14 results on '"Belo, Diogo"'
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2. Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial
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Perkovic, Vlado, Mahaffey, Kenneth W., Agarwal, Rajiv, Bakris, George, Brenner, Barry M., Cannon, Christopher P., Charytan, David M., de Zeeuw, Dick, Greene, Tom, Jardine, Meg J., Heerspink, Hiddo J.L., Levin, Adeera, Meininger, Gary, Neal, Bruce, Pollock, Carol, Wheeler, David C., Zhang, Hong, Zinman, Bernard, Jardine, Meg, Li, Nicole, Kolesnyk, Inna, Aizenberg, Diego, Pecoits-Filho, Roberto, Cherney, David, Obrador, Gregorio, Chertow, Glenn, Chang, Tara, Hawley, Carmel, Ji, Linong, Wada, Takashi, Jha, Vivekanand, Lim, Soo Kun, Lim-Abrahan, Mary Anne, Santos, Florence, Chae, Dong-Wan, Hwang, Shang-Jyh, Vazelov, Evgueniy, Rychlík, Ivan, Hadjadj, Samy, Krane, Vera, Rosivall, László, De Nicola, Luca, Dreval, Alexander, Nowicki, Michał, Schiller, Adalbert, Distiller, Larry, Górriz, Jose L., Kolesnyk, Mykola, David, Wheeler, C., Guerrero, Rodolfo Andres Ahuad, Albisu, Juan Pablo, Alvarisqueta, Andres, Bartolacci, Ines, Berli, Mario Alberto, Bordonava, Anselmo, Calella, Pedro, Cantero, Maria Cecilia, Cartasegna, Luis Rodolfo, Cercos, Esteban, Coloma, Gabriela Cecilia, Colombo, Hugo, Commendatore, Victor, Cuadrado, Jesus, Cuneo, Carlos Alberto, Cusumano, Ana Maria, Douthat, Walter Guillermo, Dran, Ricardo Dario, Farias, Eduardo, Fernandez, Maria Florencia, Finkelstein, Hernan, Fragale, Guillermo, Fretes, Jose Osvaldo, Garcia, Nestor Horacio, Gastaldi, Anibal, Gelersztein, Elizabeth, Glenny, Jorge Archibaldo, Gonzalez, Joaquin Pablo, Colaso, Patricia del Carmen Gonzalez, Goycoa, Claudia, Greloni, Gustavo Cristian, Guinsburg, Adrian, Hermida, Sonia, Juncos, Luis Isaias, Klyver, Maria Isabel, Kraft, Florencia, Krynski, Fernando, Lanchiotti, Paulina Virginia, Leon de la Fuente, Ricardo Alfonso, Marchetta, Nora, Mele, Pablo, Nicolai, Silvia, Novoa, Pablo Antonio, Orio, Silvia Ines, Otreras, Fabian, Oviedo, Alejandra, Raffaele, Pablo, Resk, Jorge Hector, Rista, Lucas, Papini, Nelson Rodriguez, Sala, Jorgelina, Santos, Juan Carlos, Schiavi, Lilia Beatriz, Sessa, Horacio, Casabella, Tomas Smith, Ulla, Maria Rosa, Valdez, Maria, Vallejos, Augusto, Villarino, Adriana, Visco, Virginia Esther, Wassermann, Alfredo, Zaidman, Cesar Javier, Cheung, Ngai Wah, Droste, Carolyn, Fraser, Ian, Johnson, David, Mah, Peak Mann, Nicholls, Kathy, Packham, David, Proietto, Joseph, Roberts, Anthony, Roger, Simon, Tsang, Venessa, Raduan, Roberto Abrão, Costa, Fernando Augusto Alves da, Amodeo, Celso, Turatti, Luiz Alberto Andreotti, Bregman, Rachel, Sanches, Fernanda Cristina Camelo, Canani, Luis Henrique, Chacra, Antônio Roberto, Borges, João Lindolfo Cunha, Vêncio, Sérgio Alberto Cunha, Franco, Roberto Jorge da Silva, d’Avila, Domingos, Portes, Evandro de Souza, de Souza, Pedro, Deboni, Luciane Mônica, Fraige Filho, Fadlo, Neto, Bruno Geloneze, Gomes, Marcus, Kohara, Suely Keiko, Keitel, Elizete, Saraiva, Jose Francisco Kerr, Lisboa, Hugo Roberto Kurtz, Contieri, Fabiana Loss de Carvalho, Milagres, Rosângela, Junior, Renan Montenegro, de Brito, Claudia Moreira, Hissa, Miguel Nasser, Sabbag, Ângela Regina Nazario, Noronha, Irene, Panarotto, Daniel, Filho, Roberto Pecoits, Pereira, Márcio Antônio, Saporito, Wladmir, Scotton, Antonio Scafuto, Schuch, Tiago, de