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243 results on '"Azuma, Miyuki"'

10. VISTA expressed in tumour cells regulates T cell function

Author

Mulati, Kumuluzi, Hamanishi, Junzo, Matsumura, Noriomi, Chamoto, Kenji, Mise, Nathan, Abiko, Kaoru, Baba, Tsukasa, Yamaguchi, Ken, Horikawa, Naoki, Murakami, Ryusuke, Taki, Mana, Budiman, Kharma, Zeng, Xiang, Hosoe, Yuko, Azuma, Miyuki, Konishi, Ikuo, and Mandai, Masaki

Published
2019
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14. An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers

Author

Morita, Hideaki, Arae, Ken, Unno, Hirotoshi, Miyauchi, Kousuke, Toyama, Sumika, Nambu, Aya, Oboki, Keisuke, Ohno, Tatsukuni, Motomura, Kenichiro, Matsuda, Akira, Yamaguchi, Sachiko, Narushima, Seiko, Kajiwara, Naoki, Iikura, Motoyasu, Suto, Hajime, McKenzie, Andrew N.J., Takahashi, Takao, Karasuyama, Hajime, Okumura, Ko, Azuma, Miyuki, Moro, Kazuyo, Akdis, Cezmi A., Galli, Stephen J., Koyasu, Shigeo, Kubo, Masato, Sudo, Katsuko, Saito, Hirohisa, Matsumoto, Kenji, and Nakae, Susumu

Published
2015
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19. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

Author

Saha, Asim, Aoyama, Kazutoshi, Taylor, Patricia A., Koehn, Brent H., Veenstra, Rachelle G., Panoskaltsis-Mortari, Angela, Munn, David H., Murphy, William J., Azuma, Miyuki, Yagita, Hideo, Fife, Brian T., Sayegh, Mohammed H., Najafian, Nader, Socie, Gerard, Ahmed, Rafi, Freeman, Gordon J., Sharpe, Arlene H., and Blazar, Bruce R.

Published
2013
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23. High density and proximity of CD8+T cells to tumor cells are correlated with better response to nivolumab treatment in metastatic pleural mesothelioma.

Author

Yin, Yuting, Sakakibara, Rie, Honda, Takayuki, Kirimura, Susumu, Daroonpan, Pissacha, Kobayashi, Masashi, Ando, Kohei, Ujiie, Hideki, Kato, Tatsuya, Kaga, Kichizo, Mitsumura, Takahiro, Nakano, Ryoji, Sakashita, Hiroyuki, Matsuge, Shinichi, Ishibashi, Hironori, Akashi, Takumi, Hida, Yasuhiro, Morohoshi, Takao, Azuma, Miyuki, and Okubo, Kenichi

Subjects
MESOTHELIOMA, IMMUNE checkpoint inhibitors, CELL physiology, RETROSPECTIVE studies, TREATMENT effectiveness, PLEURAL tumors, NIVOLUMAB, FLUORESCENT antibody technique, RESEARCH funding, CELL lines, T cells
Abstract

Background: The efficacy of immune checkpoint inhibitors (ICIs) in pleural mesothelioma has recently been established. The response to ICIs can be predicted by quantitative analysis of cells and their spatial distribution in the tumor microenvironment (TME). However, the detailed composition of the TME in pleural mesothelioma has not been reported. We evaluated the association between the TME and response to ICIs in this cancer. Methods: A retrospective analysis of 22 pleural mesothelioma patients treated with nivolumab in different centers was performed using surgical specimens. Four patients had a partial response to nivolumab (response group) and 18 patients had stable or progressive disease (nonresponse group). The number of CD4, CD8, FoxP3, CK, and PD‐L1 positive cells, cell density, and cell‐to‐cell distance were analyzed by multiplex immunofluorescence. Results: PD‐L1 expression did not differ significantly between the response and nonresponse groups. The density of total T cells and of CD8+ T cells was significantly higher in the response than in the nonresponse group. CD8+ T cells were more clustered and located closer to tumor cells, whereas regulatory T cells were located further from tumor cells in the response than in the nonresponse group. Conclusions: High density and spatial proximity of CD8+ T cells to tumor cells were associated with better response to nivolumab, whereas the proximity of regulatory T cells to tumor cells was associated with worse response, suggesting that the distinct landscape of the TME could be a potential predictor of ICI efficacy in pleural mesothelioma. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters.

Author

Nishi, Wataru, Wakamatsu, Ei, Machiyama, Hiroaki, Matsushima, Ryohei, Saito, Kensho, Yoshida, Yosuke, Nishikawa, Tetsushi, Takehara, Tomohiro, Toyota, Hiroko, Furuhata, Masae, Nishijima, Hitoshi, Takeuchi, Arata, Azuma, Miyuki, Suzuki, Makoto, and Yokosuka, Tadashi

Subjects
IMAGING systems, T cell receptors, PROGRAMMED cell death 1 receptors, MICROCLUSTERS, IMMUNE checkpoint inhibitors, IMMUNOGLOBULINS, T cells, PEMETREXED
Abstract

