1,685 results on '"Badimon A"'
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2. The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
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Kleinbongard, Petra, Arriola, Carlos Galán, Badimon, Lina, Crisostomo, Veronica, Giricz, Zoltán, Gyöngyösi, Mariann, Heusch, Gerd, Ibanez, Borja, Kiss, Attila, de Kleijn, Dominique P. V., Podesser, Bruno K., Carracedo, Rafael Ramírez, Rodríguez-Sinovas, Antonio, Ruiz-Meana, Marisol, Sanchez Margallo, Francisco M., Vilahur, Gemma, Zamorano, José Luis, Zaragoza, Carlos, Ferdinandy, Peter, and Hausenloy, Derek J.
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- 2024
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3. Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality
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Devaux, Yvan, Zhang, Lu, Lumley, Andrew I., Karaduzovic-Hadziabdic, Kanita, Mooser, Vincent, Rousseau, Simon, Shoaib, Muhammad, Satagopam, Venkata, Adilovic, Muhamed, Srivastava, Prashant Kumar, Emanueli, Costanza, Martelli, Fabio, Greco, Simona, Badimon, Lina, Padro, Teresa, Lustrek, Mitja, Scholz, Markus, Rosolowski, Maciej, Jordan, Marko, Brandenburger, Timo, Benczik, Bettina, Agg, Bence, Ferdinandy, Peter, Vehreschild, Jörg Janne, Lorenz-Depiereux, Bettina, Dörr, Marcus, Witzke, Oliver, Sanchez, Gabriel, Kul, Seval, Baker, Andy H., Fagherazzi, Guy, Ollert, Markus, Wereski, Ryan, Mills, Nicholas L., and Firat, Hüseyin
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- 2024
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4. Crosstalk of human coronary perivascular adipose-derived stem cells with vascular cells: role of tissue factor
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Arderiu, Gemma, Bejar, Maria Teresa, Civit-Urgell, Anna, Peña, Esther, and Badimon, Lina
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- 2024
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5. Prediction of COVID‐19 severity using machine learning
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Kanita Karaduzovic‐Hadziabdic, Muhamed Adilovic, Lu Zhang, Andrew I Lumley, Pranay Shah, Muhammad Shoaib, Venkata Satagopam, Prashant Kumar Srivastava, Costanza Emanueli, Simona Greco, Alisia Madè, Teresa Padro, Pedro Domingo, Mitja Lustrek, Markus Scholz, Maciej Rosolowski, Marko Jordan, Bettina Benczik, Bence Ágg, Péter Ferdinandy, Andrew H Baker, Guy Fagherazzi, Markus Ollert, Joanna Michel, Gabriel Sanchez, Hüseyin Firat, Timo Brandenburger, Fabio Martelli, Lina Badimon, Yvan Devaux, and COVIRNA consortium (www.covirna.eu)
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Medicine (General) ,R5-920 - Published
- 2024
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6. Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study
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Elshorbagy, Amany, Lyons, Alexander R.M., Vallejo-Vaz, Antonio J., Stevens, Christophe A.T., Dharmayat, Kanika I., Brandts, Julia, Catapano, Alberico L., Freiberger, Tomas, Hovingh, G. Kees, Mata, Pedro, Raal, Frederick J., Santos, Raul D., Soran, Handrean, Watts, Gerald F., Abifadel, Marianne, Aguilar-Salinas, Carlos A., Alhabib, Khalid F., Alkhnifsawi, Mutaz, Almahmeed, Wael, Alonso, Rodrigo, Al-Rasadi, Khalid, Al-Sarraf, Ahmad, Ashavaid, Tester F., Banach, Maciej, Binder, Christoph J., Bourbon, Mafalda, Brunham, Liam R., Chlebus, Krzysztof, Corral, Pablo, Cruz, Diogo, Davletov, Kairat, Descamps, Olivier S., Ezhov, Marat, Gaita, Dan, Groselj, Urh, Harada-Shiba, Mariko, Holven, Kirsten B., Kayikcioglu, Meral, Khovidhunkit, Weerapan, Lalic, Katarina, Latkovskis, Gustavs, Laufs, Ulrich, Liberopoulos, Evangelos, Lima-Martinez, Marcos M., Lin, Jie, Maher, Vincent, Marais, A. David, März, Winfried, Mirrakhimov, Erkin, Miserez, André R., Mitchenko, Olena, Nawawi, Hapizah, Nordestgaard, Børge G., Panayiotou, Andrie G., Paragh, György, Petrulioniene, Zaneta, Pojskic, Belma, Postadzhiyan, Arman, Reda, Ashraf, Reiner, Željko, Reyes, Ximena, Sadiq, Fouzia, Sadoh, Wilson E., Schunkert, Heribert, Shek, Aleksandr B., Stroes, Erik, Su, Ta-Chen, Subramaniam, Tavintharan, Susekov, Andrey V., Tilney, Myra, Tomlinson, Brian, Truong, Thanh-Huong, Tselepis, Alexandros D., Tybjærg-Hansen, Anne, Vázquez, Alejandra C., Viigimaa, Margus, Vohnout, Branislav, Wang, Luya, Yamashita, Shizuya, Arca, Marcello, Averna, Maurizio, Schreier, Laura, Pang, Jing, Ebenbichler, Christoph, Dieplinger, Hans, Innerhofer, Reinhold, Winhofer-Stöckl, Yvonne, Greber-Platzer, Susanne, Krychtiuk, Konstantin, Speidl, Walter, Toplak, Hermann, Widhalm, Kurt, Stulnig, Thomas, Huber, Kurt, Höllerl, Florian, Rega-Kaun, Gersina, Kleemann, Lucas, Mäser, Martin, Scholl-Bürgi, Sabine, Säly, Christoph, Mayer, Florian J., Sperone, Alexandra, Tanghe, Chloé, Gérard, Anne-Catherine, Pojskic, Lamija, Sisic, Ibrahim, Durak Nalbantic, Azra, Ejubovic, Malik, Jannes, Cinthia E., Pereira, Alexandre C., Krieger, Jose E., Petrov, Ivo, Goudev, Assen, Nikolov, Fedya, Tisheva, Snejana, Yotov, Yoto, Tzvetkov, Ivajlo, Baass, Alexis, Bergeron, Jean, Bernard, Sophie, Brisson, Diane, Cermakova, Lubomira, Couture, Patrick, Francis, Gordon A., Gaudet, Daniel, Hegele, Robert A., Khoury, Etienne, Mancini, G.B. John, McCrindle, Brian W., Paquette, Martine, Ruel, Isabelle, Iatan, Iulia, Cuevas, Ada, Wang, Xumin, Meng, Kang, Song, Xiantao, Yong, Qiang, Jiang, Tao, Liu, Ziyou, Duan, Yanyu, Hong, Jing, Ye, Pucong, Chen, Yan, Qi, Jianguang, Liu, Zesen, Li, Yuntao, Zhang, Chaoyi, Peng, Jie, Yang, Ya, Yu, Wei, Wang, Qian, Yuan, Hui, Cheng, Shitong, Jiang, Long, Chong, Mei, Jiao, Jian, Wu, Yue, Wen, Wenhui, Xu, Liyuan, Zhang, Ruiying, Qu, Yichen, He, Jianxun, Fan, Xuesong, Wang, Zhenjia, Chow, Elaine, Pećin, Ivan, Perica, Dražen, Symeonides, Phivos, Vrablik, Michal, Ceska, Richard, Soska, Vladimir, Tichy, Lukas, Adamkova, Vera, Franekova, Jana, Cifkova, Renata, Kraml, Pavel, Vonaskova, Katerina, Cepova, Jana, Dusejovska, Magdalena, Pavlickova, Lenka, Blaha, Vladimir, Rosolova, Hana, Nussbaumerova, Barbora, Cibulka, Roman, Vaverkova, Helena, Cibickova, Lubica, Krejsova, Zdenka, Rehouskova, Katerina, Malina, Pavel, Budikova, Milena, Palanova, Vaclava, Solcova, Lucie, Lubasova, Alena, Podzimkova, Helena, Bujdak, Juraj, Vesely, Jiri, Jordanova, Marta, Salek, Tomas, Urbanek, Robin, Zemek, Stanislav, Lacko, Jan, Halamkova, Hana, Machacova, Sona, Mala, Sarka, Cubova, Eva, Valoskova, Katerina, Burda, Lukas, Benn, Marianne, Bendary, Ahmed, Daoud, Ihab, Emil, Sameh, Elbahry, Atef, Rafla, Samir, Sanad, Osama, Kazamel, Ghada, Ashraf, Dr Mohamed, Sobhy, Mohamed, El-Hadidy, Amro, Shafy, Mohamed Abdoul, Kamal, Saif, Bendary, Mohamed, Talviste, Grete, Christmann, Jutta, Dressel, Alexander, Fath, Felix, Ferraro, Chiara, Frenzke, Lydia, Gopon, Alica, Klein, Isabel, Pienkowska, Dominika, Sietmann, Tobias, Sonntag, Antonia, Adjan, Omar, Bahrmann, Philipp, Baessler, Andrea, Barkowski, Rasmus, Beckerdjian, Raffi, Berr, Christina, Birkenfeld, Andreas, Böll, Gereon, Carstensen, Avisha, Demuth, Ilya, Finkernagel, Holger, Gouni-Berthold, Ioanna, Hahmann, Harry, Hamerle, Michael, Halder, Julian, Heide, Maria, Julius, Ulrich, Kassner, Ursula, Katzmann, Julius L, Kirschbaum, Anja, Klose, Gerald, Könemann, Stephanie, König, Christel, König, Wolfgang, Krämer, Bernhard, Kuprat, Gerrit, Koschker, Ann-Cathrin, Kilic, Özlem, Lindenmeier, Gerd, Van de Loo, Iris, Lorenz, Babette, Lorenz, Elke, Löhr, Birgit, McChord, Johanna, Maslarska, Mariya, Methe, Heiko, Merkel, Martin, Moussaoui, Zineb, Müller-Kozarez, Irina, Olivier, Christoph B, Ong, Peter, Otte, Britta, Parhofer, Klaus, Partsch, Carl-Joachim, Paulus, Michael, Pehlivanli, Sinan, Pflederer, Tobias, Pusl, Thomas, Richter, Veronika, Rosner, Stefanie, Sanin, Veronika, Schäfer, Sebastian, Schäfer, Christoph, Schatz, Ulrike, Schirmer, Stephan, Schmidt, Christine, Seeger, Wolfgang, Sisovic, Snezna, Spens, Antje, Jablonski, Ksenija Stach, Stadelmann, Alexander, Steinhagen-Thiessen, Elisabeth, Stürzebecher, Paulina, Tafelmeier, Maria, Tillack, Dörthe, Tselmin, Sergey, Tünnemann-Tarr, Adrienn, Vogt, Anja, Beckerath, Jens von, Wilke, Andreas, Wolf, Ulrich, Zemmrich, Claudia, Rizos, Christos