Almeida, Roberto Simões, Ramos, Cássio Slompo, Felício, João Soares, Thomé, Fernando, Hachmann, Jean Carlo Tibes, Yamada, Sérgio, Hayashida, Cesar Yoiti, Petry, Tarissa Beatrice Zanata, Zanella, Maria Teresa, Andreeva, Viktoria, Angelova, Angelina, Dimitrov, Stefan, Genadieva, Veselka, Genova-Hristova, Gabriela, Hristozov, Kiril, Kamenov, Zdravko, Koundurdjiev, Atanas, Lozanov, Lachezar, Margaritov, Viktor, Nonchev, Boyan, Rangelov, Rangel, Shinkov, Alexander, Temelkova, Margarita, Velichkova, Ekaterina, Yakov, Andrian, Aggarwal, Naresh, Aronson, Ronnie, Bajaj, Harpreet, Chouinard, Guy, Conway, James, Cournoyer, Serge, DaRoza, Gerald, De Serres, Sacha, Dubé, François, Goldenberg, Ronald, Gupta, Anil, Gupta, Milan, Henein, Sam, Khandwala, Hasnain, Leiter, Lawrence, Madore, François, McMahon, Alan, Muirhead, Norman, Pichette, Vincent, Rabasa-Lhoret, Remi, Steele, Andrew, Tangri, Navdeep, Torshizi, Ali, Woo, Vincent, Zalunardo, Nadia, Montenegro, María Alicia Fernández, Gonzalo Godoy Jorquera, Juan, Fariña, Marcelo Medina, Gajardo, Victor Saavedra, Vejar, Margarita, Chen, Nan, Chen, Qinkai, Gan, Shenglian, Kong, Yaozhong, Li, Detian, Li, Wenge, Li, Xuemei, Lin, Hongli, Liu, Jian, Lu, Weiping, Mao, Hong, Ren, Yan, Song, Weihong, Sun, Jiao, Sun, Lin, Tu, Ping, Wang, Guixia, Yang, Jinkui, Yin, Aiping, Yu, Xueqing, Zhao, Minghui, Zheng, Hongguang, Mendoza, Jose Luis Accini, Arcos, Edgar, Avendano, Jorge, Diaz Ruiz, Jorge Ernesto Andres, Ortiz, Luis Hernando Garcia, Gonzalez, Alexander, Triana, Eric Hernandez, Higuera, Juan Diego, Malaver, Natalia, de Salazar, Dora Inés Molina, Rosero, Ricardo, Alexandra Terront Lozano, Monica, Cometa, Luis Valderrama, Valenzuela, Alex, Vargas Alonso, Ruben Dario, Villegas, Ivan, Yupanqui, Hernan, Bartaskova, Dagmar, Barton, Petr, Belobradkova, Jana, 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Soto, Mario Burgos, Ramos, Jose Chevaile, Wong, Alfredo Chew, Correa Rotter, Jose Ricardo, Escalante, Tonatiu Diaz, Enriquez Sosa, Favio Edmundo, Lozano, Fernando Flores, Flota Cervera, Luis Fernando, Baron, Paul Frenk, Ballesteros, Cecilia Garcia, Gomez Rangel, Jose David, Herrera Jimenez, Luis Enrique, Irizar Santana, Sergio Saul, Flores, Fernando Jimenez, Molina, Hugo Laviada, Luna Ceballos, Rosa Isela, del Campo Blanco, Belia Martin, Franco, Guadalupe Morales, Moreno Loza, Oscar Tarsicio, Rocha, Cynthia Mustieles, Vera, Gregorio Obrador, Castellanos, Ricardo Orozco, Calcaneo, Juan Peralta, Reyes Rosano, Miguel Angel, Pattzi, Hiromi Rodriguez, Guzman, Juan Rosas, Rucker Joerg, Isabel Erika, Saavedra Sanchez, Sandra Berenice, Sanchez Mijangos, Jose Hector, Sanson, Pablo Serrano, Tamayo y Orozco, Juan Alfredo, Chavez, Eloisa Tellez, Cepeda, Alejandro Valdes, Carrillo, Luis Venegas, Mesa, Juan Villagordoa, Escobedo, Rolando Zamarripa, Baker, John, Noonan, Paul, Scott, Russell, Walker, Robert, Watson, Edward, Williams, Michael, Young, Simon, Abejuela, Zaynab, Agra, Jeimeen, Aquitania, Grace, Caringal, Clodoaido, Comia, Rhea Severina, Santos, Lalaine Delos, Gomez, Olivert, Jimeno, Cecilia, Tan, Gerry, Tolentino, Marsha, Yao, Christy, Yap, Yvette Ethel, Lallaine Ygpuara, Ma. 