40 results on '"Ajeh, Rogers"'
Search Results
2. Coprevalence and associations of diabetes mellitus and hypertension among people living with HIV/AIDS in Cameroon
- Author
-
Ebasone, Peter Vanes, Dzudie, Anastase, Peer, Nasheeta, Hoover, Donald, Shi, Qiuhu, Kim, Hae-Young, Brazier, Ellen, Ajeh, Rogers, Yotebieng, Marcel, Nash, Denis, Anastos, Kathryn, and Kengne, Andre Pascal more...
- Published
- 2024
- Full Text
- View/download PDF
Catalog
3. Factors influencing integration of mental health screening and treatment at HIV clinic settings in Cameroon: a qualitative study of health providers’ perspectives
- Author
-
Grimes, Kathryn E. L., Ebasone, Peter Vanes, Dzudie, Anastase, Nash, Denis, Wainberg, Milton L, Pence, Brian W., Barrington, Clare, Pefura, Eric, Yotebieng, Marcel, Anastos, Kathryn, Nsame, Denis, Ajeh, Rogers, Nyenti, Annereke, and Parcesepe, Angela M. more...
- Published
- 2024
- Full Text
- View/download PDF
4. Understanding depression and the PHQ-9 items among people living with HIV: A multiple methods qualitative study in Yaoundé, Cameroon
- Author
-
Zotova, Natalia, Watnick, Dana, Ajeh, Rogers Awoh, Moungang, Elodie Flore Tchiengang, Noumedem, Julie Laure Nguemo, Mbongo'o, Guy Calvin Nko'o, Anastos, Kathryn, and Yotebieng, Marcel
- Published
- 2024
- Full Text
- View/download PDF
5. Coping Strategies and Symptoms of Mental Health Disorders Among People with HIV Initiating HIV Care in Cameroon
- Author
-
Parcesepe, Angela M., Filiatreau, Lindsey M., Gomez, Amanda, Ebasone, Peter Vanes, Dzudie, Anastase, Pence, Brian W., Wainberg, Milton, Yotebieng, Marcel, Anastos, Kathryn, Pefura-Yone, Eric, Nsame, Denis, Ajeh, Rogers, and Nash, Denis more...
- Published
- 2023
- Full Text
- View/download PDF
6. Age-varying Associations of Depressive Symptoms and Heavy Episodic Drinking Throughout Adulthood Among People with HIV and Receiving care in Cameroon Within a National “treat all” Policy
- Author
-
Lancaster, Kathryn Elizabeth, Remch, Molly, Edmonds, Andrew, Ajeh, Rogers, Dzudie, Anastase, Adedimeji, Adebola, Nash, Denis, Anastos, Kathryn, Yotebieng, Marcel, Yone-Pefura, Eric Walter, Nsame, Denis, and Parcesepe, Angela M. more...
- Published
- 2023
- Full Text
- View/download PDF
7. Prevalence of potentially traumatic events and symptoms of depression, anxiety, hazardous alcohol use, and post-traumatic stress disorder among people with HIV initiating HIV care in Cameroon
- Author
-
Parcesepe, Angela M., Filiatreau, Lindsey M., Ebasone, Peter Vanes, Dzudie, Anastase, Pence, Brian W., Wainberg, Milton, Yotebieng, Marcel, Anastos, Kathryn, Pefura-Yone, Eric, Nsame, Denis, Ajeh, Rogers, and Nash, Denis more...
- Published
- 2023
- Full Text
- View/download PDF
8. Prevalence of stressful life events and associations with symptoms of depression, anxiety, and post-traumatic stress disorder among people entering care for HIV in Cameroon
- Author
-
Filiatreau, Lindsey M., Ebasone, Peter Vanes, Dzudie, Anastase, Ajeh, Rogers, Pence, Brian W., Wainberg, Milton, Nash, Denis, Yotebieng, Marcel, Anastos, Kathryn, Pefura-Yone, Eric, Nsame, Denis, and Parcesepe, Angela M. more...
- Published
- 2022
- Full Text
- View/download PDF
9. Depressive Symptoms, Gender, Disclosure, and HIV Care Stage Among People Living with HIV in Cameroon
- Author
-
Parcesepe, Angela M., Remch, Molly, Dzudie, Anastase, Ajeh, Rogers, Nash, Denis, Anastos, Kathryn, Yotebieng, Marcel, Adedimeji, Adebola, Pefura-Yone, Eric, and Lancaster, Kathryn
- Published
- 2022
- Full Text
- View/download PDF
10. Heavy episodic drinking and HIV disclosure by HIV treatment status among People with HIV in IeDEA Cameroon
- Author
-
Lancaster, Kathryn E., Remch, Molly, Dzudie, Anastase, Ajeh, Rogers, Adedimeji, Adebola, Nash, Denis, Anastos, Kathryn, Yotebieng, Marcel, Yone-Pefura, Eric Walter, Nsame, Denis, and Parcesepe, Angela more...
- Published
- 2021
- Full Text
- View/download PDF
11. Gender, Mental Health, and Entry Into Care with Advanced HIV Among People Living with HIV in Cameroon Under a National ‘Treat All’ Policy
- Author
-
Parcesepe, Angela M., Filiatreau, Lindsey M., Ebasone, Peter Vanes, Dzudie, Anastase, Ajeh, Rogers, Wainberg, Milton, Pence, Brian, Pefura-Yone, Eric, Yotebieng, Marcel, Nsame, Denis, Anastos, Kathryn, and Nash, Denis more...
- Published
- 2021
- Full Text
- View/download PDF
12. Accuracy of Alternative PHQ-9 Scoring Algorithms to Screen for Depression in People Living With HIV in Sub-Saharan Africa.
- Author
-
Bernard, Charlotte, Font, Hélène, Zotova, Natalia, Wools-Kaloustian, Kara, Goodrich, Suzanne, Kwobah, Edith Kamaru, Awoh, Ajeh Rogers, Nko'o Mbongo'o, Guy Calvin, Nsonde, Dominique Mahambu, Gandou, Paul, Minga, Albert, Tine, Judicaël Malick, Ndiaye, Ibrahima, Dabis, François, Seydi, Moussa, de Rekeneire, Nathalie, Yotebieng, Marcel, and Jaquet, Antoine more...
- Published
- 2025
- Full Text
- View/download PDF
13. Accuracy of nine-item Patient Health Questionnaire against psychiatric diagnosis for depression among people with HIV.
- Author
-
Yotebieng, Marcel, Zotova, Natalia, Bernard, Charlotte, Goodrich, Suzanne, Awoh, Ajeh Rogers, Watnick, Dana, Nsonde, Dominique Mahambu, Moungang, Elodie Flore Tchiengang, Noumedem, Julie Laure Nguemo, Mbongo'o, Guy Calvin Nko'o, Minga, Albert, Seydi, Moussa, Gandou, Paul, Kwobah, Edith Kamaru, Atwoli, Lukoye, Jaquet, Antoine, Wools-Kaloustian, Kara, and Anastos, Kathryn more...
- Published
- 2024
- Full Text
- View/download PDF
14. Evaluation of Viral Suppression in Paediatric Populations: Implications for the Transition to Dolutegravir-Based Regimens in Cameroon: The CIPHER-ADOLA Study.
- Author
-
Fokam, Joseph, Bouba, Yagai, Ajeh, Rogers Awoh, Guebiapsi, Dominik Tameza, Essamba, Suzane, Zeh Meka, Albert Franck, Lifanda, Ebiama, Ada, Rose Armelle, Yakouba, Liman, Mbengono, Nancy Barbara, Djomo, Audrey Raissa Dzaddi, Tetang, Suzie Ndiang, Sosso, Samuel Martin, Babodo, Jocelyne Carmen, Ambomo, Olivia Francette Ndomo, Temgoua, Edith Michele, Medouane, Caroline, Atsinkou, Sabine Ndejo, Mvogo, Justin Leonel, and Onana, Roger Martin more...
