1. OBESTATYNA -- DONIESIENIE WSTĘPNE.
- Author
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Belowska-bień, K., Gruber, K., and Zdrojewicz, Z.
- Subjects
- *
AMINO acids , *PEPTIDES , *GENES , *BIOENERGETICS , *METABOLIC syndrome , *INGESTION - Abstract
Obestatin is a 23 amino acid peptide, isolated from the rat stomach. Obestatin and ghrelin are both encoded by the same gene. Obestatin is derived from preproghrelin and plays a functional role in the regulation of energy balance, foot intake, obesity and metabolic syndrome. Obestatin inhibits thirst in rat and alters sleep and is able to cross the blood-brain barrier. So far it has been thought that the GPR 39 receptor is the major modulator in food intake, but recently a survey appeared indicating that it only plays a supportive role. Most of the experiments regarding ghrelin and obestatin are conducted on animal models. It is supposed that obestatin and ghrelin are not independent factors modifying the body's energy economy, but rather elements of a more complicated system requiring a lot of research to understand and describe. [ABSTRACT FROM AUTHOR]
- Published
- 2007