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Objective: To explore the relationship between serum tumor specific growth factor (TSGF), monocyte chemoattractant protein-1 (MCP-1), angiopoietin-2 (Ang-2) and recurrence after laparoscopic myomectomy (LM) and the construction of a nomograph prediction model. Methods: 213 uterine fibroids patients who were undergoing LM surgery admitted to our hospital from June 2018 to June 2020 were selected as study subjects. The serum levels of TSGF, MCP-1 and Ang-2 were detected in all patients. After 3 years of follow-up, patients were divided into recurrence group and non-recurrence group according to whether patients had recurred 3 years after operation, the serum levels of TSGF, MCP-1 and Ang-2 were compared between two groups. The risk factors of recurrence after LM in uterine fibroids patients were analyzed by univariate and multivariate Logistic regression analysis, and a nomograph prediction model for postoperative recurrence risk was constructed according to the risk factors. The predictive efficacy of serum MCP-1, TSGF and Ang-2 on the recurrence of LM in uterine fibroids patients were analyzed by receiver operating characteristic (ROC) curve. Results: 213 uterine fibroids patients were followed up for 3 years, and 8 patients were lost to follow-up, there were 37 cases of recurrence in 205 uterine fibroids patients 3 years after LM, and the recurrence rate was 18.05% (37/205). The serum levels of Ang-2, MCP-1 and TSGF in non-recurrence group were lower than those in recurrence group, and the differences were statistically significant(P<0.05). Multivariate Logistic regression analysis showed that, postoperative residual myoma, elevated serum TSGF, age≥35 years, elevated MCP-1, multiple fibroids and elevated Ang-2 were independent risk factors for recurrence after LM in uterine fibroids patients(P<0.05). ROC analysis showed that, the area under the curve (AUC) of serum TSGF, MCP-1, Ang-2 and nomograph prediction model was 0.873 (95%CI: 0.801~0.944), 0.721 (95%CI: 0.624~0.817), 0.803 (95%CI: 0.722~0.885), 0.986 (95%CI: 0.973~0.998). Internal validation (B=1000) showed that, the C-index was 0.972, suggesting that the nomograph prediction model had a good predictive ability. The decision analysis shows that, the threshold probability of the model was 0.01~0.95, and the net return rate was>0, which was higher than the two invalid lines. Conclusion: The increase of serum TSGF, MCP-1 and Ang-2 levels can lead to the recurrence of LM in uterine fibroids patients. Age≥35 years old, multiple fibroids, postoperative residual myoma, elevated serum TSGF, elevated MCP-1 and elevated Ang-2 are independent risk factors for recurrence after LM in uterine fibroids patients. The nomograph prediction model base on independent risk factors has a good predictive value for the recurrence of LM in uterine fibroids patients. [ABSTRACT FROM AUTHOR]

Objective To assess the potential causal relationship between gut microbiota and the risk of uterine fibroids using a Mendelian randomization approach. Methods We used the genome - wide association study (GWAS) statistics of gut microbiota published by the Netherlands Microbiome Project in 2022 (泥二7 738) and the GWAS data of uterine fibroids from the Finnish R9 database (31 661 uterine fibroid patients and 179 209 controls). Inverse variance weighting (IVW), MR 一 Egger regression and weighted median method were used to study the causal relationship between intestinal flora and uterine fibroids. Sensitivity analyses were performed to test the reliability of the results of the Mendelian randomization analysis. Results IVW results showed that Bacteroides (OR - 1. 045, 95% Cf: 1. 006 一 1. 085), Ruminococcaceae (OR 二 1. 119, 95% CI: 1. 027 - 1. 219), Roseobacter{ OR 二 L 074, 95% CI: L 004 - L 149), Lactobacillus (OR 二 L 066, 95% CI: L 017 - 1. 118) and Firmicutes (OR = 1.052, 95% CI: 1.003 - 1. 102) were positively correlated with the incidence of uterine fibroids. No significant statistical difference was fbundafter FDR correction (P > 0. 05). Bifidobacterium was negatively correlated with the incidence of uterine fibroids (OR = 0.952, 95% CI: 0. 921 一 0.985). The causal association was statistically significant after FDR correction (P < 0. 05). No significant heterogeneity and horizontal pleiotropy were found in the sensitivity analysis. Conclusion Bifidobacterium may be a protective factor for the pathogenesis of uterine fibroids, while Bacteroides, Ruminococcaceae, Roseobacter Lactobacillus and Firmicutes may be a potential risk factor for the pathogenesis of uterine fibroids. However, more studies are needed to verify the results. This study provides information about the microbiota that can be further studied, which is expected to improve the incidence and prognosis of uterine fibroids. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper summarized the nursing practice of Traditional Chinese Medicine emotion regulation in relieving anxiety of a patient undergoing total laparoscopic hysterectomy. Based on the routine care, a comprehensive plan of emotion regulation including psychological support, relaxation training; music-guided imagination and interview-based interventions were carried out to relieve the anxiety before and after surgery, and improve the patient’s sleep quality and postoperative recovery. (本文总结1例应用中医情志护理三部曲缓解腹腔镜子宫全切术患者围手术期焦虑状态的护理体会。在常规护理基础上, 采用心理支持、放松训练、引导性音乐想象及访谈干预措施, 有效缓解患者术前、术后焦虑情绪, 改善患者睡眠质量, 促进早期康复。)

Objective To evaluate the efficacy of simultaneous or staged management of uterine fibroids by transcervical resection of septum (TCRS), reproductive endocrinology and clinical prognosis. Methods Clinical data of 87 patients with uterine septum complicated with uterine fibroids were collected. All patients were divided into the simultaneous (n = 43) and staged groups (n = 44) according to different surgical methods. In the simultaneous group, hysteroscopic TCRS and transcervical resection of myoma (TCRM) were performed simultaneously, whereas staged hysteroscopic TCRS and TCRM were conducted in the staged group. Surgical conditions, postoperative myometrial healing, endometrial and subendometrial blood flow parameters (flow index (FI), vascularization flow index (VFI) and vascularization index (VI) ), endometrial thickness, reproductive endocrine indexes (luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2) ), reproductive outcomes and complications were compared between two groups. Results All patients in both groups completed the surgery successfully. The operation time, time to the first off-bed activity and the length of hospital stay in the simultaneous group were shorter than those in the staged group (all P < 0.05) . In the simultaneous group, the proportion of patients with myometrial healing at 1 month after surgery was higher than that in the staged group (P < 0.05) . The differences in subendometrial VFI, FI, VI, endometrial thickness and E2, LH and FSH levels before surgery, 1 month and 3 months after surgery were not statistically significant between two groups (all P > 0.05) . The percentage of patients who were pregnant at postoperative 6 months in the simultaneous group was higher than that in the staged group (P < 0.05) . The difference in the incidence of complication was not statistically significant between two groups (P > 0.05) . Conclusions Simultaneous management of uterine fibroids by TCRS does not affect endometrial hemodynamics, endometrial tolerance, ovarian reserve function and reproductive endocrine function. In addition, it can shorten the operation time, time to the first off-bed activity and length of hospital stay, which is conducive to postoperative pregnancy and has a certain degree of safety. [ABSTRACT FROM AUTHOR]

