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185 results on '"Abe, Kensaku"'

1. Primary total knee arthroplasty assisted by computed tomography-free navigation for secondary knee osteoarthritis following massive calcium phosphate cement packing for distal femoral giant-cell bone tumor treatment: a case report

Author

Takeuchi, Akihiko, Yamamoto, Norio, Ohmori, Takaaki, Hayashi, Katsuhiro, Miwa, Shinji, Igarashi, Kentaro, Higuchi, Takashi, Abe, Kensaku, Yonezawa, Hirotaka, Morinaga, Sei, Araki, Yoshihiro, Asano, Yohei, Saito, Shiro, and Tsuchiya, Hiroyuki

Published
2022
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2. Constitutional varus knee due to tibial deformity is common and represents a good indication for high tibial osteotomy in Japanese population: Consideration of 1010 knees.

Author

Abe, Kensaku, Goshima, Kenichi, Morinaga, Toshio, Nozaki, Masahiro, Fukushima, Hiroaki, Kato, Jiro, Hanaki, Shunta, Demura, Satoru, and Murakami, Hideki

Subjects
*JAPANESE people, *KNEE, *OSTEOTOMY, *HUMAN abnormalities, *OPERATIVE surgery
Abstract

Purpose: This study aimed to elucidate the characteristics of varus knee deformities in the Japanese population, prevalence of various around knee osteotomy procedures and influence of femoral and tibial bowing. Methods: Varus knee deformity was defined as a weight‐bearing line ratio of <50%. A total of 1010 varus knees were selected from 1814 varus knees with weight‐bearing full‐length radiographs, obtained at two facilities, based on exclusion criteria. Various parameters were measured, and around knee osteotomy simulations based on the deformity centre were conducted using digital planning tools. Bowing of the femoral and tibial shafts was measured, with bowing defined as follows: ≤ −0.6° indicating lateral bowing and ≥ 0.6° indicating medial bowing. Statistical analysis was performed to investigate age‐related correlations and their impact on surgical techniques. Results: The study revealed that the proximal tibia was the centre of deformity in Japanese varus knees (42.8%), and high tibial osteotomy was frequently indicated (81.6%). Age demonstrated a mild correlation with femoral shaft bowing (r = −0.29), leading to an increase in the mechanical lateral distal femoral angle and to a decrease in the hip–knee–ankle angle and weight‐bearing line ratio (r = −0.29, 0.221, 0.219). The tibial shaft bowing was unaffected by age (r = −0.022). Conclusion: A significant proportion of Japanese individuals with varus knees exhibit a deformity centre located in the proximal tibia, making them suitable candidates for high tibial osteotomy. No age‐related alterations were discerned in tibial morphology, indicating that the occurrence of constitutional varus knees is attributable to tibial deformities in the Japanese patient cohort. Level of Evidence: Level IV. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Reconstruction using a frozen autograft for a skull and humeral lesion of synchronous multicentric osteosarcoma after undergoing successful neoadjuvant chemotherapy: a case report and review of the literature

Author

Araki, Yoshihiro, Hayashi, Katsuhiro, Yamamoto, Norio, Takeuchi, Akihiko, Miwa, Shinji, Igarashi, Kentaro, Higuchi, Takashi, Abe, Kensaku, Taniguchi, Yuta, Yonezawa, Hirotaka, Morinaga, Sei, Asano, Yohei, Nojima, Takayuki, and Tsuchiya, Hiroyuki

Published
2021
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13. A validation study for the utility of serum microRNA as a diagnostic and prognostic marker in patients with osteosarcoma

Author

Araki, Yoshihiro, primary, Asano, Naofumi, additional, Yamamoto, Norio, additional, Hayashi, Katsuhiro, additional, Takeuchi, Akihiko, additional, Miwa, Shinji, additional, Igarashi, Kentaro, additional, Higuchi, Takashi, additional, Abe, Kensaku, additional, Taniguchi, Yuta, additional, Yonezawa, Hirotaka, additional, Morinaga, Sei, additional, Asano, Yohei, additional, Yoshida, Takeshi, additional, Hanayama, Rikinari, additional, Matsuzaki, Juntaro, additional, Ochiya, Takahiro, additional, Kawai, Akira, additional, and Tsuchiya, Hiroyuki, additional