- Subjects
YOUNG adults ,CHILD patients ,ANTIRETROVIRAL agents ,VIRAL load ,CHILD mortality - Abstract
Mortality in children accounts for 15% of all AIDS-related deaths globally, with a higher burden among Cameroonian children (25%), likely driven by poor virological response. We sought to evaluate viral suppression (VS) and its determinants in a nationally representative paediatric and young adult population receiving antiretroviral therapy (ART). A cross-sectional and multicentric study was conducted among Cameroonian children (<10 years), adolescents (10–19 years) and young adults (20–24 years). Data were collected from the databases of nine reference laboratories from December 2023 to March 2024. A conditional backward stepwise regression model was built to assess the predictors of VS, defined as a viral load (VL) <1000 HIV-RNA copies/mL. Overall, 7558 individuals (females: 73.2%) were analysed. Regarding the ART regimen, 17% of children, 80% of adolescents and 83% of young adults transitioned to dolutegravir (DTG)-based regimens. Overall VS was 82.3%, with 67.3% (<10 years), 80.5% (10–19 years) and 86.5% (20–24 years), and p < 0.001. VS was 85.1% on a DTG-based regimen versus 80.0% on efavirenz/nevirapine and 65.6% on lopinavir/ritonavir or atazanavir/ritonavir. VS was higher in females versus males (85.8% versus 78.2%, p < 0.001). The VS rate remained stable around 85% at 12 and 24 months but dropped to about 80% at 36 months after ART initiation, p < 0.009. Independent predictors of non-VS were younger age, longer ART duration (>36 months), backbone drug (non-TDF/3TC) and anchor drug (non-DTG based). In this Cameroonian paediatric population with varying levels of transition to DTG, overall VS remains below the 95% targets. Predictors of non-VS are younger age, non-TDF/3TC- and non-DTG-based regimens. Thus, efforts toward eliminating paediatric AIDS should prioritise the transition to a DTG-based regimen in this new ART era. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
15. COVID-19 associated changes in HIV service delivery over time in Central Africa: Results from facility surveys during the first and second waves of the pandemic
- Author
-
Ajeh Rogers, Ellen Brazier, Anastase Dzudie, Adebola Adedimeji, Marcel Yotebieng, Benjamin Muhoza, Christella Twizere, Patricia Lelo, Dominique Nsonde, Adolphe Mafoua, Athanase Munyaneza, Patrick Gateretse, Merlin Diafouka, Gad Murenzi, Théodore Niyongabo, Kathryn Anastos, and Denis Nash more...
- Subjects
Medicine ,Science - Abstract
Introduction The COVID-19 pandemic has impacted population health around the globe, directly and indirectly. The objective of this study was to document changes in HIV care associated with the COVID-19 pandemic at selected clinics in Central Africa, along with clinic-level strategies for minimizing disruptions in HIV care and treatment for people with HIV (PWH). Methods A 51-item questionnaire on COVID-19 pandemic-associated changes in HIV service delivery was completed by clinicians involved in HIV care at 21 clinics in five countries participating in Central Africa International epidemiology Databases to Evaluate AIDS (CA-IeDEA). The survey was completed at two timepoints: June-July 2020 and October 2020 to February 2021. Descriptive statistics were used to characterize changes in HIV care and related services. Results While 81% of sites reported at least one negative consequence of COVID-19 for clinic operations during the first survey, none reported suspending antiretroviral therapy (ART) initiation services for new patients, and 24% reported adopting telemedicine. In the follow-up survey, fewer sites (48%) reported at least one disruption to clinic operations, and more sites reported mitigation strategies, including expanding rapid ART initiation services and providing extra supplies of ART medications to reduce visit frequency. In the follow-up survey, more sites, especially in Rwanda, reported stockouts of commodities, including HIV and viral load testing and HIV pre-exposure prophylaxis. More than one-fifth of sites reported stockouts of second- or third-line ART at each survey timepoint. Conclusions While the initial wave of the COVID-19 pandemic resulted in concerning disruptions to HIV service delivery at CA-IeDEA sites, most of these disruptions attenuated over time, and many sites introduced measures to help PWH avoid frequent visits to the clinic for care and medications. The impact of HIV commodity stockouts and clinic mitigation strategies on treatment outcomes needs to be assessed. more...
- Published
- 2022
16. Challenges and opportunities associated with cervical cancer screening programs in a low income, high HIV prevalence context
- Author
-
Adedimeji, Adebola, Ajeh, Rogers, Pierz, Amanda, Nkeng, Relindis, Ndenkeh, Jackson Jr., Fuhngwa, Norbert, Nsame, Denis, Nji, Miriam, Dzudie, Anastase, Anastos, Kathryn M., and Castle, Philip E.
- Published
- 2021
- Full Text
- View/download PDF
17. Correlates of self-reported history of mental health help-seeking: a cross-sectional study among individuals with symptoms of a mental or substance use disorder initiating care for HIV in Cameroon
- Author
-
Filiatreau, Lindsey M., Ebasone, Peter Vanes, Dzudie, Anastase, Ajeh, Rogers, Pence, Brian, Wainberg, Milton, Nash, Denis, Yotebieng, Marcel, Anastos, Kathryn, Pefura-Yone, Eric, Nsame, Denis, and Parcesepe, Angela M. more...
- Published
- 2021
- Full Text
- View/download PDF
18. Intimate partner violence, depression, hazardous alcohol use, and social support among people with HIV initiating HIV care in Cameroon.
- Author
-
Grimes, Kathryn E. L., Ebasone, Peter Vanes, Dzudie, Anastase, Nash, Denis, Pence, Brian W., Wainberg, Milton, Yotebieng, Marcel, Ajeh, Rogers, and Parcesepe, Angela M.
- Subjects
HIV ,INTIMATE partner violence ,SOCIAL support ,MENTAL health services ,ALCOHOL drinking ,CONTROL (Psychology) ,ORPHANS - Abstract
Intimate partner violence (IPV) has been associated with poor mental health among people with HIV (PWH) globally. Social support may be a strategy to foster mental health among PWH. Little is known about whether the relationship between IPV and mental health differs by IPV type or level of social support. Interviews were conducted with 426 PWH initiating HIV care in Cameroon. Log binomial regression analyses were used to estimate the association between four types of IPV (controlling behavior and emotional, physical, and sexual IPV) and symptoms of depression or hazardous alcohol use, separately by IPV type and level of social support. Over half (54.8%) of respondents experienced moderate/high levels of controlling behavior, 42.0% experienced emotional IPV, 28.2% experienced physical IPV and 23.7% experienced sexual IPV. Controlling behavior was associated with greater prevalence of depressive symptoms. This relationship did not vary meaningfully by level of social support (low: aPR 2.4 [95% CI 1.2, 4.9]; high: 1.7 [95% CI 1.0, 2.7]). Emotional and physical IPV were associated with greater prevalence of depressive symptoms among those with low social support (emotional IPV: aPR 1.9 [95% CI 1.0, 3.4]; physical IPV: aPR 1.8 [95% CI 1.2, 2.8]), but not among those with high social support (emotional IPV: aPR 1.0 [95% CI 0.7, 1.6]; physical IPV: aPR 1.0 [95% CI 0.6, 1.6]). Controlling behavior, emotional IPV, and physical IPV were associated with a greater prevalence of hazardous alcohol use, with moderately larger effect estimates among those with high compared to low social support. Sexual IPV was not associated with depressive symptoms or hazardous alcohol use. Services to screen and care for people experiencing IPV are urgently needed among PWH in Cameroon. Future research to identify barriers, feasibility, acceptability, and organizational readiness to integrate IPV and mental health services into HIV care settings is needed. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
19. A comparison of screening tests for detection of high-grade cervical abnormalities in women living with HIV from Cameroon
- Author
-
Castle, Philip E., Ajeh, Rogers, Dzudie, Anastase, Kendowo, Ernestine, Fuhngwa, Norbert, Simo-Wambo, Andre Gaetan, Nsame, Denis, Orock, Enow, Hebert, Tiffany M., Pierz, Amanda J., Murokora, Daniel, Anastos, Kathryn, and Adedimeji, Adebola more...
