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18 results on '"ABBRUZZESE, CHIARA"'

1. Antibiotics Removal during Continuous Renal Replacement Therapy in Septic Shock Patients: Mixed Modality Versus “Expanded Haemodialysis”

Author

Ferrari, Fiorenza, Milla, Paola, Sartori, Marco, Zanza, Christian, Tesauro, Manfredi, Longhitano, Yaroslava, De Silvestri, Annalisa, Abbruzzese, Chiara, De Rosa, Silvia, Lassola, Sergio, Samoni, Sara, Brendolan, Alessandra, Zanella, Monica, Scaravilli, Vittorio, Grasselli, Giacomo, Arpicco, Silvia, and Ronco, Claudio

Published
2024
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4. Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS: The PROTECTION Pilot Randomized Clinical Trial

Author

Plug working group of ESICM, Papoff, Alessandra, Di Fenza, Raffaele, Gianni, Stefano, Spinelli, Elena, Lissoni, Alfredo, Abbruzzese, Chiara, Bronco, Alfio, Villa, Silvia, Russotto, Vincenzo, Iachi, Arianna, Ball, Lorenzo, Patroniti, Nicolò, Spina, Rosario, Giuntini, Romano, Peruzzi, Simone, Menga, Luca Salvatore, Fossali, Tommaso, Castelli, Antonio, Ottolina, Davide, García-de-Acilu, Marina, Santafè, Manel, Schädler, Dirk, Weiler, Norbert, Carvajal, Emilia Rosas, Calvo, César Pérez, Neou, Evangelia, Wang, Yu-Mei, Zhou, Yi-Min, Longhini, Federico, Bruni, Andrea, Leonardi, Mariacristina, Gregoretti, Cesare, Ippolito, Mariachiara, Milazzo, Zelia, Querci, Lorenzo, Ranieri, Serena, Insom, Giulia, Berden, Jernej, Noc, Marko, Mikuz, Ursa, Arzenton, Matteo, Lazzeri, Marta, Villa, Arianna, Barreto, Bruna Brandão, Oliveira Rios, Marcos Nogueira, Gusmao-Flores, Dimitri, Phull, Mandeep, Barnes, Tom, Musarat, Hussain, Conti, Sara, Mauri, Tommaso, Foti, Giuseppe, Fornari, Carla, Grasselli, Giacomo, Pinciroli, Riccardo, Lovisari, Federica, Tubiolo, Daniela, Volta, Carlo Alberto, Spadaro, Savino, Rona, Roberto, Rondelli, Egle, Navalesi, Paolo, Garofalo, Eugenio, Knafelj, Rihard, Gorjup, Vojka, Colombo, Riccardo, Cortegiani, Andrea, Zhou, Jian-Xin, D’Andrea, Rocco, Calamai, Italo, Vidal González, Ánxela, Roca, Oriol, Grieco, Domenico Luca, Jovaisa, Tomas, Bampalis, Dimitrios, Becher, Tobias, Battaglini, Denise, Ge, Huiqing, Luz, Mariana, Constantin, Jean-Michel, Ranieri, Marco, Guerin, Claude, Mancebo, Jordi, Pelosi, Paolo, Fumagalli, Roberto, Brochard, Laurent, and Pesenti, Antonio

Published
2021
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9. Pentraxin 3 in patients with severe sepsis or shock: the ALBIOS trial