V., Skoumas, Ioannis, Tziomalos, Konstantinos, Rallidis, Loukianos, Kotsis, Vasileios, Doumas, Michalis, Athyros, Vasileios, Skalidis, Emmanouil, Kolovou, Genovefa, Kolovou, Vana, Garoufi, Anastasia, Bilianou, Eleni, Koutagiar, Iosif, Kiouri, Estela, Antza, Christina, Zacharis, Evangelos, Attilakos, Achilleas, Sfikas, George, Koumaras, Charalambos, Anagnostis, Panagiotis, Anastasiou, Georgia, Liamis, George, Koutsogianni, Amalia-Despoina, Petkou, Ermioni, Milionis, Haralambos, Koulouri, Anastasia, Prodromiadou, Elisavet, Karányi, Zsolt, Harangi, Mariann, Bajnok, László, Audikovszky, Mária, Márk, László, Benczúr, Béla, Reiber, István, Nagy, Gergely, Nagy, András, Reddy, Lakshmi Lavanya, Shah, Swarup A. V, Ponde, Chandrashekhar K., Dalal, Jamshed J., Sawhney, Jitendra P.S., Verma, Ishwar C., Altaey, Mays, Al-Jumaily, Khalid, Rasul, Dilshad, Abdalsahib, Ali Fawzi, Jabbar, Amer Abdl, Al-ageedi, Mohanad, Dhamin, Mohammed, AlFil, Sarmad, Khadhim, Foad, Miahy, Sabah, Agar, Ruth, Catapano, Alberico Luigi, Calandra, Sebastiano, Tarugi, Patrizia, Casula, Manuela, Galimberti, Federica, Olmastroni, Elena, Sarzani, Riccardo, Ferri, Claudio, Repetti, Elena, Piro, Salvatore, Suppressa, Patrizia, Meregalli, Giancarla, Borghi, Claudio, Muntoni, Sandro, Calabrò, Paolo, Cipollone, Francesco, Purrello, Francesco, Pujia, Arturo, Passaro, Angelina, Marcucci, Rossella, Pecchioli, Valerio, Pisciotta, Livia, Mandraffino, Giuseppe, Pellegatta, Fabio, Mombelli, Giuliana, Branchi, Adriana, Fiorenza, Anna Maria, Pederiva, Cristina, Werba, Josè Pablo, Parati, Gianfranco, Carubbi, Francesca, Iughetti, Lorenzo, Fortunato, Giuliana, Iannuzzi, Arcangelo, Iannuzzo, Gabriella, Cefalù, Angelo Baldassare, Biasucci, Giacomo, Zambon, Sabina, Pirro, Matteo, Sbrana, Francesco, Trenti, Chiara, D'Erasmo, Laura, Federici, Massimo, Ben, Maria Del, Bartuli, Andrea, Giaccari, Andrea, Pipolo, Antonio, Citroni, Nadia, Guardamagna, Ornella, Lia, Salvatore, Benso, Andrea, Biolo, Gianni, Maroni, Lorenzo, Lupi, Alessandro, Bonanni, Luca, Rinaldi, Elisabetta, Zenti, Maria Grazia, Matsuki, Kota, Hori, Mika, Ogura, Masatsune, Masuda, Daisaku, Kobayashi, Takuya, Nagahama, Kumiko, Al-Jarallah, Mohammed, Radovic, Mirjana, Lunegova, Olga, Bektasheva, Erkayim, Abilova, Saamay, Erglis, Andrejs, Gilis, Dainus, Nesterovics, Georgijs, Saripo, Vita, Meiere, Ruta, Skudrina, Gunda, Terauda, Elizabete, Jambart, Selim, Ayoub, Carine, Ghaleb, Youmna, Aliosaitiene, Urte, Kutkiene, Sandra, Abdul Kadir, Siti Hamimah Sheikh, Kasim, Noor Alicezah Mohd, Nor, Noor Shafina Mohd, Abdul Hamid, Hasidah, Abdul Razak, Suraya, Al-Khateeb, Alyaa, Abd Muid, Suhaila, Abdul Rahman, Thuhairah, Kasim, Sazzli Shahlan, Radzi, Ahmad Bakhtiar Md, Ibrahim, Khairul Shafiq, Rosli, Marshima Mohd, Razali, Rafezah, Chua, Yung An, Razman, Aimi Zafira, Nazli, Sukma Azureen, Aziz, Nazirul, Rosman, Azhari, Abdul Murad, NorAzian, Jalaludin, Mohd Amin, Abdul Latif, Ahmad Zubaidi, Azzopardi, C., Mehta, Roopa, Martagon, Alexandro J., Ramirez, Gabriela A. Galan, Villa, Neftali E Antonio, Vazquez, Arsenio Vargas, Elias-Lopez, Daniel, Retana, Gustavo Gonzalez, Rodriguez, Betsabel, Macías, Jose J. Ceballos, Zazueta, Alejandro Romero, Alvarado, Rocio Martinez, Portano, Julieta D. Morales, Lopez, Humberto Alvares, Sauque-Reyna, Leobardo, Herrera, Laura G. Gomez, Mendia, Luis E. Simental, Aguilar, Humberto Garcia, Cooremans, Elizabeth Ramirez, Aparicio, Berenice Peña, Zubieta, Victoria Mendoza, Gonzalez, Perla A. Carrillo, Ferreira-Hermosillo, Aldo, Portilla, Nacu Caracas, Dominguez, Guadalupe Jimenez, Garcia, Alinna Y. Ruiz, Cazares, Hector E. Arriaga, Gonzalez, Jesus R., Valencia, Carla V. Mendez, Padilla, Francisco G., Prado, Ramon Madriz, Ibarra, Manuel O. De los Rios, Villicaña, Ruy D. Arjona, Rivera, Karina J. Acevedo, Carrera, Ricardo Allende, Alvarez, Jose A., Martinez, Jose C. Amezcua, Bustillo, Manuel de los Reyes Barrera, Vargas, Gonzalo Carazo, Chacon, Roberto Contreras, Andrade, Mario H. Figueroa, Ortega, Ashanty Flores, Alcala, Hector Garcia, de Leon, Laura E. Garcia, Guzman, Berenice Garcia, Garcia, Jose J. Garduño, Cuellar, Juan C. Garnica, Cruz, Jose R. Gomez, Garcia, Anell Hernandez, Almada, Jesus R. Holguin, Herrera, Ursulo Juarez, Sobrevilla, Fabiola Lugo, Rodriguez, Eduardo Marquez, Sibaja, Cristina Martinez, Rodriguez, Alma B. Medrano, Oyervides, Jose C. Morales, Vazquez, Daniel I. Perez, Rodriguez, Eduardo A. Reyes, Osorio, Ma. Ludivina Robles, Saucedo, Juan Rosas, Tamayo, Margarita Torres, Talavera, Luis A. Valdez, Arroyo, Luis E. Vera, Carrillo, Eloy A. Zepeda, Stroes, Erik S, Defesche, J, Zuurbier, L, Reeskamp, L, Ibrahim, S, Roeters van Lennep, Jeanine, Wiegman, Albert, Isara, Alphonsus, Obaseki, Darlington E., Al-Waili, Khalid, Al-Zadjali, Fahad, Al-Zakwani, Ibrahim, Al-Kindi, Mohammed, Al-Mukhaini, Suad, Al-Barwani, Hamida, Rana, Asim, Shah, Lahore Saeed Ullah, Al-Nouri, Fahad, Starostecka, Ewa, Konopka, Agnieszka, Bielecka-Dabrowa, Agata, Lewek, Joanna, Sosnowska, Bozena, Gąsior, Mariusz, Dyrbuś, Krzysztof, Jóźwiak, Jacek, Pajkowski, Marcin, Romanowska-Kocejko, Marzena, Żarczyńska-Buchowiecka, Marta, Chmara, Magdalena, Wasąg, Bartosz, Stróżyk, Aneta, Michalska-Grzonkowska, Aleksandra, Medeiros, Ana Margarida, Alves, Ana Catarina, Silva, Francisco, Lobarinhas, Goreti, Palma, Isabel, de Moura, Jose Pereira, Rico, Miguel Toscano, Rato, Quitéria, Pais, Patrícia, Correia, Susana, Moldovan, Oana, Virtuoso, Maria João, Araujo, Francisco, Salgado, Jose Miguel, Colaço, Ines, Dumitrescu, Andreea, Lengher, Calin, Mosteoru, Svetlana, Meshkov, Alexey, Ershova, Alexandra, Rozhkova, Tatiana, Korneva, Victoria, Yu, Kuznetsova T., Zafiraki, Vitaliy, Voevoda, Mikhail, Gurevich, Victor, Duplyakov, Dmitry, Ragino, Yulia, Chubykina, Uliana, Shaposhnik, Igor, Alkaf, Fahmi, Khudari, Alia, Rwaili, Nawal, Al-Allaf, Faisal, Alghamdi, Mohammad, Batais, Mohammed A, Almigbal, Turky H, Kinsara, Abdulhalim, AlQudaimi, Ashraf Hammouda Ahmed, Awan, Zuhier, Elamin, Omer A, Altaradi, Hani, Popovic, Ljiljana, Singh, Sandra, Rasulic, Iva, Petakov, Ana, Lalic, Nebojsa M., Lam, Carolyn, Le, Tan Ju, Siang, Eric Lim Tien, Dissanayake, Sanjaya, I-Shing, Justin Tang, Shyong, Tai E, Jin, Terrance Chua Siang, Ting, Sharon Pek Li, Ming, Jeremy Hoe Kian, Drum, Chester Lee, Nastar, Fathima Ashna, Jia, Loh Wann, Ya, Natalie Koh Si, Jie, Marvin Chua Wei, Dalan, Rinkoo, Wei, Yong Quek, sian, Tiong Yee, Keong, Yeo Khung, Rong, Siau Kai, Jin, Darren Seah Ee, Ming, Ian Koh Jan, Chang, Tan Hong, Peng, Fabian Yap Kok, Vasanwala, Rashida Farhad, Raslova, Katarina, Balinth, Karin, Buganova, Ingrid, Fabryova, Lubomira, Kadurova, Michaela, Klabnik, Alexander, Kozárová, Miriam, Sirotiakova, Jana, Battelino, Tadej, Cevc, Matija, Debeljak, Marusa, Torkar, Ana Drole, Fras, Zlatko, Jug, Borut, Cugalj, Barbara Kern, Kovac, Jernej, Mlinaric, Matej, Sikonja, Jaka, Pilcher, Gillian Joan, Blom, D J, Wolmarans, K H, Brice, B C, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose Luis, de Isla, Leopoldo Pérez, Fuentes, Francisco, Badimon, Lina, Martin, François, Miserez, Eleonore B., Shipton, Janine L., Ganokroj, Poranee, Chattranukulchai, Pairoj, Jiamjarasrungsi, Wiroj, Thongtang, Nuntakorn, Krittayaphong, Rungroj, Vathesatogkit, Prin, Sriphrapradang, Chutintorn, Phimphilai, Mattabhorn, Leelawattana, Rattana, Anthanont, Pimjai, Suraamornkul, Swangjit, Deerochanawong, Chaicharn, Senthong, Vichai, Torpongpun, Artit, Suteerayongprasert, Panuwat, Pengpong, Nawarat, Sathavarodom, Nattapol, Sunanta, Usanee, Porntharukchareon, Thachanun, Kiatpanabhikul, Phatharaporn, Kaewkrasaesin, Chatchon, Kongkit, Jaruwan, Umphonsathien, Mongkontida, Akbulut, Mehmet, Alici, Gökhan, Bayram, Fahri, Can, Levent Hürkan, Celik, Ahmet, Ceyhan, Ceyhun, Coskun, Fatma Yilmaz, Demir, Mesut, Demircan, Sabri, Dogan, Volkan, Durakoglugil, Emre, Dural, İbrahim Etem, Gedikli, Omer, Hacioglu, Aysa, Ildizli, Muge, Kilic, Salih, Kirilmaz, Bahadir, Kutlu, Merih, Oguz, Aytekin, Ozdogan, Oner, Onrat, Ersel, Ozer, Savas, Sabuncu, Tevfik, Sahin, Tayfun, Sivri, Fatih, Sonmez, Alper, Temizhan, Ahmet, Topcu, Selim, Tokgozoglu, Lale, Tuncez, Abdullah, Vural, Mirac, Yenercag, Mustafa, Yesilbursa, Dilek, Yigit, Zerrin, Yildirim, Aytul Belgi, Yildirir, Aylin, Yilmaz, Mehmet Birhan, Atallah, Bassam, Traina, Mahmoud, Sabbour, Hani, Abdul Hay, Dana, Luqman, Neama, Elfatih, Abubaker, Abdulrasheed, Arshad, Manla, Yosef, Kwok, See, DellOca, Nicolas, Alieva, Rano B., Fozilov, Khurshid G., Hoshimov, Shavkat U., Nizamov, Ulugbek I., Kan, Liliya E., Kim, Andrey R., Abdullaeva, Guzal J., Abdullaev, Alisher A., Do, Doan Loi, Nguyen, Mai Ngoc Thi, Kim, Ngoc Thanh, Le, Thanh Tung, Le, Hong An, and Ray, Kausik K.