Objective To evaluate the risk factors for uterine leiomyoma-associated pain syndrome in pregnancy of pregnant women with uterine fibroids and its influence on pregnancy outcomes. Methods A total of 395 pregnant women were divided into the case group of 74 cases and the control group of 321 cases according to whether uterine leiomyoma-as‐ sociated pain syndrome in pregnancy occurred or not. Univariate analysis and the multi-factor Logistic regression analysis was used to analyze the influencing factors for uterine leiomyoma-associated pain syndrome in pregnancy of pregnant wom‐ en with uterine fibroids, and additionally we compared the pregnancy outcomes of the two groups. Results Age was an influencing factor for the occurrence of uterine leiomyoma-associated pain syndrome in pregnancy and for every one-year re‐ duction in age, the risk of uterine leiomyoma-associated pain syndrome in pregnancy increased by 0. 911 times. The rate of threatened preterm labor was higher (23. 44% vs. 8. 39%) and the rate of postpartum hemorrhage was lower (22. 38% vs. 35. 69%) in the case group than in the control group (all P<0. 05) . Conclusion Age is the influencing factor for uterine leiomyoma-associated pain syndrome in pregnancy, and the syndrome can increase the rate of threatened premature labor [ABSTRACT FROM AUTHOR]

Objective: To explore the feasibility and safety of focused ultrasound ablation surgery for uterine fibroids under daytime surgical mode. Methods: Patients with uterine fibroids admitted to our hospital from January 2020 to December 2022 were selected as the research subjects. Based on the informed consent of the patients, they were randomly divided into observation group A, observation group B, and control group using a random number table method. Each group had 25 cases. The control group was treated with laparoscopic myomectomy, while the observation group A was treated with conventional hospitalization mode focused ultrasound ablation surgery, while the observation group B was treated with daytime surgery mode. Compare the treatment effectiveness of three groups of patients for uterine fibroids, including surgical time, hospital stay, postoperative VAS score, postoperative autonomous activity time, and treatment cost. Compare the incidence of postoperative adverse reactions among the three groups of patients. Finally, conduct outpatient follow-up at 3 months after surgery for all patients, evaluate the symptoms of uterine fibroids through symptom severity (SSS) score, and measure the volume of uterine fibroids through MRI imaging examination, Evaluate the quality of life of two groups of patients using the Comprehensive Quality of Life Assessment Questionnaire 74 (GQOLI-74). Results: The total effective rate of the control group was 100.00%, the observation group A was 96.00%, and the observation group B was 96.00%. There was no difference in the total effective rate among the three groups (P>0.05); There was no difference in surgical time between the three groups of patients (P>0.05). The hospitalization time, postoperative VAS score, postoperative autonomous activity time, and treatment cost of observation group B and observation group A were lower than those of the control group, and the hospitalization time and treatment cost of observation group B were lower than those of observation group A (P<0.05); The incidence of postoperative adverse reactions in Group A and Group B was lower than that in the control group (P<0.05), and there was no difference between Group A and Group B (P>0.05); There was no difference in preoperative SSS score, uterine fibroid volume, and GQOLI-74 dimension average score among the three groups of patients (P>0.05). After surgery, the SSS score and uterine fibroid volume of the three groups of patients decreased, while the GQOLI-74 dimension average score increased (P<0.05). However, there was no difference between the three groups of patients (P>0.05). Conclusion: Focused ultrasound ablation surgery has a significant therapeutic effect on uterine fibroids, and its therapeutic effect is not significantly different from laparoscopic myomectomy. However, it can reduce surgical trauma, shorten hospitalization time, and reduce postoperative pain for patients. Adopting daytime surgery mode focused ultrasound ablation surgery for uterine fibroids can further shorten patient hospitalization time, reduce surgical costs, and have high safety, There is no significant adverse effect on the prognosis of patients, and the feasibility is high. [ABSTRACT FROM AUTHOR]

目的探讨磁共振表观弥散系数（ADC）评估磁共振引导聚焦超声术（MRgFUS）治疗子宫肌瘤效果的价值。方法回顾性分析佛山市中医院2018年1月至2022年10月期间56例接受MRgFUS治疗子宫肌瘤患者治疗前、治疗3月后和6月后的MRI及临床资料，比较患者病灶ADC值与肌瘤的体积，症状严重评分（SSS）和子宫肌瘤症状-生活质量问卷（UFS-QOL）评分的相关性。使用方差分析比较治疗前后相关数据的差异，采用Pearson法进行数据的相关性分析。结果56例患者治疗前及治疗3个月后、6个月后病灶ADC值［（1.11±0.13）、（1.84±0.09）、（2.12±0.24），×10-3/（mm2/s）］、肌瘤体积（102±35.30、56.70±18.88、46.93±18.99，cm3），SSS（36.73±11.74、21.77±10.21、17.66±9.30）和UFS-QOL（59.05±17.48、76.54±16.50、82.46±12.37）评分差异有统计学意义（F值分别为557.837，73.589，53.976和37.606，P值均＜0.05）。ADC值与肌瘤体积、SSS呈负相关，与UFS-QOL评分呈正相关（相关系数分别为-0.586，-0.630和0.592，P值均＜0.05）。结论ADC值对评估MRgFUS治疗子宫肌瘤效果具有较好的临床应用价值。

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的：研究分析超声引导下微波消融治疗子宫肌瘤的有效性及安全性。方法：研究对象共选取了2021年 6月至2023年5月收治的子宫肌瘤患者200例, 这些患者接受随机分组后在治疗期间分别配合超声引导下微波消融治疗 和超声引导下射频消融治疗, 对比两组患者的治疗效果。结果：相较于对照组, 研究组患者的治疗有效率, 各项手术 指标均明显更好。组间对比差异显著 (p < 0.05)。结论：对子宫肌瘤患者实施超声引导下微波消融治疗的疗效显著, 可以有效缩小肌瘤体积, 快速安全完成手术, 且治疗对卵巢功能的影响最小。 [ABSTRACT FROM AUTHOR]