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Tatiana, Samoylova, Yulia, Sazonova, Olga, Shamkhalova, Minara, Shutemova, Elena, Shwartz, Yuriy, Uriasyev, Oleg, Vorobyev, Sergey, Zateyshchikova, Anna, Zateyshshikov, Dmitry, Zykova, Tatyana, Antic, Slobodan, Djordjevic, Miodrag, Kendereski, Aleksandra, Lalic, Katarina, Lalic, Nebojsa, Popovic-Radinovic, Vesna, Babikova, Jana, Benusova, Olga, Buganova, Ingrid, Culak, Jan, Dzupina, Andrej, Dzuponova, Jana, Fulop, Peter, Ilavska, Adriana, Martinka, Emil, Ochodnicka, Zuzana, Pella, Daniel, Smatanova, Iveta, Ahmed, Fayzal, Badat, Aysha, Breedt, Johannes, Distiller, Lawrence, Govender, Vimladhevi, Govender, Ravendran, Joshi, Mukesh, Jurgens, Jaco, Latiff, Gulam, Lombard, Landman, Mookadam, Mohamed, Ngcakani, Nomangesi, Nortje, Hendrik, Oosthuizen, Helena, Pillay-Ramaya, Larisha, Prozesky, Hans, Reddy, Jeevren, Rheeder, Paul, Seeber, Mary, Cho, Young Min, Jeong, In-Kyung, Kim, Sin Gon, Kim, Yeong Hoon, Kwon, Hyuk-Sang, Kwon, Min Jeong, Lee, Byung-Wan, Lee, JungEun, Lee, Moon-Kyu, Nam, Moon-Suk, Oh, Kook-Hwan, Park, Cheol- Young, Park, Sun-Hee, Yoon, Kun Ho, Garcia, Pere Alvarez, Mercadal, Luis Asmarats, Barrios, Clara, Castro, Fernando Cereto, Guldris, Secundino Cigarran, Lopez, Marta Dominguez, Egido de los Rios, Jesus, Fresnedo, Gema Fernandez, Serrano, Antonio Galan, Garcia, Isabel, Gonzalez Martinez, Francisco Javier, Jodar Gimeno, Jose Esteban, Mendoza, Manuel Lopez, Marin, Tamara Malek, Portillo, Cristobal Morales, Munar Vila, Maria Antonia, Torres, Manuel Muñoz, Iglesias, Javier Nieto, Perez, Jonay Pantoja, Vera, Merce Perez, Portoles Perez, Jose M., Quesada Simón, María Angustias, Canonge, Rafael Simo, Gonzalez, Alfonso Soto, Riera, Manel Terns, Tinahones Madueno, Francisco Jose, Plaza, Mercedes Velo, Chang, Chwen-Tzuei, Chuang, Lee-Ming, Hsia, Te-Lin, Hsieh, Chang-Hsun, Lin, Chih-Ching, Lu, Yung- Chuan, Sheu, Wayne H-H, Barna, Olga, Bilyk, Svitlana D., Botsyurko, Volodymyr, Dudar, Iryna, Fushtey, Ivan, Godlevska, Olga, Golovchenko, Oleksandr, Gyrina, Olga, Kazmirchuk, Anatoliy, Komisarenko, Iuliia, Korzh, Oleksii, Kravchun, Nonna, Legun, Oleg, Mankovskyy, Borys, Martynyuk, Liliya, Mostovoy, Yuriy, Pashkovska, Nataliia, Pererva, Larysa, Pertseva, Tetyana, Samoylov, Oleksandr, Smirnov, Ivan, Svyshchenko, Yevgeniya, Tomashkevych, Halyna, Topchii, Ivan, Tryshchuk, Nadiya, Tseluyko, Vira, Vizir, Vadym, Vlasenko, Maryna, Zlova, Tetiana, Zub, Liliia, Abusnana, Salah, Railey, Mohamed, Abouglila, Kamal, Ainsworth, Paul, Ali, Zishan, Arutchelvam, Vijayaraman, Barnard, Maria, Bellary, Srikanth, Davies, Emyr, Davies, Mark, Davies, Simon, Dawson, Alison, El Kossi, Mohsen, English, Patrick, Fraser, Donald, Gnudi, Luigi, Gunstone, Anthony, Hall, Timothy, Hanif, Wasim, Jackson, Alan, Johnson, Andrew, Joseph, Franklin, Krishnan, Singhan, Kumwenda, Mick, MacDougall, Iain, Nixon, Paul, O'Hare, Joseph, Philip, Sam, Ramtoola, Shenaz, Saxena, Manish, Sennik, Davesh, Simon, Godwin, Singh, Baldev, Stephens, Jeffrey, Strzelecka, Anna, Symonds, Rehan, Turner, Wayne, Wahba, Mona, Wakeling, John, Wheeler, David, Winocour, Peter, Abdallah, Joseph, Abdullah, Raied, Abramowitz, Matthew, Acosta, Idalia, Aiello, Joseph, Akright, Laura, Akyea-Djamson, Ayim, Alappan, Rajendran, Alicic, Radica, Al-Karadsheh, Amer, Allison, Dale