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Licorice is known as "Gan-Cao" in traditional Chinese Medicine (TCM), belonging to the genus Glycyrrhiza (Family: Fabaceae/Leguminosae). It has a long medicinal history and wide applications in China. Polysaccharides of licorice (LPs) are one of the key bioactive components. As herbal polysaccharides attracted increasing interest in the past several decades, their extraction, isolation, structural characterization, pharmacological activities, and medicinal application have been explored extensively. It is worth heeding that the method of extraction and purification effects LPs, apart from specie and origin specificity. This review evaluates the method of extraction and purification and demonstrates its performance in gaining specific composition and its structure-activity relationship, which might lead the readers to a fresh horizon for developing advanced treatment strategies. It is recently reported that the conformation of LPs plays a vital role as biopolymers, such as selenized modification, microencapsulation, nanocomposite, liposome formulation, drug/hydrogel combinations, biosensor device, and synergistic effect with a vaccine. In addition, LPs showed a good thermodynamics profile, as these properties enable them to interact with additional supramolecular interaction by chemical modifications or copolymerization. Functional polymers that are responsive to various external stimuli, such as physical, chemical, and biological signals, are a promising study topic. Thus, LPs are emerging as a new biomaterial that can enhance intended formulation along exerting its inherent medicinal effects. It is hoped that this review will provide a basis for the utilization and further developments of licorice polysaccharides in the vast medium. [ABSTRACT FROM AUTHOR]

The National Medical Products Administration has authorized sodium oligomannate for treating mild-to-moderate Alzheimer's disease. In this study, an LC-MS/MS method was developed and validated to quantitate sodium oligomannate in different biomatrices. The plasma pharmacokinetics, tissue distribution, and excretion of sodium oligomannate in Sprague-Dawley rats and beagle dogs were systematically investigated. Despite its complicated structural composition, the absorption, distribution, metabolism, and excretion profiles of the oligosaccharides in sodium oligomannate of different sizes and terminal derivatives were indiscriminate. Sodium oligomannate mainly crossed the gastrointestinal epithelium through paracellular transport following oral administration, with very low oral bioavailability in rats (0.6%–1.6%) and dogs (4.5%–9.3%). Absorbed sodium oligomannate mainly resided in circulating body fluids in free form with minimal distribution into erythrocytes and major tissues. Sodium oligomannate could penetrate the blood-cerebrospinal fluid (CSF) barrier of rats, showing a constant area under the concentration-time curve ratio (CSF/plasma) of approximately 5%. The cumulative urinary excretion of sodium oligomannate was commensurate with its oral bioavailability, supporting that excretion was predominantly renal, whereas no obvious biliary secretion was observed following a single oral dose to bile duct-cannulated rats. Moreover, only 33.7% (male) and 26.3% (female) of the oral dose were recovered in the rat excreta within 96 h following a single oral administration, suggesting that the intestinal flora may have ingested a portion of unabsorbed sodium oligomannate as a nutrient. [Display omitted] • ADME profiles of sodium oligomannate oligosaccharides were indiscriminate. • An LC-MS/MS method was developed and validated for the ADME study of sodium oligomannate. • Sodium oligomannate was absorbed through paracellular transport with very low BA. • Approximately 5% of sodium oligomannate penetrated the blood–CSF barrier of rats. • The absorbed drug was excreted through the kidney; unabsorbed drug was excreted in feces. [ABSTRACT FROM AUTHOR]

In this paper, grain‐size records of 128 surface samples and six sediment cores retrieved from freshwater marshes across the Sanjiang Plain were employed to reconstruct the marshes' hydrological variation during the Holocene and to discuss its links to the East Asian summer monsoon (EASM) variation. The grain‐size hydrological significance for the marshes' deposits was first interpreted by quantitative analyses of 128 modern samples. The results indicate that the sand fraction exhibits a higher level significance to modern water‐level conditions than other grain‐size parameters. Thus, the sand accumulation rates of the six cores were calculated and employed to reconstruct the Holocene hydrological regime of the marshes on the plain. Based on the cluster analysis, it can be identified that three higher water‐level stages occurred during 6.2–5.6 thousand yr BP, 5.6–4.5 thousand yr BP, and 2.8–2.4 thousand yr BP, whereas four lower water‐level stages occurred during ~8.0–6.2 thousand yr BP, 4.5–2.8 thousand yr BP, 2.4–0.7 thousand yr BP, and 0.7–0 thousand yr BP, respectively. Considering the prevalent monsoon climate on the modern Sanjiang Plain, it is reasonable to believe that the local water‐level fluctuations were mainly regulated by the EASM variation rather than local factors including flooding, waterway modification, depression infilling, and human activities. The higher water‐level stages were linked to a stronger EASM and vice versa. This study provides essential background datasets for understanding the potential controls on the marsh development and degradation on the Sanjiang Plain. [ABSTRACT FROM AUTHOR]