Author

Caironi, Pietro, Masson, Serge, Mauri, Tommaso, Bottazzi, Barbara, Leone, Roberto, Magnoli, Michela, Barlera, Simona, Mamprin, Filippo, Fedele, Andrea, Mantovani, Alberto, Tognoni, Gianni, Pesenti, Antonio, Gattinoni, Luciano, Latini, Roberto, Bruzzone, Paola, Pagan, Francesca, Russo, Riccarda, Confalonieri, Andrea, Abbruzzese, Chiara, Vergnano, Beatrice, Faenza, Stefano, Siniscalchi, Antonio, Pierucci, Elisabetta, Noto, Andrea, Pezzi, Angelo, Spanu, Paolo, Parrini, Vieri, Oggioni, Roberto, Pasetti, Giovanni Stefano, Casadio, Maria Cinzia, Buontempo, Rosa, Carrer, Sara, Piccoli, Francesca, Rizzi, Tatiana, Caricato, Anselmo, La Sala, Monica, Antonaci, Alessandra, Fassini, Paola, Paganini, Silvia, Porta, Virginia, Moise, Gabriella, Marell, Silvia, Furia, Mirella, Urbano, Maria Cristina, Carobbi, Roberta, Poleni, Simona, Kandil, Hassan, Ballotta, Andrea, Bettini, Fabrizio, Sanseverino, Manlio, Gatta, Alessandro, Cecchini, Francesca, Guatteri, Luca, Ciceri, Gabriella, Raimondi, Ferdinando, Colombo, Roberto, Ferraris, Sandra, Borelli, Massimo, Bellato, Valentina, Cancellieri, Franco, Senni, Silvia, Bertocchi, Ester, Ferri, Paola, Moioli, Gianpietro, Molin, Alexandra, Salati, Giovanni, Salsi, Pierpaolo, Brunori, Emanuela, Elisei, Daniele, Maggio, Giuseppe, Nicola, Federico Guardia, Cavana, Marco, Morelli, Giacomo, Guarino, Arturo, Isetta, Michele, Tulli, Giorgio, Mangani, Valerio, Rossi, Nicola, Ferrari, Marta, Bona, Francesco, Vay, Monica, Bartoli, Teresa, Gallo, Mauro, Vettoretto, Katiuscia, Della Morte, Mauro, Boselli, Enrico, Puscio, Daniela, Bovo, Monia, Galzerano, Antonio, Carli, Manuela, and Zagara, Giovanni

Published
2017
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10. PCSK9 is associated with mortality in patients with septic shock: data from the ALBIOS study.

Author

Vecchié, A., Bonaventura, A., Meessen, J., Novelli, D., Minetti, S., Elia, E., Ferrara, D., Ansaldo, A. M., Scaravilli, V., Villa, S., Ferla, L., Caironi, P., Latini, R., Carbone, F., Montecucco, F., Bruzzone, Paola, Pagan, Francesca, Russo, Riccarda, Confalonieri, Andrea, and Abbruzzese, Chiara

Subjects
SEPTIC shock, PROPORTIONAL hazards models, LIPOPROTEIN receptors, DEATH rate
Abstract

Background: Pro‐protein convertase subtilisin/kexin 9 (PCSK9) is a proenzyme primarily known to regulate low‐density lipoprotein receptor re‐uptake on hepatocytes. Whether PCSK9 can concurrently trigger inflammation or not remains unclear. Here, we investigated the potential association between circulating levels of PCSK9 and mortality in patients with severe sepsis or septic shock. Methods: Plasma PCSK9 levels at days 1, 2 and 7 were measured in 958 patients with severe sepsis or septic shock previously enrolled in the Albumin Italian Outcome Sepsis (ALBIOS) trial. Correlations between levels of PCSK9 and pentraxin 3 (PTX3), a biomarker of disease severity, were evaluated with ranked Spearman's coefficients. Cox proportional hazards models were used to assess the association of PCSK9 levels at day 1 with 28‐ and 90‐day mortality. Results: Median plasma PCSK9 levels were 278 [182–452] ng mL−1 on day 1. PCSK9 correlated positively with PTX3 at the three time‐points, and patients with septic shock within the first quartile of PCSK9 showed higher levels of PTX3. Similar mortality rates were observed in patients with severe sepsis across PCSK9 quartiles. Patients with septic shock with lower PCSK9 levels on day 1 (within the first quartile) showed the highest 28‐ and 90‐day mortality rate as compared to other quartiles. Conclusion: In our sub‐analysis of the ALBIOS trial, we found that patients with septic shock presenting with lower plasma PCSK9 levels experienced higher mortality rate. Further studies are warranted to better evaluate the pathophysiological role of PCSK9 in sepsis. [ABSTRACT FROM AUTHOR]

Published
2021
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11. COVID-19 multidisciplinary high dependency unit: the Milan model.