- Published
- 2020
- Full Text
- View/download PDF
20. Underestimation of Potentially Traumatic Events Resulting From Underreporting of Physical and Sexual Violence Among People Entering Care for HIV in Cameroon.
- Author
-
Filiatreau, Lindsey M., Ebasone, Peter Vanes, Dzudie, Anastase, Ajeh, Rogers, Pence, Brian W., Wainberg, Milton, Yotebieng, Marcel, Nash, Denis, Anastos, Kathryn, and Parcesepe, Angela M.
- Published
- 2024
- Full Text
- View/download PDF
21. Assessment of knowledge and self-efficacy among health professionals and clinical scientists following the Cameroon HIV/AIDS Research Forum (CAM-HERO 2022) research methodology and bioethics training.
- Author
-
Ebasone, Peter Vanes, Tiam, Appolinaire, Tchendjou, Patrice, Foaleng, Merveille, Khan, Eveline Mboh, Ajeh, Rogers, Tchounga, Boris, Shu, Emile Nforbih, Mabou, Gabriel, Melpsa, Johney, Muffih, Pius Tih, Kengne, Andre Pascal, Zoung-Kany Bisseck, Anne Cecile, Dzudie, Anastase, and Thienemann, Friedrich more...
- Subjects
MEDICAL personnel ,MIDDLE-income countries ,HEALTH literacy ,LIKERT scale ,RESEARCH methodology - Abstract
To inform public health policymakers that the generation of local evidence-based knowledge is key. Research capacity in low- and middle-income countries (LMIC) to generate medical knowledge is often weak and insufficiently resourced and efforts to tackle these challenges are not standardized. Continuous research training can equip researchers with the required knowledge and research skills, but its effectiveness largely depends on the quality and pertinence of the training methods used. We aim to assess the effectiveness of the Cameroon HIV/AIDS Research Forum (CAM-HERO) 2022 Research Methodology and Bioethics Training with the objective to describe the knowledge gained and the self-efficacy of health professionals and clinical scientists. A survey was conducted during the oneday training among health professionals and clinical scientists. Participants took an online selfadministered questionnaire before and after the training related to the topics taught. The questionnaire consisted of two parts: 1) 18 Multiple Choice Questions (MCQs) to assess knowledge and 2) Nine items to evaluate self-efficacy using a five-point Likert scale. Mean scores were calculated, analysed, and compared using paired t-test for the pre- and post-test results. A total of 30 participants (57% women) completed the sociodemographic form. The median age (IQR) of participants was 33.5 (13.3) years. We registered 38 respondents for the pre-test and 33 respondents for the post-test. There was a rise in knowledge mean score from 13.0 to 14.8 (p=0.001) and an improvement in the perception of self-efficacy with a mean score increase from 2.9 to 3.7 (p < 0.001). Knowledge and perception of self-efficacy on research methodology improved among participants after the training. These results suggest that the CAM-HERO 2022 training had an immediate positive impact on skills and selfefficacy. Hence, we recommend the implementation of this training on a larger scale, periodically, and with long-term follow-up to evaluate its impact. [ABSTRACT FROM AUTHOR] more...
- Published
- 2024
- Full Text
- View/download PDF
22. Research for Health Care and Policy on HIV/AIDS: proceedings of the third edition of the Cameroon HIV Research (CAM-HERO) 2022, Kribi, Cameroon, from 1st to 3rd December 2022.
- Author
-
Dzudie, Anastase, Tchendjou, Patrice, Khan, Eveline Mboh, Ajeh, Rogers, Thienemann, Friedrich, Tiam, Appolinaire, Tchounga, Boris, Fokam, Joseph, Ndongmo, Clement, Ebasone, Peter Vanes, Mabou, Gabriel, Goura, Andre Pascal, Shu, Emile Nforbih, Katayi, Tshimwanga, Nji, Pascal Atanga, Ngamani, Marc Lionel, Lengouh, Clarisse, Tabala, Felicite Naah, Takem, Ebako Ndip, and Bakor, Albert more...
- Subjects
AIDS ,HIV ,OPERATIONS research - Abstract
Cameroon is committed to reaching HIV epidemic control through coordinated efforts by the Ministry of Public Health, the National AIDS Control Committee, bilateral/multilateral institutions and implementing partners. The third edition of the Cameroon HIV Research Forum (CAM-HERO) was held in Kribi from December 1
st to 3rd , 2022, with the theme "Research for Health Care and Policy on HIV/AIDS." The conference brought together local and international scientists and clinicians, policymakers, and regulatory authorities to 1) disseminate HIV research findings and HIV policy; 2) foster operational research collaboration; 3) build research capacity through training on basics of research methods and CAM-HERO young investigator Awards; and 4) initiate a guideline for promoting HIV/AIDS research in Cameroon. The main activities included training on research methodology and basic principles in bioethics, presentations of selected abstracts, and awards for top research. A total of 35 abstracts (16 oral presentations, 16 posters, and 3 late-breaker-abstracts) were selected for presentation following a rigorous review. The conference ended with evidence-based recommendations and a way-forward statement for the development of a National Guide for HIV/AIDS research in Cameroon, with the aim of improving the quality and quantity of research agenda and projects nationwide. [ABSTRACT FROM AUTHOR] more...- Published
- 2023
- Full Text
- View/download PDF
23. Availability of screening and treatment for common mental disorders in HIV clinic settings: data from the global International epidemiology Databases to Evaluate AIDS (IeDEA) Consortium, 2016–2017 and 2020.
- Author
-
Parcesepe, Angela M., Stockton, Melissa, Remch, Molly, Wester, C. William, Bernard, Charlotte, Ross, Jeremy, Haas, Andreas D., Ajeh, Rogers, Althoff, Keri N., Enane, Leslie, Pape, William, Minga, Albert, Kwobah, Edith, Tlali, Mpho, Tanuma, Junko, Nsonde, Dominique, Freeman, Aimee, Duda, Stephany N., Nash, Denis, and Lancaster, Kathryn more...
- Subjects
MENTAL health services ,MENTAL illness ,MENTAL health screening ,MEDICAL screening ,CONSORTIA ,MEDICAL care ,POST-traumatic stress disorder - Abstract
Introduction: Common mental disorders (CMDs) are highly prevalent among people with HIV. Integrating mental healthcare into HIV care may improve mental health and HIV treatment outcomes. We describe the reported availability of screening and treatment for depression, anxiety and post‐traumatic stress disorder (PTSD) at global HIV treatment centres participating in the International epidemiology Databases to Evaluate AIDS (IeDEA) Consortium in 2020 and changes in availability at sites in low‐ or middle‐income countries (LMICs) between 2016/2017 and 2020. Methods: In 2020, 238 sites contributing individual‐level data to the IeDEA Consortium and in 2016/2017 a stratified random sample of IeDEA sites in LMICs were eligible to participate in site surveys on the availability of screening and treatment for CMDs. We assessed trends over time for 68 sites across 27 LMICs that participated in both surveys. Results: Among the 238 sites eligible to participate in the 2020 site survey, 227 (95%) participated, and mental health screening and treatment data were available for 223 (98%) sites across 41 countries. A total of 95 sites across 29 LMICs completed the 2016/2017 survey. In 2020, 68% of sites were in urban settings, and 77% were in LMICs. Overall, 50%, 14% and 12% of sites reported screening with a validated instrument for depression, anxiety and PTSD, respectively. Screening plus treatment in the form of counselling was available for depression, anxiety and PTSD at 46%, 13% and 11% of sites, respectively. Screening plus treatment in the form of medication was available for depression, anxiety and PTSD at 36%, 11% and 8% of sites, respectively. Among sites that participated in both surveys, screening for depression was more commonly available in 2020 than 2016/2017 (75% vs. 59%, respectively, p = 0.048). Conclusions: Reported availability of screening for depression increased among this group of IeDEA sites in LMICs between 2016/2017 and 2020. However, substantial gaps persist in the availability of mental healthcare at HIV treatment sites across global settings, particularly in resource‐constrained settings. Implementation of sustainable strategies to integrate mental health services into HIV care is needed. [ABSTRACT FROM AUTHOR] more...