Crawford, Arauz-Pacheco, Carlos, Arfeen, Shahabul, Arif, Ahmed, Arvind, Moogali, Atray, Naveen, Awad, Ahmed, Barnhill, Peggy, Barranco, Elizabeth, Barrera, Carlos, Beacom, Matthew, Behara, Venkata, Belo, Diogo, Bentley-Lewis, Rhonda, Berenguer, Ramon, Bermudez, Lidia, Bernardo, Marializa, Biscoveanu, Mihaela, Bowman-Stroud, Cynthia, Brandon, Donald, Brusco, Osvaldo, Busch, Robert, Canaan, Yamil, Chilito, Alicia, Christensen, Tom, Christiano, Cynthia, Christofides, Elena, Chuateco, Caroucel, Cohen, Kenneth, Cohen, Robert, Cohen-Stein, Debbie, Cook, Charles, Coyne, Daniel, Daboul, Nizar, Darwish, Riad, Daswani, Adarsh, Deck, Kenneth, Desouza, Cyrus, Dev, Devasmita, Dhillon, Monika, Dua, Sohan, Eder, Frank, Elosegui, Ana Maria, El-Shahawy, Mohamed, Ervin, John, Esquenazi, Alberto, Evans, John, Fishbane, Steven, Frias, Juan, Galindo-Ramos, Eugenia, Galphin, Claude, Ghazi, Adline, Gonzalez, Enrique, Gorson, David, Gowda, Anupama, Greco, Barbara, Grubb, Stephen, Gulati, Rakesh, Hammoud, Jamal, Handelsman, Stuart, Hartman, Israel, Hershon, Kenneth, Hiser, Daniel, Hon, George, Jacob, Radu, Jaime, Maria, Jamal, Aamir, Kaupke, Charles, Keightley, Gerald, Kern, Elizabeth, Khanna, Rakhi, Khitan, Zeid, Kim, Sun, Kopyt, Nelson, Kovesdy, Csaba, Krishna, Gopal, Kropp, Jeffrey (Jay), Kumar, Amrendra, Kumar, Jayant, Kumar, Neil, Kusnir, Jorge, Lane, Wendy, Lawrence, Mary, Lehrner, Lawrence, Lentz, John, Levinson, Dennis, Lewis, Derek, Liss, Kenneth, Maddux, Andreas, Maheshwari, Hiralal, Mandayam, Sreedhar, Marar, Isam, Mehta, Bhasker, Middleton, John, Mordujovich, Jorge, Moreda, Ramon, Moustafa, Moustafa, Trenche, Samuel Mujica, Narayanan, Mohanram, Narvarte, Javier, Nassar, Tareq, Newman, George, Nichol, Brian, Nicol, Philip, Nisnisan, Josier, Nossuli, A. Kaldun, Obialo, Chamberlain, Olelewe, Sarah, Oliver, Michael, O'Shaughnessy, Andrew, Padron, John, Pankhaniya, Rohit, Parker, Reginald, Patel, Devesh, Patel, Gnyandev, Patel, Nina, Pavon, Humberto, Perez, Armando, Perez, Carlos, Perlman, Alan, Pettis, Karlton, Pharr, Walter, Phillips, Andrea, Purighalla, Raman, Quesada-Suarez, Luis, Ranjan, Rajiv, Rastogi, Sanjeev, Reddy, Jakkidi, Rendell, Marc, Rich, Lisa, Robinson, Michael, Rodriguez, Hector, Rosas, Sylvia, Saba, Fadi, Sankaram, Rallabhandi, Sarin, Ravi, Schreiman, Robert, Scott, David, Sekkarie, Mohamed, Sensenbrenner, John, Shakeel, Muhammad, Shanik, Michael, Shaw, Sylvia, Smith, Stephen, Solomon, Richard, Sprague, Amy, Spry, Leslie, Suchinda, Pusadee, Sultan, Senan, Surampudi, Prasanth, Sussman, Sherry, Tan, Anjanette, Terrelonge, Antonio, Thompson, Michael, Trespalacios, Fernando, Trippe, Bruce, Trueba, Pilar, Twahirwa, Marcel, Updegrove, John, Van Buren, Peter, Vannorsdall, Mark, Varghese, Freemu, Velasquez-Mieyer, Pedro, Ventrapragada, Sailaja, Vukotic, Goga, Wadud, Khurram, Warren, Mark, Watson, Henry, Watts, Ronald, Weiner, Daniel, Welker, James, Welsh, Jean, Williams, Shelley, Zaniewski-Singh, Michelle, Yi, Tae Won, Smyth, Brendan, Di Tanna, Gian Luca, Arnott, Clare, Cardoza, Kathryn, and Kang, Amy
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- 2023
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3. The use of advanced technology for preoperative planning in cranial surgery – A survey by the EANS Young Neurosurgeons Committee
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Raffa, Giovanni, Spiriev, Toma, Zoia, Cesare, Aldea, Cristina C., Bartek Jr, Jiri, Bauer, Marlies, Ben-Shalom, Netanel, Belo, Diogo, Drosos, Evangelos, Freyschlag, Christian F., Kaprovoy, Stanislav, Lepic, Milan, Lippa, Laura, Rabiei, Katrin, Schwake, Michael, Stengel, Felix C., Stienen, Martin N., and Gandía-González, Maria L.
