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近年来，快递行业需求快速增长，物流配送行业压力剧增。无人机（UAV, unmanned aerial vehicle）配送凭借其人力成本低、灵活方便等特性成为车辆配送的有益补充。然而，无人机配送受续航能力和负载能力等因素的制约，需要低成本且能量自维持的配送和充电调度方案来支持多无人机的协同配送。提出了两阶段的能量自维持的多无人机协同配送及充电调度方案。第一阶段在满足无人机能量和载重容量约束的前提下，最小化能完成区域内所有配送任务所需的无人机数量，并给出对应配送路线。提出了无人机配送调度算法（UDSA, UAV delivery scheduling algorithm），并从理论上证明了UDSA的近似度。第二阶段对具有不同到达时间的无人机进行充电调度，最小化所有无人机的最大充电完成时间。提出了一种具有近似度的无人机充电调度算法（UCSA, UAV charging scheduling algorithm）来求解该问题。仿真实验结果表明，与基准算法相比，UDSA最多可以减少44.17%的无人机数量；UCSA最多可以缩短18.87%的最大充电完成时间。

本文观察了东北林蛙皮肤及其腺体组织形态学结构,结果表明:东北林蛙体表各部位皮肤薄厚不一,头部背侧皮肤最厚（224.4±5.46μm）,后肢腹侧皮肤最薄（135.7±5.06μm）,但基本结构相同,由表皮和真皮组成。表皮薄,为复层扁平上皮;真皮疏松层有大量腺体分布,主要是粘液腺和颗粒腺。粘液腺广泛分布于全身皮肤,颗粒腺多见于背部皮肤,以躯干背侧褶处体积最大。色素细胞分布于真皮浅层,以背侧皮肤多见。

目的 探索青年烟雾病患者的卒中类型及临床特征，分析青年烟雾病患者发生卒中的危险因素。 方法 回顾性纳入2020年1月-2021年12月解放军总医院第五医学中心收治的青年（18～45岁）卒中型烟雾病患者，将患者分为出血性卒中组和缺血性卒中组进行亚型分析，对比不同卒中类型患者的临床及影像学特征。并以同期未发生卒中的烟雾病患者作为对照组，应用多因素logistic回归分析青年烟雾病患者发生出血性或缺血性卒中的危险因素。 结果 共入组108例卒中型烟雾病患者，其中出血性卒中22例（20.4%），缺血性卒中86例（79.6%）。出血性卒中组中脑室出血12例（54.5%），脑实质出血7例（31.8%），蛛网膜下腔出血3例（13.6%）。缺血性卒中组中大动脉梗死型21例（24.4%），血流动力学梗死36例（41.9%），穿支动脉梗死29例（33.7%）。出血性卒中组与缺血性卒中组性别和合并动脉瘤者比例的差异有统计学意义。无卒中对照组共104例，多因素logistic回归分析结果显示，合并动脉瘤（OR 10.569，95%CI 1.524～73.274，P=0.017）为青年烟雾病患者发生出血性卒中的独立危险因素；增龄（OR 1.058，95%CI 1.004～1.115，P=0.034）、合并糖尿病（OR 4.005，95%CI 1.766～9.080，P=0.001）、高铃木分期（OR 1.363，95%CI 1.037～1.793，P=0.027）为青年烟雾病患者发生缺血性卒中的独立危险因素。 结论 青年烟雾病患者的卒中类型以缺血性卒中为主。血流动力学梗死和脑室出血分别是缺血性卒中和出血性卒中的主要类型。增龄、高铃木分期、合并糖尿病和颅内动脉瘤是引起青年烟雾病患者卒中的独立危险因素。 Abstract: Objective To explore the stroke types and clinical characteristics of in young patients with moyamoya disease, and to analyze the risk factors of stroke in young patients with moyamoya disease (MMD). Methods The clinical and imaging data of MMD with stroke patient (age 18 to 45 years old) between January 2020 and December 2021 who were admitted to the Fifth Medical Center of PLA General Hospital were retrospectively analyzed. The MMD patients with stroke were divided into hemorrhagic stroke and ischemic stroke groups, imaging and clinical features of patients with different stroke types were compared. The MMD patients without stroke during the same period were selected as the control group, and multivariate logistic regression analysis was used to analyze the risk factors of hemorrhagic stroke and ischemic stroke in young MMD patients. Results A total of 108 patients with stroke were enrolled, including 22 cases (20.4%) of hemorrhagic stroke and 86 cases (79.6%) of ischemic stroke. A total of 104 subjects in control group were included. In hemorrhagic stroke group, there were 12 cases (54.5%) intraventricular hemorrhage, 7 cases (31.8%)of parenchymal hemorrhage, 3 cases (13.6%) of subarachnoid hemorrhage. In ischemic stroke group, there were 21 cases (24.4%) of larger artery infarction type, 36 cases (41.9%) of hemodynamic infarction type, and 29 cases (33.7%) of perforating artery infarction type. There were statistical differences in gender and the percentage of aneurysms between hemorrhage stroke group and ischemic stroke group. Multivariate logistic regression analysis showed that aneurysm was a risk factor for hemorrhagic stroke in young MMD patients (OR 10.569, 95%CI 1.524-73.274, P=0.017); age increasing (OR 1.058, 95%CI 1.004-1.115, P=0.034), Suzuki stage (OR 1.363, 95%CI 1.037-1.793, P=0.027) and diabetes mellitus (OR 4.005, 95%CI 1.766-9.080, P=0.001) were independent risk factors for ischemic stroke in young MMD patients. Conclusions The main type of stroke in young MMD patients is ischemic stroke. For MMD patients with stoke, hemodynamic infarction type was the main type of ischemic stroke, and ventricular hemorrhage was the main type of hemorrhagic stroke. Age, Suzuki stage, diabetes mellitus and intracranial aneurysm were independent risk factors for stroke in young MMD patients.