统计观察子宫肌瘤病人，给予曲普瑞林结合不同剂量米非司酮治疗的效果差异性。方法：研究选 取2023年1-9月时段收诊的80个子宫肌瘤病例为观察研究基础，随机进行对照组（40例）、观察组（40例）划分，对 照组-曲普瑞林+传统剂量米非司酮方案治疗，观察组-曲普瑞林+小剂量米非司酮方案治疗，对组间实施效果差异性进 行比较。结果：观察组的不良反应风险低于对照组，差异显著（P < 0.05）；不同组别FSH、LH、P、E2等以及子宫、 肌瘤体积检测结果对比，无统计学差异（P > 0.05）。结论：子宫肌瘤治疗中，采取曲普瑞林+小剂量米非司酮，可以 在保证性激素与子宫、肌瘤体积得到有效改善的基础上，最大限度提升治疗安全性，临床价值较高。 [ABSTRACT FROM AUTHOR]

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effect of low-dose mifepristone combined with goserelin injection in the treatment of uterine leiomyoma and its influence on the level of sex hormones. Methods: 90 patients with hysteromyoma admitted to our hospital from January 2020 to January 2022 were selected as the research objects. All patients were divided into control group, observation group A, and observation group B, with 30 cases in each group, using random number table. The patients in the control group were treated by intravenous injection of goserelin. Observe that group A was treated with conventional dose of mifepristone combined with goserelin, and group B was treated with low-dose of mifepristone combined with goserelin. Compare the clinical treatment effects of the three groups of patients, serum levels of follicle stimulating hormone (FSH), progesterone (P), estradiol (E2) related hormones, procalcitonin (PCT) C-reactive protein (CRP) inflammatory factor level and adverse reactions. Results: The total effective rate of the three groups was different, observation group A and observation group B were higher than the control group (P<0.05), but there was no difference between observation group A and observation group B (P>0.05); There was no difference in the levels of serum FSH, P, E2 related hormones among the three groups before treatment (P>0.05). After treatment, the levels in the three groups decreased, and the levels of observation group A and observation group B were lower than those in the control group (P<0.05), but there was no difference between observation group A and observation group B (P>0.05); After treatment, the levels of CRP and PCT related inflammatory factors in the three groups decreased, and the observation group was lower than the control group (P<0.05), and the observation group A and observation group B were lower than the control group (P<0.05), but there was no difference between the observation group A and observation group B (P>0.05); The incidence of adverse reactions in the three groups was different, and the observation group B and the control group were significantly lower than the observation group A (P>0.05). Conclusion: Mifepristone combined with Goserellin injection has a significant effect in the treatment of uterine leiomyoma, both of which can improve the inflammatory reaction and sex hormone level of patients. However, low-dose Mifepristone combined with Goserellin has a lower adverse reaction and a significant effect, which is worthy of clinical application and promotion. [ABSTRACT FROM AUTHOR]

子宫肌瘤是当代女性最常见的生殖系统良性肿瘤之一，尤其是处于育龄期的女性，其诸多并发症为女性 的生活以及身心健康带来诸多困扰。超声引导下硬化治疗作为近年来新兴的治疗方式，为子宫肌瘤的微创治疗提供了 新思路。聚桂醇是我国国产硬化剂，通过破坏子宫肌瘤供血血管及肌瘤细胞等方面缩小子宫肌瘤的体积，在子宫肌瘤 微创治疗方面有着创伤小、恢复快、安全性高的优势。本文旨在对聚桂醇作为硬化剂在超声引导下治疗子宫肌瘤的研 究现状进行综述并展望其远期治疗效果。 [ABSTRACT FROM AUTHOR]

高强度聚焦超声(HIFU)目前被广泛应用于妇科子宫肌瘤的治疗, 但其术后存在一些不良反 应, 如腹部疼痛、皮肤损伤、阴道流血、骶尾部疼痛等。绝大部分的不良反应经观察或药物对症治疗后即可缓 解, 仅少数病例临床处理较为棘手。该文报道了1例43岁的女性患者接受 HIFU 治疗后发生的骶丛神经 D 级 损伤, 经3个月余的营养神经、促排小大便及综合治疗后, 患者康复出院。同时, 该文结合国内外文献, 对 HIFU 治疗及术后并发症的康复治疗进行了总结。另, 充分了解 HIFU 不良反应发生的原因, 完善术前准备, 做好术 前手术风险的预判, 及时发现并发症可能, 早期积极干预, 均需要临床医师严格把握。 [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of different doses of shikonin on the protein expression of ER, PR and P-ERK in uterine tissue of rats with uterine fibroids established by estrogen plus progesterone loading method. Methods: 60 clean-grade SD female rats were selected and divided into model group, blank control group, positive control group (estradiol group), low-dose shikonin group, middle-dose shikonin group, and high-dose shikonin group groups, 10 rats in each group. Rats in the blank control group and model group were given 10 mL/kg·d normal saline by gavage, the positive control group was given estradiol valerate tablets by gavage at a dose of 50 μg/kg·d, and the low-dose group was given 5 mg by gavage. /kg shikonin, the middle-dose group was given 10 mg/kg shikonin by gavage, and the high-dose group was given 20 mg/kg shikonin by gavage. Record the modeling results of the rats, observe the uterine morphology and uterine histopathology of the rats, and compare the uterine weight, uterine coefficient, the maximum diameter of the uterus, the maximum diameter of the cervix and the thickness of the smooth muscle layer of the rats in each group. Serum P and E2 levels of rats and ER, PR and p-ERK protein contents in uterine tissue of rats in each group. Results: The uterine weight, uterine coefficient, the maximum diameter of the uterus, the maximum diameter of the cervix and the thickness of the smooth muscle layer of the six groups of rats were compared, and the differences were statistically significant (P<0.05). Pairwise comparison of the inflammatory cell infiltration score and the uterine wall smooth muscle thickness score in the six rats (P<0.05); The difference was statistically significant (P<0.05); the ER, PR, p-ERK protein levels in the uterine tissue of the six groups of rats were compared with each other, and the difference was statistically significant (P<0.05). Conclusion: Shikonin has the effect of anti-uterine fibroid activity. With the increase of shikonin dose, the anti-uterine fibroid activity increases obviously, which may be related to the decrease of ER, PR and P-ERK activities and serum P, E2 in uterine tissue. [ABSTRACT FROM AUTHOR]