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- 2023
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4. Transformation of neurosurgical training from “see one, do one, teach one” to AR/VR & simulation – A survey by the EANS Young Neurosurgeons
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Stengel, Felix C., Gandia-Gonzalez, Maria L., Aldea, Cristina C., Bartek, Jiri, Jr., Belo, Diogo, Ben-Shalom, Netanel, De la Cerda-Vargas, María F., Drosos, Evangelos, Freyschlag, Christian F., Kaprovoy, Stanislav, Lepic, Milan, Lippa, Laura, Rabiei, Katrin, Raffa, Giovanni, Sandoval-Bonilla, Bayron A., Schwake, Michael, Spiriev, Toma, Zoia, Cesare, and Stienen, Martin N.
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- 2022
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5. Multidisciplinary Approach to Spinal Metastases and Metastatic Spinal Cord Compression—A New Integrative Flowchart for Patient Management.
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Esperança-Martins, Miguel, Roque, Diogo, Barroso, Tiago, Abrunhosa-Branquinho, André, Belo, Diogo, Simas, Nuno, and Costa, Luis
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FUNCTIONAL status ,METASTASIS ,UNCERTAINTY ,CANCER patients ,NEUROLOGIC manifestations of general diseases ,RISK assessment ,HEALTH care teams ,QUALITY of life ,DECISION making in clinical medicine ,SPINAL tumors ,SPINAL cord compression ,COMORBIDITY ,DISEASE risk factors ,DISEASE complications - Abstract
Simple Summary: The prevalence of metastatic spine disease is progressively increasing, affecting a growing group of heterogeneous and complex patients. A multidisciplinary, personalized approach, enriched by the expertise of each involved specialty (namely oncologists, radiotherapists, neurosurgeons, orthopedic surgeons, hematologists, and neuroradiologists), is pivotal and achieves superior results in terms of clinical outcomes. We reviewed the most recent data regarding the pathophysiology of metastatic spine disease, prognostic scores, and available treatment options and formulated a proposal for an updated algorithmic approach to the pathology according to the clinical scenario of each patient. A flowchart-based approach to patients offers an evidence-based management of metastatic spine disease, providing a valuable clinical decision tool in a context of high uncertainty and quick-acting need. Nevertheless, we underline that the goal of this type of approach is to assist in clinical decisions, not to replace a case-by-case reflection concerning the specificities of each patient. Metastatic spine disease (MSD) and metastatic spinal cord compression (MSCC) are major causes of permanent neurological damage and long-term disability for cancer patients. The development of MSD is pathophysiologically framed by a cooperative interaction between general mechanisms of bone growth and specific mechanisms of spinal metastases (SM) expansion. SM most commonly affects the thoracic spine, even though multiple segments may be affected concomitantly. The great majority of SM are extradural, while intradural-extramedullary and intramedullary metastases are less frequently seen. The management of patients with SM is particularly complex and challenging, with multiple factors—such as the spinal stability status, primary tumor radio and chemosensitivity, cancer biological burden, patient performance status and comorbidities, and patient's oncological prognosis—influencing the clinical decision-making process. Different frameworks were developed in order to systematize and support this process. A multidisciplinary, personalized approach, enriched by the expertise of each involved specialty, is crucial. We reviewed the most recent evidence and proposed an updated algorithmic approach to patients with MSD according to the clinical scenario of each patient. A flowchart-based approach offers an evidence-based management of MSD, providing a valuable clinical decision tool in a context of high uncertainty and quick-acting need. [ABSTRACT FROM AUTHOR]
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- 2023
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6. The EANS Young Neurosurgeons Committee’s vision of the future of European Neurosurgery.
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ZOIA, Cesare, RAFFA, Giovanni, ALDEA, Cristina C., Jr, Jiri BARTEK, BEN-SHALOM, Netanel, BELO, Diogo, DROSOS, Evangelos, FREYSCHLAG, Christian F., KAPROVOY, Stanislav, LEPIC, Milan, LIPPA, Laura, RABIEI, Katrin, SCHWAKE, Michael, SPIRIEV, Toma, STIENEN, Martin N., and GANDÍA-GONZÁLEZ, Maria L.