The Holocene hydrological regime on the Heixiazi Island is critical for understanding the evolution of the East Asian summer monsoon (EASM) for the island's climate-sensitive location on the northern fringe of the EASM domain. In this paper, a marsh depression on the central island was selected to reconstruct the locally hydrological variation and to discuss its indications for the Holocene EASM evolution. This work is based on multi-proxy (magnetic susceptibility, grain size, loss-on-ignition, and carbonate content) analyses of 22 modern sedimentary samples with a water-level gradient of 0–66 cm and 100 cored sedimentary samples covering last ~ 9.0 ka BP. The proxies' hydrological significance was previously interpreted by the 22 modern samples using linear regression equations to construct their relationships to water-level changes. Among these proxies, the magnetic susceptibility, carbonate content, as well as the Md and sand fraction of grain size exhibit high-level relationships against the water-level changes with R2 > 0.6. Thus, these four proxies' linear-regression equations were selected and used on the 100 cored samples, and the Holocene water-level changes in the studied depression were quantitatively reconstructed. It shows that two relatively high water-level stages with strengthened EASM occurred during 8.0–4.5 ka BP and 3.0–1.4 ka BP, which were alternated by three low water-level stages with declined EASM during ~ 9.0–8.0 ka BP, 4.5–3.0 ka BP, and 1.4–0 ka BP, respectively. Among these fluctuations, the highest water-level stage with most strengthened EASM which is defined as the Holocene Monsoon Maximum occurred during 6.4–4.5 ka BP. Such a new evolution pattern of the EASM can be further supported by a large variety of records from monsoon-margin regions. We suggest the Holocene EASM evolution was generally associated with the thermal conditions in both the inner Eurasia landmass and the West Pacific Ocean, with an exception of the weak EASM before 8.0 ka BP due to the enhanced Siberia High with the dominance of the Eurasia ice sheet in the early Holocene. [ABSTRACT FROM AUTHOR]

A comprehensive and integrative view of East Asian monsoon evolution during the Holocene is still under debate, and additional high-resolution proxy records from climatically sensitive locations are requisite to solve this complex issue. In this paper, we present three well-dated mud/peat cores from a paleo-pingo depression in the Sanjiang Plain, a climatically sensitive region to monsoon variation, to reveal the paleoenvironmental history of the wetland and discuss the regional impacts from monsoon evolution. A paleolake developed in the study area before 5.5 ka BP, and a peatland initiated thereafter consequent upon the gradual shrinking of the paleolake. This transition lasted until 4.5 ka BP, when the paleolake changed entirely to a wetland. Considering the prevalent monsoon climate in the Sanjiang Plain, we suggest that the lake-to-wetland transition from 5.5 to 4.5 ka BP indicates a rapid decline of the East Asian summer monsoon in addition to autogenic basin infilling processes. Such a remarkable monsoon weakening event has been documented across northern China, and we associate this with ocean–atmosphere interactions throughout low-latitude regions. [ABSTRACT FROM AUTHOR]

Understanding the response of wetlands to climate changes could provide useful insights toward predicting the wetlands future in a warmer world. Here, we present a well-dated peat/mud profile with multiple proxies to reconstruct the historic development of Honghe wetland and discuss its response to the East Asian monsoon variations during the Holocene. The results show that the Honghe wetland developed as a shallow-water lake in the mid-early Holocene during a time of high precipitation from the East Asian monsoon. At 4600 years BP, peat layers appeared with sharp increases in the accumulation rate, grain-size Md and arboreal plants, marking a decline in water levels with the relative dry climate. Moreover, the transition corresponds well to the mid-Holocne monsoon weakening event and we suggest the decrease of the monsoon associated precipitation plays a critical role in driving the lake-peatland transition in Honghe. Facing the intensified summer monsoon in future, we suggest some practical measures should be taken to protect the present wetlands from changing back to lakes. [ABSTRACT FROM AUTHOR]