- Published
- 2023
- Full Text
- View/download PDF
24. Laboratory Based Surveillance of HIV-1 Acquired Drug Resistance in Cameroon: Implications for Use of Tenofovir-Lamivudine-Dolutegravir (TLD) as Second- or Third-Line Regimens.
- Author
-
Fokam, Joseph, Chenwi, Collins Ambe, Takou, Desire, Santoro, Maria Mercedes, Tala, Valere, Teto, George, Beloumou, Grace, Semengue, Ezechiel Ngoufack Jagni, Dambaya, Beatrice, Djupsa, Sandrine, Kembou, Etienne, Bouba, Nounouce Pamen, Ajeh, Rogers, Cappelli, Giulia, Mbanya, Dora, Colizzi, Vittorio, Ceccherini-Silberstein, Francesca, Perno, Carlo-Federico, and Ndjolo, Alexis more...
- Subjects
TENOFOVIR ,DRUG resistance ,RESOURCE-limited settings ,HIV ,RALTEGRAVIR ,ANTI-HIV agents ,ATAZANAVIR - Abstract
Increased HIV drug resistance (HIVDR) with antiretroviral therapy (ART) rollout may jeopardize therapeutic options, especially in this era of transition to fixed-dose tenofovir-lamivudine-dolutegravir (TLD). We studied acquired HIVDR (ADR) patterns and describe potentially active drugs after first- and second-line failure in resource-limited settings (RLS) like Cameroon. A laboratory-based study with 759 patients (≥15 years) experiencing virological failure was carried out at the Chantal Biya International Reference Centre (CIRCB), Yaoundé, Cameroon. Socio-demographic, therapeutic and immunovirological data from patient records were analysed according to HIV-1 genotypic profiles. Median (IQR) ART-duration was 63 (50–308) months. Median CD4 and viremia were 153 (IQR:50–308) cells/mm
3 and 138,666 (IQR:28,979–533,066) copies/mL, respectively. Overall ADR was high (93.4% first-line; 92.9%-second-line). TDF, potentially active in 35.7% of participants after first-line and 45.1% after second-line, suggested sub-optimal TLD-efficacy in second-line (64.3%) and third-line (54.9%). All PI/r preserved high efficacy after first-line failure while only DRV/r preserved high-level efficacy (87.9%) after second-line failure. In this resource-limited setting (RLS), ADR is high in ART-failing patients. PI/r strategies remain potent backbones for second-line ART, while only DRV/r remains very potent despite second-line failure. Though TLD use would be preferable, blind use for second- and third-line regimens may be sub-optimal (functional monotherapy with dolutegravir) with high risk of further failure, thus suggesting strategies for selective ART switch to TLD in failing patients in RLS. [ABSTRACT FROM AUTHOR] more...- Published
- 2023
- Full Text
- View/download PDF
25. Active case finding: comparison of the acceptability, feasibility and effectiveness of targeted versus blanket provider-initiated-testing and counseling of HIV among children and adolescents in Cameroon
- Author
-
Yumo, Habakkuk Azinyui, Kuaban, Christopher, Ajeh, Rogers Awoh, Nji, Akindeh Mbuh, Nash, Denis, Kathryn, Anastos, Beissner, Marcus, and Loescher, Thomas
- Published
- 2018
- Full Text
- View/download PDF
26. Pre-Treatment HIV Drug Resistance and Genetic Diversity in Cameroon: Implications for First-Line Regimens.
- Author
-
Fokam, Joseph, Chenwi, Collins Ambe, Tala, Valère, Takou, Désiré, Santoro, Maria Mercedes, Teto, George, Dambaya, Beatrice, Anubodem, Felix, Semengue, Ezechiel Ngoufack Jagni, Beloumou, Grace, Djupsa, Sandrine, Assomo, Edgar, Fokunang, Charles, Alteri, Claudia, Billong, Serge, Bouba, Nounouce Pamen, Ajeh, Rogers, Colizzi, Vittorio, Mbanya, Dora, and Ceccherini-Silberstein, Francesca more...
- Subjects
ANTI-HIV agents ,DRUG resistance ,GENETIC variation ,ANTIRETROVIRAL agents ,HIV - Abstract
The efficacy of first-line antiretroviral therapy (ART) may be hampered by the presence of HIV drug resistance (HIVDR). We described HIV-1 pre-treatment drug resistance (PDR) patterns, effect of viral clades on PDR, and programmatic implications on first-line regimens in Cameroon. A sentinel surveillance of PDR was conducted from 2014 to 2019. Sequencing of HIV-1 protease and reverse transcriptase was performed, and HIVDR was interpreted using Stanford HIVdb.v.9.4. In total, 379 sequences were obtained from participants (62% female, mean age 36 ± 10 years). The overall PDR rate was 15.0% [95% CI: 11.8–19.0] nationwide, with significant disparity between regions (p = 0.03). NNRTI PDR was highest (12.4%), of which 7.9% had DRMs to EFV/NVP. Two regions had EFV/NVP PDR above the 10% critical threshold, namely the Far North (15%) and East (10.9%). Eighteen viral strains were identified, predominated by CRF02_AG (65.4%), with no influence of genetic diversity PDR occurrence. TDF-3TC-DTG predictive efficacy was superior (98.4%) to TDF-3TC-EFV (92%), p < 0.0001. The overall high rate of PDR in Cameroon, not substantially affected by the wide HIV-1 genetic diversity, underscores the poor efficacy of EFV/NVP-based first-line ART nationwide, with major implications in two regions of the country. This supports the need for a rapid transition to NNRTI-sparing regimens, with TDF-3TC-DTG having optimal efficacy at the programmatic level. [ABSTRACT FROM AUTHOR] more...
- Published
- 2023
- Full Text
- View/download PDF
27. HIV-Related Stigma, Social Support, and Symptoms of Mental Health Disorders Among People with HIV Initiating HIV Care in Cameroon.
- Author
-
Parcesepe, Angela M., Filiatreau, Lindsey M., Gomez, Amanda, Ebasone, Peter Vanes, Dzudie, Anastase, Pence, Brian W., Wainberg, Milton, Yotebieng, Marcel, Anastos, Kathryn, Pefura-Yone, Eric, Nsame, Denis, Ajeh, Rogers, and Nash, Denis more...
- Subjects
HIV infections & psychology ,MENTAL illness risk factors ,HIV infections ,FRIENDSHIP ,SOCIAL support ,ALCOHOLISM ,CONFIDENCE intervals ,SOCIAL stigma ,INTERVIEWING ,FAMILIES ,POST-traumatic stress disorder ,MENTAL depression ,DESCRIPTIVE statistics ,RESEARCH funding ,ANXIETY - Abstract
HIV-related stigma has been associated with poor mental health among people with HIV (PWH). Social support is a potentially modifiable factor that may buffer negative mental health sequelae of HIV-related stigma. Little is known about the extent to which the modifying effect of social support differs across mental health disorders. Interviews were conducted with 426 PWH in Cameroon. Log binomial regression analyses were used to estimate the association between high anticipated HIV-related stigma and low social support from family or friends and symptoms of depression, anxiety, post-traumatic stress disorder (PTSD), and harmful alcohol use, separately. Anticipated HIV-related stigma was commonly endorsed with ∼80% endorsing at least 1 of 12 stigma-related concerns. In multivariable analyses, high anticipated HIV-related stigma was associated with greater prevalence of symptoms of depression {adjusted prevalence ratio (aPR) 1.6 [95% confidence interval (CI) 1.1–2.2]} and anxiety [aPR 2.0 (95% CI 1.4–2.9)]. Low social support was associated with greater prevalence of symptoms of depression [aPR 1.5 (95% CI 1.1–2.2)], anxiety [aPR 1.7 (95% CI 1.2–2.5)], and PTSD [aPR 1.6 (95% CI 1.0–2.4)]. However, social support did not meaningfully modify the relationship between HIV-related stigma and symptoms of any mental health disorders explored. Anticipated HIV-related stigma was commonly reported among this group of PWH initiating HIV care in Cameroon. Social concerns related to gossip or losing friends were of the greatest concern. Interventions focused on reducing stigma and strengthening support systems may be particularly beneficial and have the potential to improve the mental health of PWH in Cameroon. [ABSTRACT FROM AUTHOR] more...
