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Objective: Several cases of Guillain-Barre syndrome (GBS) associated with SARSCoV-2 infection have been described. This study illustrated the demographic, clinical, and neurophysiological characteristics of patients with GBS and COVID-19, as well as associated factors with disability at discharge. Materials and methods: A retrospective analytical observational study was conducted. It included patients diagnosed with GBS admitted in a national reference center in Peru between 2019 and 2021. Epidemiological, clinical, neurophysiological, and cerebrospinal fluid data were analyzed. A multivariate analysis, using the generalized linear model, was performed, considering the presence of disability at discharge as the dependent variable. Results: Eight-one subjects diagnosed with GBS were included. The mean age was 46.8 years (SD: 15.2), with a predominance of males (61.73%). The most frequent clinical presentation was the classic sensory-motor form in 74 cases (91.36%) with AIDP (82.35%) as the most frequent neurophysiological pattern in the group with COVID-19, while AMAN pattern predominated (59.26%) in those without COVID-19 (p = <0.000). The disability prevalence ratio at discharge between subjects with COVID-19 and those without COVID-19 was 1.89 (CI 1.06-3.34), p = 0.030, adjusted for age, sex, and neurophysiological subtype. Conclusion: The neurophysiologic subtype AIDP, and a higher disability were associated with the presence of COVID-19. [ABSTRACT FROM AUTHOR]

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Objective: To analyze the factors associated with the alteration of baseline glycemia in the first post-hospitalization checkup in patients with type 2 diabetes mellitus (T2DM). Materials and methods: A retrospective observational case-control study was performed in a 1:1 ratio. One hundred (100) medical records of patients of both genders and over 18 years of age with T2DM who had a medical checkup within the first 3 months after hospitalization were analyzed. Cases were defined as those with high baseline glycemia (> 130 mg/dL) and controls were defined as those who had normal glycemic levels (= 130 mg/dL). Mean and percentages were estimated using the chi-square test and binary logistic regression. Results: Elevated glycemic levels at admission (OR: 2.7, p <0.05), elevated glycemic levels at discharge (OR: 3.7, p <0.005), HbA1c = 9 % during hospitalization (OR: 2.9, p <0.05), high levels of triglycerides (OR: 2.6, p <0.05), and failure to comply with prescribed treatment (OR: 2.15, p <0.005) were associated with high baseline glycemia in the first posthospitalization checkup. Conclusions: High levels of triglycerides and non-compliance with indications are risk factors associated with poor glycemic control at the first outpatient visit after hospitalization. [ABSTRACT FROM AUTHOR]

Objetivo: analizar los datos de carga por enfermedades psiquiátricas en Perú para 1990-2015 y evaluar su evolución según sexo, edad y tipo de trastorno. Métodos: estudio descriptivo que usó los datos epidemiológicos disponibles del Institute for Health Metrics and Evaluation que incluye el The Global Burden of Desease desde el año 1990 al 2015. La medida de carga utilizada fue los años de vida ajustado por discapacidad (AVAD), que resulta de sumar los años de vida perdidos por mortalidad prematura (AVP) y los años vividos con discapacidad (AVD). Los AVAD se ajustaron por comorbilidad y se estimaron con intervalos de confianza del 95%. Se seleccionaron los datos para el Perú en dichos años para AVAD, AVP y AVD por año, sexo, edad y tipo de trastorno psiquiátrico o por consumo. Resultados: la carga por trastornos psiquiátricos representó el 11,7% del total de AVAD por todas las causas para el Perú en el 2015, siendo el doble de 1990 (5,3%). Las cinco principales causas fueron: trastornos depresivos (4,2% del total de AVAD), trastornos de ansiedad, trastornos por abuso de drogas, esquizofrenia y trastorno bipolar. Las diferencias por sexo fueron mínimas (las mujeres representaron el 5,9% y los varones el 5,7% del total de AVAD). Los máximos AVAD se concentraron entre los 10 y 54 años siendo mayor entre 20 a 29 años. Del total del AVP, los trastornos psiquiátricos representaron solo el 0,7%, siendo el abuso de drogas la principal en el 2015, y el abuso de alcohol en 1990. Del total de AVD, los trastornos psiquiátricos representaron el 23,4% siendo los trastornos depresivos y por ansiedad los principales. Conclusiones: Los trastornos psiquiátricos representan una importante causa de discapacidad en el 2015 para Perú, siendo los trastornos depresivos y por ansiedad los más discapacitantes, presentándose en todos los grupos etarios y con predominio en el sexo femenino. [ABSTRACT FROM AUTHOR]