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Carbolines are a prominent class of tricyclic alkaloids omnipresent in natural products and bioactive compounds. Four different carboline regioisomers are known (α‐, β‐, γ‐, and δ‐carbolines), which can be classified according to the nitrogen atom position inside the pyridine ring. As an emerging structural motif in drug discovery, a multitude of synthetic methods have been established for the construction of carboline frameworks, which in general requires customized approaches for the assembly of each regioisomer. Distinguishingly, their frameworks are also accessible from unified approaches, which are capable of generating multiple regioisomers, thus suitable for introducing diversity in isomeric carbolines. In this review, the construction of isomeric carbolines based on unified synthetic approaches is summarized. [ABSTRACT FROM AUTHOR]

A facile synthesis of various 2-(carbazolyl)benzothiazoles has been developed by one-pot CuBr-catalyzed three-component reactions of 2-iodoanilines, arylaldehydes, and elemental sulfur. Unlike traditional approach, this reaction exhibited a good functional group tolerance to produce the corresponding 2-(carbazolyl)benzothiazoles in good yields in the absence of any additive. [ABSTRACT FROM AUTHOR]

Oxidation of carbazole-3-carboxyaldehydes promoted by a 70% aqueous solution of tert-butylhydroperoxide leads to the corresponding carbazole-3-carboxylic acids in good yields. This transitionmetal- free oxidation protocol is attractive for the synthesis of pharmaceutically important carbazole analogues. [ABSTRACT FROM AUTHOR]

The reactions of N -(carbazol-3-yl)acetamides with N , N -dimethylformamide in the presence of phosphorus oxychloride (POCl 3 ) at 90 °C gave the corresponding (carbazol-3-yl)formamidines in good yields. The method is compatible with a variety of functional groups. [ABSTRACT FROM AUTHOR]

A simple protocol for the reaction of (carbazolyl)acetamides with DMF to give the corresponding formamides as sufficiently pure materials without any purification is developed. [ABSTRACT FROM AUTHOR]