[Display omitted] • The bacterial variation within microhabitats associated with the black stone of the Black Gobi desert were investigated. • Bacterial communities within microhabitats were highly different in the desert ecosystems. • Microhabitats formed by black stones support highly diverse and biologically active bacterial communities. • Major environmental controls were water content, total carbon, and total nitrogen. Desert soil around the black stones is highly complex, which substantially affects the diversity and composition of inhabiting microbes. The existence of black stones in the southern part of the Black Gobi desert of China could provide microhabitats for diverse bacterial communities that remain unexplored. Hence, Illumina MiSeq sequencing was used to determine the differences in bacterial communities associated within microhabitats in three sites of the Black Gobi desert, China. Our results show that bacterial communities are significantly affected by each microhabitat. For instance, the α -diversity of bacterial communities indicated more remarkable diversity and richness in these microhabitats. Considering β -diversity, variances were reported mainly in the Proteobacteria (30%), Actinobacteria (26%), Chloroflexi (19%), and Firmicutes (9%). Firmicutes were markedly enriched in the upper surface, especially in site 1. Compared to other microhabitats, the relative abundance of Proteobacteria was greater in the subsurface, and they were also more dominant in the other two sites. Network analysis of soil factors and bacterial genera showed that the most significant-occurrences were positively correlated, demonstrating potential synergistic interactions. Collective with the predicted function profiles and the redundancy analysis, these results indicated the highest variances in bacterial community structure and function in Black Gobi Desert ecosystems. These differences are likely closely related to the soil parameters, mainly water content, total carbon, and total nitrogen, and might be associated with black stones. This study concludes that microhabitats formed by black stones support highly diverse and biologically active bacterial communities. These microhabitats with extreme environmental conditions deliver new opportunities to explore soil bacterial communities at relevant spatial scales in the Black Gobi desert. [ABSTRACT FROM AUTHOR]

Abstract: In this paper, we report 3780-m-thick Neogene deposits accumulated in the Kuqa foreland basin of southern Tianshan range, providing great potential for studying both tectonics and paleoclimatic changes. Based on palynological evidence, we discuss the paleoenvironmental changes as well as the interplay between regional uplift and climatic change in the region studied. Our results indicate that the vegetation and climatic changes from 13.3 to 7Ma were response to global climatic changes. After 7Ma, the uplift of the southern Tianshan range partially affects vegetation and climatic changes. Both global cooling and the rainshadow effect of uplifted high mountains affect the enhanced arid climate initiated ca. 5.23Ma ago. Such climatic changes are important archives in reconstructing paleoclimate of the Asian interior. [ABSTRACT FROM AUTHOR]

Abstract: Thick Cenozoic deposits were shed into the foreland basin of the Tian Shan Range, providing great potential for understanding the relationship between tectonic history and paleoclimatic changes. In the present study, we compiled a pollen record for the interval 26.5–2.6 Ma based on a palynological analysis of a latest Oligocene–Pliocene stratigraphic sequence in the northern foreland basin of the Tian Shan. Our results indicate that a remarkable warm climate occurred at ca. 18–15 Ma ago, corresponding to the Mid-Miocene Climatic Optimum, while a change to an arid climate occurred at 6 Ma, marked by an increase in the drought-tolerant herb taxa Artemisia and Chenopodiaceae. This latter change was coincident with the late Cenozoic climatic deterioration recorded at high latitudes in the Northern Hemisphere. These inferred climatic events are further supported by the results of principal component analysis of the pollen data, such records are important archives in reconstructing the paleoclimate of the Asian interior. [Copyright &y& Elsevier]

Schematic figure showing climate driving mechanisms on wetland hydrological and vegetational evolution. The relatively strong East Asian summer monsoon (EASM) with high precipitation tends to generate a higher water-level condition with more hygrophilous herbaceous plants while blocking the deposition of coarse grain-size fractions (a), and vise versa for weak EASM stages (b). [Display omitted] • The late-Holocene hydrological and vegetational regimes were reconstructed. • An ecological lake-to-wetland transition occurred at ~4.5 ka BP. • The wetlands evolution was largely controlled by monsoonal precipitation. The responding mechanism of wetland ecosystem to climate change is currently unclear due to a lack of long-term records incorporating multiple ecological factors. This paper presents a well-dated and multi-proxy cored record from a natural freshwater wetland developed in a paleo-pingo-related depression on the Sanjiang Plain. The study aims to reconstruct the wetland water-level and vegetational regimes during the past ~6.0 ka BP and discuss the wetland evolution response to the East Asian summer monsoon (EASM) circulation. The results show that a shallow-water lake with hygrophilous herbs developed in the depression with a strong EASM during ~6.0–4.5 ka BP. The paleolake was succeeded by a wetland with a lowered mean water level and an increase in tree cover controlled by the weakened EASM during the past 4.5 ka BP. Such an ecological lake-to-wetland transition corresponds well to the sharp decline of the EASM around 4.5 ka BP which has been well documented in various geological records across the EASM domain. During the wetland developing stage over the past 4.5 ka BP, the water-level and vegetational changes in the studied depression were also closely related to the EASM variations. The strengthened EASM usually generated higher water levels with more hygrophilous herbs around 4.0 ka BP, 3.5 ka BP, 3.0 ka BP, 2.0 ka BP, and 1.3 ka BP. Considering the prevalent EASM climate serving as the predominant water supply for the wetlands on the modern Sanjiang Plain, we suggest the EASM circulation has played a critical role in driving the wetland ecological evolution during the mid-to-late Holocene Epoch. The past 0.4 ka BP is an exception as the local Trees/Herbs ratio visibly increased with the declined water level, while the monsoonal precipitation shows no equivalent shift. The wetland evolution at this stage was attributed to human interference. [ABSTRACT FROM AUTHOR]