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Objective: To investigate the effect of LncRNA SNHG1 expression on AD cell damage model, and to study its rela- tionship with miR-361-3p/Nfat5 pathway. Methods: Establish an AD cell model. To SH-SY 5 Y cells to SNHG 1-shRNA to reduce SNHG 1 expression and to miR-361-3p-mimic to overexpress miR-361-3p. The expression levels of SNHG 1 and miR-361, apoptosis, and protein expression were examined, and miR-361-3p was bound to SNHG 1. Results: Compared with the blank control group, the AD model group showed decreased miR-361-3p expression, but increased SNHG 1 expression and increased apoptosis rate (P<0.05). Knock- down of reduced SNHG 1 expression decreased the apoptosis rate (P<0.05). Overexpression of miR-361-3p reduces the level of SNHG 1 expression. In the AD model group, Nfat 5 and p-Tau were increased, while Nestin protein decreased (P<0.05); knockdown of SNHG 1 decreased the expression of Nfat 5 and p-Tau and increased the Nestin protein expression. Conclusion: Knockdown of SNHG1 can re- duce the damage induced by Aẞ25-35 protein in AD cell models, and the mechanism is related to the activation of miR-361-3p/Nfat5 pathway. [ABSTRACT FROM AUTHOR]

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OBJECTIVE: To evaluate the clinical efficacy of five kinds of Chinese patent medicine combined with conventional Western medicine in the treatment of allergic rhinitis (AR) in adults. METHODS: Chinese or English randomized controlled trials (RCTs) on Biyuan Tongqiao granules, Yupingfeng granules, Tongqiao Biyan granules (capsules), Biyankang tablets, Xiangju capsules in the treatment of AR in adults were retrieved from CNKI, SinoMed, Wanfang Data, VIP, PubMed, Embase, Web of Science and the Cochrane Library databases, the searching time was from base-building to Feb. 21st, 2024. The Stata 16 software was used to perform network Meta-analysis, Risk of bias 2 was used to gain the risk of bias map. RESULTS: A total of 106 RCTs were enrolled, with a sample size of 11 966, including 5 996 cases in the observation group (given one of the above 5 specific kinds of Chinese patent medicine based on conventional Western medicine) and 5 970 cases in the control group ( conventional Western medicine). Results of network Meta-analysis indicated that in terms of improving the clinical total effective rate, Biyankang tablets + conventional Western medicine treatment showed the best clinical effect. In terms of reducing serum immunological indicators (immunoglobulin E), Yupingfeng granules + conventional Western medicine showed the best clinical effect. CONCLUSIONS: Current evidence suggests that different Chinese patent medicine in combination with conventional Western medicines has better efficacy in the treatment of AR in adults. Due to the uneven quality of the enrolled studies, more large-scale, high-quality and diversified RCTs are needed in the future to further validate this conclusion. [ABSTRACT FROM AUTHOR]