Published
2023
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20. A Viability Analysis of Tumor-Bearing Frozen Autograft for the Reconstruction After Resection of Malignant Bone Tumors Using 99mTc-MDP Scintigraphy

Author

Araki, Yoshihiro, primary, Yamamoto, Norio, additional, Hayashi, Katsuhiro, additional, Takeuchi, Akihiko, additional, Miwa, Shinji, additional, Igarashi, Kentaro, additional, Higuchi, Takashi, additional, Abe, Kensaku, additional, Taniguchi, Yuta, additional, Yonezawa, Hirotaka, additional, Morinaga, Sei, additional, Asano, Yohei, additional, Nojima, Takayuki, additional, Taki, Junichi, additional, and Tsuchiya, Hiroyuki, additional

Published
2022
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27. Management of Soft-tissue Tumors With a Size of 2-5 cm, Including Malignancy

Author

ARAKI, YOSHIHIRO, primary, YAMAMOTO, NORIO, additional, MAEDA, TORU, additional, KIMURA, HIROAKI, additional, OTA, TAKASHI, additional, SHIMOZAKI, SHINGO, additional, KATO, TAKASHI, additional, INOUE, DAISUKE, additional, HIGUCHI, TAKASHI, additional, ABE, KENSAKU, additional, TANIGUCHI, YUTA, additional, and TSUCHIYA, HIROYUKI, additional

Published
2022
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28. A Validation Study for the Utility of Serum microRNA as a Diagnostic and Prognostic Marker in High-Grade Osteosarcoma Patients

Author

Araki, Yoshihiro, primary, Asano, Naofumi, additional, Yamamoto, Norio, additional, Hayashi, Katsuhiro, additional, Takeuchi, Akihiko, additional, Miwa, Shinji, additional, Igarashi, Kentaro, additional, Higuchi, Takashi, additional, Abe, Kensaku, additional, Taniguchi, Yuta, additional, Yonezawa, Hirotaka, additional, Morinaga, Sei, additional, Asano, Yohei, additional, Yoshida, Takeshi, additional, Hanayama, Rikinari, additional, Matsuzaki, Juntaro, additional, Ochiya, Takahiro, additional, Kawai, Akira, additional, and Tsuchiya, Hiroyuki, additional

Published
2022
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29. Delayed Initiation of Treatment Is Associated With Metastasis of Soft-tissue Sarcoma

Author

Yoshihiro Araki, Yohei Asano, Shinji Miwa, Higuchi Takashi, Norio Yamamoto, Hiroyuki Tsuchiya, Kentaro Igarashi, Yuta Taniguchi, Sei Morinaga, Abe Kensaku, Akihiko Takeuchi, Hirotaka Yonezawa, and Katsuhiro Hayashi

Subjects
Adult, Oncology, Cancer Research, medicine.medical_specialty, Multivariate analysis, Adolescent, Referral, Time-to-Treatment, Metastasis, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, In patient, Neoplasm Metastasis, Child, Aged, Aged, 80 and over, business.industry, Soft tissue sarcoma, Univariate, Sarcoma, General Medicine, Middle Aged, medicine.disease, 030220 oncology & carcinogenesis, business, Early referral
Abstract

Background/aim The delayed initiation of treatment is associated with poor clinical outcomes in patients with malignancies. However, few previous studies have investigated prognostic factors, including the delayed initiation of treatment, in soft-tissue sarcoma. Patients and methods One hundred and fifty-three patients with soft-tissue sarcoma were enrolled. Univariate and multivariate analyses were performed to identify factors predicting metastasis, including factors that delay the initiation of treatment. Results The multivariate analysis revealed that high histological grade (p 5-month delay from symptom initiation to consultation of general practitioner (p=0.02), and >29-day delay in referral to a specialized hospital by general practitioners (p=0.03) were independently associated with metastasis of soft tissue sarcoma. Conclusion Early consultation of a general practitioner and early referral to a specialized hospital might be essential for preventing metastasis of soft-tissue sarcoma.