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- 2024
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7. Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology
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Bonifay, Amandine, Mackman, Nigel, Hisada, Yohei, Sachetto, Ana Teresa Azevedo, Hau, Chi, Gray, Elaine, Hogwood, John, Aharon, Anat, Badimon, Lina, Barile, Lucio, Baudar, Justine, Beckmann, Lennart, Benedikter, Birke, Bolis, Sara, Bouriche, Tarik, Brambilla, Marta, Burrello, Jacopo, Camera, Marina, Campello, Elena, Ettelaie, Camille, Faille, Dorothée, Featherby, Sophie, Franco, Corentin, Guldenpfennig, Maite, Hansen, John-Bjarne, Judicone, Coralie, Kim, Yohan, Kristensen, Soren Risom, Laakmann, Katrin, Langer, Florian, Latysheva, Nadezhda, Lucien, Fabrice, de Menezes, Erika Marques, Mullier, François, Norris, Philip, Nybo, Jette, Orbe, Josune, Osterud, Bjarne, Paramo, Jose A., Radu, Claudia M., Roncal, Carmen, Samadi, Nazanin, Snir, Omri, Suades, Rosa, Wahlund, Casper, Chareyre, Corinne, Abdili, Evelyne, Martinod, Kimberly, Thaler, Johannes, Dignat-George, Françoise, Nieuwland, Rienk, and Lacroix, Romaric
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- 2024
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8. CD66b+/CD68+ circulating extracellular vesicles, lactate dehydrogenase and neutrophil‐to‐lymphocyte ratio can differentiate coronavirus disease 2019 severity during and after infection
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Rosa Suades, Maria Francesca Greco, Paula Prieto, Teresa Padró, Yvan Devaux, Pere Domingo, and Lina Badimon
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coronavirus disease 2019 ,extracellular vesicles ,inflammatory markers ,microvesicles ,severe acute respiratory syndrome coronavirus‐2 ,Cytology ,QH573-671 - Abstract
Abstract Coronavirus disease 2019 (COVID‐19) has been a major public health burden. We hypothesised that circulating extracellular vesicles (cEVs), key players in health and disease, could trace the cell changes during COVID‐19 infection and recovery. Therefore, we studied the temporal trend of cEV and inflammatory marker levels in plasma samples of COVID‐19 patients that were collected within 24 h of patient admission (baseline, n = 80) and after hospital discharge at day‐90 post‐admission (n = 59). Inflammatory markers were measured by standard biochemical methods. cEVs were quantitatively and phenotypically characterized by high‐sensitivity nano flow cytometry. In patients recovered from COVID‐19 lower levels of inflammatory markers were detected. cEVs from vascular (endothelial cells) and blood (platelets, distinct immune subsets) cells were significantly reduced at day‐90 compared to admission levels, a pattern also observed for cEVs from progenitor, perivascular and epithelial cells. The best discriminatory power for COVID‐19 severity was found for inflammatory markers lactate dehydrogenase and neutrophil‐to‐lymphocyte ratio and for granulocyte/macrophage‐released CD66b+/CD68+‐cEVs. Albeit inflammatory markers were good indicators of systemic inflammatory response and discriminators of COVID‐19 remission, they do not completely reveal cell stress and organ damage states. cEVs reaching baseline pre‐infection levels at 90 days post‐infection in recovered patients discriminate parental cells affected by disease.
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- 2024
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9. Long-term sex differences in atherosclerotic cardiovascular disease in individuals with heterozygous familial hypercholesterolaemia in Spain: a study using data from SAFEHEART, a nationwide, multicentre, prospective cohort study
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de Isla, Leopoldo Pérez, Vallejo-Vaz, Antonio J, Watts, Gerald F, Muñiz-Grijalvo, Ovidio, Alonso, Rodrigo, Diaz-Diaz, Jose L, Arroyo-Olivares, Raquel, Aguado, Rocio, Argueso, Rosa, Mauri, Marta, Romero, Manuel J, Álvarez-Baños, Pilar, Mañas, Dolores, Cepeda, José María, Gonzalez-Bustos, Pablo, Casañas, Marta, Michan, Alfredo, Muñoz-Torrero, Juan F Sánchez, Faedo, Ceferino, Barba, Miguel A, Dieguez, Marta, de Andrés, Raimundo, Hernandez, Antonio M, Gonzalez-Estrada, Aurora, Padró, Teresa, Fuentes, Francisco, Badimon, Lina, and Mata, Pedro
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- 2024
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10. Empagliflozin effects on iron metabolism as a possible mechanism for improved clinical outcomes in non-diabetic patients with systolic heart failure
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Angermann, Christiane E., Santos-Gallego, Carlos G., Requena-Ibanez, Juan Antonio, Sehner, Susanne, Zeller, Tanja, Gerhardt, Louisa M. S., Maack, Christoph, Sanz, Javier, Frantz, Stefan, Fuster, Valentin, Ertl, Georg, and Badimon, Juan J.
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- 2023
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11. The efficacy of intensive lipid-lowering therapies on the reduction of LDLc and of major cardiovascular events
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Cordero, Alberto, Fernández Olmo, Rosa, Badimon, Lina, Santos-Gallego, Carlos G., Castellano, José M., Fácila, Lorenzo, Rodriguez-Manero, Moisés, Bonanad, Clara, Vilahur, Gemma, Escribano, David, Badimon, Juan J., and González-Juanatey, José R.
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- 2023
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12. New approaches to triglyceride reduction: Is there any hope left?
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Filtz, Annalisa, Parihar, Siddhant, Greenberg, Garred S., Park, Christine M., Scotti, Andrea, Lorenzatti, Daniel, Badimon, Juan J, Soffer, Daniel E., Toth, Peter P., Lavie, Carl J., Bittner, Vera, Virani, Salim S., and Slipczuk, Leandro
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- 2024
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13. Circulating miR-6821-5p levels and coronary calcification in asymptomatic familial hypercholesterolemia patients
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Escate, Rafael, Padró, Teresa, Pérez de Isla, Leopoldo, Fuentes, Francisco, Alonso, Rodrigo, Mata, Pedro, and Badimon, Lina
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- 2024
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14. Antithrombotic and prohemorrhagic actions of different concentrations of apixaban in patients exposed to single and dual antiplatelet regimens
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Julia Martinez-Sanchez, Leticia Castrillo, Didac Jerez, Sergi Torramade-Moix, Marta Palomo, Guiomar Mendieta, M. Urooj Zafar, Ana Belén Moreno-Castaño, Pablo Sanchez, Juan Jose Badimon, Maribel Diaz-Ricart, Gines Escolar, and Mercè Roqué
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Medicine ,Science - Abstract
Abstract We evaluated modifications in the hemostatic balance of different concentrations of apixaban (APIX) in 25 healthy donors and 53 patients treated with aspirin (ASA, n = 21), ASA and clopidogrel (ASA + CLOPI, n = 11), or ASA and ticagrelor (ASA + TICA, n = 21). Blood samples from participants were spiked ex vivo with apixaban 0 (APIX0), 40 (APIX40), and 160 ng/mL (APIX160). We assessed the effects of APIX on (1) clot formation, by ROTEM thromboelastometry; (2) thrombin generation primed by platelets; and (3) platelet and fibrin interactions with a thrombogenic surface, in a microfluidic model with circulating blood. APIX caused dose-related prolongations of clotting time with minimal impact on other ROTEM parameters. Thrombin generation was significantly inhibited by APIX160, with ASA + TICA actions showing the strongest inhibition (p
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- 2023
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15. Traditional risk factors and premature acute coronary syndromes in South Eastern Europe: a multinational cohort study
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Bugiardini, Raffaele, Cenko, Edina, Yoon, Jinsung, Bergami, Maria, Vasiljevic, Zorana, Mendieta, Guiomar, Zdravkovic, Marija, Vavlukis, Marija, Kedev, Sasko, Miličić, Davor, Badimon, Lina, and Manfrini, Olivia
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- 2024
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16. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial
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Alcala-Diaz, Juan F, Almaden Peña, Yolanda, Aranda, Enrique, Arenas de Larriva, Antonio P, Badimon, Lina, Badimon, Juan J, Blanco-Molina, Angeles, Blanco-Rojo, Ruth, Bolivar-Muñoz, Julia, Caballero-Villarraso, Javier, Camargo, Antonio, Chica, Javier, Corina, Andreea, Criado-Garcia, Juan, Cruz-Teno, Cristina, Daponte-Codina, Antonio, de Teresa Galvan, Eduardo, Delgado-Casado, Nieves, Delgado-Lista, Javier, Estruch, Ramon, Fernandez, Juan M, Fernandez-Gandara, Carolina, Fuentes-Jimenez, Francisco, Garcia-Carpintero Fernandez-Pacheco, Sonia, Garcia-Rios, Antonio, Gomez-Delgado, Francisco, Gomez-Garduño, Angela, Gomez-Luna, Purificacion, Gomez-Luna, Maria J, Gonzalez-Guardia, Lorena, Gonzalez-Requero, Ana I., Gutierrez-Mariscal, Francisco M, Haro-Mariscal, Carmen M, Jimenez-Lucena, Rosa, Jimenez-Morales, Ana I., Leon-Acuña, Ana, Lopez-Miranda, Jose, Lopez-Segura, Fernando, Marin-Hinojosa, Carmen, Meneses Alvarez, Maria E, Mesa-Luna, Dolores, Moya-Garrido, Maria N, Muñoz-Carvajal, Ignacio, Navarro-Martos, Vanessa, Ochoa, Juan J, Ordovas, Jose M, Ortiz-Minuesa, Juan A, Ortiz-Morales, Ana M, Pan, Manuel, Peña-Orihuela, Patricia, Perez-Caballero, Ana I, Perez-Corral, Isabel, Perez-Jimenez, Francisco, Perez-Martinez, Pablo, Pi-Sunyer, Francesc X, Quintana-Navarro, Gracia M, Ramirez-Lara, Irene, Rangel-Zuñiga, Oriol A, Rodriguez-Artalejo, Fernando, Rodriguez-Cantalejo, Fernando, Romero, Miguel A, Roncero-Ramos, Irene, Ruano-Ruiz, Juan A., Ruiz de Castroviejo, Joaquin, Sanchez-Villegas, Pablo, Suarez de Lezo, Jose, Suarez de Lezo, Javier, Torres-Peña, Jose D, Vals-Delgado, Cristina, Valverde, Roberto, Visioli, Francisco, Yubero-Serrano, Elena M, Fuentes, Francisco, and Gonzalez-Requero, Ana I
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- 2022
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17. Changes in circulating ApoJ-Glyc levels in patients with suspected acute coronary syndrome: The EDICA trial
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Kaski, Juan Carlos, Lluch, Nuria, Lopez-Sendon, Jose-Luis, Gorog, Diana A., Antorrena-Miranda, Isabel, Avanzas, Pablo, Herrero Puente, Pablo, Sionis, Alessandro, González-Juanatey, José R., Íñiguez, Andrés, Cordero, Alberto, Ako, Emmanuel, Fernández-Avilés, Francisco, Atienza, Felipe, Recio-Mayoral, Alejandro, Wu, Alan H.B., Crea, Filippo, Storey, Robert, Badimon, Lina, and Cubedo, Judit
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- 2023
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18. Uncovering the Role of Epicardial Adipose Tissue in Heart Failure With Preserved Ejection Fraction
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Goldman, Sarah A., Requena-Ibanez, Juan Antonio, Devesa, Ana, Santos-Gallego, Carlos G., Badimon, Juan José, and Fuster, Valentin
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- 2023
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19. Update of HDL in atherosclerotic cardiovascular disease
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Schoch, Leonie, Alcover, Sebastián, Padró, Teresa, Ben-Aicha, Soumaya, Mendieta, Guiomar, Badimon, Lina, and Vilahur, Gemma
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- 2023
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20. ¿Qué es el riesgo cardiovascular residual? Etiología, lípidos e inflamación
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Badimon, Lina, Vilahur, Gemma, Padro, Teresa, and Mendieta, Guiomar
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- 2023
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21. Sex Differences in Heart Failure Following Acute Coronary Syndromes
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Cenko, Edina, Manfrini, Olivia, Yoon, Jinsung, van der Schaar, Mihaela, Bergami, Maria, Vasiljevic, Zorana, Mendieta, Guiomar, Stankovic, Goran, Vavlukis, Marija, Kedev, Sasko, Miličić, Davor, Badimon, Lina, and Bugiardini, Raffaele
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- 2023
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22. The Influence of Metabolic Risk Factors on the Inflammatory Response Triggered by Myocardial Infarction: Bridging Pathophysiology to Treatment
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Lisaidy Ramos-Regalado, Sebastià Alcover, Lina Badimon, and Gemma Vilahur
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myocardial infarction ,inflammatory response ,innate immune response ,bone marrow ,spleen ,metabolic risk factors ,Cytology ,QH573-671 - Abstract
Myocardial infarction (MI) sets off a complex inflammatory cascade that is crucial for effective cardiac healing and scar formation. Yet, if this response becomes excessive or uncontrolled, it can lead to cardiovascular complications. This review aims to provide a comprehensive overview of the tightly regulated local inflammatory response triggered in the early post-MI phase involving cardiomyocytes, (myo)fibroblasts, endothelial cells, and infiltrating immune cells. Next, we explore how the bone marrow and extramedullary hematopoiesis (such as in the spleen) contribute to sustaining immune cell supply at a cardiac level. Lastly, we discuss recent findings on how metabolic cardiovascular risk factors, including hypercholesterolemia, hypertriglyceridemia, diabetes, and hypertension, disrupt this immunological response and explore the potential modulatory effects of lifestyle habits and pharmacological interventions. Understanding how different metabolic risk factors influence the inflammatory response triggered by MI and unraveling the underlying molecular and cellular mechanisms may pave the way for developing personalized therapeutic approaches based on the patient’s metabolic profile. Similarly, delving deeper into the impact of lifestyle modifications on the inflammatory response post-MI is crucial. These insights may enable the adoption of more effective strategies to manage post-MI inflammation and improve cardiovascular health outcomes in a holistic manner.
