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164 results on '"Andrieux, Annie"'

5. Short- and long-term efficacy of electroconvulsive stimulation in animal models of depression: The essential role of neuronal survival

Author

Jonckheere, Julie, Deloulme, Jean-Christophe, Dall’Igna, Gaëlle, Chauliac, Nicolas, Pelluet, Albane, Nguon, Anne-Sophie, Lentini, Celia, Brocard, Jacques, Denarier, Eric, Brugière, Sabine, Couté, Yohann, Heinrich, Christophe, Porcher, Christophe, Holtzmann, Jérôme, Andrieux, Annie, Suaud-Chagny, Marie-Françoise, and Gory-Fauré, Sylvie

Published
2018
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9. A Vital Role of Tubulin-Tyrosine-Ligase for Neuronal Organization

Author

Erck, Christian, Peris, Leticia, Andrieux, Annie, Meissirel, Claire, Gruber, Achim D., Vernet, Muriel, Schweitzer, Annie, Saoudi, Yasmina, Pointu, Hervé, Bosc, Christophe, Salin, Paul A., Job, Didier, Wehland, Juergen, and Vale, Ronald D.

Published
2005

11. Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

Author

Aillaud, Chrystelle, Bosc, Christophe, Peris, Leticia, Bosson, Anouk, Heemeryck, Pierre, Van Dijk, Juliette, Le Friec, Julien, Boulan, Benoit, Vossier, Frédérique, Sanman, Laura E., Syed, Salahuddin, Amara, Neri, Couté, Yohann, Lafanechère, Laurence, Denarier, Eric, Delphin, Christian, Pelletier, Laurent, Humbert, Sandrine, Bogyo, Matthew, Andrieux, Annie, Rogowski, Krzysztof, and Moutin, Marie-Jo

Published
2017

16. A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines

Author

Peris, Leticia, Bisbal, Mariano, Martinez-Hernandez, José, Saoudi, Yasmina, Jonckheere, Julie, Rolland, Marta, Sebastien, Muriel, Brocard, Jacques, Denarier, Eric, Bosc, Christophe, Guerin, Christophe, Gory-Fauré, Sylvie, Deloulme, Jean Christophe, Lanté, Fabien, Arnal, Isabelle, Buisson, Alain, Goldberg, Yves, Blanchoin, Laurent, Delphin, Christian, and Andrieux, Annie

Published
2018
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25. Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

Author

Poirier, Karine, Lebrun, Nicolas, Broix, Loic, Tian, Guoling, Saillour, Yoann, Boscheron, Cécile, Parrini, Elena, Valence, Stephanie, Pierre, Benjamin Saint, Oger, Madison, Lacombe, Didier, Geneviève, David, Fontana, Elena, Darra, Franscesca, Cances, Claude, Barth, Magalie, Bonneau, Dominique, Bernadina, Bernardo Dalla, N'Guyen, Sylvie, Gitiaux, Cyril, Parent, Philippe, des Portes, Vincent, Pedespan, Jean Michel, Legrez, Victoire, Castelnau-Ptakine, Laetitia, Nitschke, Patrick, Hieu, Thierry, Masson, Cecile, Zelenika, Diana, Andrieux, Annie, Francis, Fiona, Guerrini, Renzo, Cowan, Nicholas J, Bahi-Buisson, Nadia, and Chelly, Jamel

Published
2013
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26. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy

Author

Tadmouri, Abir, Kiyonaka, Shigeki, Barbado, Maud, Rousset, Matthieu, Fablet, Katell, Sawamura, Seishiro, Bahembera, Eloi, Pernet‐Gallay, Karin, Arnoult, Christophe, Miki, Takafumi, Sadoul, Karin, Gory‐Faure, Sylvie, Lambrecht, Caroline, Lesage, Florian, Akiyama, Satoshi, Khochbin, Saadi, Baulande, Sylvain, Janssens, Veerle, Andrieux, Annie, Dolmetsch, Ricardo, Ronjat, Michel, Mori, Yasuo, and De Waard, Michel

Published
2012
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28. Altered expression of synaptic protein mRNAs in STOP (MAP6) mutant mice

Author

Eastwood, Sharon L., Lyon, Louisa, George, Lydia, Andrieux, Annie, Job, Didier, and Harrison, Paul J.