Published
2020

31. Pretreatment Neutrophil Count and Platelet-lymphocyte Ratio as Predictors of Metastasis in Patients With Osteosarcoma

Author

ARAKI, YOSHIHIRO, primary, YAMAMOTO, NORIO, additional, HAYASHI, KATSUHIRO, additional, TAKEUCHI, AKIHIKO, additional, MIWA, SHINJI, additional, IGARASHI, KENTARO, additional, HIGUCHI, TAKASHI, additional, ABE, KENSAKU, additional, TANIGUCHI, YUTA, additional, YONEZAWA, HIROTAKA, additional, MORINAGA, SEI, additional, ASANO, YOHEI, additional, and TSUCHIYA, HIROYUKI, additional

Published
2022
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32. Primary Osteosarcoma in Patients Over 75 Years of Age: A Case Series and Literature Review

Author

ARAKI, YOSHIHIRO, primary, YAMAMOTO, NORIO, additional, HAYASHI, KATSUHIRO, additional, TAKEUCHI, AKIHIKO, additional, MIWA, SHINJI, additional, IGARASHI, KENTARO, additional, HIGUCHI, TAKASHI, additional, ABE, KENSAKU, additional, TANIGUCHI, YUTA, additional, YONEZAWA, HIROTAKA, additional, MORINAGA, SEI, additional, ASANO, YOHEI, additional, NOJIMA, TAKAYUKI, additional, and TSUCHIYA, HIROYUKI, additional

Published
2022
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33. Delayed Initiation of Treatment Is Associated With Metastasis of Malignant Bone Tumor

Author

ARAKI, YOSHIHIRO, primary, YAMAMOTO, NORIO, additional, HAYASHI, KATSUHIRO, additional, TAKEUCHI, AKIHIKO, additional, MIWA, SHINJI, additional, IGARASHI, KENTARO, additional, HIGUCHI, TAKASHI, additional, ABE, KENSAKU, additional, TANIGUCHI, YUTA, additional, YONEZAWA, HIROTAKA, additional, MORINAGA, SEI, additional, ASANO, YOHEI, additional, and TSUCHIYA, HIROYUKI, additional

Published
2021
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34. Additional file 1 of Efficacy of perioperative chemotherapy for synovial sarcoma: a retrospective analysis of a Nationwide database in Japan

Author

Xu, Gang, Aiba, Hisaki, Yamamoto, Norio, Hayashi, Katsuhiro, Takeuchi, Akihiko, Miwa, Shinji, Higuchi, Takashi, Abe, Kensaku, Taniguchi, Yuta, Araki, Yoshihiro, Saito, Shiro, Yoshimura, Kenichi, Murakami, Hideki, Tsuchiya, Hiroyuki, and Kawai, Akira

Subjects
stomatognathic diseases
Abstract

Additional file 1. The characteristics of stage III patients before and after MPA.

Published
2021
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35. Additional file 2 of Efficacy of perioperative chemotherapy for synovial sarcoma: a retrospective analysis of a Nationwide database in Japan

Author

Xu, Gang, Aiba, Hisaki, Yamamoto, Norio, Hayashi, Katsuhiro, Takeuchi, Akihiko, Miwa, Shinji, Higuchi, Takashi, Abe, Kensaku, Taniguchi, Yuta, Araki, Yoshihiro, Saito, Shiro, Yoshimura, Kenichi, Murakami, Hideki, Tsuchiya, Hiroyuki, and Kawai, Akira

