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6. Effect of a Cooperation Strategy between Primary Care Physicians and Hospital Liver Units on HBV Care in Campania, Italy

Author

Rosa Zampino, Nicolina Capoluongo, Adriana Boemio, Margherita Macera, Martina Vitrone, Luigi Elio Adinolfi, Pietro Filippini, Evangelista Sagnelli, Caterina Sagnelli, Emanuele Durante-Mangoni, and Nicola Coppola

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Aims. This study is aimed at assessing the efficacy of an active search and treat strategy for HBV-infected subjects in an endemic area (Campania, Italy). To do this, we created a cooperation bundle between 24 General Practitioners (GPs) and 3 Hospital Liver Units (HLU). We assessed whether this strategy improved the detection of HBV infection in patients at risk and the overall quality of care, with the aim of reducing liver disease progression. Methods. We estimated that, among about 20,000 patients cared for by the 24 GPs, approximately 280 patients unaware of or underestimating HBV infection would be found. Identified patients were to be referred to the HLU for clinical evaluation and treatment from February 2016 for 12 months. Results. Unexpectedly, screening and enrolment were poor (48 patients only). GP workloads, patient financial difficulties, and patients' refusal were the major causes of enrolment failure according to GPs. All patients referred to HLU completed the program; most of them were HBV inactive carriers. Conclusions. This program failed to scavenge chronic HBV-infected patients in an endemic area and establish a successful clinical collaboration between GPs and HLU. Underlying reasons are diverse and call for new strategies to implement cooperation between primary care providers and hospital specialists.

Published
2018
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12. Cannabinoid receptor 2-63 QQ variant is associated with persistently normal aminotransferase serum levels in chronic hepatitis C.

Author

Nicola Coppola, Rosa Zampino, Caterina Sagnelli, Giulia Bellini, Aldo Marrone, Maria Stanzione, Nicolina Capoluongo, Adriana Boemio, Carmine Minichini, Luigi Elio Adinolfi, Sabatino Maione, Emanuele Miraglia Del Giudice, Evangelista Sagnelli, and Francesca Rossi

Subjects
Medicine, Science
Abstract

Background and aimTo evaluate in anti-HCV-positive patients the clinical impact of the rs35761398 variant of the CNR2 gene leading to the substitution of Gln (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with Arg (R).Patients and methods253 consecutive anti-HCV-/HCV-RNA-positive patients were enrolled, of whom 53 were HCV carriers with persistently normal ALT (PNALT group) and 200 had a history of steadily abnormal serum ALT values (abnormal ALT group). All patients were naive for antiviral therapy and were screened for the CNR2 rs35761398 polymorphism by a TaqMan assay.ResultsSubjects in the PNALT group, compared with those in the abnormal ALT group were older (58.5±12 vs. 50.7±12.4 years, p = 0.001), more frequently female (66% vs. 42%, p = 0.003), with lower body mass index (BMI) (24.5±3.1 vs. 26.6±4.6, p = 0.003), and more frequently with HCV genotype 2 (43.1% vs 17.7%, p = 0.0002) and CB2-63 QQ variant (34% vs. 11%, p = 0.0001). Considering all 253 patients, no difference in the demographic, biochemical, or virological data was observed between patients in the different CB2-63 variants. The logistic regression analysis identified CB2-63 QQ, HCV genotype 2, older age and lower BMI as independent predictors of PNALT (pDiscussionThe CB2-63 QQ variant in HCV patients was independently associated with the PNALT status.

Published
2014
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14. Using population health‐based strategies to optimize use of direct‐acting oral anticoagulants in atrial fibrillation.

Author

Nigro, Stefanie C. and Boemio, Nicholas

Subjects
ORAL medication, ATRIAL fibrillation, ANTICOAGULANTS, GASTROINTESTINAL hemorrhage, OLDER people
Abstract