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- 2024
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23. Comparison of a human acellular dermal matrix and a polypropylene mesh for pelvic floor reconstruction: a randomized trial study in a rabbit model
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Marta Pero, Cristina Castells-Sala, Leticia Alserawan, Laura Casani, Josep Oriol Juan Babot, Ignasi Jorba, Maria Luisa Pérez, Esther Moga, Jorge Otero, Patricia López-Chicón, Lina Badimon, Anna Vilarrodona Serrat, and Oriol Porta-Roda
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Medicine ,Science - Abstract
Abstract Non-absorbable polypropylene (PP) meshes have been widely used in surgical reconstruction of the pelvic floor disorders. However, they are associated with serious complications. Human acellular dermal matrices (hADM) have demonstrated safety and efficacy in reconstructive medicine, but their suitability and efficacy at vaginal level is not known. This study compares the biological performance of PP mesh and a newly developed hADM. 20 rabbits were randomized to receive the hADM graft or the PP mesh. Grafts were surgically implanted in the abdominal wall and vagina. After 180 days, grafts were explanted and evaluated. The vaginal mesh extrusion rate was higher in the PP group (33% vs. 0%, p = 0.015). Full integration of the vaginal grafts was more frequent in the hADM group, where 35% of the grafts were difficult to recognize. In the PP group, the vaginal mesh was identified in 100% of the animals (p = 0.014). In PP group, the infiltrates had a focal distribution and were mostly located in the internal part of the epithelium, while in the hADM group, the infiltrates had a diffuse distribution. Additionally, the hADM group also presented more B-lymphocytes and less T-lymphocytes. Biomechanical analysis showed that hADM had lower resistance to stress. Moreover, PP mesh stiffness and elasticity were higher. Then, hADM is associated with fewer clinical complications, as well as better tissue integration. However, it shows greater incorporation into the surrounding native tissue, especially in the vaginal location, undergoing a reduction in its biomechanical properties 6 months after implantation.
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- 2022
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24. Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID‐19 and Preexisting Cardiovascular Disease
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Maria Bergami, Olivia Manfrini, Stefano Nava, Gaetano Caramori, Jinsung Yoon, Lina Badimon, Edina Cenko, Antonio David, Ilir Demiri, Maria Dorobantu, Natalia Fabin, Oana Gheorghe‐Fronea, Radmilo Jankovic, Sasko Kedev, Nebojsa Ladjevic, Ratko Lasica, Goran Loncar, Giuseppe Mancuso, Guiomar Mendieta, Davor Miličić, Petra Mjehović, Marijan Pašalić, Milovan Petrović, Lidija Poposka, Marialuisa Scarpone, Milena Stefanovic, Mihaela van der Schaar, Zorana Vasiljevic, Marija Vavlukis, Maria Laura Vega Pittao, Vladan Vukomanovic, Marija Zdravkovic, and Raffaele Bugiardini
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acute heart failure ,azithromycin ,cardiovascular diseases ,COVID‐19 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Empiric antimicrobial therapy with azithromycin is highly used in patients admitted to the hospital with COVID‐19, despite prior research suggesting that azithromycin may be associated with increased risk of cardiovascular events. Methods and Results This study was conducted using data from the ISACS‐COVID‐19 (International Survey of Acute Coronavirus Syndromes‐COVID‐19) registry. Patients with a confirmed diagnosis of SARS‐CoV‐2 infection were eligible for inclusion. The study included 793 patients exposed to azithromycin within 24 hours from hospital admission and 2141 patients who received only standard care. The primary exposure was cardiovascular disease (CVD). Main outcome measures were 30‐day mortality and acute heart failure (AHF). Among 2934 patients, 1066 (36.4%) had preexisting CVD. A total of 617 (21.0%) died, and 253 (8.6%) had AHF. Azithromycin therapy was consistently associated with an increased risk of AHF in patients with preexisting CVD (risk ratio [RR], 1.48 [95% CI, 1.06–2.06]). Receiving azithromycin versus standard care was not significantly associated with death (RR, 0.94 [95% CI, 0.69–1.28]). By contrast, we found significantly reduced odds of death (RR, 0.57 [95% CI, 0.42–0.79]) and no significant increase in AHF (RR, 1.23 [95% CI, 0.75–2.04]) in patients without prior CVD. The relative risks of death from the 2 subgroups were significantly different from each other (Pinteraction=0.01). Statistically significant association was observed between AHF and death (odds ratio, 2.28 [95% CI, 1.34–3.90]). Conclusions These findings suggest that azithromycin use in patients with COVID‐19 and prior history of CVD is significantly associated with an increased risk of AHF and all‐cause 30‐day mortality. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT05188612.
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- 2023
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25. SGLT2i in heart failure: can their benefits be expanded across the entire spectrum of ejection fraction?
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Requena-Ibáñez, Juan Antonio, Santos-Gallego, Carlos G., and Badimón, Juan José
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- 2022
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26. Los iSGLT2 en la insuficiencia cardiaca. ¿Sus beneficios pueden extenderse a todo el espectro de la fracción de eyección?
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Requena-Ibáñez, Juan Antonio, Santos-Gallego, Carlos G., and Badimón, Juan José
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- 2022
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27. DJ-1 interacts with the ectopic ATP-synthase in endothelial cells during acute ischemia and reperfusion
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Alex Gallinat and Lina Badimon
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Medicine ,Science - Abstract
Abstract Endothelial cells (ECs) play a central role in ischemia. ATP-Synthase is now recognized to be ectopically expressed in the cell surface of many cell types, with putative roles described in angiogenesis, proliferation, and intracellular pH regulation. DJ-1 is a multifunctional protein, involved in cell protection against ischemia, ischemia–reperfusion (I/R), and oxidative stress, that regulates mitochondrial ATP-synthase. Here we focused on the characterization of the endothelial dynamics of DJ-1, and its implication in the regulation of the ectopic ATP-synthase (ecATP-S) activity, during acute ischemia and I/R in ECs. We found that DJ-1 is secreted from ECs, by a mechanism enhanced in ischemia and I/R. A cleaved form of DJ-1 (DJ-1∆C) was found only in the secretome of ischemic cells. The ecATP-S activity increased following acute ischemia in ECs, coinciding with DJ-1 and DJ-1∆C secretion. The inhibition of DJ-1 expression inhibited the ecATP-S response to ischemia by ∼ 50%, and its exogenous administration maximized the effect, together with an enhanced Akt phosphorylation and angiotube-formation potential at reperfusion. Immunoprecipitation studies showed direct interaction between DJ-1 and the ecATP-S. Altogether suggesting that DJ-1 is actively cleaved and released from ischemic ECs and plays an important role in the regulation of the ecATP-S activity during acute ischemia and reperfusion.
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- 2022
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28. Acute effect of coffee on arterial stiffness and endothelial function in overweight and obese individuals: A randomized clinical trial
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Pavão, Tábata P., Chemello, Diego, Ferigollo, Ariélen, Saffi, Marco Aurélio Lumertz, Moresco, Rafael Noal, Stein, Carolina dos Santos, Emanuelli, Tatiana, Somacal, Sabrina, Moriguchi, Emilio Hideyuki, Badimon, Lina, and Chagas, Patrícia
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- 2022
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29. Probiotics: A Potential Strategy for Preventing and Managing Cardiovascular Disease.
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López-Yerena, Anallely, de Santisteban Villaplana, Victoria, Badimon, Lina, Vilahur, Gemma, and Padro, Teresa
- Abstract
Probiotics are gaining recognition as a viable strategy for mitigating cardiovascular risk factors. Specifically, recent studies highlight their potential benefits in managing cholesterol levels, blood pressure, and inflammation, which are critical components in the prevention of cardiovascular diseases (CVD). This comprehensive review aims to elucidate the impact of probiotic consumption on major cardiovascular risk factors, including individuals with hypertension, type II diabetes mellitus, metabolic syndrome, hypercholesterolemia, and in secondary prevention in coronary artery disease. Scientific evidence based on human studies suggests that probiotic consumption is associated with positive effects on anthropometric measures, inflammation markers, blood pressure, glucose metabolism markers, lipid profiles, and endothelial function. However, these findings should be interpreted pragmatically and acknowledge the significant variability in results. This variability may be attributed to factors such as probiotic composition (single strain or multiple strains), the characteristics of the delivery matrix (food, capsules, and sachets), the duration of the intervention, the dosage regimen, and baseline health profiles of the participants. Incorporating probiotics as part of a comprehensive and healthy lifestyle approach can be considered a feasible strategy for both the prevention and management of CVD. However, further research is needed on factors influencing the effect of probiotics, such as: (i) optimal probiotic strain(s), (ii) appropriate dosage, (iii) duration of treatment, (iv) optimal delivery vehicle, and (v) sex-specific differences. [ABSTRACT FROM AUTHOR]
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- 2025
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30. Differentiation of Adipose Tissue Mesenchymal Stem Cells into Endothelial Cells Depends on Fat Depot Conditions: Regulation by miRNA
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Gemma Arderiu, Anna Civit-Urgell, Alberto Díez-Caballero, Fabrizio Moscatiello, Carlos Ballesta, and Lina Badimon
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adipose tissue ,miRNAs ,angiogenesis ,ASCs ,endothelial cells ,Cytology ,QH573-671 - Abstract
The development of obesity is associated with substantial modulation of adipose tissue (AT) structure. The plasticity of the AT is reflected by its remarkable ability to expand or reduce in size throughout the adult lifespan, which is linked to the development of its vasculature. This increase in AT vasculature could be mediated by the differentiation of adipose tissue-derived stem cells (ASCs) into endothelial cells (ECs) and form new microvasculature. We have already shown that microRNA (miRNA)-145 regulates the differentiation of ASCs into EC-like (ECL) cells. Here, we investigated whether ASCs-differentiation into ECs is governed by a miRNAs signature that depends on fat depot location and /or the metabolic condition produced by obesity. Human ASCs, which were obtained from white AT by surgical procedures from lean and obese patients, were induced to differentiate into ECL cells. We have identified that miRNA-29b-3p in both subcutaneous (s)ASCs and visceral ASCs and miRNA-424-5p and miRNA-378a-3p in subcutaneous (s)ASCs are involved in differentiation into EC-like cells. These miRNAs modulate their pro-angiogenic effects on ASCs by targeting FGFR1, NRP2, MAPK1, and TGF-β2, and the MAPK signaling pathway. We show for the first time that miRNA-29b-3p upregulation contributes to ASCs’ differentiation into ECL cells by directly targeting TGFB2 in both sASCs and visceral ASCs. Moreover, our results reveal that, independent of sASCs’ origin (obese/lean), the upregulation of miRNA-378a-3p and the downregulation of miRNA-424-5p inhibit MAPK1 and overexpress FGFR1 and NRP2, respectively. In summary, both the adipose depot location and obesity affect the differentiation of resident ASCs through the expression of specific miRNAs.