- Published
- 2023
- Full Text
- View/download PDF
28. Service delivery challenges in HIV care during the first year of the COVID‐19 pandemic: results from a site assessment survey across the global IeDEA consortium.
- Author
-
Brazier, Ellen, Ajeh, Rogers, Maruri, Fernanda, Musick, Beverly, Freeman, Aimee, Wester, C. William, Lee, Man‐Po, Shamu, Tinei, Crabtree Ramírez, Brenda, d'Almeida, Marcelline, Wools‐Kaloustian, Kara, Kumarasamy, N., Althoff, Keri N., Twizere, Christella, Grinsztejn, Beatriz, Tanser, Frank, Messou, Eugène, Byakwaga, Helen, Duda, Stephany N., and Nash, Denis more...
- Subjects
- *
COVID-19 pandemic , *CONSORTIA , *HIV , *VIRAL load , *HIGH-income countries , *MEDICAL telematics - Abstract
Introduction: Interruptions in treatment pose risks for people with HIV (PWH) and threaten progress in ending the HIV epidemic; however, the COVID‐19 pandemic's impact on HIV service delivery across diverse settings is not broadly documented. Methods: From September 2020 to March 2021, the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium surveyed 238 HIV care sites across seven geographic regions to document constraints in HIV service delivery during the first year of the pandemic and strategies for ensuring care continuity for PWH. Descriptive statistics were stratified by national HIV prevalence (<1%, 1–4.9% and ≥5%) and country income levels. Results: Questions about pandemic‐related consequences for HIV care were completed by 225 (95%) sites in 42 countries with low (n = 82), medium (n = 86) and high (n = 57) HIV prevalence, including low‐ (n = 57), lower‐middle (n = 79), upper‐middle (n = 39) and high‐ (n = 50) income countries. Most sites reported being subject to pandemic‐related restrictions on travel, service provision or other operations (75%), and experiencing negative impacts (76%) on clinic operations, including decreased hours/days, reduced provider availability, clinic reconfiguration for COVID‐19 services, record‐keeping interruptions and suspension of partner support. Almost all sites in low‐prevalence and high‐income countries reported increased use of telemedicine (85% and 100%, respectively), compared with less than half of sites in high‐prevalence and lower‐income settings. Few sites in high‐prevalence settings (2%) reported suspending antiretroviral therapy (ART) clinic services, and many reported adopting mitigation strategies to support adherence, including multi‐month dispensing of ART (95%) and designating community ART pick‐up points (44%). While few sites (5%) reported stockouts of first‐line ART regimens, 10–11% reported stockouts of second‐ and third‐line regimens, respectively, primarily in high‐prevalence and lower‐income settings. Interruptions in HIV viral load (VL) testing included suspension of testing (22%), longer turnaround times (41%) and supply/reagent stockouts (22%), but did not differ across settings. Conclusions: While many sites in high HIV prevalence settings and lower‐income countries reported introducing or expanding measures to support treatment adherence and continuity of care, the COVID‐19 pandemic resulted in disruptions to VL testing and ART supply chains that may negatively affect the quality of HIV care in these settings. [ABSTRACT FROM AUTHOR] more...
- Published
- 2022
- Full Text
- View/download PDF
29. Psychiatric comorbidity and psychosocial stressors among people initiating HIV care in Cameroon.
- Author
-
Parcesepe, Angela M., Filiatreau, Lindsey M., Ebasone, Peter Vanes, Dzudie, Anastase, Pence, Brian W., Wainberg, Milton, Yotebieng, Marcel, Anastos, Kathryn, Pefura-Yone, Eric, Nsame, Denis, Ajeh, Rogers, and Nash, Denis more...
- Subjects
MENTAL health services ,HIV-positive persons ,COMORBIDITY ,MENTAL illness ,POST-traumatic stress disorder ,HIV - Abstract
Background: Psychiatric comorbidity, the presence of two or more mental health disorders, has been associated with suboptimal HIV treatment outcomes. Little is known about the prevalence of psychiatric comorbidity among people with HIV (PWH) in sub-Saharan Africa. Methods: We conducted interviews with PWH initiating HIV care in Cameroon between June 2019 and March 2020. Depression, anxiety, post-traumatic stress disorder (PTSD), and harmful drinking were dichotomized to represent those with and without symptoms of each. Psychiatric comorbidity was defined as having symptoms of two or more disorders assessed. Moderate or severe household hunger, high anticipatory HIV-related stigma, low social support, and high number of potentially traumatic events were hypothesized as correlates of psychiatric comorbidity. Bivariable log binomial regression models were used to estimate unadjusted associations between psychosocial stressors and psychiatric comorbidity. Results: Among 424 participants interviewed, the prevalence of psychiatric comorbidity was 16%. Among those with symptoms of at least one mental health or substance use disorder (n = 161), the prevalence of psychiatric comorbidity was 42%. The prevalence of psychiatric comorbidity was 33%, 67%, 76%, and 81% among those with symptoms of harmful drinking, depression, anxiety, and PTSD, respectively. Among individuals with symptoms of a mental health or substance use disorder, a high number of potentially traumatic events (prevalence ratio (PR) 1.71 [95% CI 1.21, 2.42]) and high anticipatory HIV-related stigma (PR 1.45 [95% CI 1.01, 2.09]) were associated with greater prevalence of psychiatric comorbidity. Conclusion: Psychiatric comorbidity was common among this group of PWH in Cameroon. The effectiveness and implementation of transdiagnostic or multi-focus mental health treatment approaches in HIV care settings should be examined. [ABSTRACT FROM AUTHOR] more...
- Published
- 2022
- Full Text
- View/download PDF
30. Seroprevalence of hepatitis B virus among people screened at a primary care hospital in Bamenda: a cross-sectional study.
- Author
-
Funeh, Cyprine Neba, Vanes Ebasone, Peter, Mbah Chunga, Eric, Nkwawir, Fonyuy, Ajeh, Rogers, Barche, Blaise, and Fonyong Tebid, Ignatius
- Subjects
HEPATITIS B virus ,HEPATITIS associated antigen ,HOSPITAL care ,PRIMARY care ,SEROPREVALENCE - Abstract
Introduction: about 257 million people are infected with hepatitis B virus (HBV) worldwide and the infection is endemic in Africa. The general population HBV seroprevalence remains under-reported in Cameroon. Methods: this was a cross-sectional study including, 1208 consenting adults selected through consecutive sampling, from April 2015 to November 2018, in the Bamenda Health District. Participants' demographic data were collected and their blood samples were drawn and tested for hepatitis B Surface Antigen (HBsAg). Data were analysed using SPSS version 24 and Chi-squared and Fisher's exact tests were used to assess bivariate associations. Results: the participants' mean age (years) was 35.9±11.8, and the majority were females 720 (59.6%). The seroprevalence of HBV infection was 5.8% (95% CI: 4.5-7.3), and was significantly higher in males 8.4% (95% CI: 6.2-11.1), p=0.001, age group 30-39 years 8.4% (95% CI: 5.8-11.6), p=0.007 and the Mankon health area (12.7%; 95% CI: 9.1-17.1), p=0.026. Conclusion: the results suggest that HBV infection could be intermediately endemic in Bamenda, with a higher burden in males, people in their third decade and those from the Mankon health area. This study further underscores a need for extensive screening and vaccination campaigns in Cameroon. [ABSTRACT FROM AUTHOR] more...
- Published
- 2022
- Full Text
- View/download PDF
31. Mental health and initiation of antiretroviral treatment at enrolment into HIV care in Cameroon under a national "treat all" policy: a cross‐sectional analysis.
- Author
-
Parcesepe, Angela M., Filiatreau, Lindsey M., Ebasone, Peter Vanes, Dzudie, Anastase, Pence, Brian W., Wainberg, Milton, Yotebieng, Marcel, Anastos, Kathryn, Pefura‐Yone, Eric, Ajeh, Rogers, and Nash, Denis more...