Introduction: Pharmacists deploy a variety of population‐health strategies to identify needs related to pharmacotherapy. One area that deserves closer attention is medication management in atrial fibrillation (AF) since managing stroke prevention in older adults with AF requires delicately balancing the risk of thrombosis with the risk of bleeding. Objective(s): Evaluate direct‐acting oral anticoagulant (DOAC) prescribing trends and explore strategies for mitigating gastrointestinal bleeding (GIB) risk in older adults prescribed a DOAC for stroke prevention in AF. Methods: A quality improvement project was conducted and included Managed‐Medicare patients from a single primary care organization prescribed a DOAC for AF. Pharmacists estimated risk of benefit and harm from the prescribed DOAC using established algorithms and patient characteristics documented in the medical record. They then forecasted the change in net clinical benefit if the prescribed DOAC was switched to a different DOAC. Results: Overall, 200 patients met the inclusion criteria. Based on distribution of DOACs in the original study population, 52% of patients were in the definitive benefit group (benefit in reducing stroke risk outweigh risk of bleeding by 2‐fold or greater), with 37% and 10.5% in the leaning benefit (reduction in stroke risk was up to 2‐fold greater than bleeding risk) and leaning risk (bleeding risk was up to 2‐fold greater than stroke risk reduction) groups, respectively. Calculation of risk should the prescribed DOAC be changed from rivaroxaban to apixaban was estimated to improve the net clinical benefit and reduce the risk of a patient falling in a negative clinical benefit group when compared to rivaroxaban and the original study population, respectively; 92% (relative risk [RR] 0.08 [0.026‐0.277; P < 0.0001]) and 81% (RR 0.19 [0.067‐0.545; P = 0.0002]). Conclusion: Population health‐based strategies centered on DOAC use in older adults can help identify prescribing trends and allow organizations to explore ways to mitigate risk of GIB. Preferential use of apixaban could reduce bleeding risk among older adults requiring anticoagulation for AF. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Impact of Diabetes on Cardiac Sympathetic Innervation in Patients With Heart Failure: A 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study

Author

Paolillo, Stefania, Rengo, Giuseppe, Pagano, Gennaro, Pellegrino, Teresa, Savarese, Gianluigi, Femminella, Grazia D., Tuccillo, Marianna, Boemio, Antonio, Attena, Emilio, Formisano, Roberto, Petraglia, Laura, Scopacasa, Francesco, Galasso, Gennaro, Leosco, Dario, Trimarco, Bruno, Cuocolo, Alberto, and Perrone-Filardi, Pasquale

Published
2013
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19. Poster Session 1: Sunday 3 May 2015, 08:30-18:00 * Room: Poster Area