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- 2024
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31. Effects of electret coating technology on coronary stent thrombogenicity
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M. Urooj Zafar, Jose Javier Bravo-Cordero, Sergi Torramade-Moix, Gines Escolar, Didac Jerez-Dolz, Eli I. Lev, and Juan Jose Badimon
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electret ,platelet ,stent ,stent coating ,thrombosis ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Stent thrombosis (ST) is a catastrophic event and efforts to reduce its incidence by altering blood-stent interactions are longstanding. A new electret coating technology that produces long-lasting negative charge on stent surface could make them intrinsically resistant to thrombosis. We assessed the thrombogenicity of stents using an annular perfusion model with confocal microscopy, and determined the efficacy of electret coating technology to confer thrombo-resistant properties to standard stents. Using an annular perfusion chamber, Bare Metal Stent (BMS), standard uncoated DES (DES), and Electret-coated DES (e-DES) were exposed to human blood under arterial flow conditions. Deposits of fibrinogen and platelets on the stent surface were analyzed using immunofluorescence staining and confocal microscopy. Surface coverage by fibrinogen and platelets and the deposit/aggregate size were quantified using computerized morphometric analysis. The experimental methodology produced consistent, quantifiable results. Area of stent surface covered by fibrinogen and platelets and the average size of the deposits/aggregates were lowest for e-DES and highest on BMS, with DES in the middle. The size of fibrinogen–deposits showed no differences between the stents. The testing methodology used in our study successfully demonstrated that electret coating confers significant antithrombotic property to DES stents. These findings warrant confirmation in a larger study.
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- 2022
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32. Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
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Vallejo-Vaz, Antonio J., Stevens, Christophe A.T., Lyons, Alexander R.M., Dharmayat, Kanika I., Freiberger, Tomas, Hovingh, G. Kees, Mata, Pedro, Raal, Frederick J., Santos, Raul D., Soran, Handrean, Watts, Gerald F., Abifadel, Marianne, Aguilar-Salinas, Carlos A., Alhabib, Khalid F., Alkhnifsawi, Mutaz, Almahmeed, Wael, Alnouri, Fahad, Alonso, Rodrigo, Al-Rasadi, Khalid, Al-Sarraf, Ahmad, Al-Sayed, Nasreen, Araujo, Francisco, Ashavaid, Tester F., Banach, Maciej, Béliard, Sophie, Benn, Marianne, Binder, Christoph J., Bogsrud, Martin P., Bourbon, Mafalda, Chlebus, Krzysztof, Corral, Pablo, Davletov, Kairat, Descamps, Olivier S., Durst, Ronen, Ezhov, Marat, Gaita, Dan, Genest, Jacques, Groselj, Urh, Harada-Shiba, Mariko, Holven, Kirsten B., Kayikcioglu, Meral, Khovidhunkit, Weerapan, Lalic, Katarina, Latkovskis, Gustavs, Laufs, Ulrich, Liberopoulos, Evangelos, Lima-Martinez, Marcos M., Lin, Jie, Maher, Vincent, Marais, A. David, März, Winfried, Mirrakhimov, Erkin, Miserez, André R., Mitchenko, Olena, Nawawi, Hapizah, Nordestgaard, Børge G., Panayiotou, Andrie G., Paragh, György, Petrulioniene, Zaneta, Pojskic, Belma, Postadzhiyan, Arman, Raslova, Katarina, Reda, Ashraf, Reiner, Željko, Sadiq, Fouzia, Sadoh, Wilson Ehidiamen, Schunkert, Heribert, Shek, Aleksandr B., Stoll, Mario, Stroes, Erik, Su, Ta-Chen, Subramaniam, Tavintharan, Susekov, Andrey V., Tilney, Myra, Tomlinson, Brian, Truong, Thanh Huong, Tselepis, Alexandros D., Tybjærg-Hansen, Anne, Vázquez Cárdenas, Alejandra, Viigimaa, Margus, Wang, Luya, Yamashita, Shizuya, Kastelein, John J.P., Bruckert, Eric, Vohnout, Branislav, Schreier, Laura, Pang, Jing, Ebenbichler, Christoph, Dieplinger, Hans, Innerhofer, Reinhold, Winhofer-Stöckl, Yvonne, Greber-Platzer, Susanne, Krychtiuk, Konstantin, Speidl, Walter, Toplak, Hermann, Widhalm, Kurt, Stulnig, Thomas, Huber, Kurt, Höllerl, Florian, Rega-Kaun, Gersina, Kleemann, Lucas, Mäser, Martin, Scholl-Bürgi, Sabine, Säly, Christoph, Mayer, Florian J., Sablon, Gaelle, Tarantino, Eric, Nzeyimana, Charlotte, Pojskic, Lamija, Sisic, Ibrahim, Nalbantic, Azra D., Jannes, Cinthia E., Pereira, Alexandre C., Krieger, Jose E., Petrov, Ivo, Goudev, Assen, Nikolov, Fedya, Tisheva, Snejana, Yotov, Yoto, Tzvetkov, Ivajlo, Baass, Alexis, Bergeron, Jean, Bernard, Sophie, Brisson, Diane, Brunham, Liam R., Cermakova, Lubomira, Couture, Patrick, Francis, Gordon A., Gaudet, Daniel, Hegele, Robert A., Khoury, Etienne, Mancini, G.B. John, McCrindle, Brian W., Paquette, Martine, Ruel, Isabelle, Cuevas, Ada, Asenjo, Sylvia, Wang, Xumin, Meng, Kang, Song, Xiantao, Yong, Qiang, Jiang, Tao, Liu, Ziyou, Duan, Yanyu, Hong, Jing, Ye, Pucong, Chen, Yan, Qi, Jianguang, Liu, Zesen, Li, Yuntao, Zhang, Chaoyi, Peng, Jie, Yang, Ya, Yu, Wei, Wang, Qian, Yuan, Hui, Cheng, Shitong, Jiang, Long, Chong, Mei, Jiao, Jian, Wu, Yue, Wen, Wenhui, Xu, Liyuan, Zhang, Ruiying, Qu, Yichen, He, Jianxun, Fan, Xuesong, Wang, Zhenjia, Chow, Elaine, Pećin, Ivan, Perica, Dražen, Symeonides, Phivos, Vrablik, Michal, Ceska, Richard, Soska, Vladimir, Tichy, Lukas, Adamkova, Vera, Franekova, Jana, Cifkova, Renata, Kraml, Pavel, Vonaskova, Katerina, Cepova, Jana, Dusejovska, Magdalena, Pavlickova, Lenka, Blaha, Vladimir, Rosolova, Hana, Nussbaumerova, Barbora, Cibulka, Roman, Vaverkova, Helena, Cibickova, Lubica, Krejsova, Zdenka, Rehouskova, Katerina, Malina, Pavel, Budikova, Milena, Palanova, Vaclava, Solcova, Lucie, Lubasova, Alena, Podzimkova, Helena, Bujdak, Juraj, Vesely, Jiri, Jordanova, Marta, Salek, Tomas, Urbanek, Robin, Zemek, Stanislav, Lacko, Jan, Halamkova, Hana, Machacova, Sona, Mala, Sarka, Cubova, Eva, Valoskova, Katerina, Burda, Lukas, Bendary, Ahmed, Daoud, Ihab, Emil, Sameh, Elbahry, Atef, Rafla, Samir, Sanad, Osama, Kazamel, Ghada, Ashraf, Mohamed, Sobhy, Mohamed, El-Hadidy, Amro, Shafy, Mohamed A., Kamal, Saif, Bendary, Mohamed, Talviste, Grete, Angoulvant, Denis, Boccara, Franck, Cariou, Bertrand, Carreau, Valérie, Carrie, Alain, Charrieres, Sybil, Cottin, Yves, Di-Fillipo, Mathilde, Ducluzeau, Pierre H., Dulong, Sonia, Durlach, Vincent, Farnier, Michel, Ferrari, Emile, Ferrieres, Dorota, Ferrieres, Jean, Gallo, Antonio, hankard, Regis, Inamo, Jocelyne, Lemale, Julie, Moulin, Philippe, Paillard, François, Peretti, Noel, Perrin, Agnès, Pradignac, Alain, Rabes, Jean P., Rigalleau, Vincent, Sultan, Ariane, Schiele, François, Tounian, Patrick, Valero, René, Verges, Bruno, Yelnik, Cécile, Ziegler, Olivier, Haack, Ira A., Schmidt, Nina, Dressel, Alexander, Klein, Isabel, Christmann, Jutta, Sonntag, Antonia, Stumpp, Christine, Boger, Diana, Biedermann, Dana, Usme, Monica M.N., Beil, F. Ulrich, Klose, Gerald, König, Christel, Gouni-Berthold, Ioanna, Otte, Britta, Böll, Gereon, Kirschbaum, Anja, Merke, Jürgen, Scholl, Johannes, Segiet, Thomas, Gebauer, Marco, Predica, Florentina, Mayer, Manfred, Leistikow, Frank, Füllgraf-Horst, Sabine, Müller, Cornelius, Schüler, Melanie, Wiener, Judith, Hein, Konrad, Baumgartner, Peter, Kopf, Stefan, Busch, Reinhold, Schömig, Michael, Matthias, Stephan, Allendorf-Ostwald, Nicole, Fink, Bruno, Böhm, Dieter, Jäkel, Alexander, Koschker, Ann-Cathrin, Schweizer, Rüdiger, Vogt, Anja, Parhofer, Klaus, König, Wolfgang, Reinhard, Wibke, Bäßler, Andrea, Stadelmann, Alexander, Schrader, Volker, Katzmann, Julius, Tarr, Adrienne, Steinhagen-Thiessen, Elisabeth, Kassner, Ursula, Paulsen, Gerret, Homberger, Jürgen, Zemmrich, Claudia, Seeger, Wolfgang, Biolik, Kathrin, Deiss, Dorothee, Richter, Corinna, Pantchechnikova, Elina, Dorn, Elena, Schatz, Ulrike, Julius, Ulrich, Spens, Antje, Wiesner, Tobias, Scholl, Michael, Rizos, Christos V., Sakkas, Nikolaos, Elisaf, Moses, Skoumas, Ioannis, Tziomalos, Konstantinos, Rallidis, Loukianos, Kotsis, Vasileios, Doumas, Michalis, Athyros, Vasileios, Skalidis, Emmanouil, Kolovou, Genovefa, Garoufi, Anastasia, Bilianou, Eleni, Koutagiar, Iosif, Agapakis, Dimitrios, Kiouri, Estela, Antza, Christina, Katsiki, Niki, Zacharis, Evangelos, Attilakos, Achilleas, Sfikas, George, Koumaras, Charalambos, Anagnostis, Panagiotis, Anastasiou, Georgia, Liamis, George, Koutsogianni, Amalia-Despoina, Karányi, Zsolt, Harangi, Mariann, Bajnok, László, Audikovszky, Mária, Márk, László, Benczúr, Béla, Reiber, István, Nagy, Gergely, Nagy, András, Reddy, Lakshmi L., Shah, Swarup A.V., Ponde, Chandrashekhar K., Dalal, Jamshed J., Sawhney, Jitendra P.S., Verma, Ishwar C., Altaey, Mays, Al-Jumaily, Khalid, Rasul, Dilshad, Abdalsahib, Ali F., Jabbar, Amer A., Al-ageedi, Mohanad, Agar, Ruth, Cohen, Hofit, Ellis, Avishay, Gavishv, Dov, Harats, Dror, Henkin, Yaacov, Knobler, Hila, Leavit, Leah, Leitersdorf, Eran, Rubinstein, Ardon, Schurr, Daniel, Shpitzen, Shoshi, Szalat, Auryan, Casula, Manuela, Zampoleri, Veronica, Gazzotti, Marta, Olmastroni, Elena, Sarzani, Riccardo, Ferri, Claudio, Repetti, Elena, Sabbà, Carlo, Bossi, Antonio Carlo, Borghi, Claudio, Muntoni, Sandro, Cipollone, Francesco, Purrello, Francesco, Pujia, Arturo, Passaro, Angelina, Marcucci, Rossella, Pecchioli, Valerio, Pisciotta, Livia, Mandraffino, Giuseppe, Pellegatta, Fabio, Mombelli, Giuliana, Branchi, Adriana, Fiorenza, Anna Maria, Pederiva, Cristina, Werba, Josè Pablo, Parati, Gianfranco, Carubbi, Francesca, Iughetti, Lorenzo, Iannuzzi, Arcangelo, Iannuzzo, Gabriella, Calabrò, Paolo, Averna, Maurizio, Biasucci, Giacomo, Zambon, Sabina, Roscini, Anna Rita, Trenti, Chiara, Arca, Marcello, Federici, Massimo, Del Ben, Maria, Bartuli, Andrea, Giaccari, Andrea, Pipolo, Antonio, Citroni, Nadia, Guardamagna, Ornella, Bonomo, Katia, Benso, Andrea, Biolo, Gianni, Maroni, Lorenzo, Lupi, Alessandro, Bonanni, Luca, Zenti, Maria Grazia, Matsuki, Kota, Hori, Mika, Ogura, Masatsune, Masuda, Daisaku, Kobayashi, Takuya, Nagahama, Kumiko, Al-Jarallah, Mohammed, Radovic, Mirjana, Lunegova, Olga, Bektasheva, Erkayim, Khodzhiboboev, Elyor, Erglis, Andrejs, Gilis, Dainus, Nesterovics, Georgijs, Saripo, Vita, Meiere, Ruta, Upena-RozeMicena, Arta, Terauda, Elizabete, Jambart, Selim, Khoury, Petra E., Elbitar, Sandy, Ayoub, Carine, Ghaleb, Youmna, Aliosaitiene, Urte, Kutkiene, Sandra, Kasim, Noor A.M., Nor, Noor S.M., Ramli, Anis S., Razak, Suraya A., Al-Khateeb, Alyaa, Kadir, Siti H.S.A., Muid, Suhaila A., Rahman, Thuhairah A., Kasim, Sazzli S., Radzi, Ahmad B.M., Ibrahim, Khairul