- Subjects
ANTIRETROVIRAL agents ,MENTAL illness ,MENTAL health services ,MENTAL health ,POLICY analysis - Abstract
Introduction: Rapid antiretroviral treatment (ART) initiation reduces time from HIV infection to viral suppression, decreasing HIV transmission risk. Mental health symptoms may influence timing of ART initiation. This study estimated the prevalence of ART initiation at enrolment into HIV care and the relationship between mental health and ART initiation at enrolment into HIV care. Methods: We conducted interviews with 426 individuals initiating HIV care in Cameroon between June 2019 and March 2020 to estimate the association between mental health and timing of ART initiation. Depression (Patient Health Questionnaire‐9; cut‐point 10), anxiety (Generalized Anxiety Disorder‐7; cut‐point 10), post‐traumatic stress disorder (PTSD) (PTSD Checklist for DSM‐5; cut‐point 31) and harmful alcohol use (Alcohol Use Disorders Identification Test; cut‐point 16) were dichotomized to represent those with and without each exposure at first HIV care appointment. Date of ART initiation (date ART prescribed) was ascertained from medical records. Separate multivariable log‐binomial regression models were used to estimate the association between mental health exposures and ART initiation at enrolment into care. Results and discussion: Overall, 87% initiated ART at enrolment into HIV care. Approximately 20% reported depressive symptoms, 15% reported PTSD symptoms, 12% reported anxiety symptoms and 13% reported harmful alcohol use. In multivariable analyses, individuals with moderate to severe depressive symptoms had 1.7 (95% confidence interval [CI] 1.1, 2.7) times the prevalence of not initiating ART at enrolment into HIV care compared to those with no or mild depressive symptoms. Those with symptoms of PTSD, compared to those without, had 1.9 (95% CI 1.2, 2.9) times the prevalence of not initiating ART at enrolment into HIV care. Symptoms of anxiety or harmful drinking were not associated with ART initiation at enrolment into HIV care in multivariable models. Conclusions: Symptoms of depression and PTSD were associated with lower prevalence of ART initiation at enrolment into HIV care among this sample of individuals initiating HIV care in Cameroon under a "treat all" policy. Research should examine barriers to timely ART initiation, whether incorporating mental health services into HIV care improves timely ART initiation, and whether untreated symptoms of depression and PTSD drive suboptimal HIV care outcomes. [ABSTRACT FROM AUTHOR] more...
- Published
- 2021
- Full Text
- View/download PDF
32. Outcomes of the first meeting of the CAMEROON HIV RESEARCH FORUM (CAM-HERO).
- Author
-
Tchounga, Boris, Ajeh, Rogers, Djikeussi, Tatiana, Ebasone, Peter Vanes, Tchendjou, Patrice, Anoubissi, Jean, Jagni Semengue, Ezekiel Ngoufack, Kouanfack, Charles, Kamgang, Fabrice Youbi, Varloteaux, Marie, Youngui, Boris, Tabala, Felicite Naah, Atanga, Benjamin, Simo, Leonie, Ateudjieu, Jerome, Zemsi, Armel, Nasah, Lainsi Judith, Ngeke, Njie George, Ndiforkwah, Nicoline, and Bouseko, Mireille Teno more...
- Subjects
- *
HIV , *OPERATIONS research , *TRANSLATIONAL research , *FORUMS , *RESEARCH & development - Abstract
Research is a vital component for the development of any country. In Cameroon, HIV Operational research is rapidly growing, however, it faces some intractable problems which can only be solved through an urgent, strategic, efficient, and collaborative approach involving key stakeholders. The Kribi meeting (09 and 10th December 2020) brought together under the auspices of the Ministry of Public Health leading HIV research organisations and connected HIV researchers and actors from different sectors. These actors disseminated and discussed recent research findings and worked out mechanisms to advance HIV research development, developed new ideas and identified priority research areas, with emphasis on translational research. The official launching and consolidation of Cam-HERO was a critical step and it is hoped that these synergistic efforts will catalyse attainment of the 95-95-95 goals in Cameroon. [ABSTRACT FROM AUTHOR] more...
- Published
- 2021
- Full Text
- View/download PDF
33. Determinants of retention in HIV antiretroviral treatment (ART) in the Cameroon International epidemiology Database to Evaluate AIDS (IeDEA) study clinics: the context of the HIV treat all strategy in Cameroon.
- Author
-
Ajeh, Rogers Awoh, Gregory, Halle Ekane, Noela, Nsah Awachwi, Thomas, Egbe Obinchemti, Jules, Assob Nguedia, Dzudie, Anastase, and Adedimeji, Adebola
- Subjects
- *
ANTIRETROVIRAL agents , *AIDS , *CHI-squared test , *HIV , *MEDICAL disclosure - Abstract
Introduction: retaining patients in antiretroviral treatment (ART) is essential for successful outcomes. Unfortunately, Cameroon continues to report suboptimal ART retention. This study focused on identifying determinants of ART retention in three HIV clinics in Cameroon within the HIV treat all context. Methods: a medical chart review of 423 subjects who initiated ART between July and September 2016 in the Limbe, Bamenda and Jamot Hospitals. Patients' sociodemographic and clinical characteristics and ART retention data were abstracted using structured paper forms. Chi square test was used to assess bivariate associations. Logistic regression was used to adjust for confounders. P-value was set at <0.05 at 95% confidence interval. Results: the mean age was 40±11 years, and 65.1% were females. Antiretroviral treatment retention after 24 months was 309/392 (78.83%) and 30/423 (7.1%) were transferred-out, 11/423 (2.6%) reported dead and 73/423 (17.3%) lost to follow-up. HIV status disclosure (AOR 0.16 95% CI: 0.05-0.51, p<0.01) and age group 31-50 years (AOR 3.63, 95% CI: 1.04- 12.59, P= 0.04) were associated with lower and higher ART retention respectively. Conclusion: about a quarter of the participants were not retained in ART after 24 months. Patient-level factors determined ART retention. These factors should be considered in designing strategies to improve ART retention. More research is needed to identify other determinants of ART retention under the HIV treat all strategy. [ABSTRACT FROM AUTHOR] more...
- Published
- 2021
- Full Text
- View/download PDF
34. Research priorities for accelerating the achievement of three 95 HIV goals in Cameroon: a consensus statement from the Cameroon HIV Research Forum (CAM-HERO).
- Author
-
Dzudie, Anastase, Tchounga, Boris, Ajeh, Rogers, Kouanfack, Charles, Ebasone, Peter Vanes, Djikeussi, Tatiana, Nyoto, Léonard Bonono, Fokam, Joseph, Ateudjieu, Jérôme, Tchendjou, Patrice, Jagni Semengue, Ezechiel Ngoufack, Kamgang, Fabrice Youbi, Anoubessi, Jean, Varloteaux, Marie, Youngui, Boris, Tabala, Felicite Naah, Atanga, Benjamin, Simo, Leonie, Zemsi, Armel, and Shu, Emile Nforbih more...
- Subjects
HIV ,HIV prevention ,DELPHI method ,ANTIRETROVIRAL agents - Abstract
Introduction: the Treat-All remains the globally endorsed approach to attain the 95-95-95 targets and end the AIDS pandemic by 2030, but requires some country-level contextualization. In Cameroon, the specific research agenda to inform strategies for improving HIV policy was yet to be defined. Methods: under the patronage of the Cameroon Ministry of health, researchers, policy makers, implementing partners, and clinicians from 13 institutions, used the Delphi method to arrive at a consensus of HIV research priorities. The process had five steps: 1) independent literature scan by 5 working groups; 2) review of the initial priority list; 3) appraisal of priorities list in a larger group; 4) refinement and consolidation by a consensus group; 5) rating of top research priorities. Results: five research priorities and corresponding research approaches, resulted from the process. These include: 1) effectiveness, safety and active toxicity monitoring of new and old antiretrovirals; 2) outcomes of Antiretroviral Therapy (ART) with focus in children and adolescents; 3) impact of HIV and ART on aging and major chronic diseases; 4) ART dispensation models and impact on adherence and retention; 5) evaluations of HIV treatment and prevention programs. Conclusion: the research priorities resulted from a consensus amongst a multidisciplinary team and were based on current data about the pandemic and science to prevent, treat, and ultimately cure HIV. These priorities highlighted critical areas of investigation with potential relevance for the country, funders, and regulatory bodies. [ABSTRACT FROM AUTHOR] more...