Aim: Diminished ovarian reserve can be characterized by poor response to ovulation and low number of eggs. The risk factors include endometriosis, receiving cancer treatment, luteal phase deficiency and gynecologic surgery. Uterine fibroids and ovarian cysts are the most common benign gynecological diseases in women globally. This prospective study evaluated the influence of laparoscopic surgery treating benign gynecological diseases on ovarian reserve. Methods: A total of 121 patients with uterine fibroids or benign ovarian cysts who received laparoscopic surgeries (41 with hysterectomy, 36 with myomectomy, 18 with adnexectomy, and 26 with ovarian cystectomy) were included. The ovarian reserve status defined as serum anti-Mullerian hormone concentration was assessed at 1 month before and after surgery, respectively. Results: The anti-Mullerian hormone reduction level was 22.34% in cystectomy, 44.1% in adnexectomy, 24.92% in myomectomy, and 47.61% in hysterectomy (p < 0.001). Multivariate analysis showed that adnexectomy had significantly high risk of high serum anti-Mullerian hormone reduction level (adjusted odds ratio (aOR): 14.90, 95% confidence interval (CI): 2.56-86.93, p = 0.003). Conclusions: These 4 laparoscopic surgeries all reduced the AMH levels 1 month after the procedure. Further prospective studies with longer follow-up are necessary to know the real impact on the ovarian reserve. Adnexectomy was an independent factor of reduced ovarian reserve in 1 month after surgery. [ABSTRACT FROM AUTHOR]

Objective: To investigate the curative effect of Cangsha Baijie decoction combined with GnRH-a in the treatment of uterine leiomyoma and its effect on ovarian function, serum bFGF and NF-κB levels. Methods: 110 patients with uterine fibroids treated in our hospital from May 2019 to May 2021 were selected as the research objects, and the patients were divided into observation group and control group, 55 cases in each group. The control group received GnRH-a treatment, and the observation group received Cangsha Baijie Decoction combined with GnRH-a treatment. The total effective rate of clinical treatment, progesterone (P) level, follicle stimulating hormone (FSH) level, estradiol (E2) level, vascular endothelial growth factor (VEGF) level, basic fibroblast growth factor (bFGF) level, matrix metalloproteinase 3 (MMP-3) level, nuclear factor-κB subtype P65 (NF-κB P65 ) levels, tumor-specific growth factor (TSGF) levels. Results: The total effective rate of the observation group was higher than that of the control group (P<0.05); there was no difference in the levels of P, FSH, and E2 between the two groups before treatment (P>0.05), and the levels of P, FSH, and E2 in the two groups decreased after treatment, and the observation group was lower than the control group (P<0.05); the levels of VEGF, bFGF and MMP-3 in the two groups had no difference before treatment (P>0.05), and the levels of VEGF, bFGF and MMP-3 in the two groups after treatment The levels of NF-κB P65 and TSGF in the two groups had no difference before treatment (P>0.05), and the levels of NF-κB P65 and TSGF in the two groups after treatment All decreased, and the observation group was lower than the control group (P<0.05). Conclusion: Using Cangsha Baijie Decoction combined with GnRH-a in the treatment of uterine fibroids can improve the clinical therapeutic effect, regulate the level of sex hormones, improve the levels of VEGF, bFGF, MMP-3, NF-κB P65, and TSGF, and is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

目的 分析子宫肌瘤宫腔镜电切术后并发经尿道前列腺电切术 (TURP) 综合征的危险因素, 据此构建并 验证并发TURP综合征风险的列线图预测模型。方法 选择行宫腔镜电切术治疗的子宫肌瘤患者120例, 根据术后 是否并发TURP综合征分为并发TURP综合征者与未并发TURP综合征者, 采用多因素Logistic回归模型分析子宫肌 瘤宫腔镜电切术后并发TURP综合征的危险因素, 据此构建并发TURP综合征风险的列线图预测模型, 采用受试者 工作特征 (ROC) 曲线评估该模型的预测效能, 绘制校准曲线并采用Bootstrap法检验该模型的校准度。结果 多因 素Logistic回归分析显示, 手术时间, 膨宫压力, 膨宫液吸收量, 输卵管直径, 血糖, 中心静脉压均为子宫肌瘤宫腔镜 电切术后并发TURP综合征的独立危险因素 (P均<0. 05)。以上述危险因素作为预测指标, 构建子宫肌瘤宫腔镜电 切术后并发TURP综合征风险的列线图预测模型。ROC曲线分析显示, 该模型预测子宫肌瘤宫腔镜电切术后并发 TURP综合征的曲线下面积为0. 855 (95% CI：0. 779~0. 912), 其预测灵敏度和特异度分别为75. 00%, 86. 00%。运 用 Bootstrap法对该模型进行验证, 其-致性指数为 0. 835, 校正曲线与标准曲线贴合度较好, 模型校准度良好。结 论 手术时间, 膨宫压力, 膨宫液吸收量, 输卵管直径, 血糖, 中心静脉压均为子宫肌瘤宫腔镜电切术后并发 TURP 综合征的危险因素, 据此构建了并发TURP综合征风险的列线图预测模型, 经验证其预测效能较好. [ABSTRACT FROM AUTHOR]

Objective: To investigate the value of contrast-enhanced ultrasound (CEUS) contrasted with magnetic resonance imaging (MRI) in the detection and characterization of uterine fibroids. Methods: A total of 46 patients with uterine fibroids confirmed by pathology during May 2016 to March 2022 in The first medical center of the General Hospital of the Chinese people's Liberation Army were selected as the research objects. CEUS and MRI examinations were performed on all patients before surgery, and the number, size, location, and enhancement of uterine fibroids were analyzed and recorded. t test was used to compare the size of uterine fibroids detected by MRI and CEUS. The number, location and enhancement of uterine fibroids detected by MRI and CEUS were compared by x2 test. Pearson correlation coefficient was used to analyze the correlation between the number, size, location and enhancement of uterine fibroids by MRI and CEUS imaging methods. Results: A total of 115 uterine fibroids were detected by postoperative pathology in 46 patients. 111 (96.52%) were detected by MRI and 106 (92.17%) by CEUS. The mean size of uterine fibroids measured by MRI and CEUS were (4.66± 1.83) cm and (4.51± 1.74) cm. There were 103 of uterine fibroids detected by CEUS and 107 of uterine fibroids detected by MRI. In CEUS examination, 99 uterine fibroids showed enhancement; On MRI, 102 uterine fibroids showed enhancement. There were no significant differences in the number, size, location and enhancement of uterine fibroids detected by the two imaging methods (all P>0.05). Pearson correlation coefficient analysis showed that the correlation between the number, size, location and enhancement of uterine fibroids detected by MRI and CEUS were 0.95, 0.96, 0.94 and 0.97 respectively (all P<0.001). Conclusion: CEUS has the same diagnostic value as MRI in the detection and qualitative diagnosis of uterine fibroids, and can be used as an alternative imaging method to evaluate uterine fibroids. [ABSTRACT FROM AUTHOR]