S., Razali, Salmi, Ismail, Zaliha, Ghani, Rohana A., Hafidz, Muhammad I.A., Chua, Ang L., Rosli, Marshima M., Annamalai, Muthukkaruppan, Teh, Lay K., Razali, Rafezah, Chua, Yung A., Rosman, Azhari, Sanusi, Abdul R., Murad, Nor A.A., Jamal, A. Rahman A., Nazli, Sukma A., Razman, Aimi Z., Rosman, Norhidayah, Rahmat, Radzi, Hamzan, Nur S., Azzopardi, C., Mehta, Roopa, Martagon, Alexandro J., Ramirez, Gabriela A.G., Villa, Neftali E.A., Vazquez, Arsenio V., Elias-Lopez, Daniel, Retana, Gustavo G., Rodriguez, Betsabel, Macías, Jose J.C., Zazueta, Alejandro R., Alvarado, Rocio M., Portano, Julieta D.M., Lopez, Humberto A., Sauque-Reyna, Leobardo, Herrera, Laura G.G., Mendia, Luis E.S., Aguilar, Humberto Garcia, Cooremans, Elizabeth R., Aparicio, Berenice P., Zubieta, Victoria M., Gonzalez, Perla A.C., Ferreira-Hermosillo, Aldo, Portilla, Nacu C., Dominguez, Guadalupe J., Garcia, Alinna Y.R., Cazares, Hector E.A., Gonzalez, Jesus R., Valencia, Carla V.M., Padilla, Francisco G., Prado, Ramon M., De los Rios Ibarra, Manuel O., Villicaña, Ruy D.A., Rivera, Karina J.A., Carrera, Ricardo A., Alvarez, Jose A., Martinez, Jose C.A., de los Reyes Barrera Bustillo, Manuel, Vargas, Gonzalo C., Chacon, Roberto C., Andrade, Mario H.F., Ortega, Ashanty F., Alcala, Hector G., de Leon, Laura E.G., Guzman, Berenice G., Garcia, Jose J.G., Cuellar, Juan C.G., Cruz, Jose R.G., Garcia, Anell Hernandez, Almada, Jesus R.H., Herrera, Ursulo J., Sobrevilla, Fabiola L., Rodriguez, Eduardo M., Sibaja, Cristina M., Rodriguez, Alma B.M., Oyervides, Jose C.M., Vazquez, Daniel I.P., Rodriguez, Eduardo A.R., Osorio, Ma L.R., Saucedo, Juan R., Tamayo, Margarita T., Talavera, Luis A.V., Arroyo, Luis E.V., Carrillo, Eloy A.Z., Isara, Alphonsus, Obaseki, Darlington E., Al-Waili, Khalid, Al-Zadjali, Fahad, Al-Zakwani, Ibrahim, Al-Kindi, Mohammed, Al-Mukhaini, Suad, Al-Barwani, Hamida, Rana, Asim, Shah, Lahore S.U., Starostecka, Ewa, Konopka, Agnieszka, Lewek, Joanna, Bartłomiejczyk, Marcin, Gąsior, Mariusz, Dyrbuś, Krzysztof, Jóźwiak, Jacek, Gruchała, Marcin, Pajkowski, Marcin, Romanowska-Kocejko, Marzena, Żarczyńska-Buchowiecka, Marta, Chmara, Magdalena, Wasąg, Bartosz, Parczewska, Aleksandra, Gilis-Malinowska, Natasza, Borowiec-Wolna, Justyna, Stróżyk, Aneta, Woś, Marlena, Michalska-Grzonkowska, Aleksandra, Medeiros, Ana M., Alves, Ana C., Silva, Francisco, Lobarinhas, Goreti, Palma, Isabel, de Moura, Jose P., Rico, Miguel T., Rato, Quitéria, Pais, Patrícia, Correia, Susana, Moldovan, Oana, Virtuoso, Maria J., Salgado, Jose M., Colaço, Ines, Dumitrescu, Andreea, Lengher, Calin, Mosteoru, Svetlana, Meshkov, Alexey, Ershova, Alexandra, Rozkova, Tatiana, Korneva, Victoria, Yu, Kuznetsova T., Zafiraki, Vitaliy, Voevoda, Mikhail, Gurevich, Victor, Duplyakov, Dmitry, Ragino, Yulia, Safarova, Maya, Shaposhnik, Igor, Alkaf, Fahmi, Khudari, Alia, Rwaili, Nawal, Al-Allaf, Faisal, Alghamdi, Mohammad, Batais, Mohammed A., Almigbal, Turky H., Kinsara, Abdulhalim, AlQudaimi, Ashraf H.A., Awan, Zuhier, Elamin, Omer A., Altaradi, Hani, Rajkovic, Natasa, Popovic, Ljiljana, Singh, Sandra, Stosic, Ljubica, Rasulic, Iva, Lalic, Nebojsa M., Lam, Carolyn, Le, Tan J., Siang, Eric L.T., Dissanayake, Sanjaya, I-Shing, Justin T., Shyong, Tai E., Jin, Terrance C.S., Balinth, Karin, Buganova, Ingrid, Fabryova, Lubomira, Kadurova, Michaela, Klabnik, Alexander, Kozárová, Miriam, Sirotiakova, Jana, Battelino, Tadej, Kovac, Jernej, Mlinaric, Matej, Sustar, Ursa, Podkrajsek, Katarina T., Fras, Zlatko, Jug, Borut, Cevc, Matija, Pilcher, Gillian J., Blom, D.J., Wolmarans, K.H., Brice, B.C., Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose L., de Isla, Leopoldo P., Fuentes, Francisco, Badimon, Lina, Martin, François, Lux, Angela, Chang, Nien-Tzu, Ganokroj, Poranee, Akbulut, Mehmet, Alici, Gökhan, Bayram, Fahri, Can, Levent H., Celik, Ahmet, Ceyhan, Ceyhun, Coskun, Fatma Y., Demir, Mesut, Demircan, Sabri, Dogan, Volkan, Durakoglugil, Emre, Dural, Ibrahim E., Gedikli, Omer, Hacioglu, Aysa, Ildizli, Muge, Kilic, Salih, Kirilmaz, Bahadir, Kutlu, Merih, Oguz, Aytekin, Ozdogan, Oner, Onrat, Ersel, Ozer, Savas, Sabuncu, Tevfik, Sahin, Tayfun, Sivri, Fatih, Sonmez, Alper, Temizhan, Ahmet, Topcu, Selim, Tuncez, Abdullah, Vural, Mirac, Yenercag, Mustafa, Yesilbursa, Dilek, Yigit, Zerrin, Yildirim, Aytul B., Yildirir, Aylin, Yilmaz, Mehmet B., Atallah, Bassam, Traina, Mahmoud, Sabbour, Hani, Hay, Dana A., Luqman, Neama, Elfatih, Abubaker, Abdulrasheed, Arshad, Kwok, See, Oca, Nicolas D., Reyes, Ximena, Alieva, Rano B., Kurbanov, Ravshanbek D., Hoshimov, Shavkat U., Nizamov, Ulugbek I., Ziyaeva, Adolat V., Abdullaeva, Guzal J., Do, Doan L., Nguyen, Mai N.T., Kim, Ngoc T., Le, Thanh T., Le, Hong A., Tokgozoglu, Lale, Catapano, Alberico L., and Ray, Kausik K.
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33. Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets
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Chiva-Blanch, Gemma, Peña, Esther, Cubedo, Judit, García-Arguinzonis, Maisa, Pané, Adriana, Gil, Pedro A, Perez, Antonio, Ortega, Emilio, Padró, Teresa, and Badimon, Lina
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- 2021
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34. Mechanistic Insights of Empagliflozin in Nondiabetic Patients With HFrEF: From the EMPA-TROPISM Study
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Requena-Ibáñez, Juan Antonio, Santos-Gallego, Carlos G., Rodriguez-Cordero, Anderly, Vargas-Delgado, Ariana P., Mancini, Donna, Sartori, Samantha, Atallah-Lajam, Farah, Giannarelli, Chiara, Macaluso, Frank, Lala, Anuradha, Sanz, Javier, Fuster, Valentin, and Badimon, Juan José
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- 2021
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35. Extracellular vesicles in atherothrombosis and cardiovascular disease: Friends and foes
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Giró, Oriol, Jiménez, Amanda, Pané, Adriana, Badimon, Lina, Ortega, Emilio, and Chiva-Blanch, Gemma
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- 2021
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36. Smoking and sex differences in first manifestation of cardiovascular disease
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Vasiljevic, Zorana, Scarpone, Marialuisa, Bergami, Maria, Yoon, Jinsung, van der Schaar, Mihaela, Krljanac, Gordana, Asanin, Milika, Davidovic, Goran, Simovic, Stefan, Manfrini, Olivia, Mickovski-Katalina, Natasa, Badimon, Lina, Cenko, Edina, and Bugiardini, Raffaele
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- 2021
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37. The role of triglycerides in the origin and progression of atherosclerosis
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Padro, Teresa, Muñoz-Garcia, Natalia, and Badimon, Lina
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- 2021
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38. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum
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Vilahur, Gemma, Sutelman, Pablo, Mendieta, Guiomar, Ben-Aicha, Soumaya, Borrell-Pages, María, Peña, Esther, Crespo, Javier, Casaní, Laura, and Badimon, Lina
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- 2021
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39. Leuko-platelet index predicts thrombotic events in patients with acute coronary syndrome
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Cohen Arazi, Hernán, Chirino, Daniel, Costabel, Juan Pablo, Pulmari, Camilo A., Hirschson Prado, Alfredo, Barba, Virginia, Agüero, Pablo, and Badimon, Juan José
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- 2021
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40. Overview of Aspirin and Platelet Biology
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Santos-Gallego, Carlos G and Badimon, Juan
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- 2021
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41. New factors in heart failure pathophysiology: Immunity cells release of extracellular vesicles
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Alba Vilella-Figuerola, Teresa Padró, Eulàlia Roig, Sònia Mirabet, and Lina Badimon
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extracellular microvesicles (EVs) ,chronic heart failure ,immune cells ,inflammation ,liquid biopsies ,extracellular vesicle (EV) ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Leukocyte-shed extracellular vesicles (EVs) can play effector roles in the pathophysiological mechanisms of different diseases. These EVs released by membrane budding of leukocytes have been found in high amounts locally in inflamed tissues and in the circulation, indicating immunity cell activation. These EVs secreted by immune cell subsets have been minimally explored and deserve further investigation in many areas of disease. In this study we have investigated whether in heart failure there is innate and adaptive immune cell release of EVs. Patients with chronic heart failure (cHF) (n = 119) and in sex- and age-matched controls without this chronic condition (n = 60). Specifically, EVs were quantified and phenotypically characterized by flow cytometry and cell-specific monoclonal antibodies. We observed that even in well medically controlled cHF patients (with guideline-directed medical therapy) there are higher number of blood annexin-V+ (phosphatidylserine+)-EVs carrying activated immunity cell-epitopes in the circulation than in controls (p < 0.04 for all cell types). Particularly, EVs shed by monocytes and neutrophils (innate immunity) and by T-lymphocytes and natural-killer cells (adaptive immunity) are significantly higher in cHF patients. Additionally, EVs-shed by activated leukocytes/neutrophils (CD11b+, p = 0.006; CD29+/CD15+, p = 0.048), and T-lymphocytes (CD3+/CD45+, p < 0.02) were positively correlated with cHF disease severity (NYHA classification). Interestingly, cHF patients with ischemic etiology had the highest levels of EVs shed by lymphocytes and neutrophils (p < 0.045, all). In summary, in cHF patients there is a significant immune cell activation shown by high-release of EVs that is accentuated by clinical severity of cHF. These activated innate and adaptive immunity cell messengers may contribute by intercellular communication to the progression of the disease and to the common affectation of distant organs in heart failure (paracrine regulation) that contribute to the clinical deterioration of cHF patients.