Abstract

Additional file 2 The Kaplan-Meier curves of stage III patients before and after MPA. Kaplan-Meier analyses of oncologic outcomes (extracted stage III patients). The oncologic outcomes of patients who did (cx+) or did not (cx-) receive neoadjuvant chemotherapy were compared (red curve: cx + group, black curve: cx- group). a–c: outcomes before propensity-score matching (n = 147); d–f: outcomes after propensity-score matching (n = 52). Triangles indicate the censored cases. (a) The overall survival of patients with/without chemotherapy before propensity-score matching. (b) The local control rate of patients with/without chemotherapy before propensity-score matching. (c) The distant progression-free survival of patients with/without chemotherapy before propensity-score matching. (d) The overall survival of patients with/without chemotherapy after propensity-score matching. (e) The local control rate of patients with/without chemotherapy after propensity-score matching. (f) The distant progression-free survival of patients with/without chemotherapy after propensity-score matching.

Published
2021
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37. Structural Origin and Surgical Complications of Peripheral Schwannomas

Author

YONEZAWA, HIROTAKA, primary, MIWA, SHINJI, additional, YAMAMOTO, NORIO, additional, HAYASHI, KATSUHIRO, additional, TAKEUCHI, AKIHIKO, additional, IGARASHI, KENTARO, additional, TADA, KAORU, additional, LANGIT, MICKHAEL B., additional, HIGUCHI, TAKASHI, additional, ABE, KENSAKU, additional, TANIGUCHI, YUTA, additional, MORINAGA, SEI, additional, ARAKI, YOSHIHIRO, additional, ASANO, YOHEI, additional, and TSUCHIYA, HIROYUKI, additional

Published
2020
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38. Pretreatment C-reactive protein and neutrophil counts as a predictor of metastasis in patients with osteosarcoma

Author

Araki, Yoshihiro, primary, Yamamoto, Norio, additional, Hayashi, Katsuhiro, additional, Takeuchi, Akihiko, additional, Miwa, Shinji, additional, Igarashi, Kentaro, additional, Higuchi, Takashi, additional, Abe, Kensaku, additional, Taniguchi, Yuta, additional, Yonezawa, Hirotaka, additional, Morinaga, Sei, additional, Asano, Yohei, additional, and Tsuchiya, Hiroyuki, additional

Published
2020
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39. Efficacy of Neoadjuvant Chemotherapy for Synovial Sarcoma: Retrospective Analysis of a Nationwide Database in Japan

Author

Xu, Gang, primary, Aiba, Hisaki, additional, Yamamoto, Norio, additional, Hayashi, Katsuhiro, additional, Takeuchi, Akihiko, additional, Miwa, Shinji, additional, Higuchi, Takashi, additional, Abe, Kensaku, additional, Taniguchi, Yuta, additional, Araki, Yoshihiro, additional, Saito, Shiro, additional, Yoshimura, Kenichi, additional, Murakami, Hideki, additional, Tsuchiya, Hiroyuki, additional, and Kawai, Akira, additional

Published
2020
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40. Glycogen synthase kinase 3β as a potential therapeutic target in synovial sarcoma and fibrosarcoma

Author

Abe, Kensaku, primary, Yamamoto, Norio, additional, Domoto, Takahiro, additional, Bolidong, Dilireba, additional, Hayashi, Katsuhiro, additional, Takeuchi, Akihiko, additional, Miwa, Shinji, additional, Igarashi, Kentaro, additional, Inatani, Hiroyuki, additional, Aoki, Yu, additional, Higuchi, Takashi, additional, Taniguchi, Yuta, additional, Yonezawa, Hirotaka, additional, Araki, Yoshihiro, additional, Aiba, Hisaki, additional, Minamoto, Toshinari, additional, and Tsuchiya, Hiroyuki, additional

Published
2019
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41. Anti-tumor Effects of Cyclolinopeptide on Giant-cell Tumor of the Bone