子宫肌瘤是女性生殖系统最常见的良性肿瘤。子宫黏膜下肌瘤的发生相对较少,会较大程度 地影响宫腔环境,导致一系列临床症状和不良后果。临床手术方式的选择需要根据肌瘤的术前分型决定。多 发、体积较大的肌瘤手术较困难且易出现术后不良反应,更有部分患者需要切除子宫。因此,为了进一步改善 生活质量,降低心理创伤,保留生育能力,避免出现不可逆的严重后果,需要做到早发现、早诊断、早治疗。该文 结合相关文献及病例报道,探讨子宫黏膜下肌瘤的常用影像学诊断方法及优缺点,分析不同影像学检查方法的 临床价值,帮助临床医生选择更合适的检查方式,进行准确诊断及有效治疗。 [ABSTRACT FROM AUTHOR]

Objective: To observe the changes of endometrial receptivity and sex hormones in patients with hysteromyoma who have fertility requirements before and after ablation with high intensity focused ultrasound (HIFU), and to analyze the influencing factors of pregnancy outcome. Methods: 176 eligible patients with hysteromyoma who received HIFU ablation in our hospital from November 2018 to June 2020 were selected. They all received HIFU ablation. The changes of endometrial receptivity, sex hormones and complications before and after treatment were observed. They were divided into pregnancy group and non pregnancy group according to whether they were pregnant after treatment. The influencing factors of pregnancy outcome were analyzed by univariate and multivariate logistic regression. Results: 3 months after operation, the endometrial thickness, endometrial volume, vascularization index (VI) and blood flow index (FI) of patients with hysteromyoma were thicker than those before operation (P<0.05). There were no significant changes in estradiol (E2), follicle growth hormone (FSH) and luteinizing hormone (LH) 3 months after operation, and there was no significant difference between the groups (P>0.05). Among the patients treated with HIFU, the incidence of complications was 2.84%. Among the 176 patients, 118 pregnant patients were included in the pregnancy group, and the remaining 58 non pregnant patients were included in the non pregnancy group. The pregnancy rate was 67.05%. Univariate comparison showed that the pregnancy outcome was related to age, preoperative infertility history, postoperative symptom improvement, myoma classification, postoperative target myoma volume reduction rate 逸 50% and body mass index (P<0.05). Multivariate logistic regression analysis showed that age, preoperative infertility history and myoma classification were the influencing factors of pregnancy outcome(P<0.05). Conclusion: After HIFU ablation, the endometrial receptivity of patients with hysteromyoma with fertility requirements is significantly improved, and has no significant effect on the secretion of sex hormones. It is safe and reliable. In addition, age, preoperative infertility history and myoma classification are the influencing factors of pregnancy outcome. [ABSTRACT FROM AUTHOR]

Objective: To retrospectively analyze the clinical efficacy of laparoscopic uterine vascular occlusion combined with hysteromyoma enucleation in the treatment of hysteromyoma. Methods: The clinical data of patients with hysteromyoma who treated in our hospital from June 2017 to July 2019 were analyzed (n=150). According to different surgical methods, the patients were divided into group A (laparoscopic hysteromyoma enucleation treatment, 73 cases) and group B (laparoscopic uterine vascular occlusion combined with hysteromyoma enucleation treatment, 77 cases). The intraoperative, endocrine hormones, postoperative recovery indexes, pregnancy situation, complication rate and recurrence rate were compared between the two groups. Results: There was no statistical difference in the operative time between the two groups (P>0.05), the intraoperative blood loss in group B was less than that in group A, and the postoperative exhaust time, hospitalization days and out of bed activity time were shorter than those in group A (P<0.05). There were no significant differences in the levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol (E2) in group A at before surgery, 3 months after surgery and 6 months after surgery (P>0.05). In group B, the level of E2decreased and then increased before surgery, 3 months after surgery and 6 months after surgery, while the levels of LH and FSH increased and then decreased (P<0.05). The levels of LH and FSH in group B were higher than those in group A, and the level of E2was lower than that in group A at 3months after surgery (P<0.05). Compared with group A, the complication rate in group B was significantly decreased, and the difference between groups was statistically significant (P<0.05). The pregnancy rate in group B was higher than that in group A, and the recurrence rate of hysteromyoma was lower than that in group A (P<0.05). There was no significant difference in abortion rate between the two groups (P>0.05). Conclusion: Compared with simple hysteromyoma enucleation, the treatment of hysteromyoma patients combined with laparoscopic uterine vascular occlusion can reduce the intraoperative blood loss, promote the postoperative recovery of patients, and reduce the complication rate and recurrence rate. Although it has a slight and transient impact on ovarian function, it can recover gradually and improve the pregnancy rate. [ABSTRACT FROM AUTHOR]