Subjects
Gene expression -- Research, Polypeptides -- Properties -- Research, Schizophrenia -- Research, Synapses -- Properties -- Research, Messenger RNA -- Research, Microtubules -- Properties -- Research, Proteins -- Properties -- Research, Pharmaceuticals and cosmetics industries, Psychology and mental health, Research, Properties
Abstract

Stable tubule-only polypeptide (STOP) proteins are a family of microtubule associated proteins (MAPs) important in microtubule stabilization. Data indicating a role for microtubules in synaptic function has come from studies of the STOP null mouse, which exhibits synaptic deficits, in association with behavioural changes that are alleviated by antipsychotic treatment. These findings suggested that STOP mutant mice may be useful in studies of synaptic function, and could be especially relevant to schizophrenia, postulated to be a disorder of the synapse. Moreover, a genetic association between STOP and schizophrenia has been reported. This study aimed to further characterize synaptic alterations in STOP null and heterozygous mice. Using in situ hybridization histochemistry, the mRNA expression of three pre-synaptic (synaptophysin; growth associated protein-43 (GAP-43); vesicular glutamate transporter-1 (VGlut1)) and two post-synaptic (spinophilin; MAP2) proteins, was quantified in female STOP null (n = 7), heterozygous (n = 5) and wild type (n = 6) mice. For STOP null and heterozygous mice, synaptophysin, VGlut1, GAP-43 and spinophilin mRNAs were decreased in the hippocampus, whilst in addition in the null mice, synaptophysin, VGlut1 and spinophilin mRNAs were decreased in the cerebellum. Alterations in synaptic protein mRNA expression were also detected in the frontal and occipital cortex. MAP2 mRNA expression was unchanged in all brain regions. The profile of mRNA changes is broadly similar to that observed in schizophrenia. Together the data provide supporting evidence for a role for microtubules in synaptic function, and suggest that STOP, or other microtubule proteins, may contribute to the synaptic pathology of schizophrenia. Key words in situ hybridization histochemistry, MAP6, microtubules, mRNA, MAP2) proteins, was quanti?ed in female STOP null (n =7), heterozygous schizophrenia, synapse, Introduction Stable tubule-only polypeptide (STOP) proteins are a family of calmodulin binding and regulated microtubule associated proteins (MAPs), encoded by a single gene (mouse (Mtap6), Denarier et al., 1998b; human [...]

Published
2007

35. The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders

Author

Andrieux, Annie, Salin, Paul A., Vernet, Muriel, Kujala, Pekka, Baratier, Julie, Gory-Faure, Sylvie, Bosc, Christophe, Pointu, Herve, Proietto, Dominique, Schweitzer, Annie, Denarier, Eric, Klumperman, Jucith, and Job, Dider

Subjects
Cytochemistry -- Research, Synapses -- Genetic aspects, Mice, mutant strains -- Usage, Microtubules -- Physiological aspects, Biological sciences
Abstract

Suppression of brain cold-stable microtubules in mice has been found to induce synaptic defects associated with neuroleptic-sensitive behavioral disorders. STOP-null mice, lacking cold-stable microtubules, were generated, and surprisingly, they had no detectable defects in brain anatomy, but had synaptic defects. Stop-null mice may lead to a model for study of neuroleptics in illnesses such as schizophrenia, which is thought to come from synaptic defects.

