9 ng/m 3 ). The background means (up to 1.4 ng/m 3 in 2004) accounted for approximately 40–90% of those at the traffic-oriented sites in the same town. The presence of a coke plant was incompatible with the attainment of the target value, while the adoption of technical measures on a carbon electrode plant was successful in attaining concentrations lower than the target value. In heavy traffic areas in Italy, the attainment of the target value hardly appears feasible under the current conditions of traffic congestion. [ABSTRACT FROM AUTHOR]