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目的 探讨音乐疗法结合肌肉放松训练应用于子宫肌瘤患者术前访视中的效果。方法 选取 2017年5月至2020年5月江南大学附属医院收治的子宫肌瘤患者88例,随机分为对照组及观察组,各44例。 对照组行常规干预,观察组行音乐疗法结合肌肉放松训练。对比两组不良情绪、疼痛程度及术后恢复情况。结 果 观察组汉密尔顿焦虑、抑郁量表评分均较对照组低,差异均有统计学意义(P<0.05);观察组不同手术方式 患者术后6、24h视觉疼痛模拟评分均较对照组低,差异均有统计学意义(P<0.05);观察组肛门首次排气时 间、首次下床时间及总住院时间均较对照组短,差异均有统计学意义(P<0.05)。结论 音乐疗法结合肌肉放 松训练应用于子宫肌瘤患者术前访视中可有效缓解患者不良情绪,减轻其疼痛程度,利于术后快速恢复. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Based on health technology assessment method, to perform rapid health technology assessment on gonadotropin releasing hormone agonist (GnRH-a) in the treatment of uterine fibroids, so as to provide evidence-based basics for clinical decision and drug evaluation. METHODS: Systematic reviews, Meta-analysis, health economics researches and health technology assessments were retrieved from Pubmed, Embase, CNKI, Wanfang Data, after double-checking, article de-duplicate, primary selection based on title and abstract, and re-selection based on full text, relevant literature was enrolled and information was extracted, the assessment of multiple sys-tematic reviews (AMSTAR) scale and overview of quality assessment questionnaire (OQAQ) scale were adopted to evaluate the methodological quality of systematic reviews and Meta-analysis, and the consolidated health economic evaluation reporting standards (CHEERS) scale was used to evaluated the methodological quality of health economics researches, so that a comprehensive evaluation on GnRH-a in the treatment of uterine fibroids was made. RESULTS: A total of 9 studies were finally enrolled, including 7 systematic reviews and Meta-analysis and 2 pharmacoeconomic studies, no relevant health technology assessment reports were retrieved. Analysis of comprehensive research results revealed that GnRH-a did not show significant improvement in terms of operative duration and other aspects for the preoperative hysteroscopic treatment. While GnRH-a showed significant effect in reducing the volume of uterus and fibroids in laparoscopic and transabdominal surgery, yet its effect on the operative duration was still controversial; GnRH-a had significant adverse drug reactions; meanwhile, in terms of economic evaluation, the cost of GnRH-a for laparoscopic and transabdominal surgery outweighed the benefit, except for its advantage in combination with high intensity focused ultrasound therapy. CONCLUSIONS: The treatment of uterine fibroids with GnRH-a requires assessment of drug regimen according to different types of surgery, and monitoring of adverse drug reactions, while the economical efficiency of GnRH-a need to be investigated. [ABSTRACT FROM AUTHOR]

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

磁共振纹理分析(MRTA)及影像组学技术是一种新型的辅助分析技术,已应用于子宫肌瘤的 诊断及鉴别诊断、子宫肌瘤治疗及预后评估中,并显示出巨大的潜力。该文就MRTA 及影像组学技术在子宫 肌瘤中的应用及研究进展进行了综述。 [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of Gonadotropin releasing hormone (GnRH) analogues on blood viscosity, uterine coefficient and inflammatory cell infiltration in rat models of uterine fibroids. Methods: Rat models of uterine fibroids (n=36) were equally randomly divided into three groups-model group, mifepristone group and GnRH analogue group. The three groups were given intraperitoneal injection of 0.15 mL of normal saline, 2 mg/kg of mifepristone, 2 mg/kg GnRH analogue, once a week for 8 weeks. Results: The values of whole blood specific viscosity, follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the 4th and 8th weeks of treatment in the mifepristone group and GnRH analog group were lower than those of the model group (P<0.05), the GnRH analog group were lower than mifepristone group (P<0.05). Uterine coefficient, uterine interleukin (IL)-10 and tumor necrosis factor (TNF)-α expression levels in the mifepristone group and GnRH analog group at the 8th week of treatment were lower than those in the model group (P<0.05), GnRH analog The group were lower than the mifepristone group (P<0.05). The endometrial thickness, gland-to- interstitial area ratio, gland area and gland cavity area of the mifepristone group and the GnRH analog group were higher than the model group at the 8th week of treatment (P<0.05), and the GnRH analog group were higher than that in the GnRH analog group Mifepristone group (P<0.05). The relative expression levels of Wnt5b and β-catenin protein in the uterine tissue of the mifepristone group and the GnRH analog group were lower than the model group at the 8th week of treatment (P<0.05), and the GnRH analog group were lower than the mifepristone group (P< 0.05). Conclusion: The application of GnRH analogues in rat models of uterine fibroids can reduce blood viscosity, inhibit the secretion of serum sex hormones, increase uterine coefficient, and inhibit the expression of Wnt5b and β-catenin proteins, thereby improving morphology of the endometrium uterine fibroids and the infiltration state of inflammatory cells in rats. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 研究子宫肌瘤的发生与胰岛素样生长因子-1 (IGF-1)、代谢综合征(MS)的相关性,为子 宫肌瘤的防治提供参考。方法 选取并分析 285 例子宫肌瘤患者(观察组)和 325 例非子宫肌瘤健康体检女性 (对照组)的血清 IGF-1 水平和相关 MS 指标, MS 指标包括体重指数 (BMI))、血压[收缩压(SBP)/舒张压 (DBP)]、空腹血糖 (BG)、三酰甘油 (TG)、高糖化血红蛋白 (HbA1c)、胆固醇 (TC)、高密度脂蛋白胆固醇 (HDLC) 、低密度脂蛋白胆固醇 (LDL-C)。同时采用单因素、多因素logistic回归分析子宫肌瘤和IGF-1、MS指标之 间的相关性。结果 观察组 IGF-1、BMI、SBP、DBP、BG、TG、LDL-C 显著高于对照组,差异均有统计学意义 (P <0.05)。单因素logistic回归结果发现,BMI、SBP、DBP、IGF-1、BG、HbA1c、LDL-C、TG 与TC是子宫肌 瘤发生的危险因素 (P <0.05)。多因素 logistic 回归分析显示,血清 IGF-1、HbA1c、TC、LDL-C 水平是影响子 宫肌瘤发生的独立危险因素 (P <0.05)。结论 子宫肌瘤的发生和MS相关指标密切相关,其中血清 IGF-1水 平,BG、TC、LDL-C 水平是子宫肌瘤发生的危险因素。 [ABSTRACT FROM AUTHOR]

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Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　To evaluate the differential diagnosis of uterine adenomyosis and uterine fibroids by intravenous contrast-enhanced ultrasound （CEUS）. Methods　Routine ultrasonography and intravenous CEUS were performed in patients with uterine fibroids and adenomyosis in the department of obstetrics and gynecology， the First Affiliated Hospital of Kunming Medical University from December 2017 to December 2019. The results of postoperative pathological examination were compared， the accuracy of conventional ultrasound and intravenous CEUS was analyzed， and the characteristics of CEUS for uterine fibroids and adenomyosis were also analyzed. Results　1. The accuracy rates of conventional ultrasound and CEUS in the diagnosis of uterine fibroids were 92% and 98%，respectively， with statistically significant differences （P < 0.05）. The accuracy of adenomyosis diagnosis was 91% and 100%，respectively， with statistically significant difference （P < 0.05）. 2. According to intravenous contrast-enhanced ultrasonography， the onset time of adenomyosis was earlier than that of adenomyoma， and the peak time was earlier than that of uterine fibroids， and the peak intensity was lower than that of uterine fibroids， with statistically significant difference （P < 0.05）. Conclusions　1. Intravenous CEUS is superior to conventional ultrasonography in the diagnosis of adenomyosis and uterine fibroids. 2. Adenomyosis and hysteromyoma have different characteristic changes in contrast-enhanced ultrasonography， which can be used as the key point to differentiate them. [ABSTRACT FROM AUTHOR]

