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In summer 2018, brown stripe symptoms were observed on leaf blades of perennial ryegrass (Lolium perenne L.) used as a turfgrass in an athletic field in Saitama Prefecture, Japan. Bacterial ooze exuded from lesions, from which a pathogenic bacterium was isolated. Inoculation of blades of perennial ryegrass with the isolates reproduced the same symptoms. Pathogenicity and bacteriological properties of the isolates were almost identical to those of Acidovorax avenae, and the identification was supported by phylogenetic analysis. This is the first report of the brown stripe on perennial ryegrass caused by A. avenae (= A. avenae subsp. avenae) in Japan. [ABSTRACT FROM AUTHOR]

Background: Olaparib maintenance therapy for platinum-sensitive relapsed ovarian cancer has been approved in Japan since April 2018. Here, we report the experience administering this therapy in our hospital, with the aim of evaluating efficacy and safety in the Japanese population. Methods: The study included 52 patients with platinum-sensitive relapsed ovarian, fallopian tube, and primary peritoneal cancer. All patients started olaparib at a dose of 300 mg twice daily. Information about treatment efficacy and adverse effects was collected retrospectively from medical records. Results: Median age was 58 years old (range: 33–80), and 82.7% of the patients were diagnosed with high-grade serous carcinoma. Sixteen patients (30.8%) possessed the BRCA1/2 pathogenic variant (15 germline and 1 tissue), 3 (5.8%) possessed variants of unknown significance (2 germline and 1 tissue), 16 (30.8%) possessed wild type, and 17 (32.7%) were not analyzed. Median progression-free survival was 15.3 months (95% CI 9.0–21.6). Patients with BRCA1/2 pathogenic variants showed significantly longer PFS than patients with wild-type BRCA1/2 (p = 0.007). Disease progression caused 34 cases to discontinue olaparib. Eighteen (34.6%) individuals exhibited ≥ grade 3 anemia, although they recovered in response to appropriate management. One patient discontinued olaparib because of prolonged renal dysfunction. Another patient presented with grade 3 fatigue, but recovered after 2 weeks of interruption and continued olaparib treatment. Conclusion: Olaparib maintenance therapy for platinum-sensitive recurrent ovarian cancer in the Japanese population is sufficiently safe and no less effective than reports from previous studies. [ABSTRACT FROM AUTHOR]