- Published
- 2021
- Full Text
- View/download PDF
35. Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.
- Author
-
Dzudie, Anastase, Hoover, Donald, Kim, Hae-Young, Ajeh, Rogers, Adedimeji, Adebola, Shi, Qiuhu, Pefura Yone, Walter, Nsame Nforniwe, Denis, Thompson Njie, Kinge, Pascal Kengne, Andre, Ebasone, Peter Vanes, Barche, Blaise, Bissek Anne Cecile, Zoung-Kany, Nash, Denis, Yotebieng, Marcel, and Anastos, Kathryn more...
- Subjects
HIV-positive persons ,CROSS-sectional method ,EPIDEMIOLOGY ,ANTIHYPERTENSIVE agents ,HYPERTENSION risk factors ,CARDIOVASCULAR diseases risk factors ,COMORBIDITY ,AIDS - Abstract
Background: Antiretroviral therapy (ART) success has led people to live longer with HIV/AIDS (PLWH) and thus be exposed to increasing risk of cardiovascular diseases (CVD). Hypertension (HTN), the biggest contributor to CVD burden, is a growing concern among PLWH. The current report describes the prevalence and predictors of HTN among PLWH in care in Cameroon. Methods: This cross-sectional study included all PLWH aged 20 years and above who received care between 2016 and 2019 at one of the three Central Africa International Epidemiology Databases to Evaluate AIDS (CA-IeDEA) sites in Cameroon (Bamenda, Limbe, and Yaoundé). HTN was defined as blood pressure (BP) ≥140/90 mm Hg or self-reported use of antihypertensive medication. Logistic regressions models examined the relationship between HTN and clinical characteristics, and HIV-related factors. Results: Among 9,839 eligible PLWH, 66.2% were women and 25.0% had prevalent HTN [age-standardized prevalence 23.9% (95% CI: 22.2–25.6)], among whom 28 (1.1%) were on BP lowering treatment, and 6 of those (21.4%) were at target BP levels. Median age (47.4 vs. 40.5 years), self-reported duration of HIV infection (5.1 vs 2.8 years years), duration of ART exposure (4.7 vs 2.3 years), and CD4 count (408 vs 359 cell/mm
3 ) were higher in hypertensives than non-hypertensives (all p<0.001). Age and body mass index (BMI) were independently associated with higher prevalent HTN risk. PLWH starting ART had a 30% lower risk of prevalent HTN, but this advantage disappeared after a cumulative 2-year exposure to ART. There was no significant association between other HIV predictive characteristics and HTN. Conclusion: About a quarter of these Cameroonian PLWH had HTN, driven among others by age and adiposity. Appropriate integration of HIV and NCDs services is needed to improve early detection, treatment and control of common comorbid NCD risk factors like hypertension and safeguard cardiovascular health in PLWH. [ABSTRACT FROM AUTHOR] more...- Published
- 2021
- Full Text
- View/download PDF
36. Trends in demographic and clinical characteristics and initiation of antiretroviral therapy among adult patients enrolling in HIV care in the Central Africa International epidemiology Database to Evaluate AIDS (CA‐IeDEA) 2004 to 2018.
- Author
-
Adedimeji, Adebola A, Hoover, Donald R, Shi, Qiuhu, Kim, Hae‐Young, Brazier, Ellen, Ross, Jonathan, Murenzi, Gad, Twizere, Christella, Lelo, Patricia, Nsonde, Dominique, Ajeh, Rogers, Dzudie, Anastase, Nash, Denis, Yotebieng, Marcel, Anastos, Kathryn, Pélagie, Nimbona, Gateretse, Patrick, Munezero, Jeanine, Nitereka, Valentin, and Niyongabo, Théodore more...
- Subjects
ADULTS ,HIV-positive persons ,ANTIRETROVIRAL agents ,DEMOGRAPHIC characteristics ,AIDS patients - Abstract
Introduction: The Central Africa International epidemiology Database to Evaluate AIDS (CA‐IeDEA) is an open observational cohort study investigating impact, progression and long‐term outcomes of HIV/AIDS among people living with HIV (PLWH) in Burundi, Cameroon, Democratic Republic of Congo (DRC), Republic of Congo (ROC) and Rwanda. We describe trends in demographic, clinical and immunological characteristics as well as antiretroviral therapy (ART) use of patients aged > 15 years entering into HIV care in the participating CA‐IeDEA site. Methods: Information on sociodemographic characteristics, height, weight, body mass index (BMI), CD4 cell count, WHO staging and ART status at entry into care from 2004 through 2018 were extracted from clinic records of patients aged > 15 years enrolling in HIV care at participating clinics in Burundi, Cameroon, DRC, ROC and Rwanda. We assessed trends in patient characteristics at enrolment in HIV care including ART initiation within the first 30 days after enrolment in care and calculated proportions, means and medians (interquartile ranges) for the main variables of interest. Results: Among 69,176 patients in the CA‐IeDEA cohort, 39% were from Rwanda, 24% from ROC, 18% from Cameroon, 14% from Burundi and 5% from DRC. More women (66%) than men enrolled in care and subsequently initiated ART. Women were also younger than men (32 vs. 38 years, P < 0.001) at enrolment and at ART initiation. Trends over time show increases in median CD4 cell count at enrolment from 190 cells/µL in 2004 to 334 cells/µL in 2018 at enrolment. Among those with complete data on CD4 counts (60%), women had a higher median CD4 cell count at care entry than men (229 vs. 249 cells/µL, P < 0.001). Trends in the proportion of patients using ART within 30 days of enrolment at the participating site show an increase from 16% in 2004 to 75% in 2018. Conclusions: Trends from 2004 to 2018 in the characteristics of patients participating in the CA‐IeDEA cohort highlight improvements at entry into care and subsequent ART initiation including after the implementation of Treat All guidelines in the participating sites. [ABSTRACT FROM AUTHOR] more...
- Published
- 2021
- Full Text
- View/download PDF
37. Parental and child-level predictors of HIV testing uptake, seropositivity and treatment initiation among children and adolescents in Cameroon.
- Author
-
Yumo, Habakkuk A., Ajeh, Rogers A., Sieleunou, Isidore, Ndenkeh, Jackson N., Jordan, Michael R., Sam-Agudu, Nadia A., Kuaban, Christopher, and Loescher, Thomas
- Subjects
- *
HIV-positive children , *HIV , *CLINICAL trial registries , *HIV seroconversion , *TEENAGERS , *AFRICANS , *CLERKS - Abstract
Background: There is a growing body of evidence positioning targeted provider-initiated testing and counselling (tPITC, also known as index case testing) as a promising HIV case-finding and linkage strategy among children and adolescents. However, the effectiveness and efficiency of this strategy is limited by low HIV testing uptake and case detection rates. Despite this fact, there is very little literature on factors associated with HIV testing uptake, HIV seropositivity and ART-enrolment in tPITC implementation among African children. This study aims to bridge this information gap and contribute in improving the effectiveness and efficiency of tPITC among children and adolescents in Cameroon and beyond. Methods: In three ART clinics where tPITC was previously inexistent, we introduced the routine implementation of this strategy by inviting parents living with HIV/AIDS in care to have their biological children (6 weeks-19 years) HIV-tested. Children of consenting parents were HIV-tested; those testing positive were enrolled on ART. Parental and child-level characteristics associated with HIV testing uptake, seropositivity and ART-enrollment were assessed using bivariate and multivariate regression analysis at 5% significance level. Results: We enrolled 1,236 parents, through whom 1,990 children/adolescents were recruited for HIV testing. Among enrolled parents, 46.2% (571/1,236) had at least one child tested, and 6.8% (39/571) of these parents had at least one HIV-positive child. Among enrolled children/adolescents, 56.7% (1,129/1,990) tested for HIV and 3.5% (40/1129) tested HIV-positive. Parental predictors of HIV testing uptake among children/adolescents were sex, occupation and duration on ART: female [aOR = 1.6 (1.1–2.5)], office workers/students [aOR = 2.0 (1.2–3.3)], and parents with ART duration > 5 years [aOR = 2.0 (1.3–2.9)] had significantly higher odds to test a child than male, farmers/traders, and parents with ART duration < 5 years respectively. The only child-level predictor of testing uptake was age: children < 18 months [aOR = 5(2–10)] had significantly higher odds to test for HIV than adolescents > 15 years. Parents of children identified as HIV-positive were more likely to be female, aged 40–60 years, farmers/traders, widows/divorcees and not on ART. Children found HIV-positive and who were ART-enrolled were more likely to be female and aged 5–9 years. However, none of the above-mentioned associations was statistically significant. Conclusions: Parents who were male, farmers/traders, and on ART for ≤ 5 years were less likely to test their children for HIV. Also, adolescents 10–19 years old were less likely to be tested. Therefore, these groups should be targeted with intensive counseling and follow-up to facilitate optimal testing uptake. No association was found between parental or child-level characteristics and HIV seropositivity among tested children. This finding prompts for further research to investigate approaches to better identify and target HIV testing to children/adolescents with the highest likelihood of HIV seropositivity. Clinical trial registration: Reg: CinicalTrials.gov # NCT03024762. [ABSTRACT FROM AUTHOR] more...