Author

Y. Taniguchi, Y. Takahashi, T. Toba, S. Yamada, K. Yokoi, S. Kobayashi, S. Okajima, A. Shimane, H. Kawai, Y. Yasaka, P. Smanio, M. A. Oliveira, L. Machado, P. Cestari, E. Medeiros, S. Fukuzawa, S. Okino, A. Ikeda, J. Maekawa, S. Ichikawa, N. Kuroiwa, K. Yamanaka, A. Igarashi, M. Inagaki, K. Patel, M. Mahan, K. Ananthasubramaniam, M. Mouden, S. Yokota, J. Ottervanger, S. Knollema, J. Timmer, P. Jager, K. Padron, A. Peix, L. Cabrera, V. Pena Bofill, D. Valera, L. Rodriguez Nande, R. Carrillo Hernandez, E. Mena Esnard, Y. Fernandez Columbie, E. Bertella, A. Baggiano, S. Mushtaq, C. Segurini, M. Loguercio, E. Conte, V. Beltrama, M. Petulla', D. Andreini, G. Pontone, B. Guzic Salobir, M. Dolenc Novak, B. Jug, B. Kacjan, Z. Novak, M. Vrtovec, V. Volpato, A. Formenti, M. Pepi, R. Ajanovic, A. Husic-Selimovic, A. Zujovic-Ajanovic, R. Mlynarski, A. Mlynarska, K. Golba, M. Sosnowski, D. Ameta, M. Goyal, D. Kumar, S. Chandra, R. Sethi, A. Puri, S. K. Dwivedi, V. S. Narain, R. K. Saran, S. Nekolla, C. Rischpler, S. Nicolosi, N. Langwieser, R. Dirschinger, K. Laugwitz, M. Schwaiger, J. L. Goral, J. Napoli, P. Forcada, N. Zucchiatti, A. Damico, D. Olivieri, M. Lavorato, E. Dubesarsky, O. Montana, C. Salgado, A. Jimenez-Heffernan, C. Ramos-Font, J. Lopez-Martin, E. Sanchez De Mora, R. Lopez-Aguilar, A. Manovel, A. Martinez, F. Rivera, E. Soriano, N. Maroz-Vadalazhskaya, E. Trisvetova, O. Vrublevskaya, R. Abazid, M. Kattea, H. Saqqah, S. Sayed, O. Smettei, S. Winther, M. Svensson, H. Birn, H. Jorgensen, H. Botker, P. Ivarsen, M. Bottcher, T. Maaniitty, I. Stenstrom, A. Saraste, E. Pikkarainen, V. Uusitalo, H. Ukkonen, S. Kajander, J. Bax, J. Knuuti, T. Choi, H. Park, C. Lee, J. Lee, Y. Seo, Y. Cho, E. Hwang, D. Cho, C. Sanchez Enrique, C. Ferrera, C. Olmos, A. Jimenez - Ballve, M. J. Perez - Castejon, C. Fernandez, D. Vivas, I. Vilacosta, S. Nagamachi, H. Onizuka, R. Nishii, Y. Mizutani, K. Kitamura, M. Lo Presti, V. Polizzi, P. Pino, G. Luzi, D. Bellavia, R. Fiorilli, A. Madeo, J. Malouf, V. Buffa, F. Musumeci, S. Rosales, A. Puente, N. Zafrir, T. Shochat, A. Mats, A. Solodky, R. Kornowski, A. Lorber, A. Boemio, T. Pellegrino, S. Paolillo, V. Piscopo, R. Carotenuto, B. Russo, S. Pellegrino, G. De Matteis, P. Perrone-Filardi, A. Cuocolo, M. Petretta, N. Amirov, M. Ibatullin, A. Sadykov A, G. Saifullina, R. Ruano, M. Diego Dominguez, T. Rodriguez Gabella, A. Diego Nieto, L. Diaz Gonzalez, J. Garcia-Talavera, P. Sanchez Fernandez, A. Leen, I. Al Younis, S. Zandbergen-Harlaar, H. Verberne, A. Gimelli, C. Veltman, R. Wolterbeek, A. Scholte, D. Mooney, J. Rosenblatt, T. Dunn, S. Vasaiwala, K. Okuda, K. Nakajima, K. Nystrom, L. Edenbrandt, S. Matsuo, H. Wakabayashi, M. Hashimoto, S. Kinuya, V. Iric-Cupic, S. Milanov, G. Davidovic, V. Zdravkovic, K. Ashikaga, K. Yoneyama, Y. Akashi, Z. Shugushev, D. Maximkin, A. Chepurnoy, O. Volkova, V. Baranovich, A. Faibushevich, M. El Tahlawi, A. Elmurr, S. Alzubaidi, A. Sakrana, M. Gouda, R. El Tahlawi, A. Sellem, S. Melki, W. Elajmi, H. Hammami, M. Okano, T. Kato, M. Kimura, M. Funasako, E. Nakane, S. Miyamoto, T. Izumi, T. Haruna, M. Inoko, T. Massardo, E. Swett, R. Fernandez, V. Vera, J. Zhindon, R. Alay, S. Ohshima, M. Nishio, A. Kojima, S. Tamai, T. Kobayashi, T. Murohara, S. Burrell, A. Van Rosendael, I. Van Den Hoogen, M. De Graaf, J. Roelofs, L. Kroft, I. Rjabceva, G. Krumina, A. Kalvelis, F. Chanakhchyan, M. Vakhromeeva, E. Kankiya, J. Koppes, R. Knol, M. Wondergem, T. Van Der Ploeg, F. Van Der Zant, S. V. Lazarenko, V. S. Bruin, X. B. Pan, J. M. Declerck, F. M. Van Der Zant, R. J. J. Knol, L. E. Juarez-Orozco, E. Alexanderson, R. Slart, R. Tio, R. Dierckx, C. Zeebregts, H. Boersma, H. Hillege, M. Martinez-Aguilar, A. Jordan-Rios, T. E. Christensen, K. A. Ahtarovski, L. E. Bang, L. Holmvang, H. Soeholm, A. A. Ghotbi, H. Andersson, N. Ihlemann, A. Kjaer, P. Hasbak, M. Gulya, Y. B. Lishmanov, K. Zavadovskii, D. Lebedev, M. Stahle, S. Hellberg, H. Liljenback, J. Virta, O. Metsala, S. Yla-Herttuala, P. Saukko, A. Roivainen, J. Thackeray, Y. Wang, J. Bankstahl, K. Wollert, F. Bengel, Y. Saushkina, V. Evtushenko, S. Minin, I. Efimova, A. Evtushenko, K. Smishlyaev, Y. Lishmanov, L. Maslov, Y. Kirihara, S. Sugino, J. Taki, A. Ahmadian, J. Berman, P. Govender, F. Ruberg, E. Miller, N. Piriou, A. Pallardy, F. Valette, Z. Cahouch, C. Mathieu, K. Warin-Fresse, J. Gueffet, J. Serfaty, J. Trochu, F. Kraeber-Bodere, J. Van Dijk, J. Van Dalen, H. Ofrk, M. Vaturi, Y. Hassid, D. Belzer, A. Sagie, M. Kaminek, I. Metelkova, M. Budikova, P. Koranda, L. Henzlova, E. Sovova, V. Kincl, A. Drozdova, M. Jordan, F. Shahid, Y. Teoh, R. Thamen, N. Hara, M. Onoguchi, O. Hojyo, Y. Kawaguchi, M. Murai, F. Udaka, Y. Matsuzawa, D. S. Bulugahapitiya, M. Avison, J. Martin, Y.-H. Liu, J. Wu, C. Liu, A. Sinusas, D. Daou, R. Sabbah, H. Bouladhour, C. Coaguila, S. Aguade-Bruix, M. Pizzi, G. Romero-Farina, J. Candell-Riera, J. Castell-Conesa, N. Patchett, A. Sverdlov, S. Boulaamayl El Fatemi, L. Sallam, D. Snipelisky, J. Park, J. Ray, B. Shapiro, M. Kostkiewicz, W. Szot, K. Holcman, A. Lesniak-Sobelga, P. Podolec, O. Clerc, M. Possner, R. Liga, J. Vontobel, F. Mikulicic, C. Graeni, D. Benz, B. Herzog, O. Gaemperli, and P. Kaufmann