Author

TANIGUCHI, YUTA, primary, YAMAMOTO, NORIO, additional, HAYASHI, KATSUHIRO, additional, TAKEUCHI, AKIHIKO, additional, MIWA, SHINJI, additional, IGARASHI, KENTARO, additional, HIGUCHI, TAKASHI, additional, ABE, KENSAKU, additional, YONEZAWA, HIROTAKA, additional, ARAKI, YOSHIHIRO, additional, MORINAGA, SEI, additional, KAMEI, JUNZO, additional, NUGROHO, ALFARIUS EKO, additional, KANEDA, TOSHIO, additional, MORITA, HIROSHI, additional, and TSUCHIYA, HIROYUKI, additional

Published
2019
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42. Clinical course of grafted cartilage in osteoarticular frozen autografts for reconstruction after resection of malignant bone tumor involving an epiphysis

Author

Hayashi, Katsuhiro, primary, Yamamoto, Norio, additional, Takeuchi, Akihiko, additional, Miwa, Shinji, additional, Igarashi, Kentaro, additional, Higuchi, Takashi, additional, Abe, Kensaku, additional, Taniguchi, Yuta, additional, Aiba, Hisaki, additional, Araki, Yoshihiro, additional, Yonezawa, Hirotaka, additional, Morinaga, Sei, additional, and Tsuchiya, Hiroyuki, additional

Published
2019
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43. Additional file 1: of Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo

Author

Abe, Kensaku, Yamamoto, Norio, Hayashi, Katsuhiro, Takeuchi, Akihiko, and Tsuchiya, Hiroyuki

Abstract

Figure S1. The results of R2 and R3 regimen for LM8. Effects of cisplatin (CDDP), 6 mg/kg of body weight, alone or with caffeine (caf) or citrate (CA) at 50 mg/kg or caffeine citrate (cafCA) at 100 mg/kg (R2-chemotherapy) and cisplatin (CDDP), 3 mg/kg of body weight, alone or with caffeine (caf) or citrate (CA) at 100 mg/kg or caffeine citrate (cafCA) at 200 mg/kg (R3-chemotherapy) to treat mice implanted mouse osteosarcoma. Tumor sizes were measured 2 times a week and the volumes calculated, and mean weights of the tumors removed at necropsy. (PDF 466 kb)

Published
2019
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44. Determining Patient Satisfaction and Treatment Desires in Patients With Musculoskeletal Sarcoma of the Knee After Joint-preservation Surgery Using a Questionnaire Survey

Author

ABE, KENSAKU, primary, YAMAMOTO, NORIO, additional, HAYASHI, KATSUHIRO, additional, TAKEUCHI, AKIHIKO, additional, KATO, SATOSHI, additional, MIWA, SHINJI, additional, IGARASHI, KENTARO, additional, INATANI, HIROYUKI, additional, AOKI, YU, additional, HIGUCHI, TAKASHI, additional, TANIGUCHI, YUTA, additional, and TSUCHIYA, HIROYUKI, additional

Published
2019
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45. Satisfaction After Joint-preservation Surgery in Patients With Musculoskeletal Knee Sarcoma Based on Various Scores

Author

ABE, KENSAKU, primary, YAMAMOTO, NORIO, additional, HAYASHI, KATSUHIRO, additional, TAKEUCHI, AKIHIKO, additional, KATO, SATOSHI, additional, MIWA, SHINJI, additional, IGARASHI, KENTARO, additional, INATANI, HIROYUKI, additional, AOKI, YU, additional, HIGUCHI, TAKASHI, additional, TANIGUCHI, YUTA, additional, and TSUCHIYA, HIROYUKI, additional

Published
2019
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47. Efficacy of radio-hyperthermo-chemotherapy as salvage therapy for recurrent or residual malignant soft tissue tumors

Author

Aiba, Hisaki, primary, Yamada, Satoshi, additional, Mizutani, Jun, additional, Yamamoto, Norio, additional, Okamoto, Hideki, additional, Hayashi, Katsuhiro, additional, Takeuchi, Akihiko, additional, Miwa, Shinji, additional, Higuchi, Takashi, additional, Abe, Kensaku, additional, Taniguchi, Yuta, additional, Tsuchiya, Hiroyuki, additional, and Otsuka, Takanobu, additional

Published
2018
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48. Glycogen synthase kinase 3β as a potential therapeutic target in synovial sarcoma and fibrosarcoma.

