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Eyal Klang,1– 3,&ast; Shelly Soffer,3– 5,&ast; Yiftach Barash,1– 3 Eyal Shachar,2,6 Adi Lahat2,6 1Department of Diagnostic Imaging, Sheba Medical Center, Ramat Gan, Israel; 2Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; 3DeepVision Lab, Sheba Medical Center, Ramat Gan, Israel; 4Internal Medicine B, Samson Assuta Ashdod University Hospital, Ashdod, Israel; 5Ben-Gurion University of the Negev, Be’er Sheva, Israel; 6Department of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel&ast;These authors contributed equally to this workCorrespondence: Shelly Soffer, Internal Medicine B, Samson Assuta Ashdod University Hospital, Ha-Refu’a St 7, Ashdod, 7747629, Israel, Tel +973-8-300-4100, Fax +972-3-5357315, Email soffer.shelly@gmail.comBackground: Since the discovery of Helicobacter pylori (H. pylori) 40 years ago, treatment options have changed dramatically adjacent to new drugs development and the emergence of multi-drug resistance. In this study, we aimed to assess published literature on treatment regimens for H. pylori in the past four decades, with regards to specific drug resistance and geographic distribution.Methods: We have queried PubMed for all available H. pylori-related entries published during 1987– 2020. For each entry, we retrieved the title, abstract, and keywords. Two gastrointestinal specialists decided in consensus on a list of terms to classify entries. The terms specify types of treatment and different types of regimens. Annual trends of publications were plotted for different treatment types and sub-analyses.Results: Overall, 47,170 H. pylori-related entries were published between 1987 and 2020. Medication treatment showed the highest number of total publications 6183/47,170 (13.1%), followed by antibiotics 5493/47,170 (11.6%), and probiotic which was substantially lower (0.7%). For treatment regimens type, triple therapy had the highest number of publications 2400/47,170 (5.1%) followed by sequential therapy 342/47,170 (0.7%), and bismuth quadruple therapy 115/47,170 (0.2%). Analysis by antibiotic resistance showed that clarithromycin treatment had the highest number of publications 3537/47,170 (7.5%). Since 2013, there is a steep upward slope (5.1± 0.7 publications/year, p < 0.001) for publications originating from China.Conclusion: Our findings reflect the changes of the commonly prescribed regimens along the years, following the occurrence and the rise of H. pylori antibiotic resistance. In recent years, there is a steep rise in publications in countries with policies of screening and eradication for gastric cancer prevention, which is currently not applied in Western countries. A text-mining analysis of H. pylori publications contributes to the understanding of treatment options and development trends worldwide.Keywords: Helicobacter pylori, antibiotics, treatment regimens, antibiotic resistance

Eyal Klang,1– 3 Yiftach Barash,1,3 Asaf Levartovsky,2,4 Noam Barkin Lederer,2,4 Adi Lahat2,4 1Department of Diagnostic Imaging, Chaim Sheba Medical Center, Tel Hashomer, Israel; 2Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; 3DeepVision Lab (3), Chaim Sheba Medical Center, Tel Hashomer, Israel; 4Department of Gastroenterology, Chaim Sheba Medical Center, Tel Hashomer, IsraelCorrespondence: Adi LahatDepartment of Gastroenterology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, IsraelEmail zokadi@gmail.comBackground and Aim: Endoscopic differentiation between malignant and benign gastric ulcers (GU) affects further evaluation and prognosis. The aim of our study was to evaluate a deep learning algorithm for discrimination between benign and malignant GU in a database of endoscopic ulcer images.Methods: We retrospectively collected consecutive upper gastrointestinal endoscopy images of GU performed between 2011 and 2019 at the Sheba Medical Center. All ulcers had a corresponding histopathology result of either benign peptic ulcer or gastric adenocarcinoma. A convolutional neural network (CNN) was trained to classify the images into either benign or malignant. Endoscopies from 2011 to 2017 were used for training (2011– 2015) and validation (2016– 2017). Hyper-parameters, image augmentation and pre-training on Google images obtained images were evaluated on the validation data. Held-out data from 2018 to 2019 was used for testing the final model.Results: Overall, the Sheba dataset included 1978 GU images; 1894 images from benign GU and 84 images of malignant ulcers. The final CNN model showed an AUC 0.91 (95% CI 0.85– 0.96) for detecting malignant ulcers. For cut-off probability 0.5, the network showed a sensitivity of 92% and specificity of 75% for malignant ulcers.Conclusion: Our study displays the applicability of a CNN model for automated evaluation of gastric ulcers images for malignant potential. Following further research, the algorithm may improve accuracy of differentiating benign from malignant ulcers during endoscopies and assist in patients’ stratification, allowing accelerated patients management and individualized approach towards surveillance endoscopy.Keywords: gastric ulcer, malignant, benign, artificial intelligence, AI, deep learning

To increase the competitiveness of railway transport the authors propose to develop of railway tourism in Ukraine. The article aims to systematize the advantages and disadvantages of railway and automobile tourism and develop efficient areas of their use in this context. Moreover, the authors set a goal to develop a methodical approach to determine the costs of the company that will organize transportations on the specific tourist route. Studies have shown that tourist traffic by railway transport has high potential, provided that it will use modern comfortable rolling stock and have in its structure not only the cars for tourist transportation, but also dining car, casino car, disco car (during the day game car for kids) and others. The above mentioned set of cars should be recommended for cruise travel with a period from 8 to 28 days, for shorter journeys the tourist train may not include casino car, disco car (during the day game car for kids) and others. The final choice of tourist traffic should be justified by economic calculations using the method proposed by this article. The approach is based on accounting all complex of costs associated with the technological process of tourism services. It includes the costs for the process of transportation itself, delivery of additional services of infrastructure and rolling stock owners, pay for transfer transportations, services of hotels, restaurants, cafes, travel agencies, advertising organizations and own costs of travel company. It makes possible to determine the costs of travel package more accurately, taking into account the demand for this type of tourist traffic. As a result of the proposed measures one can expect increase of passenger traffic on the railroad, image improvement of the Ukrainian railways within the country and abroad, attraction of additional funds to renew the outdated infrastructure and rolling stock, restoration of the objects of cultural and historical significance, creation of new jobs, and restraining of migration processes in western Ukraine. [ABSTRACT FROM AUTHOR]

Superconducting loops exhibit macroscopic quantum phenomena that have far-reaching implications; magnetic flux periodicity and flux quantization are the key to our understanding of fundamental properties of superconductors and are the basis for many applications. In superconducting rings, the electrical current responds to a magnetic flux by having a periodicity of h/2e, where the ratio of Planck’s constant and the elementary charge defines the magnetic flux quantum h/e. The well-known h/2e periodicity is a hallmark for electronic pairing in superconductors and is considered evidence for the existence of Cooper pairs. Here, we show that in contrast to this long-held belief, rings of many superconductors bear an h/e periodicity. These superconductors include the high-temperature superconductors, Sr2RuO4, the heavy-fermion superconductors, as well as all other unconventional superconductors with nodes (zeros) in the energy gap, and conventional s-wave superconductors with small gaps. As we show, the 50-year-old Bardeen–Cooper–Schrieffer theory of superconductivity implies that for loops of such superconductors the ground-state energies and consequently also the supercurrents are generically h/e periodic. [ABSTRACT FROM AUTHOR]