Abstract: The expansion of C4 plants is one of the most prominent vegetation changes in the global ecosystem during the Cenozoic Era. Although C4 plant expansions in the latest Miocene have been widely reported, factors driving the expansions are still in debate, and the details of vegetation changes during the Quaternary have not been well studied. Here we present high-resolution carbon isotope time series of both organic matter and bulk carbonates, covering the past 2.58 Ma, derived from the loess–soil successions on the southern Chinese Loess Plateau. The organic matter δ13C values indicate stepwise C4 plant expansions initiated at ∼1.6 and at ∼0.43 Ma, respectively. We conclude that such tectonic time scale C4 plant expansions are controlled by enhanced seasonality of precipitation (relatively more precipitation in the warm growing season) as well as regional aridity, and this long-term fluctuation superimposes on the orbital scale variations of C4 plants, while the latter appears phase-locked with cyclical changes of summer monsoon circulations. [Copyright &y& Elsevier]

Abstract A high-resolution pollen record in a peat sequence from the Altai Mountains of Xinjiang, China, allows reconstruction of the regional vegetation and climate changes that occurred during the Holocene. Pollen distributions from the sequence indicate that the vegetation community in the Altai Mountains region transitioned through five general phases: forest and desert steppe, wet steppe, desert steppe, steppe, and finally forest and desert steppe. These vegetative phases imply that the regional climate changed from a cold and dry early Holocene to a warmer and wetter early-mid Holocene and then to a cold and rather dry mid-Holocene that was followed by a cool and wet late Holocene and finally by warm and dry conditions for the last millennium. These regional changes in climate are roughly consistent with local changes previously reconstructed from organic geochemical paleoclimate proxies in the same peat sequence by Zhang et al. (2016), but with some minor but important differences that reflect local factors. Regional comparisons reveal that the Holocene climate changes in the Altai Mountains are generally consistent with those of most arid central Asian regions that are influenced mainly by westerlies. However, they are out-of-phase with the climate histories of regions controlled by the Asian monsoons, indicating that the Asian monsoons did not extend to the high-altitude mountain regions of arid central Asia during the Holocene. We postulate that the regional Holocene moisture variations have been mainly modulated by NAO variations that affected transport of water vapor from the North Atlantic Ocean by the westerlies. Moreover, local factors that include topography of the mountains and glacial meltwater events in the high-altitude regions also contributed to the climate changes in the Altai Mountains. In addition, air temperatures related to summer insolation of the Northern Hemisphere might have played an important role in modulating moisture in the region, but only after the local montane ice-sheets had disappeared by the mid-Holocene. Highlights • Pollen records from a peat sequence from Xinjiang Altai Mountains reveal Holocene vegetation changes. • Pollen-based reconstruction of Holocene climate changes in the Altai Mountains. • Comparisons of Holocene climate changes in Altai Mountains with arid central Asian and monsoonal Asian regions. • Explanations proposed for Holocene vegetation and climate changes in the Altai Mountains. [ABSTRACT FROM AUTHOR]