Author

Abe, Kensaku, Yamamoto, Norio, Domoto, Takahiro, Bolidong, Dilireba, Hayashi, Katsuhiro, Takeuchi, Akihiko, Miwa, Shinji, Igarashi, Kentaro, Inatani, Hiroyuki, Aoki, Yu, Higuchi, Takashi, Taniguchi, Yuta, Yonezawa, Hirotaka, Araki, Yoshihiro, Aiba, Hisaki, Minamoto, Toshinari, and Tsuchiya, Hiroyuki

Abstract

Soft tissue sarcomas (STSs) are a rare cancer type. Almost half are unresponsive to multi‐pronged treatment and might therefore benefit from biologically targeted therapy. An emerging target is glycogen synthase kinase (GSK)3β, which is implicated in various diseases including cancer. Here, we investigated the expression, activity and putative pathological role of GSK3β in synovial sarcoma and fibrosarcoma, comprising the majority of STS that are encountered in orthopedics. Expression of the active form of GSK3β (tyrosine 216‐phosphorylated) was higher in synovial sarcoma (SYO‐1, HS‐SY‐II, SW982) and in fibrosarcoma (HT1080) tumor cell lines than in untransformed fibroblast (NHDF) cells that are assumed to be the normal mesenchymal counterpart cells. Inhibition of GSK3β activity by pharmacological agents (AR‐A014418, SB‐216763) or of its expression by RNA interference suppressed the proliferation of sarcoma cells and their invasion of collagen gel, as well as inducing their apoptosis. These effects were associated with G0/G1‐phase cell cycle arrest and decreased expression of cyclin D1, cyclin‐dependent kinase (CDK)4 and matrix metalloproteinase 2. Intraperitoneal injection of the GSK3β inhibitors attenuated the growth of SYO‐1 and HT1080 xenografts in athymic mice without obvious detrimental effects. It also mitigated cell proliferation and induced apoptosis in the tumors of mice. This study indicates that increased activity of GSK3β in synovial sarcoma and fibrosarcoma sustains tumor proliferation and invasion through the cyclin D1/CDK4‐mediated pathway and enhanced extracellular matrix degradation. Our results provide a biological basis for GSK3β as a new and promising therapeutic target for these STS types. [ABSTRACT FROM AUTHOR]

Published
2020
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49. Efficacy and Limitations of F-18-fluoro-2-deoxy-D-glucose Positron Emission Tomography to Differentiate Between Malignant and Benign Bone and Soft Tissue Tumors

Author

MIWA, SHINJI, primary, MOCHIZUKI, TAKAFUMI, additional, YAMAMOTO, NORIO, additional, SHIRAI, TOSHIHARU, additional, HAYASHI, KATSUHIRO, additional, TAKEUCHI, AKIHIKO, additional, INATANI, HIROYUKI, additional, IGARASHI, KENTARO, additional, HIGUCHI, TAKASHI, additional, ABE, KENSAKU, additional, TANIGUCHI, YUTA, additional, AIBA, HISAKI, additional, IKEDA, HIROKO, additional, and TSUCHIYA, HIROYUKI, additional

Published
2018
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50. Factors Associated With Discharge Destination in Advanced Cancer Patients With Bone Metastasis in a Japanese Hospital

Author

Hayashi, Katsuhiro, primary, Yahata, Tetsutaro, additional, Muramoto, Ryota, additional, Yamamoto, Norio, additional, Takeuchi, Akihiko, additional, Miwa, Shinji, additional, Higuchi, Takashi, additional, Abe, Kensaku, additional, Taniguchi, Yuta, additional, Aiba, Hisaki, additional, Araki, Yoshihiro, additional, and Tsuchiya, Hiroyuki, additional

Published
2018
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