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Background and study aims Neoplasia-related indicators, such as adenoma detection rate (ADR), are a priority in the quality improvement process for colonoscopy. Our aim was to assess and compare different detection and characterization indicators in fecal immunochemical test (FIT)-positive colonoscopies, to determine associated factors, and to propose benchmarks. Patients and methods Retrospective analysis of prospectively collected data from all colonoscopies performed between 2015 and 2019 after a positive quantitative FIT in the population-based colorectal cancer screening program conducted in Alsace, part of the French national program. Detection indicators included ADR, mean number of adenomas per colonoscopy, and proximal serrated lesion (SL) detection rate. Characterization indicators included rate of non-neoplastic polyp (NNP) detection. Results Overall, 13,067 FIT-positive colonoscopies were evaluated, performed by 80 community gastroenterologists. The overall ADR was 57.6 %, and a 10 µg/g increase in fecal hemoglobin concentration was significantly associated with higher ADR (odds ratio [95 % confidence interval] = 1.02 [1.02–1.03]). Endoscopists whose ADR was ≥ 55 % were high detectors for all neoplasia, including proximal SLs and number of adenomas. The rate of detection of NNPs was 39.5 % in highest detectors (ADR > 70 %), significantly higher than in lower detectors (21.4 %) (P

Background and study aims The aim of this study was to analyze presentation, management, and outcomes of large polyps (LPs; ≥ 20 mm) detected in a colorectal cancer (CRC) screening program using a quantitative fecal immunochemical test (FIT). Patients and methods This was a retrospective community- and population-based observational study of all LPs detected in patients aged 50 to 74 years between 2015 and 2019 during FIT-positive colonoscopies within the screening program organized in Alsace (France). Results Among 13,633 FIT-positive colonoscopies, 1256 LPs (8.5 % malignant and 51.8 % nonpedunculated) were detected by 102 community gastroenterologists in 1164 patients (one in 12 colonoscopies). The sensitivity of optical diagnosis of malignancy was 54 % for nonpedunculated and 27 % for pedunculated T1 CRCs. The endoscopic resection rate was 82.7 % (95 % confidence interval [CI] 80.3–84.9) for benign LPs (70.2 % [95 % CI 66.4–74.1]) nonpedunculated, 95.2 % [95 % CI 93.4–97.1] pedunculated), varying from 0 to 100 % depending on the endoscopist. It was correlated with cecal intubation (Pearson r = 0.49, P

Background and study aims The aim of this study was to assess adverse events (AEs) associated with colonoscopy in the French colorectal cancer screening program with fecal occult blood test (FOBT). Patients and methods A retrospective cohort study was performed of all colonoscopies performed from 2015 to 2018 for a positive fecal immunochemical test (FIT) in patients aged 50 to 74 years within the screening program in progress in Alsace, part of the French program. AEs were recorded through prospective voluntary reporting by community gastroenterologists and retrospective postal surveys addressed to individuals screened. They were compared with those recorded in the previous program following colonoscopies performed from 2003 to 2014 for a positive guaiac-based FOBT (gFOBT). Results Of 9576 colonoscopies performed for a positive FIT, 6194 (64.7 %) were therapeutic. Overall, 180 AEs were recorded (18.8 ‰, 95 % CI 16.1–21.5), 114 of them (11.9 ‰, 95 % CI 9.7–14.1) requiring hospitalization, 55 (5.7‰, 95 % CI 4.2–7.3) hospitalization > 24 hours, and eight (0.8 ‰, 95 % CI 0.3–1.4) surgery. The main complications requiring hospitalization were perforation (n = 18, 1.9 ‰, 95 % CI 1.0–2.7) and bleeding (n = 31, 3.2 ‰, 95 % CI 2.1–4.4). Despite a significant increase in several risk factors for complication, the rate of AEs remained stable between gFOBT and FIT programs. Overall, we observed one death (1/27,000 colonoscopies) and three splenic injuries. Conclusions The harms of colonoscopy in a colorectal cancer screening program with FIT are more frequent than usually estimated. This study revealed six AEs requiring hospitalization > 24 hours (three bleeds, two perforations), one necessitating surgery, and 50 minor complications per 1000 colonoscopies.

The Geant4 electromagnetic (EM) physics sub-packages are a component of LHC experiment simulations. During long shutdown 2 for LHC, these packages are under intensive development and we report progress of EM physics in Geant4 versions 10.5 and 10.6, which includes faster computation, more accurate EM models, and extensions to the validation suite. New approaches are developed to simulate radiation damage for silicon vertex detectors and for configuration of multiple scattering per detector region. Improvements in user interfaces developed for low-energy and the Geant4-DNA project are used also for LHC simulation optimisation.

The author intends to give out a very general study. First of all, he indicates that hens are traditionally classified into European races and Asian races, and then mentions some important historic facts. In France, little can be found on the races of hens in the agronomic literature until the publication of Charles Jacque's fundamental work, Le poulailler, in 1858. The introduction of Asian races in Europe, which began in England, took a noteworthy importance: heavier and more productive than the native races, they were widely crossbred with the latter and new populations stood out from them. The variations, especially morphological, which are one of the means to classify races, are briefly presented. Finally, some races are taken as examples, such as the four "big" which prevail in the branch of industry but are used in crossbreedings: Leghorn, Rhode Island, Cornish, White Rock.

We report on developments of the Geant4 electromagnetic physics sub-libraries of Geant4 release 10.4 and beyond. Modifications are introduced to the models of photoelectric effect, bremsstrahlung, gamma conversion, single and multiple scattering. The theory-based Goudsmit-Saunderson model of electron/positron multiple scattering has been recently reviewed and a new improved version, providing the most accurate results for scattering of electrons and positrons, was made available. The updated interfaces, models and configurations have already been integrated into LHC applications and may be useful for any type of simulations.

At first a broad outline of the history of the horse and the Administration of Stud Farms is given until the end of the Ancien Regime. After admitting that horse breeds can prudently be mentioned in the XVIIIth century, the author gives an account devoted to french breeds strictly speaking, which have hardly attracted the attention of the scientists and experts in hippology of the time. The only breeds that counted were the foreign breeds which, by being crossbred, were supposed to improve the indigenous populations. Views relating to the improvement of horse breeds are then tackled. Though they appear greatly questionable compared to current knowledge the pieces of advice given by scientists and practitioners are marked with some commonsense, which could have led to good results. Such was not the case and it was before all because France was backward as regards agronomy. It will not become obvious before the XIXth century and a new crossbreeding period.