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- 2022
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7. Ferric Citrate Dosing in Iron Deficiency Anemia in Nondialysis-Dependent Chronic Kidney Disease.
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Pergola, Pablo E., Belo, Diogo, Crawford, Paul, Moustafa, Moustafa, Luo, Wenli, Goldfarb-Rumyantzev, Alexander, and Farag, Youssef M.K.
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IRON deficiency anemia ,CHRONIC kidney failure ,RED blood cell transfusion ,CITRATES ,GLOMERULAR filtration rate ,ADULTS - Abstract
Introduction: Ferric citrate (FC) is indicated as an oral iron replacement for iron deficiency anemia in adult patients with chronic kidney disease (CKD) not on dialysis. The recommended starting dose is one 1-g tablet three times daily (TID). This study investigated long-term efficacy and safety of different FC dosing regimens for treating anemia in nondialysis-dependent CKD (NDD-CKD). Methods: In this phase 4, randomized, open-label, multicenter study, patients with anemia with NDD-CKD (estimated glomerular filtration rate, ≥20 mL/min and <60 mL/min) were randomized 1:1 to one FC tablet (1-g equivalent to 210 mg ferric iron) TID (3 g/day) or 2 tablets twice daily (BID; 4 g/day). At week 12, dosage was increased to 2 tablets TID (6 g/day) or 3 tablets BID (6 g/day) in patients whose hemoglobin (Hb) levels increased <0.5 g/dL or were <10 g/dL. Primary endpoint was mean change in Hb from baseline to week 24. Results: Of 484 patients screened, 206 were randomized and 205 received FC. Mean (standard deviation) changes from baseline in Hb at week 24 were 0.77 (0.84) g/dL with FC TID 3 g/day and 0.70 (0.98) g/dL with FC BID 4 g/day. Discussion/Conclusions: FC administered BID and TID for 48 weeks was safe and effective for treating anemia in this population, supporting potentially increased dosing flexibility. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Cervical spine multiple myeloma and isolated radiotherapy.
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Belo, Diogo, Reis, José Hipólito, and Teixeira, Joaquim Cruz
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CERVICAL vertebrae , *MULTIPLE myeloma , *MAGNETIC resonance imaging , *SPINAL instability , *COMPUTED tomography , *EOSINOPHILIC granuloma , *RADIOTHERAPY - Abstract
Multiple myeloma is a hematologic malignancy frequently presenting with spinal lytic lesions. The authors report the case of a patient with an extensively destructive osteolytic MM lesion in the cervical spine treated exclusively with radiotherapy. Computed tomography and magnetic resonance imaging scans showed an arrest of further progression of instability and resolution of the lytic lesion, showing signs of new bone formation. Whereas surgery should be considered for cases of spinal instability and potential neurological injury, this case demonstrates that isolated radiotherapy can be used in select cases to treat MM lesions and restore the structural integrity of the spinal elements. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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9. Safety and efficacy of iron isomaltoside 1000/ferric derisomaltose versus iron sucrose in patients with chronic kidney disease: the FERWON-NEPHRO randomized, open-label, comparative trial.
- Author
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Bhandari, Sunil, Kalra, Philip A, Berkowitz, Mario, Belo, Diogo, Thomsen, Lars L, and Wolf, Myles
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CHRONIC kidney failure ,IRON deficiency anemia ,CHRONICALLY ill ,IRON deficiency diseases ,SUCROSE - Abstract
Background The optimal intravenous (IV) iron would allow safe correction of iron deficiency at a single infusion over a short time. The FERWON-NEPHRO trial evaluated the safety and efficacy of iron isomaltoside 1000/ferric derisomaltose (IIM) in patients with non-dialysis-dependent chronic kidney disease and iron deficiency anaemia. Methods In this randomized, open-label and multi-centre trial conducted in the USA, patients were randomized 2:1 to a single dose of 1000 mg IIM or iron sucrose (IS) administered as 200 mg IV injections up to five times within a 2-week period. The co-primary endpoints were serious or severe hypersensitivity reactions and change in haemoglobin (Hb) from baseline to Week 8. Secondary endpoints included incidence of composite cardiovascular adverse events (AEs). Results A total of 1538 patients were enrolled (mean estimated glomerular filtration rate 35.5 mL/min/1.73 m
2 ). The co-primary safety objective was met based on no significant difference in the incidence of serious or severe hypersensitivity reactions in the IIM and IS groups [0.3% versus 0%; risk difference: 0.29% (95% confidence interval: –0.19; 0.77; P > 0.05)]. Incidence of composite cardiovascular AEs was significantly lower in the IIM versus IS group (4.1% versus 6.9%; P = 0.025). Compared with IS, IIM led to a more pronounced increase in Hb during the first 4 weeks (P ≤ 0.021), and change in Hb to Week 8 showed non-inferiority, confirming that the co-primary efficacy objective was met. Conclusions Compared with multiple doses of IS, a single dose of IIM induced a non-inferior 8-week haematological response, comparably low rates of hypersensitivity reactions, and a significantly lower incidence of composite cardiovascular AEs. [ABSTRACT FROM AUTHOR]- Published
- 2021
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10. Postoperative Brown-Séquard syndrome: case report and review of the literature.