To investigate the effects of laparoscopic myomectomy and laparotomy on endocrine status, immune function and prognosis of patients with uterine fibroids. From January 2014 to January 2019, 90 patients with hysteromyoma in our hospital were selected, they were divided into group A (n=44) and group B (n=46) according to the different operation methods. Group A received laparotomy, and group B received laparoscopic hysteromyomectomy. The clinical indexes, endocrine status, immune function, complications and prognosis of the two groups were compared. There was no statistical difference in the operation time between the two groups (P>0.05). The intraoperative hemorrhage in group B was less than that in group A, and the hospitalization time and recovery time of anal exhaust after operation were shorter than those in group A (P<0.05). Follicular stimulating hormone (FSH) and luteinizing hormone (LH) in both groups at 1 month after operation were increased than before operation, and estradiol (E2) was decreased than before operation (P<0.05). FSH and LH in group B at 1 month after operation were lower that in group A, and E2 was higher than that in group A (P<0.05). CD3+, CD4+, CD4+ /CD8+ in both groups at 1d after operation were lower than before operation, but the group B were higher than group A (P<0.05). CD8+ was higher than before operation, but the group B were lower than group A (P<0.05). The incidence of complications in group B was lower than that in group A (P<0.05). There were no significant differences between the two groups in the normal rate of uterine morphology, the recurrence rate and the normal rate of menstrual transition (P>0.05). Compared with laparotomy, laparoscopic myomectomy can significantly reduce the damage to the endocrine state and immune function of patients with hysteromyoma, promote the postoperative recovery of patients, reduce the incidence of complications, and at the same time, it can obtain the same short-term prognosis as laparotomy. [ABSTRACT FROM AUTHOR]

Objective: To explore the effects of Cangsha Baijie decoction and Pingxiao capsule on T-lymphocyte subgroup, sex hormone level and uterine artery blood flow index in patients with hysteromyoma. Methods: 90 patients with hysteromyoma who were admitted to our hospital from December 2018 to December 2019 were selected as the study subjects. The patients were divided into control group (30 cases, treated with mifepristone tablets), observation group 1 (30 cases, treated with mifepristone tablets, Pingxiao capsule) and observation group 2 (30 cases, treated with mifepristone tablets, Cangsha Baijie decoction, Pingxiao capsule) by random number table method and random remainder grouping method. 3 months after treatment, the clinical efficacy, myoma volume, T lymphocyte subsets, sex hormone levels, uterine artery blood flow index and adverse reactions of the three groups were compared. Results: The total clinical effective rate was 96.67% in the observation group 2, 86.67% in the observation group 1 and 70.00% in the control group. There was significant difference in the three groups (P<0.05). 3 months after treatment, The levels of follicle stimulating hormone (FSH), progesterone (P), estradiol (E2) were lower than those before treatment, the observation group 2 were lower than those in the observation group 1, the observation group 1 was lower than those in the the control group. The resistance index (RI) and pulsation index (PI) of uterine artery in the observation group 2 were better than those in the observation group 1 and the control group, the differences were significant (P<0.05). 3 months after treatment, the levels of CD3+, CD4+ and CD4+/CD8+ in the three groups were significantly higher than those before treatment, the level of CD8+ was significantly lower than that before treatment. The levels of CD3+, CD4+ and CD4+/CD8+ in observation group 1 and observation group 2 were higher than those in control group, while the levels of CD8+ in observation group 1 and observation group 2 were lower than those in control group, the differences were significant (P<0.05). There was no significant difference in the incidence of adverse reactions among the three groups. Cangsha Baijie decoction combined with Pingxiao capsule can improve the therapeutic effect, T lymphocyte subsets, sex hormone level and uterine artery blood flow index of patients with hysteromyoma, without increasing adverse drug reactions. [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study the effects of Guizhi Fuling bolus combine with mifepristone on hemorheology, hemoglobin (Hb) and human epididymis protein 4 (HE4) in patients with hysteromyoma. Methods: 172 patients with hysteromyoma treated in 3201 Hospital Affiliated to Medical College of Xi'an Jiaotong University from March 2016 to May 2017 were selected, the patients were randomly divided into the observation group (n=86) and the control group (n=86). The control group was treated with mifepristone, the observation group was treated with Guizhi Fuling bolus on the basis of the control group, the efficacy was compared between the two groups after 3 months treatment, the Hb, HE4, myoma volume, blood rheology indexes were compared between the two groups before treatment and after 3 months treatment, the adverse reaction was compared between the two groups. Results: The total effective rate of the observation group was 97.67%, which was higher than 89.53%of the control group (P<0.05). After treatment, the levels of Hb in both groups were significantly higher than before treatment, which in the observation group was higher than the control group (P<0.05). The level of HE4 in both groups was lower than that before treatment, the observation group was lower than that in the control group (P<0. 05), and the fibroid volume was smaller than that before treatment, and the observation group was smaller than that in the control group (P<0.05). After treatment, the total blood viscosity (HBV), total blood viscosity (LBV), plasma viscosity (PV) and platelet aggregation rate (PAR) of the two groups were lower than before treatment, and the observation group was lower than the control group (P<0.05). The total incidence of adverse reactions in the observation group and control group were 13.95% and 10.47%, which was no significant difference (P>0.05). Conclusion: Guizhi poring bolus combined with mifepristone is effective in treating uterine fibroids, which can improve the level of hemorheology, Hb, HE4 and other indicators, with good safety and worth popularizing. [ABSTRACT FROM AUTHOR]

High -intensity focused ultrasound (HIFU) ablation for uterine leiomyoma, as a new non - invasive treatment, has been more and more widely used in the treatment of uterine leiomyoma. However, there are few literature reports on the early pregnancy and pregnancy outcome after the improper timing of HIFU treatment for uterine leiomyoma. We report a case of inappropriate timing of high-intensity focused ultrasound ablation for uterine leiomyoma in a pregnant woman，with literature review. We summarize the influence of uterine leiomyoma on pregnancy, the influence of different treatment methods on pregnancy, the timing of HIFU ablation for uterine leiomyoma, the problem of fetal retention when HIFU ablation for uterine leiomyoma combined with pregnancy, and the effect of HIFU ablation for uterine leiomyoma on abortion operation, etc. Even more important, we discuss the indication of HIFU ablation for uterine leiomyoma, the appropriate treatment time, and the appropriate pregnancy opportunity after HIFU operation [ABSTRACT FROM AUTHOR]

