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This paper investigates the convergence properties and applications of the three-operator splitting method, also known as the Davis-Yin splitting (DYS) method, integrated with extrapolation and plug-and-play (PnP) denoiser within a nonconvex framework. We first propose an extrapolated DYS method to effectively solve a class of structural nonconvex optimization problems that involve minimizing the sum of three possibly nonconvex functions. Our approach provides an algorithmic framework that encompasses both extrapolated forward-backward splitting and extrapolated Douglas-Rachford splitting methods. To establish the convergence of the proposed method, we rigorously analyze its behavior based on the Kurdyka-Łojasiewicz property, subject to some tight parameter conditions. Moreover, we introduce two extrapolated PnP-DYS methods with convergence guarantee, where the traditional regularization step is replaced by a gradient step-based denoiser. This denoiser is designed using a differentiable neural network and can be reformulated as the proximal operator of a specific nonconvex functional. We conduct extensive experiments on image deblurring and image superresolution problems, where our numerical results showcase the advantage of the extrapolation strategy and the superior performance of the learning-based model that incorporates the PnP denoiser in terms of achieving high-quality recovery images. [ABSTRACT FROM AUTHOR]

Glioblastomas are the most aggressive primary brain tumor. Despite treatment with surgery, radiation and chemotherapy, these tumors remain uncurable and few significant increases in survival have been observed over the last half-century. We recently employed a combined theoretical and experimental approach to predict the effectiveness of radiation administration schedules, identifying two schedules that led to superior survival in a mouse model of the disease (Leder et al., Cell 156(3):603-616, ). Here we extended this approach to consider fractionated schedules to best minimize toxicity arising in early- and late-responding tissues. To this end, we decomposed the problem into two separate solvable optimization tasks: (i) optimization of the amount of radiation per dose, and (ii) optimization of the amount of time that passes between radiation doses. To ensure clinical applicability, we then considered the impact of clinical operating hours by incorporating time constraints consistent with operational schedules of the radiology clinic. We found that there was no significant loss incurred by restricting dosage to an 8:00 a.m. to 5:00 p.m. window. Our flexible approach is also applicable to other tumor types treated with radiotherapy. [ABSTRACT FROM AUTHOR]

A solution method for solving optimization problems with a max-separable objective function and min-separable inequality constraints is suggested. The method is based on the results of 5, 6. Application in some location problems and small illustrative numerical examples are presented. [ABSTRACT FROM AUTHOR]