Author

Aliberti, Stefano, Amati, Francesco, Pappalettera, Maria, Di Pasquale, Marta, D'Adda, Alice, Mantero, Marco, Gramegna, Andrea, Simonetta, Edoardo, Oneta, Anna Maria, Privitera, Emilia, Gori, Andrea, Bozzi, Giorgio, Peyvandi, Flora, Minoia, Francesca, Filocamo, Giovanni, Abbruzzese, Chiara, Vicenzi, Marco, Tagliabue, Paola, Alongi, Salvatore, and Blasi, Francesco

Subjects
COVID-19, COVID-19 pandemic, INFECTION control, SARS-CoV-2, DISEASE complications
Abstract

COVID-19 is a complex and heterogeneous disease. The pathogenesis and the complications of the disease are not fully elucidated, and increasing evidence shows that SARS-CoV-2 causes a systemic inflammatory disease rather than a pulmonary disease. The management of hospitalized patients in COVID-19 dedicated units is advisable for segregation purpose as well as for infection control. In this article we present the standard operating procedures of our COVID-19 high dependency unit of the Policlinico Hospital, in Milan. Our high dependency unit is based on a multidisciplinary approach. We think that the multidisciplinary involvement of several figures can better identify treatable traits of COVID-19 disease, early identify patients who can quickly deteriorate, particularly patients with multiple comorbidities, and better manage complications related to off-label treatments. Although no generalizable to other hospitals and different healthcare settings, we think that our experience and our point of view can be helpful for countries and hospitals that are now starting to face the COVID-19 outbreak. [ABSTRACT FROM AUTHOR]

Published
2020
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16. Adjuvant treatment of severe varicella pneumonia with intravenous varicella zoster virus-specific immunoglobulins.

Author

Mangioni, Davide, Grasselli, Giacomo, Abbruzzese, Chiara, Muscatello, Antonio, Gori, Andrea, and Bandera, Alessandra

Subjects
*CHICKENPOX, *THERAPEUTICS, *PNEUMONIA, *PUBLIC hospitals, *VARICELLA-zoster virus, *IMMUNOCOMPROMISED patients
Abstract

• Pneumonia is a major complication of varicella zoster virus (VZV) infection in adults, especially in immunocompromised patients. • We describe an immunocompromised adult with VZV pneumonia treated successfully with intravenous VZV-specific IgG in addition to acyclovir. • Hospitals and national health agencies should increase their efforts in providing easier access to this treatment for at-risk patients. Varicella zoster virus (VZV) pneumonia is associated with significant mortality, especially in the immunocompromised host. VZV-specific immunoglobulins (VZIG) are currently used as post-exposure prophylaxis for at-risk patients, but not as adjunctive therapy. A novel case of VZV pneumonia in an immunocompromised patient, treated successfully with intravenous VZIG in combination with acyclovir, is reported here. [ABSTRACT FROM AUTHOR]

Published
2019
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18. Interdependence between elevated intra-abdominal, pleural, and airway opening pressure in severe acute respiratory distress syndrome with extracorporeal membrane oxygenation.

Author

Mauri, Tommaso, Spinelli, Elena, Caccioppola, Alessio, Marongiu, Ines, Colombo, Sebastiano M., Abbruzzese, Chiara, Lissoni, Alfredo, Tagliabue, Paola, Grasselli, Giacomo, and Pesenti, Antonio

Subjects
*ADULT respiratory distress syndrome, *EXTRACORPOREAL membrane oxygenation, *COVID-19, *INTRA-abdominal hypertension, *ADULT respiratory distress syndrome treatment, *CORONAVIRUS disease treatment, *ABDOMEN, *ARTIFICIAL respiration, *COMPARATIVE studies, *CRITICAL care medicine, *EPIDEMICS, *RESEARCH methodology, *MEDICAL cooperation, *PLEURA, *PRESSURE, *RESEARCH, *RESPIRATORY organs, *RESPIRATORY obstructions, *VIRAL pneumonia, *EVALUATION research, *DISEASE complications
Published
2020
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