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Wound healing is a complex phenomenon particularly owing to the rise in antimicrobial resistance. This has attracted the attention of the scientific community to search for new alternative solutions. Among these, silver being antimicrobial has been used since ancient times. Considering this fact, the main goal of our study was to evaluate the wound-healing ability of mycofabricated silver nanoparticles (AgNPs). We have focused on the formulation of silver nanogel for the management of wounds in albino Wistar rats. Mycosynthesized AgNPs from Fusarium oxysporum were used for the development of novel wound-healing antimicrobial silver nanogel with different concentrations of AgNPs, i.e., 0.1, 0.5, and 1 mg g−1. The formulated silver nanogel demonstrated excellent wound-healing activity in the incision, excision, and burn wound-healing model. In the incision wound-healing model, silver nanogel at a concentration of 0.5 mg g−1 exhibited superior wound-healing effect, whereas in the case of excision and burn wound-healing model, silver nanogel at the concentrations of 0.1 and 1 mg g−1 showed enhanced wound-healing effect, respectively. Moreover, silver nanogel competently arrests the bacterial growth on the wound surface and offers an improved local environment for scald wound healing. Histological studies of healed tissues and organs of the rat stated that AgNPs at less concentration (1 mg g−1) do not show any toxic or adverse effect on the body and promote wound healing of animal tissue. Based on these studies, we concluded that the silver nanogel prepared from mycosynthesized AgNPs can be used as a promising antimicrobial wound dressing. [ABSTRACT FROM AUTHOR]

Noble metals and their compounds have been used as therapeutic agents from the ancient time in medicine for the treatment of various infections. Recently, much progress has been made in the field of nanobiotechnology towards the development of different kinds of nanomaterials with a wide range of applications. Among the metal nanoparticles, noble metal nanoparticles have demonstrated potential biomedical applications. Due to the small size, nanoparticles can easily interact with biomolecules both at surface and inside cells, yielding better signals and target specificity for diagnostics and therapeutics. Noble metal nanoparticles inspired the researchers due to their remarkable role in detection and treatment of dreadful diseases. In this review, we have attempted to focus on the biomedical applications of noble metal nanoparticles particularly, silver, gold, and platinum in diagnosis and treatment of dreaded diseases such as cancer, human immunodeficiency virus (HIV), tuberculosis (TB), and Parkinson disease. In addition, the role of silver nanoparticles (AgNPs) such as novel antimicrobials, gold nanoparticles (AuNPs) such as efficient drug carrier, uses of platinum nanoparticles (PtNPs) in bone allograft, dentistry, etc. have been critically reviewed. Moreover, the toxicity due to the use of metal nanoparticles and some unsolved challenges in the field have been discussed with their possible solutions. [ABSTRACT FROM PUBLISHER]

Abstract: Copper nanoparticles play an important role in the field of optics and electronics, and also as a novel antimicrobial. In the present study, we report antifungal activity of copper nanoparticles against selected crop pathogenic fungi. Copper nanoparticles were synthesized by chemical reduction of Cu2+ in the presence of Cetyl Trimethyl Ammonium Bromide and isopropyl alcohol. Characterizations of copper nanoparticles were carried out by UV–visible spectroscopy, nanoparticles tracking analysis (NTA), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) which revealed that synthesized nanoparticles were coated by Cetyl Trimethylammonium Bromide (CTAB) having particle size of 3–10nm. Copper nanoparticles demonstrated significant antifungal activity against plant pathogenic fungi: Phoma destructiva (DBT-66), Curvularia lunata (MTCC no. 2030), Alternaria alternata (MTCC No. 6572) and Fusarium oxysporum (MTCC No. 1755). Since for the synthesis of copper nanoparticles the present chemical method by using C-TAB-IPA is found to be simple, economic and fast, the synthesized copper nanoparticles can be used as a novel antifungal agent in agriculture to control the plant pathogenic fungi as well as potent disinfectant in poultry and animal husbandry. [Copyright &y& Elsevier]