Published
2002

41. Dopaminergic transmission in STOP null mice

Author

Brun, Philippe, Bégou, Mélina, Andrieux, Annie, Mouly-Badina, Laurence, Clerget, Magali, Schweitzer, Annie, Scarna, Hélène, Renaud, Bernard, Job, Didier, and Suaud-Chagny, Marie-Françoise

Published
2005

43. Abnormal nociception and opiate sensitivity of STOP null mice exhibiting elevated levels of the endogenous alkaloid morphine

Author

Aunis Dominique, Van Dorsselaer Alain, Bianchi Enrica, Delalande François, Stuber Denise, Deloulme Jean-Christophe, Schweitzer Annie, Kemmel Véronique, Laux Alexis, Muller Arnaud H, Charlet Alexandre, Andrieux Annie, Poisbeau Pierrick, and Goumon Yannick

Subjects
Pathology, RB1-214
Abstract

Abstract Background- Mice deficient for the stable tubule only peptide (STOP) display altered dopaminergic neurotransmission associated with severe behavioural defects including disorganized locomotor activity. Endogenous morphine, which is present in nervous tissues and synthesized from dopamine, may contribute to these behavioral alterations since it is thought to play a role in normal and pathological neurotransmission. Results- In this study, we showed that STOP null brain structures, including cortex, hippocampus, cerebellum and spinal cord, contain high endogenous morphine amounts. The presence of elevated levels of morphine was associated with the presence of a higher density of mu opioid receptor with a higher affinity for morphine in STOP null brains. Interestingly, STOP null mice exhibited significantly lower nociceptive thresholds to thermal and mechanical stimulations. They also had abnormal behavioural responses to the administration of exogenous morphine and naloxone. Low dose of morphine (1 mg/kg, i.p.) produced a significant mechanical antinociception in STOP null mice whereas it has no effect on wild-type mice. High concentration of naloxone (1 mg/kg) was pronociceptive for both mice strain, a lower concentration (0.1 mg/kg) was found to increase the mean mechanical nociceptive threshold only in the case of STOP null mice. Conclusions- Together, our data show that STOP null mice displayed elevated levels of endogenous morphine, as well as an increase of morphine receptor affinity and density in brain. This was correlated with hypernociception and impaired pharmacological sensitivity to mu opioid receptor ligands.

Published
2010
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44. Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories.

Author

Cuveillier, Camille, Boulan, Benoit, Ravanello, Charlotte, Denarier, Eric, Deloulme, Jean-Christophe, Gory-Fauré, Sylvie, Delphin, Christian, Bosc, Christophe, Arnal, Isabelle, and Andrieux, Annie

Subjects
MICROTUBULE-associated proteins, NEURON development, CENTRAL nervous system, CYTOSKELETON, NEUROPLASTICITY
Abstract

The development and function of the central nervous system rely on the microtubule (MT) and actin cytoskeletons and their respective effectors. Although the structural role of the cytoskeleton has long been acknowledged in neuronal morphology and activity, it was recently recognized to play the role of a signaling platform. Following this recognition, research into Microtubule Associated Proteins (MAPs) diversified. Indeed, historically, structural MAPs—including MAP1B, MAP2, Tau, and MAP6 (also known as STOP);—were identified and described as MT-binding and -stabilizing proteins. Extensive data obtained over the last 20 years indicated that these structural MAPs could also contribute to a variety of other molecular roles. Among multi-role MAPs, MAP6 provides a striking example illustrating the diverse molecular and cellular properties of MAPs and showing how their functional versatility contributes to the central nervous system. In this review, in addition to MAP6's effect on microtubules, we describe its impact on the actin cytoskeleton, on neuroreceptor homeostasis, and its involvement in signaling pathways governing neuron development and maturation. We also discuss its roles in synaptic plasticity, brain connectivity, and cognitive abilities, as well as the potential relationships between the integrated brain functions of MAP6 and its molecular activities. In parallel, the Collapsin Response Mediator Proteins (CRMPs) are presented as examples of how other proteins, not initially identified as MAPs, fall into the broader MAP family. These proteins bind MTs as well as exhibiting molecular and cellular properties very similar to MAP6. Finally, we briefly summarize the multiple similarities between other classical structural MAPs and MAP6 or CRMPs.In summary, this review revisits the molecular properties and the cellular and neuronal roles of the classical MAPs, broadening our definition of what constitutes a MAP. [ABSTRACT FROM AUTHOR]

Published
2021
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46. AutoNeuriteJ: An ImageJ plugin for measurement and classification of neuritic extensions.