With recent advances in immune checkpoint inhibitors (ICIs), immunotherapy has become the standard treatment for various malignant tumors. Their indications and dosages have been determined empirically, taking individually conducted clinical trials into consideration, but without a standard method to evaluate them. Here we establish an advanced imaging system to visualize human PD-1 microclusters, in which a minimal T cell receptor (TCR) signaling unit co-localizes with the inhibitory co-receptor PD-1 in vitro. In these microclusters PD-1 dephosphorylates both the TCR/CD3 complex and its downstream signaling molecules via the recruitment of a phosphatase, SHP2, upon stimulation with the ligand hPD-L1. In this system, blocking antibodies for hPD-1-hPD-L1 binding inhibits hPD-1 microcluster formation, and each therapeutic antibody (pembrolizumab, nivolumab, durvalumab and atezolizumab) is characterized by a proprietary optimal concentration and combinatorial efficiency enhancement. We propose that our imaging system could digitally evaluate PD-1-mediated T cell suppression to evaluate their clinical usefulness and to develop the most suitable combinations among ICIs or between ICIs and conventional cancer treatments. Immune checkpoint inhibitors are now routinely used in cancer therapy, however, the dosage and integration into conventional cancer therapy is determined via empirical experience rather than mechanistic rationale. Here authors establish an advanced single-molecule imaging method, by with which they are directly monitoring and evaluating the effect of immune checkpoint inhibitors on T cell signaling. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine (2),(3)-dioxygenase

Author

Sharma, Madhav D., Baban, Babak, Chandler, Phillip, Hou, De-Yan, Singh, Nagendra, Yagita, Hideo, Azuma, Miyuki, Blazar, Bruce R., Mellor, Andrew L., and H. Munn, David

Subjects
Dendritic cells -- Genetic aspects, Dendritic cells -- Research, Oxidases -- Physiological aspects, Oxidases -- Research, Immune response -- Regulation, Immune response -- Research, Immune response -- Observations
Abstract

A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine (2),(3)-dioxygenase (IDO). We show that these [IDO.sup.+] pDCs directly activate resting [CD4.sup.+][CD25.sup.+][Foxp3.sup.+] Tregs [...]

Published
2007

43. Accessory cell function of airway epithelial cells

Author

Oei, Erwin, Kalb, Thomas, Beuria, Prarthana, Allez, Matthieu, Nakazawa, Atsushi, Azuma, Miyuki, Timony, Michael, Stuart, Zanetta, Chen, Houchu, and Sperber, Kirk

Subjects
Epithelial cells -- Research, Biological sciences
Abstract

Accessory cell function of airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 287: L318-L331, 2004; 10.1152/ajplung.00174.2003.--We previously demonstrated that airway epithelial cells (AECs) have many features of accessory cells, including expression of class II molecules CD80 and CD86 and functional Fc[gamma] receptors. We have extended these studies to show that freshly isolated AECs have mRNA for cathepsins S, V, and H [proteases important in antigen (Ag) presentation], invariant chain, human leukocyte antigen (HLA)-DM-[alpha] and HLA-DM-[beta], and CLIP, an invariant chain breakdown product. A physiologically relevant Ag, ragweed, was colocalized with HLA-DR in AECs, and its uptake was increased by granulocyte-macrophage colony-stimulating factor and IFN-[gamma] treatments, which had no effect on CD80 and CD86 expression. We demonstrate the presence of other costimulatory molecules, including B7h and B7-H1, on AECs and the increased expression of B7-H1 on AECs after treatment with granulocyte-macrophage colony-stimulating factor and IFN-[gamma]. Finally, we compared T cell proliferation after allostimulation with AECs and dendritic cells (DCs). The precursor frequency of peripheral blood T cells responding to AECs was 0.264% compared with 0.55% for DCs. DCs stimulated CD45R[O.sup.+], CD45R[A.sup.+], CCR[7.sup.+] and CCR[7.sup.-]CD[4.sup.+], and CD[8.sup.+] T cells, whereas AECs stimulated only CD45R[O.sup.+], CD45R[A.sup.-], CCR[7.sup.-], CD[4.sup.+], and CD[8.sup.+] T cells. There was no difference in cytokine production, type of memory T cells stimulated (effector vs. long-term memory), or apoptosis by T cells cocultured with AECs and DCs. The localization of AECs exposed to the external environment may make them important in the regulation of local immune responses. dendritic cells; immune responses; ragweed; lymphocytes; bronchoalveolar lavage

Published
2004

47. Progress reports on immune gene therapy for stage IV renal cell cancer using lethally irradiated granulocyte-macrophage colony-stimulating factor-transduced autologous renal cancer cells

Author

Tani, Kenzaburo, Nakazaki, Yukoh, Hase, Hidenori, Takahashi, Keisuke, Azuma, Miyuki, Ohata, Junko, Kitamura, Reiko, Komine, Fumihiko, Oiwa, Maki, Masunaga, Atsuko, Maekawa, Taira, Satoh, Noriharu, Adachi, Daiki, Soda, Yasushi, Machida, Utako, Endo, Muneomi, Yamazaki, Tomoko, Watari, Kiyoshi, Tojo, Arinobu, Yamashita, Naohide, Tomikawa, Shinji, Eriguchi, Masazumi, Hamada, Hirofumi, Wakumoto, Yoshiaki, Hanazawa, Kisaburo, Okumura, Koh, Fujime, Makoto, Shuin, Taro, Kawai, Kouji, Akaza, Hideyuki, Clift, Shirley, Ando, Dale, Sherwin, Stephan, Mulligan, Richard, and Asano, Shigetaka

Published
2000
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