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PURPOSE Scintillators and photoconductors used in energy integrating detectors (EIDs) have inherent variations in their imaging response to single-detected X-rays due to variations in X-ray energy deposition and secondary quanta generation and transport, which degrades DQE(f). The imaging response of X-ray scintillators to single X-rays may be recorded and studied using single X-ray imaging (SXI) experiments; however, no method currently exists for relating SXI experimental results to EID DQE(f). This work proposes a general analytical framework for computing and analyzing the DQE(f) performance of EIDs from single X-ray image ensembles using a spatial frequency-dependent pulse-height spectrum. METHODS A spatial frequency (f)-dependent gain, g∼(f) , is defined as the Fourier transform of the imaging response of an EID to a single-detected X-ray. A f-dependent pulse-height spectrum, Pr[g∼(f)] , is defined as the 2D probability density function of g∼(f) over the complex plane. Pr[g∼(f)] is used to define a f-dependent Swank factor, AS (f), which fully characterizes the DQE(f) degradation due to single X-ray noise. AS (f) is analyzed in terms of its degradation due to Swank noise, variations in the frequency-dependent attenuation of |g∼(f)| , and noise in argg∼(f) which occurs due to variations in the asymmetry in each single X-ray's imaging response. Three example imaging systems are simulated to demonstrate the impact of depth-dependent variation in g∼(f) , remote energy deposition, and a finite number of secondary quanta, on Pr[g∼(f)] , AS (f), MTF(f), and NPS(f)/NPS(0), which are computed from ensembles of single X-ray images. The same is also demonstrated by simulating a realistic imaging system; that is, a Gd2 O2 S-based EID. Using the latter imaging system, the convergence of AS (f) estimates is investigated as a function of the number of detected X-rays per ensemble. RESULTS Depth-dependent g∼(f) variation resulted in AS (f) degradation exclusively due to depth-dependent optical Swank noise and the Lubberts effect. Conversely, the majority of AS (f) degradation caused by remote energy deposition and finite secondary quanta occurred due to variations in argg∼(f) . When using input X-ray energies below the K-edge of Gd, variations in the frequency-dependent attenuation of |g∼(f)| accounted for the majority of AS (f) degradation in the GOS-based EID, and very little Swank noise and variations in argg∼(f) were observed. Above the K-edge, however, AS (f) degradation due to Swank noise and variations in argg∼(f) greatly increased. The convergence of AS (f) was limited by variation in argg∼(f) ; imaging systems with more variation in argg∼(f) required more detected X-rays per ensemble. CONCLUSIONS An analytical framework is proposed that generalizes the pulse-height spectrum and Swank factor to arbitrary f. The impact of single X-ray noise sources, such as the Lubberts effect, remote energy deposition, and finite secondary quanta on detector performance, may be represented using Pr[g∼(f)] , and quantified using AS (f). The approach may be used to compute MTF(f), NPS(f), and DQE(f) from ensembles of single X-ray images and provides an additional tool to analyze proposed EID designs.

Purpose The detective quantum efficiency (DQE) of indirect flat panel detectors (I-FPDs) is limited at higher x-ray energies (e.g., 100-140 kVp) by low absorption in their scintillating x-ray conversion layer. While increasing the thickness of the scintillator can improve its x-ray absorption efficiency, this approach is potentially limited by reduced spatial resolution and increased noise due to depth dependence in the scintillator's response to x rays. One strategy proposed to mitigate these deleterious effects is to irradiate the scintillator through the pixel sensor in a "back-irradiation" geometry. This work directly evaluates the impact of irradiation geometry on the inherent imaging performance of I-FPDs composed with columnar CsI:Tl and powder Gd2 O2 S:Tb (GOS) scintillators. Methods A "bidirectional" FPD was constructed which allows scintillator samples to be interchangeably coupled with the detector's active matrix to compose an I-FPD. Radio-translucent windows in the detector's housing permit imaging in both "front-irradiation" (FI) and "back-irradiation" (BI) geometries. This test device was used to evaluate the impact of irradiation geometry on the x-ray sensitivity, modulation transfer function (MTF), noise power spectrum (NPS), and DQE of four I-FPDs composed using columnar CsI:Tl scintillators of varying thickness (600-1000 µm) and optical backing, and a Fast Back GOS screen. All experiments used an RQA9 x-ray beam. Results Each I-FPD's x-ray sensitivity, MTF, and DQE was greater or equal in BI geometry than in FI. The I-FPD composed with CsI:Tl (1 mm) and an optically absorptive backing had the largest variation in sensitivity (17%) between FI and BI geometries. The detector composed with GOS had the largest improvement in limiting resolution (31%). Irradiation geometry had little impact on MTF(f) and DQE(f) measurements near zero frequency, however, the difference between FI and BI measurements generally increased with spatial frequency. The CsI:Tl scintillator with optically absorptive backing (1 mm) in BI geometry had the highest spatial resolution and DQE over all frequencies. Conclusions Back irradiation may improve the inherent x-ray imaging performance of I-FPDs composed with CsI:Tl and GOS scintillators. This approach can be leveraged to improve tradeoffs between detector dose efficiency, spatial resolution and noise for higher energy x-ray imaging.