Author

Boulan, Benoit, Beghin, Anne, Ravanello, Charlotte, Deloulme, Jean-Christophe, Gory-Fauré, Sylvie, Andrieux, Annie, Brocard, Jacques, and Denarier, Eric

Subjects
TUBULINS, NEURONS, VOXEL-based morphometry, CLASSIFICATION
Abstract

Morphometry characterization is an important procedure in describing neuronal cultures and identifying phenotypic differences. This task usually requires labor-intensive measurements and the classification of numerous neurites from large numbers of neurons in culture. To automate these measurements, we wrote AutoNeuriteJ, an imageJ/Fiji plugin that measures and classifies neurites from a very large number of neurons. We showed that AutoNeuriteJ is able to detect variations of neuritic growth induced by several compounds known to affect the neuronal growth. In these experiments measurement of more than 5000 mouse neurons per conditions was obtained within a few hours. Moreover, by analyzing mouse neurons deficient for the microtubule associated protein 6 (MAP6) and wild type neurons we illustrate that AutoNeuriteJ is capable to detect subtle phenotypic difference in axonal length. Overall the use of AutoNeuriteJ will provide rapid, unbiased and accurate measurement of neuron morphologies. [ABSTRACT FROM AUTHOR]

Published
2020
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47. A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval.

Author

Ramirez-Rios, Sacnicte, Michallet, Sophie, Peris, Leticia, Barette, Caroline, Rabat, Clotilde, Feng, Yangbo, Fauvarque, Marie-Odile, Andrieux, Annie, Sadoul, Karin, and Lafanechère, Laurence

Subjects
KINASE inhibitors, TUBULINS, TREATMENT effectiveness, MICROTUBULES, ANTINEOPLASTIC agents
Abstract

Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays since there is not a significant visual difference between normal and stabilized microtubule networks. Here, we describe a quantitative cell-based assay, suitable for automation, which allows the detection of stabilized microtubules without the need of microscopic examination. The rationale of this assay is based on the drug-induced resistance of the microtubule network to the depolymerizing agent combretastatin A4 and the subsequent detection of the residual microtubules by immunoluminescence. Using this assay to screen a kinase inhibitor library allowed the selection of seven known kinase inhibitors: selonsertib, masatinib, intedanib, PF0477736, SNS-314 mesylate, MPI0479605, and ponatinib. The yet undescribed ability of these inhibitors to stabilize cellular microtubules was confirmed using additional markers of stable microtubules and time-lapse video-microscopy to track individual microtubules in living cells. None of the compounds interacted, however, directly with tubulin. By employing other inhibitors of the same kinases, which have structurally unrelated scaffolds, we determined if the microtubule stabilizing effect was due to the inhibition of the targeted kinase, or to an off-target effect. Many of these inhibitors are clinically approved or currently assayed in phase 2 or phase 3 clinical trials. Their microtubule-stabilizing effect may account for their therapeutic effect as well as for some of their adverse side effects. These results indicate also a possible repurposing of some of these drugs. [ABSTRACT FROM AUTHOR]

Published
2020
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50. STOP Proteins

Author

Bosc, Christophe, Andrieux, Annie, and Job, Didier

Subjects
Microtubules -- Analysis, Polypeptides -- Research, Protein binding -- Analysis, Biological sciences, Chemistry
Abstract

Resistance of microtubules to the cold is largely due to polymer association with a class of microtubule-associated proteins called stable tubule only polypeptides (STOPs). Importance of STOPs for synaptic plasticity is discussed along with the disorders induced by their suppression in whole animals.

Published
2003

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