A wide-spread terrestrialization process has been reported occurring across the Sanjiang Plain in the Holocene Epoch, while little is known for its detailed process and links to regional climate variation. Here, we present high-resolution palynological and lithological data of a peatland's sedimentary profile in the central Sanjiang Plain. The study aims to reconstruct the local terrestrialization process and discuss its significance to the Holocene East Asian summer monsoon (EASM) evolution. The results indicate that a paleolake surrounded by broadleaved forests developed during ~7.4-4.5 ka BP, corresponding to a wet and warm stage with strengthened EASM. Thereafter, a wetland dominated by Cyperaceae and Poaceae was initiated with the terrestrialization process. This process lasted until 3.9 ka BP when a lithological mud-to-peat transition occurred indicating a peatland began to develop after the extinction of the paleolake. Considering the prevalent EASM climate on the modern Sanjiang Plain, this paleolake-to-peatland transition during 4.5-3.9 ka BP was attributed to the mid-Holocene EASM retreat in addition to the paleolake's autogenic infilling process. During the peatland developing stage, four dry intervals with weakened EASM occurred in 3.9-3.2 ka BP, 2.0-1.3 ka BP, 1.0-0.5 ka BP, and 0.1-0.0 ka BP. They were alternated with three wet stages of the strengthened EASM during 3.2-2.0 ka BP, 1.3-1.0 ka BP, and 0.5-0.1 ka BP. Our findings are supported by a series of paleoclimatic records across the monsoonal regions of China. We suggest that the EASM evolution associated with the tropical ocean-atmosphere interactions was initially modulated by the solar output variation., Competing Interests: Declaration of competing interest We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, and there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, this manuscript., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Sleep problems among frontline medical staff during the COVID-19 epidemic require attention. A total of 249 frontline medical staff who were recruited to support Wuhan completed this cross-sectional study. A web-based questionnaire about insomnia, depression, anxiety, and fatigue was used to assess mental health status. The prevalence of sleep disorders among frontline medical staff was 50.6%. More time spent in Wuhan and a history of insomnia, depression, anxiety, and fatigue were associated with a higher risk of insomnia. People who stayed in Wuhan for a long time with a history of insomnia, depression, anxiety, and fatigue symptoms might be at high risk of insomnia.

Objective: To evaluate the mental health status of hospitalized patients with coronavirus disease 2019 (COVID-19) and to explore the related factors., Method: This was a cross-sectional survey among COVID-19 inpatients in two isolation wards of a designated hospital in Wuhan, China, from March 7, 2020, to March 24, 2020. Participants' demographic data, clinical data and levels of circulating inflammatory markers were collated. Mental health symptoms were evaluated with questionnaires, which included the Insomnia Severity Index (ISI) scale, the 9-item Patient Health Questionnaire (PHQ-9), the 7-item Generalized Anxiety Disorder (GAD-7) scale, and questions about patients' self-perceived illness severity. Multivariate linear regression analysis was performed to explore factors that associated with mental symptoms, and a structural equation model (SEM) was used to assess the possible relationships between those factors and the patients' mental health., Results: Among the 85 participants, 45.9% had symptoms of depression (PHQ-9 ≥ 5), 38.8% had anxiety (GAD-7 ≥ 5), and 54.1% had insomnia (ISI ≥ 8). According to multivariate regression analysis, female sex, a higher level of interleukin (IL)-1β and greater self-perceived illness severity were all significantly associated with a higher PHQ-9 score, higher GAD-7 score and higher ISI score. In addition, the disease duration and the neutrophil to lymphocyte ratio (NLR) were positively related to patients' self-perceived illness severity. The results of the SEM analyses suggested that sex (β = 0.313, P < 0.001), self-perceived illness severity (β = 0.411, P < 0.001) and levels of inflammatory markers (β = 0.358, P = 0.002) had direct effects on patients' mental health. The disease duration (β = 0.163, P = 0.003) and levels of inflammatory markers (β = 0.101, P = 0.016) also indirectly affected patients' mental health, with self-perceived illness severity acting as a mediator., Conclusion: A majority of COVID-19 infected inpatients reported experiencing mental health disturbances. Female sex, disease duration, levels of inflammatory markers and self-perceived illness severity are factors that could be used to predict the severity of patients' mental symptoms., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Microbial communities play crucial roles in the global carbon cycle, particularly in peatland ecosystems under climate change. The peatlands of the Sanjiang Plain could be highly vulnerable to global warming because they are mainly located at the southern limit of northern peatlands. In this study, the alpha diversity and composition of bacterial communities in three different minerotrophic fens along a chronosequence were investigated. We captured a rich microbial community that included many rare operational taxonomic units (OTUs) but was dominated by a few bacterial classes that have frequently been detected in other peatland ecosystems. Notably, a large diversity of methanotrophs affiliated with Alpha- and Gammaproteobacteria was also detected. Bacterial alpha diversity and composition varied as a function of peat depth and its associated physical-chemical properties, such as total carbon, total nitrogen, pH and bulk density. We also found that bacterial community turnover (beta diversity) to be significantly correlated with soil age, whereas bacterial alpha diversity was not.