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Three carriers（ Bumpy clay, Carrageenan and Diatomaceous earth） were selected for the preparation of immobilized microbial particles, and the different particle properties, pollutant removal performance and influencing factors were investigated in the present paper. The particle performance studies showed that the mechanical strength of the immobilized particles was high for Bumpy clay and Diatomaceous earth and low for Carrageenan; with nutrient supplementation, Bumpy clay and Carrageenan could stably release 1. 50×106 CFU/mL and 2. 60×105 CFU/mL of microorganisms, while the release of Diatomaceous earth was poor. According to fitting results of the Monod equation, it could be obtained that the Diatomaceous earth immobilized microbial particles had the largest specific degradation rate （μmax） for CODMn. Carrageenan was comparable to it, and the lowest μmax was observed for Bumpy clay. While the Ks of Diatomaceous earth particles was significantly lower than that of the other two particles. Also, the kinetics of ammonia degradation showed a similar pattern to that of CODMn. The effect of environmental conditions on the degradation performance of the immobilized microbial particles showed that the highest first-order rate constants （k1） for CODMn were found under neutral （pH=7） condition for the three materials. The k1 for ammonia degradation were higher for Bumpy clay and US diatomaceous earth under neutral and alkaline conditions, however the highest rate of ammonia degradation was found for Carrageenan under neutral conditions. The k1 of CODMn and ammonia by immobilized microbial particles increased with the increase of temperature, among which the Bumpy clay was more sensitive to the change of temperature. Except for the Diatomaceous earth particles, the k1 for CODMn degradation by the other two immobilized microorganisms increased significantly（ P < 0. 05） with the increase of the initial concentration of the pollutant. There was no significant difference in the k1 of CODMn at different aeration intensities （P > 0. 05）, and higher aeration intensity was beneficial to the degradation of ammonia. [ABSTRACT FROM AUTHOR]

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Small vessel disease (SVD) is a clinical and imaging syndrome characterized by damage to small blood vessels in the brain, which can lead to stroke, vascular cognitive impairment, neuropsychological diseases, and other functional impairments. Since the publication of the standards for reporting vascular changes on neuroimaging (STRIVE) in 2013, the neuroimaging features of SVD have been preliminarily classified and standardized. However, there are still inconsistencies and lack of standardization in the understanding and application of SVD imaging features in clinical practice and scientific research. With the deepening exploration of the pathophysiological mechanisms of SVD and the continuous advancement of imaging technology, new imaging features and quantitative biomarkers of SVD have been discovered, providing more comprehensive and accurate information for the diagnosis and assessment of SVD. Based on this, the STRIVE-2 has been developed to comprehensively reveal the effects of SVD on brain function and structure. In order to standardize the neuroimaging evaluation and diagnosis of SVD in China, this consensus will provide a detailed interpretation of the neuroimaging features of SVD based on the STRIVE-2, combined with the specific national conditions of China, aiming to promote the standardization of the terms of SVD imaging diagnosis, improve the accuracy of clinical diagnosis, and further promote the research and progress in related fields. [ABSTRACT FROM AUTHOR]

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Tn order to improve the photocatalytic performance of TiO2 and investigate the effect of metal ion doping on photocatalytic performance of TiO2, the electrospinning technology and calcination process were used to prepare La3+/TiO2 nanofiber membrane. The morphology and structure of the material were characterized by SEM, XRD, FT-TR, and TG tests. With methylene blue as the target degradation agent, the mechanism of photocatalytic oxid at ion and degradation of dyes by La3+ modified TiO2 was further studied. The results showed that when the dye concentration was 1 0 mg/L and the concentration of La>+ doped modified TiO2 nanofibers was 1 5 mg/1 0 ml>, the degradation rate was 63.41 % after 10 minutes of catalysis, and 99.87% after 70 min of catalysis, which was 6.36% higher than the degradation rate of undoped TiO2 nanofibers. Tt can be seen that La3+ doping improves the photocatalytic degradation rate of TiO2, reducing the required time. [ABSTRACT FROM AUTHOR]