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Belo, Diogo, Teixeira, Joaquim Cruz, and Lavrador, José Pedro
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LITERATURE reviews , *SPINAL cord compression , *NEUROLOGICAL disorders , *SURGICAL decompression , *SYNDROMES , *BURNING mouth syndrome - Abstract
Brown-Séquard syndrome (BSS) is a rare neurological condition caused by a hemi-lesion of the spinal cord and was first described in the 1800s. BSS is characterized by an ipsilateral absence of motor control and discriminatory/proprioceptive/vibratory sensation at and below the spinal level involved, associated with loss of contralateral temperature and pain sensation a couple of vertebral segments below the lesion. BSS is commonly associated with trauma, but can also be iatrogenic. The authors report a case of a patient who presented with neoplastic dorsal spinal cord compression and developed a BSS after surgical decompression and review of the literature of postoperative BSS cases. [ABSTRACT FROM AUTHOR]
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- 2020
- Full Text
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11. Giant Malignant Peripheral Nerve Sheath Tumor of the Scalp: Case Report and Review of the Literature.
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Cubas Farinha, Nuno, Belo, Diogo, Freitas, Hugo, and Coiteiro, Domingos
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PERIPHERAL nerve tumors , *SCHWANNOMAS , *NERVOUS system tumors , *LATISSIMUS dorsi (Muscles) , *SCALP , *LITERATURE reviews - Abstract
Malignant peripheral nerve sheath tumors (MPNSTs) are rare nervous system tumors that rarely appear on the scalp. About half of the scalp MPNSTs described in the literature have reached giant dimensions at the time of diagnosis. The surgical treatment is the gold standard for this type of tumor. Some authors suggest adjuvant radiotherapy for local tumor control, although there is uncertainty about its advantages and its use is not without risks. We present the case of a 31-year-old man who presented with a large necrotic scalp tumor of the left frontoparietal convexity. magnetic resonance imaging showed a large extra-axial tumor, measuring 17 x 17 x 8 cm, centered on the soft tissues, with skull erosion and signs of dural invasion, although with no intradural component. The tumor was surgically removed and the osteocutaneous defect was reconstructed with a latissimus dorsi muscle free flap. The anatomopathologic diagnosis was MPNST. The patient then underwent adjuvant radiotherapy. After 7 months he developed a progressive right hemiparesis and magnetic resonance imaging showed results compatible with cerebral radiation necrosis. This motor deficit improved with corticotherapy. After 9 months the patient went back to his home country and was subsequently lost to follow-up. Giant MPNSTs of the scalp are highly aggressive lesions that should primarily be treated in a surgical fashion. Although adjuvant radiotherapy has been used routinely for local tumor control, there is uncertainty about its advantages. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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12. Complications in Deep Brain Stimulation - Surgical Revision Approaches.
- Author
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Belo, Diogo, Lavrador, José Pedro, Cattoni, Maria Begoña, and Carvalho, Herculano
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Background: The non-elective surgical revision of deep brain stimulation (DBS) patients is a growing concern amongst neurosurgeons. Scarce literature is available concerning the surgical management of DBS complications, particularly the noninfectious kind and there are no globally accepted guidelines on how to handle these complications. Furthermore, both the epidemiology and surgical management provided in each case vary greatly and are therefore worthy of study. Methods: Retrospective cohort study of patients submitted to DBS surgery between 2006 and 2016 at our centre. The demographics - gender, age - and clinical variables - disease, the reason for non-elective re-intervention, and the performed surgical technique - were analysed. Results: 195 patients were included (119 males; 76 females). The majority suffered from Parkinson's disease (PD)-166 (85.1%) versus 25(12.8%) with Dystonia (DYST) and 2 (1%) with Essential Tremor (ET) and 2 (1%) with Tourette Syndrome. 18 non-elective surgical interventions were performed- 9% of treated patients (88.9% DP-16 patients and 11.1% DYST-2 patients). In this subgroup, 8 patients had an infection (44.4%), 1 had a central nervous system infection, 5 presented with hardware exposure and 4 displayed a foreign body reaction. An initial system-preserving technique (non-removal of the entire system) was used for every patient as a first line treatment. Only 3 patients (16.7%) required a second surgery for removal of the entire system, of which 2 presented with an infection of the subclavian IPG pouch and 1 with hardware exposure. Neither PD, nor DYST were related with an increased risk for non-programmed surgical intervention (p-value=0.596). Conclusion: Even though entire system removal has been the consensual approach to DBS-related complications, this data supports that a system-preserving technique is of high-value and should be taken into consideration whilst planning for a surgical revision of patients presenting with these complications. [ABSTRACT FROM AUTHOR]
