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During the current study, the phenolic and flavonoid contents were measured in Physalis acutifolia extracts with Folin–Ciocalteu and AlCl3 methods, respectively. Various antioxidant assays, including 1,1-diphenyl-2-picrylhydrazyl, ABTS, reducing power, Fe2+-phenanthroline reduction, and silver nanoparticle assays, were also conducted, along with anti-enzymatic assays. The cytotoxicity of the ethanolic extract was assessed on cancer cell lines (i.e., CAPAN-1 and dld-1) and a healthy cell line (i.e., L929). Optimal parameters for polyphenol extraction were determined: extraction time of 72 h, solvent-to-plant ratio of 10 mL/1 g, and plant concentration of 90%. The n-butanol extract showed the highest phenolic and flavonoid contents (i.e., 263.84 mg GAE/g dw and 72.03 QE/g dw, respectively), along with superior antioxidant and anti-enzymatic activities with IC50 values of 49.77 and 187.12 µg/mL with acetylcholinesterase and butyrylcholinesterase assays, respectively. LC-ESI-MS/MS analysis revealed 12 components, with hesperidin being the most abundant (i.e., 1829.0001 µg/g). The ethanolic extract exhibited cytotoxic effects on cancer cell lines, with an IC50 value of 0.959 mg/mL for dld-1, but with no effect on healthy cells. The bioavailability scores of the identified components support the in vitro findings and confirm the different assessed therapeutic effects.

Optical resonators are structures that utilize wave interference and feedback to confine light in all three dimensions. Depending on the feedback mechanism, resonators can support either standing- or traveling-wave modes. Over the years, the distinction between these two different types of modes has become so prevalent that nowadays it is one of the main characteristics for classifying optical resonators. Here, we show that an intermediate link between these two rather different groups exists. In particular, we introduce a new class of photonic resonators that supports a hybrid optical mode, i.e. at one location along the resonator the electromagnetic fields associated with the mode feature a purely standing-wave pattern, while at a different location, the fields of the same mode represent a pure traveling wave. The proposed concept is general and can be implemented using chip-scale photonics as well as free-space optics. Moreover, it can be extended to other wave phenomena such as microwaves and acoustics.