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This research report investigated the impacts of the COVID-19 lockdown restrictions on CO, SO2, and NO2 trends in Durban from 2019 to 2021. The COVID-19 lockdown restrictions proved to decrease greenhouse gas (GHG) emissions globally; however, the decrease in GHG emissions was for a short period only. Space-borne technology has been used by researchers to understand the spatial and temporal trends of GHGs. This study used Sentinel-5P to map the spatial distribution of CO, SO2, and NO2. Use was also made of the Atmospheric Infrared Sounder (AIRS), Modern-Era Retrospective Analysis for Research and Applications, Version 2 (MERRA-2), and the Ozone Monitoring Instrument (OMI) to understand the temporal trends of CO, SO2, and NO2, respectively. To validate the results of this study, we used the Sequential Mann–Kendall (SQMK) test. This study indicated that there were no significant changes in all the investigated gases. Therefore, this study failed to reject the null hypothesis of the SQMK test that there was no significant trend for all investigated gasses. Increasing trends were observed for CO, SO2, and NO2 trends during winter months throughout the study period, whereas a decreasing trend was observed in all investigated gases during the spring months. This shows that meteorological factors play a significant role in the accumulation of air pollutants in the atmosphere. Most importantly, this study has noted that there was an inverse relationship between the trends of all investigated gases and the COVID-19 lockdown restrictions. [ABSTRACT FROM AUTHOR]