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- 2022
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42. Prevalencia de la enfermedad renal crónica y factores asociados en la población asistida en atención primaria de España: resultados del estudio IBERICAN
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García, Alfonso Barquilla, Rodríguez, Ángel Díaz, Cervantes, Carlos Escobar, Moreno, Francisco Javier Alonso, Roca, Gustavo Cristóbal Rodríguez, Martín, Jesús Vergara, Caro, José Luis Llisterri, Badimón, Juan José, García, José Polo, Padial, Luis Rodríguez, Prieto, Miguel Ángel, Pérez, Rafael Vidal, Sanjurjo, Sergio Cinza, Jiménez, Sonia Miravet, Zancada, Sonsoles Velilla, Téllez, Antonio López, de Los Ángeles Ortega Osuna, Maria, Cid, Cristóbal Prieto, Fajardo, María José Hidalgo, Serna, José Lorente, Requena, Ángel Domínguez, Cañizares, Ricardo Alberola, Peña, Manuel Ruiz, Collado, Filomena Herrero, Vázquez, Marcela Montes, Garrido, Rafael Ángel Carrascal, Lozano, María Reyes Herrera, Oliva, Beatriz Ortiz, Anguita, Francisco José, Ibáñez, Carmen Pérez, Rodríguez, Carlos Alberto Cabrera, Rodríguez, María José Cruz, Ruiz, Sandra Bonilla, González, Rocío Reina, Sánchez, Salomé Abad, Martínez, Inmaculada Santana, Jordán, Rafael Sánchez, Navas-Parejo, Juan María Ramos, Torres, José Manuel Ramírez, Poveda, José María Beltrán, Benayas, María Adoración de Cruz, Gil, Carmen Fernandez, Alcaine, Jon Iñaki Esturo, Quintero, Antonio Mora, Cepas, Fernando Leiva, Martín, José Luis Carrasco, Criado, Emilio García, Blanco, Mercedes Vázquez, Ortiz, Isabel Mora, Mendoza, Leovigildo Ginel, Rodríguez, Juan Carlos Aguirre, Rodríguez, Esperanza María Romero, Vázquez, José Acevedo, Ballesteros, Juan Gabriel García, Lara, María de La Paz Fernández, Moreno, Patricia Agüera, Maturana, Eduardo Paños, Expósito, Juan Manuel Ignacio, Peñas, Noelia Carrillo, Faya, Carmen María Abad, Duque, Ana Marina Almagro, Camisón, Rubén Torrescusa, Polo, Paloma Menéndez, García, Marina Peña, Fernández, Cristina López, Torres, Ascensión Estepa, Jansen, Miguel Gutiérrez, González, Esperanza Loizaga, Matarin, Lisardo García, Luna, Enrique José Gamero de, Rivero, Javier Benítez, Gómez González, María José, Montes, Carmen Gómez, Calvo, Eva Trillo, Calvo, Concepción Bayod, Natividad, Susana Larripa de La, Lambea, Germán Grasa, Marín, Emilio Jiménez, Gonzalvo, Ana Cristina Navarro, Martínez Barseló, Antonio Pablo, León, Irene Peña, Fernández, E. Lidia Gutiérrez, Mantecón, Fernando Andrés, Garrido, Ana Belén García, Escalante, Asunción Velez, Rentería, Luisa Alonso, Jiménez, Jesús Sainz, Alles, Guillermo Pombo, Garrote, Juan Antonio Divison, Sotodosos, Pedro Martínez, Fuster, Juan Antonio Vivancos, Palencia, María García, Moraleda, José Ambrosio Torres, Ballesteros, Sara González, Adrados, Ana Carmen Gil, Cabrera, Antonio González, Fernández, Miguel Ángel Babiano, García, Guillermo Rico, Criado-Álvarez, Juan José, Moreno, Pilar Torres, Aguirregaviria, Francisco Javier Arribas, Martínez, Alicia Sahuquillo, Béjar, Lourdes María Santos, Peralta, Miguel Laborda, Castro, Raúl Piedra, Altozano, Carlos Santos, Polo, Lucía González-Tarrio, Maresca, Pedro Valiente, Santana, Reinilda Mota, Ledesma, Noemi Elizabeth Terrero, Espada, Noelia Garrido, Calvi, Gabriela Delia Rosa Zambrana, Montero, Juan Lorenzo Gutiérrez, Gil, Juan Ignacio López, Ortega, María Dolores Fernández, Roncal, Miren Elizari, Serrano, María Ascensión López, Fuente, Nuria Esther Adrián de La, Larrea, Belén Angulo Fdez. de, Fernández, Naiara Cubelos, Gómez, Guiomar Luz Ferreiro, Rodríguez, Diana Gómez, Tuñón, Sonia María Andrés, González, María Ajenjo, Olea, Serafín de Abajo, Regueras, Juan José León, Nieto, César Manuel Gallego, Mallada, Delio Vázquez, García, Maria de La O Gutiérrez, Rodríguez, Pablo Baz, García, José Ignacio Ferradal, Martínez, Blanca Delia de Román, Pérez, Ana Arconada, Atoui, Omar Mahmoud, Bayón, Álvaro Morán, Olmo, María Teresa Armenteros del, Herreros, Fco. Javier García-Norro, Rodríguez, Enrique Méndez, Pineda, Diana María Narganes, Ainaga, Verónica Ortiz, Guevara, Milagros Sonlei Sánchez, Ferreiro, Laura Villota, Grande, M. Teresa Grande, Gracía, Francisco Vicente Martínez, García, María Dolores Moriano, Muñoz, Beatriz Jiménez, Marcelino, Gemma Rovira, Valverde, Diana Elizabeth Fernández, Bernadó, Roser Rodó, Lupiáñez, María Teresa Ortiz, Najih, Najlaa, Parra, José María Diéguez, Acebo, María Rosa Benedicto, Vicien, Mari Luz Bravo, Estella, Alberto Ramón León, Gómez, Juan Antonio Muñoz, Muntané, Alicia Mostazo, Abarca, Isabel Ortega, Fargas, Anna Gasol, Escudero, Brenda Elizabeth Riesgo, Riesgo, Susana Elizabeth, Castellvi, Edgar Zaballos, Sagarra, Celia Cols, Fernández, Marta Herranz, Presas, Josep Alins, Pérez, Idaira Damas, García, Rosa M. Alcolea, Collado, Inés Monte, Martínez, Roberto Genique, Villanueva, María José Guasch, Martínez, Teresa Rama, Pena, Lucio Pinto, Royo, Josefa María Panisello, Gil, Inés Gil, Montero, Alberto Calderón, Gómez, María del Mar Zamora, Cebrián, Elena Alarcón, Acin, María José Piñero, Sacristán, Celia Pecharromán, Vicente, M. Soledad Mayayo, Unanua, María Paz Pérez, Henrich, Nuria Marañón, Monreal, Saray Gómez, Pedro, Sonia Redondo de, Pozo, Blanca Sanz, Martínez, Irene Moreno, Uriarte, Beatriz López, Velasco, Carmelina Sanz, Aguirre, Amaya Gárriz, Teijido, Montserrat Rivera, Jaén, Germán Reviriego, Pascual-Salcedo, José Ignacio Aza, Gallego, Josefa Vázquez, Rodilla, Julia Caballer, Herrera, Aida, Martínez, Ezequiel Arranz, Calvo, Ana María Gómez, Oliva, Paula Morán, Béjar, María Milagros González, Hitos, Julio Antonio Heras, Vallejo, Olga García, Vargas, Manuel de Jesús Frías, Boguerin, María Jesús Castillejo, Lerin, Aurora García, Tablado, Miguel Ángel María, García, Elena Concepción García, Acero, Leticia de Miguel, Oñate, Carmen Zárate, Apoita, Aránzazu Barranco, Belloso, María Ester Montes, Velasco, Ana María Huertas, Jiménez, Rafael Sáez, Pascual, Julia Natividad García, Zuluaga, María Clemencia Zuluaga, Perez, María Cruz Díez, García, Antonio Ruiz, Jelsbak, Cristina Murillo, Oria, Virginia Lasso, Gamarra, Amelia González, Fuster, Vicente Pascual, Bort, María Dolores Aicart, Gómez, Natividad Vázquez, Gasco, Carlos Lluna, Barber, Teresa Amoros, Cano, Pedro Antonio Medina, Moncho, Miguel Monteagudo, Muñoz, María Jesús Larré, Hernández, Raquel Navarro, Egea, Francisco José Martínez, Tramontano, Antonio, Royo, Marta Ferrer, Saura, Belén Persiva, Torres, Juan A. Contreras, Moliner, José María Tirado, Penalba, Alejandro Salanova, Alberola, Ariadna Cucó, Ros, Fernando María Navarro I., Llicer, Enrique Beltrán, Novás, Ana Seoane, Valls, Inmaculada Martín, Mahiques, Gracia Verdú, Forcada, Enrique Peña, Gómez, Nieves Aguilar, García, Francisco Javier Sanz, Bueso, M. Dolores Paradís, Romero, María Eugenia Alegre, Camus, Antonio Francés, Peinado, María Amparo Antón, Santos, Rosa Latorre, Marín, María Asunción Palomar, García, María Carmen Botella, Fresquet, Eva Sánchez, Paños, Pedro Sala, Ruiz, Tomás Sánchez, Valero, Rosa Ana Valero, Vicente, María Seoane, Llinares, Magdalena Martín, Alegre, Antonio Masiá, Verdú, Irene Lluch, Carratala, Vicente Pallares, Roca, Francisco Valls, Pérez, Rafael Manuel Micó, García, Jacinto Espinosa, Romo, José Ignacio Prieto, Fernández, Leandro Fernández, Sierratapia, Javier, Regidor, Nieves Moreno, Sánchez, Francisco Javier Zaballos, Moreno, Ana Moreno, Barrera, Francisco Carramiñana, Vázquez, Juan José Torres, Samino, María José Gamero, Rodríguez, Miguel Ángel de Santiago, Martínez, Pablo Rafael Gómez, Becerra, Antonio Carlos Elías, Olivera, Javier Soto, Cambero, Víctor, Ávila, Julián Domínguez, Fuentes, Andrés Simón, Jiménez, Jorge Manuel de Nicolás, Fraile, Dimas Igual, Barco, Guadalupe Nieto, Ramos, Ignacio Araujo, Berrocal, María Luz Serrano, Ramírez, Francisco Buitrago, Marcos, Minerva Gallego, González, Félix Suárez, Carrasco, Victoriano Chavero, Peguero, Francisco Guerra, Vega, Francisco Javier Sánchez, Mas, Manuel Tejero, Donoso, Alba Palmerín, Yedro, Miguel Turégano, Rojas, María Beatriz Esteban, Moreno, Fátima Cabezudo, Saldaña, Nawson Elver Quevedo, Fenés, María del Mar García, Florencio, Timotea Garrote, Toro, José María Fernández, Rañal, Alejandra Rey, Río, Elena García del, Pol, Enrique Nieto, Fernández, Julio Álvarez, Álvarez, Pilar Alonso, Gómez, María Luisa Jorge, Guerrero, Antonio Calvo, Colomina, Isabel Celemín, Casal, Lucía Barreiro, Moreno, Juana Fernández, Martínez, María Angelines Carballal, Rodríguez, Nabor Díaz, Paredes, Carlos Moral, García, Dolores Recarey, Mato, Fco. Javier Iglesias, Ulloa, Antonio Fouz, González, Amparo Fidalgo, Parada, Noelia Dios, Sabarís, Patricia Conde, Pérez, Ana Isabel Rodríguez, Palacio, Ana Inés García, Varela, Víctor Julio Quesada, Iglesias, Lidia Romero, Llerena, Ángel Lado, Rodríguez, Carmen Lires, Diaz, María Luisa Carretero, Arias, José Carreira, Camino, Jose Luis Vázquez, Penas, María del Carmen Torreiro, Freire, Sandra Yáñez, Aldana, Daniel Rey, Díaz, Carlos Piñeiro, Romanos, Fernando García, González, Antonia Moreno, Sastre, María Lara Amengual, Palli, Susana Martínez, Bauza, José Alfonso Ramón, Bolinches, José Ortiz, Fernández, Carmen Fernández, Vázquez, María Isabel Orlandis, Mezquita, Ana Sanchís, Aramburu, Fernando Unceta, Morant, Juan Fernando Peiró, Amengual, Ana Moyá, García, Isidro Godoy, Sevillano, Fernando Rubio, González, María Isabel González, Souto, Marta Pérez, Contreras, Raquel de León, González, Sara Isabel Almeida, Diez, Irene Almería, Sánchez, Virginia María Mirabal, Lavado, Francisco José Escobar, Pérez, Yoel Anta, Hernández, Nayra Sánchez, Jerez, Juan Luis Alonso, Koch, Ricardo, Mendoza, Nayra Ramírez, Hernández, Héctor Suárez, Escobar, Francisco Jesús Morales, Zancada, Sonsoles María Velilla, Sabarís, Rafael Crespo, Jiménez, Óscar Fernando Isaula, Puga, Jesús Manuel González, Ávila, Jorge Antonio Benaín, González, Óscar del Toro, Íñigo, Laura Sánchez, Pérez, Inés Sanz, Nubla, José Félix Zuazagoitia, Ituiño, Ana Echebarría, Tris, Gregorio Mediavilla, Bosch, María Carmen Noriega, González, Esther, Macho, María Luisa Ruiz, Olmo, Ruth Sendino del, Prado, Asunción Olagorta de, Muguerza, Ana López de Viñaspre, Iriso, Jesús Iturralde, Martínez, María José Pérez, Carbonell, Ana Piera, Fernández, Margarita Alonso, Cuadrado, María Montserrat Rueda, Rodríguez, Rodrigo Abad, Cabo, José Miguel Álvarez, Rodríguez, Rubén Sánchez, Cabo, Eva María Cano, Secin, Anny Romero, Díaz, Miguel Ángel Prieto, Fernández, Juan Jesús García, Bueno, Vicente Llorca, Pérez, Ana María Ballesteros, López, Domingo J. Rubira, Franco, María Dolores Esteve, Pablo, Elena Sánchez, López, María Teresa Palacios, Meroño, Juan Castillo, Martínez, José María Lobo, Martínez, Isabel María Peral, Carrasco, J. Eduardo Carrasco, González, Armando Santo, Llisterri, José Luis, Micó-Pérez, Rafael Manuel, Velilla-Zancada, Sonsoles, Rodríguez-Roca, Gustavo Cristóbal, Prieto-Díaz, Miguel Ángel, Martín-Sánchez, Vicente, Barquilla, Alfonso, Polo-García, José, Segura-Fragoso, Antonio, and Cinza-Sanjurjo, Sergio
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- 2021
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43. Empagliflozin Ameliorates Diastolic Dysfunction and Left Ventricular Fibrosis/Stiffness in Nondiabetic Heart Failure: A Multimodality Study
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Santos-Gallego, Carlos G., Requena-Ibanez, Juan Antonio, San Antonio, Rodolfo, Garcia-Ropero, Alvaro, Ishikawa, Kiyotake, Watanabe, Shin, Picatoste, Belen, Vargas-Delgado, Ariana P., Flores-Umanzor, Eduardo J., Sanz, Javier, Fuster, Valentin, and Badimon, Juan J.