- Published
- 2017
13. Anatomical Landmarks for Deep Brain Stimulation Shift.
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Lavrador, José Pedro, Batista, Pedro, Miranda, Bruno, Belo, Diogo, Simão, Diogo, Coelho, Miguel, Guedes, Leonor, Gonçalves-Ferreira, António, Cattoni, Maria Begoña, and Carvalho, Manuel Herculano
- Abstract
Introduction: The effectiveness of intraoperative measures to avoid brain shift in Deep Brain Stimulation surgery is still to be proven. Our aim is to assess bran shift in the presence of these measures and to identify anatomical landmarks that help to predict it. Methods: Retrospective cohort study of Parkinson Disease (PD) and Dystonia (DYST) patients admitted for DBS surgery (January 2013-January 2015) in a single centre. STN and GPi stereotactic coordinates, the implanted electrode, the chronic stimulated pole, the first site to be implanted and the time between eletrodes placement were evaluated for each patient. AC-PC, 3rd Ventricular width and vertical diameters and the distance between both temporal and frontal horns were evaluated in the pre-op MRI for each patient. Results: 42 patients were considered (14 DYST and 28 PD; 84 nuclei evaluated - 28 GPi and 56 STN). The mean values of each coordinate were right GPi (X- 21.38 ± 0.53; Y- 0.66 ± 0.47; Z- -1.59 ± 0.55), left GPI (X- -18.13 ± 3.25; Y- 0.28 ± 0.48; Z- -2.67 ± 0.50), right STN (X- 12.53 ± 0.53; Y- -1.91 ± 0.16; Z- -4.29 ± 0.22) and left STN (X- -12.31 ± 0.52; Y- -2.06 ± 0.20; Z- -4.56 ± 0.13). The adjusted analysis revealed that the X coordinate variate bilaterally and consistently (STN and GPi) with the distance between both temporal horns. Left electrode was the first to be placed in 52.8% (n = 19) of the cases. Time difference between the first and second electrode placement was 132.5 ± 4.6 minutes (no difference between DP and DYST). Central electrode was placed in 66.7% (n = 16) - left side - and 52.2% (n = 12) - right side - of the cases. The second pole (counting from the extremity) was the most frequent in chronic stimulation (left - 44.4%, n = 8; right - 52.6%, n = 10). Although the unadjusted analysis showed no difference between the first and the second implanted eletrodes, the ventricular dimensions adjusted analysis revealed an increase AC-PC and 3rd Ventricular width produces a more anterior and medial contralateral final electrode with no variation in the chronic stimulated pole (p < 0.05). There was no influence of the vertical dimension in either electrode or chronic stimulated pole in the second implanted site. (p > 0.05). Conclusion: STN and GPi X coordinate variates with the distance between both temporal horns. AC-PC and 3rd Ventricular width influenced the final position of the second implanted electrode. Both findings support CSF as an important player in intraoperative brain shift. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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14. DBS and Parkinson's Disease - Two-Step Strategy.
- Author
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Belo, Diogo, Lavrador, José Pedro, Carvalho, Herculano, and Cattoni, Maria Begoña
- Abstract
Introduction: Implant infection in DBS surgery is one feared complication. The growing number of DBS surgeries performed and use in a broader number of pathologies, may lead to a rising number of infections. There are no globally accepted guidelines for preventing this complication. Methods: A cohort study was perfomed including all patients submitted to DBS surgery for Parkinson's disease during the time period ranging from 2006 to 2016. Our group adopted in 2010 a two-step surgery, dividing the long DBS surgery procedure into two shorter ones. Data was divided into early infections (occurring in the first 90 days) and late infections (after 90 days). Our primary outcome was the infection rate in both groups and secondary outcomes were early infection rate (=90 days), late infection rate (>90 days), time-to-infection, infection per year, infection site and involved microorganism. Results: Total population included 190 patients (61.58% (n = 117) males, 38.42% (n = 73) females), 40.5% (n = 77) in the 1-procedure group and 59.47% (n = 113) in the 2-procedure group. Considering our primary outcome, 8 infections were diagnosed in the 1-procedure group (infection rate of 8.2%) and 1 in the two-procedure group (infections rate of 0.54%) - p value = 0.041. Early infections were detected only in the 1-procedure group (2.1% - n = 4 - versus 0%, p-value = 0.033). Conclusions: A standardized definition of surgical site infection and treatment guidelines are required. Our results indicate that splitting DBS surgery for Parkinson's into a two-phase surgery may actually decrease the rate of infection, as opposed to the classic procedure practiced in most centers. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
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