- Published
- 2020
- Full Text
- View/download PDF
38. Effectiveness of symptom-based diagnostic HIV testing versus targeted and blanket provider-initiated testing and counseling among children and adolescents in Cameroon.
- Author
-
Yumo, Habakkuk A., Ajeh, Rogers A., Beissner, Marcus, Jr.Ndenkeh, Jackson N., Sieleunou, Isidore, Jordan, Michael R., Sam-Agudu, Nadia A., and Kuaban, Christopher
- Subjects
- *
HIV-positive children , *ADOLESCENCE , *DIAGNOSIS methods , *CHILDREN , *AGE groups - Abstract
Objectives: The concurrent implementation of targeted (tPITC) and blanket provider-initiated testing and counselling (bPITC) is recommended by the World Health Organization (WHO) for HIV case-finding in generalized HIV epidemics. This study assessed the effectiveness of this intervention compared to symptom-based diagnostic HIV testing (DHT) in terms of HIV testing uptake, case detection and antiretroviral therapy (ART) enrollment among children and adolescents in Cameroon, where estimated HIV prevalence is relatively low at 3.7%. Methods: In three hospitals where DHT was the standard practice before, tPITC and bPITC were implemented by inviting HIV-positive parents in care at the ART clinics to have their biological children (6 weeks-19 years) tested for HIV (tPITC). Concurrently, at the outpatient departments, similarly-age children/adolescents were systematically offered HIV testing via accompanying parents/guardians. The mean monthly number of children tested for HIV, identified HIV-positive and ART-enrolled were used to compare the outcomes of different HIV testing strategies before and after the intervention. Results: In comparing DHT to bPITC, there was a significant increase in the mean monthly number of children/adolescents tested for HIV (223.0 vs 348.3, p = 0.0073), but with no significant increase in the mean monthly number of children/adolescents: testing HIV-positive (10.5 vs 9.7, p = 0.7574) and ART- enrolled (7.3 vs 6.3, p = 0.5819). In comparing DHT to tPITC, there was no significant difference in the mean monthly number of children/adolescents: tested for HIV (223 vs 193.8, p = 0.4648); tested HIV-positive (10.5 vs 10.6, p = 0.9544), and ART-enrolled (7.3 vs 5.8, p = 0.4672). When comparing DHT versus bPITC+tPITC, there was a significant increase in the mean monthly number of children/adolescents: tested for HIV (223.0 to 542.2, p<0.0001), testing HIV-positive (10.5 vs 20.3, p = 0.0256), and ART-enrolled (7.3 vs 12.2, p = 0.0388). Conclusions: These findings suggest that concurrent implementation of bPITC+tPITC was more effective compared to DHT in terms of HIV testing uptake, case detection and ART enrolment. However, considering that DHT and bPITC had comparable outcomes with regards to case detection and ART enrolment, bPITC+tPITC may not be efficient. Thus, this finding does not support concurrent bPITC+tPITC implementation as recommended by WHO. Rather, continued DHT+tPITC could effectively and efficiently accelerate HIV case detection and ART coverage among children and adolescents in Cameroon and similar low-prevalence context. [ABSTRACT FROM AUTHOR] more...
- Published
- 2019
- Full Text
- View/download PDF
39. Implementation of a REDCap-Based Research Data Collection System in Cameroon.
- Author
-
Ngamani, Lionel, Ajeh, Rogers, Mbuh, Akindeh, Dzudie, Anastase, and Duda, Stephany N.
- Subjects
MEDICAL databases ,HIV infections ,INTERNET access ,ACQUISITION of data - Abstract
Implementing electronic data collection for health research can be challenging in resource-limited settings, where electricity, Internet access, and study staff with computer training may be limited. Our team has established a successful research data infrastructure using the REDCap software at three HIV clinics and one coordinating center in Cameroon. We describe our recommended network architecture and guidance for study data teams working in similar settings. [ABSTRACT FROM AUTHOR] more...
- Published
- 2019
- Full Text
- View/download PDF
40. Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon.
- Author
-
Adedimeji, Adebola, Ajeh, Rogers, Dzudie, Anastase, Kendowo, Ernestine, Fuhngwa, Norbert, Nsame, Denis, Simo-Wambo, Andre Gaetan, Orock, Enow, Hebert, Tiffany M., Pierz, Amanda J., Murokora, Daniel, Anastos, Kathryn, and Castle, Philip E. more...
- Subjects
- *
PAPILLOMAVIRUSES , *HIV-positive women , *HUMAN DNA , *HIV , *CD4 lymphocyte count , *HIV status - Abstract
• There are limited data on cervical HPV prevalence in Cameroon and none from its Anglophone region. Study was conducted in Cameroon among a convenience sample 295 HIV negative women and 560 women living with HIV. • Crude HPV prevalence was 22 % for HIV[-] women and 47 % for WLWH (p < 0.001). Among WLWH, older age and higher CD4 counts were associated with lower HPV prevalence. There was a good-to-excellent agreement for HPV detection between specimens. • Self-collected were more likely than provider-collected specimens to test HPV positive, for all women and stratified by HIV status. • HIV-related immunosuppression was a risk factor for HPV prevalence in this population and HPV testing of self-collected specimens appeared to be less specific than HPV testing of provider-collected specimens. There are limited data on cervical HPV prevalence in Cameroon and none from its Anglophone region. We investigated cervical HPV prevalence in HIV-uninfected (HIV[-]) and HIV-infected (WLWH) women living in the region. A convenience sample of consecutively recruited HIV[-] women (n = 295) and women living with HIV (WLWH) (n = 560) attending the Limbé Regional Hospital were enrolled into a cervical screening study. Women underwent screening that included HPV testing of self-collected and provider-collected specimens. We calculated the HPV prevalence by HIV status, overall and stratified by age, and among WLWH, stratified by CD4 counts. We compared the concordance for the detection of HPV between self- and provider-collected specimens. Crude HPV prevalence was 21.69 % (95 % confidence interval [95 %CI] = 17.21–26.48 %) for HIV[-] women and 46.43 % (95 %CI = 42.24–50.66 %) for WLWH (p < 0.001). Among WLWH, older age (p trend = 0.01) and higher CD4 counts (p trend = 0.007) were associated with lower HPV prevalence. There was a good-to-excellent agreement for HPV detection between specimens, and self-collected were more likely than provider-collected specimens to test HPV positive, for all women and stratified by HIV status. HIV-related immunosuppression was a risk factor for HPV prevalence in this population. HPV testing of self-collected specimens appeared to be less specific than HPV testing of provider-collected specimens. [ABSTRACT FROM AUTHOR] more...
- Published
- 2020
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.