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- 2021
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44. Mortality associated with cardiovascular disease in patients with COVID-19
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Cordero, Alberto, Santos García-Gallego, Carlos, Bertomeu-González, Vicente, Fácila, Lorenzo, Rodríguez-Mañero, Moisés, Escribano, David, Castellano, José M., Zuazola, Pilar, Núñez, Julio, Badimón, Juan J., and González-Juanatey, José Ramón
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- 2021
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45. Are the antidiabetic SGLT2 inhibitors a cardiovascular treatment?
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Vargas Delgado, Ariana P., Requena Ibañez, Juan Antonio, Santos-Gallego, Carlos G., and Badimon, Juan Jose
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- 2021
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46. ¿Son los inhibidores del receptor SGLT2 fármacos antidiabéticos o cardiovasculares?
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Vargas Delgado, Ariana P., Requena Ibañez, Juan Antonio, Santos-Gallego, Carlos G., and Badimon, Juan Jose
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- 2021
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47. First time ACS in patients with on‐target lipid levels: Inflammation at admission and re‐event rate at follow‐up.
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Muñoz‐García, Natàlia, Cordero, Alberto, Padro, Teresa, Mendieta, Guiomar, Vilahur, Gemma, Flores, Emilio, and Badimon, Lina
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NUCLEAR magnetic resonance ,VENTRICULAR ejection fraction ,MYOCARDIAL injury ,C-reactive protein ,HOSPITAL admission & discharge ,CHEST pain - Abstract
Background: Dyslipidaemia, inflammation and elevated Lp(a) levels are associated with the progression of atherosclerosis. This study investigates whether patients with a first‐time presentation of chest pain and on‐target LDL‐C levels and intermediate FRS/ESC‐Score risks, display a high inflammatory burden linked to myocardial injury and whether inflammation at admission affects the re‐event rate up to 6 years follow‐up. Methods: Blind assessments of novel inflammatory markers such as Glycoprotein A and B via nuclear magnetic resonance (NMR), cytokines, hsCRP, Neutrophil‐to‐Lymphocyte ratio (NLR) and Lipoprotein(a) levels were examined. Out of 198 chest pain patients screened, 97 met the inclusion criteria at admission. Results: cTnI(+) patients (>61 ng/L) with elevated Lipoprotein(a), showed significantly increased levels of Glycoprotein A and B, hsCRP, IL‐6, a high NLR and a reduced left ventricular ejection fraction (%) compared to cTnI(−) individuals. Those patients, with a higher inflammatory burden at hospital admission (hsCRP, IL‐6, Glycoprotein A and B, and Lipoprotein(a)) had a higher re‐event rate at follow‐up. Conclusions: Inflammation and Lipoprotein(a) levels were particularly prominent in patients presenting with reduced left ventricular ejection fraction. Notably, Glycoproteins A/B emerge as novel markers of inflammation in these patients. Our study highlights the significantly higher impact of inflammatory burden in patients with chest pain and high level of myocardial damage than in those with lower myocardial affectation, even when they all had lipid levels well controlled. Inflammation at the time of admission influenced the re‐event rate over a follow‐up period of up to 6 years. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Early coronary revascularization among 'stable' patients with non-ST-segment elevation acute coronary syndromes: the role of diabetes and age.
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Fabin, Natalia, Cenko, Edina, Bergami, Maria, Yoon, Jinsung, Vadalà, Giuseppe, Mendieta, Guiomar, Kedev, Sasko, Kostov, Jorgo, Vavlukis, Marija, Vraynko, Elif, Miličić, Davor, Vasiljevic, Zorana, Zdravkovic, Marija, Badimon, Lina, Galassi, Alfredo R, Manfrini, Olivia, and Bugiardini, Raffaele
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ACUTE coronary syndrome ,VENTRICULAR arrhythmia ,PEOPLE with diabetes ,CARDIAC patients ,CARDIAC arrest - Abstract
Aims To investigate the impact of an early coronary revascularization (<24 h) compared with initial conservative strategy on clinical outcomes in diabetic patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) who are in stable condition at hospital admission. Methods and results The International Survey of Acute Coronary Syndromes database was queried for a sample of diabetic and nondiabetic patients with diagnosis of NSTE-ACS. Patients with cardiac arrest, haemodynamic instability, and serious ventricular arrhythmias were excluded. The characteristics between groups were adjusted using logistic regression and inverse probability of treatment weighting models. Primary outcome measure was all-cause 30-day mortality. Risk ratios (RRs) and odds ratios (ORs) with their 95% confidence intervals (CIs) were employed. Of the 7589 NSTE-ACS patients identified, 2343 were diabetics. The data show a notable reduction in mortality for the elderly (>65 years) undergoing early revascularization compared to those receiving an initial conservative strategy both in the diabetic (3.3% vs. 6.7%; RR: 0.48; 95% CI: 0.28–0.80) and nondiabetic patients (2.7% vs. 4.7%: RR: 0.57; 95% CI: 0.36–0.90). In multivariate analyses, diabetes was a strong independent predictor of mortality in the elderly (OR: 1.43; 95% CI: 1.03–1.99), but not in the younger patients (OR: 1.04; 95% CI: 0.53–2.06). Conclusion Early coronary revascularization does not lead to any survival advantage within 30 days from admission in young NSTE-ACS patients who present to hospital in stable conditions with and without diabetes. An early invasive management strategy may be best reserved for the elderly. Factors beyond revascularization are of considerable importance for outcome in elderly diabetic subjects with NSTE-ACS. Clinical trial number ClinicalTrials.gov : NCT01218776. [ABSTRACT FROM AUTHOR]
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- 2024
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49. Effect of Moderate Beer Intake on the Lipid Composition of Human Red Blood Cell Membranes.
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López-Yerena, Anallely, Muñoz-García, Natalia, de Santisteban Villaplana, Victoria, Padro, Teresa, and Badimon, Lina
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Background/Objectives: Growing evidence suggests that erythrocyte membrane lipids are subject to changes during their lifespan. Factors such as the type of dietary intake and its composition contribute to the changes in red blood cell (RBC) membranes. Due to the high antioxidant content of beer, we aimed to investigate the effect of moderate beer consumption on the lipid composition of RBCs membranes from healthy overweight individuals. Methods: We conducted a four-weeks, prospective two-arm longitudinal crossed-over study, where participants (n = 36) were randomly assigned to alcohol-free beer group or traditional beer group. The lipids of RBCs membranes were assessed at the beginning and the end of the intervention by thin-layer chromatography. Results: Four-weeks of alcohol-free beer promoted changes in fatty acids (FA), free cholesterol (FC), phosphatidylethanolamine (PE) and phosphatidylcholine (PC) (p < 0.05). Meanwhile, traditional beer intake led to changes in FA, FC, phospholipids (PL), PE and PC (p < 0.05). The observed alterations in membrane lipids were found to be independent of sex and BMI as influencing factors. Conclusions: The lipid composition of erythrocyte membranes is distinctly but mildly influenced by the consumption of both non-alcoholic and conventional beer, with no effects on RBC membrane fluidity. [ABSTRACT FROM AUTHOR]
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- 2024
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50. Efficacy of Food Industry By-Product β-Glucan/Chitin–Chitosan on Lipid Profile of Overweight and Obese Individuals: Sustainability and Nutraceuticals.
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Santisteban, Victoria, Muñoz-Garcia, Natàlia, López-Yerena, Anallely, Puntes, Montserrat, Badimon, Lina, and Padro, Teresa
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Fat-binding nutraceutical supplements have gained considerable attention as potential cholesterol-lowering strategies to address dyslipidemia in overweight and obese individuals. This study aimed to evaluate the effects of a polysaccharide-rich compound containing β-glucan/chitin–chitosan (βGluCnCs) on lipid profiles and lipoprotein function. In a prospective, two-arm clinical trial, 58 overweight and obese individuals were randomized to receive either 3 g/day of βGluCnCs or a placebo (microcrystalline cellulose) for 12 weeks. Serum lipids and lipoprotein functions were assessed at baseline and at 4-week intervals throughout the study. The administration of βGluCnCs led to a significant increase in HDL cholesterol (HDLc) levels and improved HDLc/non-HDLc and HDLc/total cholesterol (TC) ratios, while reducing apolipoprotein B (ApoB) levels (p < 0.05). However, the intervention did not affect HDL particle diameter, particle number, or lipoprotein functionality. Women demonstrated greater sensitivity to changes in HDLc during βGluCnCs supplementation, whereas men exhibited a significant reduction in ApoB levels. When stratified by baseline LDL cholesterol (LDLc) levels (cut-off: 130 mg/dL), the increase in HDLc and the ApoA1/ApoB ratio was found in the low-LDL group. In contrast, the high-LDL group experienced a significant reduction in atherogenic non-LDLc and LDLc, along with an improvement in HDL's antioxidant capacity after βGluCnCs intervention. These changes were not statistically significant in the placebo group. In conclusion, our study demonstrated that daily supplementation with βGluCnCs significantly improved lipid profiles, with effects that varied based on sex and baseline LDLc levels. [ABSTRACT FROM AUTHOR]
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- 2024
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