目的分析阴式子宫肌瘤剔除术和腹腔镜子宫肌瘤剔除术治疗子宫肌瘤的临床疗效，以及对患者术后机体综合应激状态﹑宫颈局部微循环的影响。方法于 2016 年 3 月至 2017 年 3 月，将 130 例子宫肌瘤患者随机分为对照组和观察组，各 65 例。对照组行腹腔镜子宫肌瘤剔除术，观察组行阴式子宫肌瘤剔除术。分析不同术式临床疗效，患者术前﹑术后 1 周宫颈局部微循环情况、机体综合应激状态，术前、术后 6 个月卵巢动脉血流及卵巢储备功能，以及术后 12 个月子宫肌瘤症状及健康相关生活质量问卷（UFS-QOL 问卷）评分结果。结果观察组手术时间、术中出血量、住院天数、术后疼痛消失时间、术后镇痛剂使用情况、肠蠕动恢复时间等手术效果指标均优于对照组（P＜0.05）。术后 1 周，观察组血清炎性应激指标、氧化应激指标、疼痛应激指标水平均低于对照组（P＜0.05）。术后 1 周，观察组宫颈毛细血管管径、血流灌注、微血管管径均高于对照组（P＜0.05）。术后6个月，对照组卵巢动脉血流及卵巢储备功能指标变化显著（P＜0.05），观察组则无明显变化（P＞0.05），且观察组各指标优于对照组（P＞0.05）。术后 12 个月，观察组 UFS 评分和 QOL 评分优于对照组（P＜0.05）。结论阴式子宫肌瘤剔除术具有低侵袭、高疗效、高美观等优势，有助于降低术后疼痛程度，减少卵巢储备功能的影响，稳定宫颈局部微循环，将术后机体综合应激程度降至最低，有助于提高患者术后生活质量，改善远期预后。 [ABSTRACT FROM AUTHOR]

Objective: To study the efficacy of Hongjin Xiao jie Capsule and mifepristone in the treatment of hysteromyoma and its effect on the serum Ang-2, EGF and NF-kappa Bp65 levels. Methods: 103 patients with hysteromyoma were selected from May 2017 to May 2018 in our hospital. They were divided into the observation group (53 cases) and the control group (50 cases) by the random nurnber table method. The control group was treated with mifepristone, while the observation group was treated with Hongjin Xiao jie Capsule on the basis of control group. The two groups of patients stopped taking medicine during menstruation and were treated continuously for 3 months. The clinical efficacy, changes of serum Ang-2, EGF, NF-kappa Bp65, uterine volume and turnors, follicular estrogen (FSH), luteinizing hormone (LH), estradtol (E2) levels and incidence of adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of observation group was 94.34%, which was significantly higher than 78% in the control group (p<0.05); the serum levels of Ang-2, EGF, NF-kappa Bp65, FSH, LH and E2 were significantly lower than those of the control group (P<0.05); the uterine volume and uterine leiomyoma volume of the observation group were smaller than those of the control group(P<0.05), there was no significant difference in the incidence of adverse reaction between the two groups(P>0.05). Conclusion: The clinical efficacy of Hongjin Xiao jie Capsule combined with mifepristone in the treatment of uterine leiomyoma is significantly better than that of mifepristone alone. it can significantly improve the sex hormone level of patients and reduce the volume of uterine and uterine leiomyoma, which maybe related to the reduction of serum Ang-2, EGF and NF-kappa B p65 levels. [ABSTRACT FROM AUTHOR]

目的 探讨子宫腺肌症合并多发性子宫肌瘤采用米非司酮联合促性腺激素释放激素激动剂 (GnRH-a)治疗的效果,并探讨其对患者血清8-异前列腺素F2α(PGF2α)、前列腺素E2(PGE2)及β-内啡肽的影 响。方法 选取2015年3月至2017年1月南京市江宁医院收治的140例子宫腺肌症合并多发性子宫肌瘤的 患者作为研究对象,将其分为对照组和联合组,各70例。对照组采用GnRH-a治疗,观察组采用米非司酮联合 GnRH-a治疗,对比两组治疗后的临床效果。结果 治疗后6个月,联合组患者的月经增多率为4.29%,低于 对照组的15.71%,差异有统计学意义(P <0.05);联合组月经正常率为90.00%,高于对照组的74.29%,差异 有统计学意义(P <0.05);治疗前及治疗后3个月,两组患者的最大肌瘤直径比较,差异无统计学意义(P > 0.05);治疗后的6个月及停药3个月,观察组患者的最大肌瘤直径较对照组明显的缩小,差异有统计学意义 (P <0.05); 治疗前两组患者的血清PGF2α、PGE2及β-内啡肽水平比较,差异均无统计学意义(P >0.05);治 疗后3、6个月联合组患者的血清PGF2α水平显著低于对照组,而PGE2及β-内啡肽水平均高于对照组,差异均 有统计学意义(P <0.05)。结论 子宫腺肌症合并多发性子宫肌瘤采用GnRH-a治疗的基础上,配伍米非司 酮能够显著改善患者体内的氧化应激性指标,改善患者的临床症状,缩小子宫肌瘤体积。 [ABSTRACT FROM AUTHOR]

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To study and observe the effects of cold knife excision by hysteroscopy for the local microcirculation and inflammatory reaction of patients with hysteromyoma．Methods 86 patients with hysteromyoma admitted in our hospital from March 2016 to July 2017 were selected as the research objects，and the patients were divided into control group with 43 cases and observation group with 43 cases according to the method of random number table．The control group were treated with monopolar electric knife excision by hysteroscopy，while the observation group treated with cold knife excision by hysteroscopy．Then the local microcirculation and inflammatory reaction indexes of two groups at different time before and after the operation were detected．Results The local microcirculation and inflammatory reaction indexes of two groups before the operation were compare，no significant differences found （P ＞0.05）；the local microcirculation indexes of observation group after the operation were significantly better than those of the control group，the inflammatory reaction indexes were significantly lower than those of the control group，both with statistical significance（P ＜0.05） .Conclusion The cold knife excision by hysteroscopy has better clinical effects in the control of local microcirculation and inflammatory reaction in patients with hysteromyoma，so it has higher application value in the patients with hysteromyoma. [ABSTRACT FROM AUTHOR]