Subjects
Medical education, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2015
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20. Abdominal fat interacts with PNPLA3 I148M, but not with the APOC3 variant in the pathogenesis of liver steatosis in chronic hepatitis C

Author

Rosa Zampino, E. Miraglia del Giudice, Aldo Marrone, Nicola Coppola, Grazia Cirillo, Laura Perrone, Evangelista Sagnelli, Le Adinolfi, Adriana Boemio, Margherita Macera, Mariantonietta Pisaturo, Zampino, R., Coppola, N., Cirillo, G., Boemio, A., Pisaturo, M., Marrone, A., Macera, M., Sagnelli, E., Perrone, L., Adinolfi, L. E., and Miraglia Del Giudice, E.

Subjects
APOC3, Adult, Male, medicine.medical_specialty, Genotype, Population, Abdominal Fat, Mutation, Missense, Polymorphism, Single Nucleotide, liver steatosi, Young Adult, Liver disease, Mutant Protein, Polymorphism (computer science), Virology, Internal medicine, medicine, chronic hepatitis C, Humans, education, Membrane Protein, PNPLA3, Aged, Aged, 80 and over, Hepatitis, Apolipoprotein C-III, education.field_of_study, Hepatology, business.industry, Membrane Proteins, Lipase, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Fatty Liver, Infectious Diseases, Endocrinology, Italy, Female, Mutant Proteins, Apolipoprotein C3, Steatosis, business, Human
Abstract

The patatin-like phospholipase domain-containing 3 gene (PNPLA3) and the apolipoprotein C3 gene (APOC3) have been studied in relation to liver steatosis and liver disease outcome. The aim of this study was to evaluate the influence of PNPLA3 p.I148M and APOC3 rs2854116 and rs2854117 polymorphisms on the clinical and histological presentation of chronic hepatitis C in an Italian population and their relationship with viral and anthropometric parameters. Patients with hepatitis C (n = 166) entered the study receiving a clinical, histological, virological and biochemical evaluation. APOC3 (rs2854116 and rs2854117) and PNPLA3 (p.I148M) variants were genotyped. PNPLA3 polymorphisms were associated with liver steatosis, which was significantly higher in patients with p.148I/M (P = 0.034) and p.148M/M (P = 0.004) variants than those homozygous for the PNPLA3 wild type. Excluding patients with HCV genotype 3, the association with liver steatosis and PNPLA3 variants was more marked (p.148I/I genotype vs p.148I/M, P = 0.02, and vs p.148M/M, P = 0.005). The APOC3 polymorphism was not associated with any of the evaluated parameters. Among the interacting factors, BMI and waist circumference correlated with liver steatosis (P = 0.008 and 0.004, respectively). Relationship between waist circumference and liver steatosis was analysed for the different PNPLA3 genotypes. Homozygous 148M patients showed a stronger correlation between waist circumference and steatosis than those carrying the other genotypes (P = 0.0047). In our hepatitis C-infected population, the PNPLA3 polymorphism influenced the development of liver steatosis, but not fibrosis progression. APOC3 polymorphisms had no effect on the development of steatosis and no influence on the PNPLA3 polymorphism. The amount of abdominal fat can increase the association of PNPLA3 p.I148M with liver steatosis. © 2013 John Wiley & Sons Ltd.

Published
2013
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21. Moderated Poster Session 3: Monday 4 May 2015, 10:00-11:00 * Room: Moderated Poster Area

Author

T. Pellegrino, M. Petretta, A. Boemio, V. Piscopo, R. Carotenuto, B. Russo, S. Pellegrino, G. De Matteis, A. Cuocolo, D. V. Ryzhkova, I. Kostina, M. Azevedo Coutinho, N. Cortez-Dias, G. Cantinho, T. Guimaraes, G. Silva, M. Menezes, A. Francisco, R. Placido, I. Conceicao, F. Pinto, K. Nakajima, T. Nakata, S. Matsuo, A. Jacobson, C. A. Paterson, A. J. Al Jabri, J. Robinson, W. Martin, S. Reid, S. A. Smith, H. Harms, L. Tolbod, T. Kero, K. Bouchelouche, J. Frokiaer, J. Sorensen, S. Kinuya, and M. Yamagishi

Subjects
Gerontology, Medical education, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2015
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22. Impact of Diabetes on Cardiac Sympathetic Innervation in Patients With Heart Failure

Author

Teresa Pellegrino, Alberto Cuocolo, Gennaro Pagano, Bruno Trimarco, Dario Leosco, Stefania Paolillo, Francesco Scopacasa, Marianna Tuccillo, Gennaro Galasso, Pasquale Perrone-Filardi, Roberto Formisano, Laura Petraglia, Emilio Attena, Grazia Daniela Femminella, Gianluigi Savarese, Antonio Boemio, and Giuseppe Rengo

Subjects
Advanced and Specialized Nursing, Cardiac function curve, medicine.medical_specialty, Sympathetic nervous system, Ejection fraction, medicine.diagnostic_test, business.industry, Endocrinology, Diabetes and Metabolism, Scintigraphy, medicine.disease, Endocrinology, Blood pressure, medicine.anatomical_structure, Heart failure, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Cardiology, In patient, business
Abstract

OBJECTIVE Impaired parasympathetic and sympathetic nervous system activity have been demonstrated in patients with diabetes mellitus (DM) and correlated with worse prognosis. Few data are available on the effect of DM on cardiac neuropathy in heart failure (HF). The aim of the current study was to assess cardiac sympathetic activity in HF patients with and without DM. RESEARCH DESIGN AND METHODS Patients with severe HF (n = 75), with (n = 37) and without DM (n = 38), and 14 diabetic patients with normal cardiac function underwent 123I meta-iodobenzylguanidine scintigraphy from which early and late heart-to-mediastinum (H/M) ratios were calculated. Clinical, echocardiographic, and biochemical data were measured. RESULTS DM compared with non-DM patients showed significantly lower early (1.65 ± 0.21 vs. 1.75 ± 0.21; P < 0.05) and late H/M ratios (1.46 ± 0.22 vs. 1.58 ± 0.24; P < 0.03). Early and late H/M were significantly higher in DM patients without HF (2.22 ± 0.35 and 1.99 ± 0.24, respectively) than HF patients with (P < 0.0001) and without (P < 0.0001) DM. In HF patients, an inverse correlation between early or late H/M ratio and hemoglobin A1c (HbA1c) (Pearson = −0.473, P = 0.001; Pearson = −0.382, P = 0.001, respectively) was observed. In DM, in multivariate analysis, HbA1c and ejection fraction remained significant predictors of early H/M; HbA1c remained the only significant predictor of late H/M. No correlation between early or late H/M and HbA1c was found in non-DM patients. CONCLUSIONS Diabetic patients with HF show lower cardiac sympathetic activity than HF patients not having DM or than DM patients with a similar degree of autonomic dysfunction not having HF. HbA1c correlated with the degree of reduction in cardiac sympathetic activity.

Published
2013
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23. Probable Tamsulosin-Induced Hyperglycemia: A Case Study.

Author

Nigro, Stefanie C., Nolan, Ryan, and Boemio, Nicholas

Subjects
ADRENERGIC alpha blockers, GLYCOSYLATED hemoglobin, HYPERGLYCEMIA, URINATION disorders, BLOOD sugar monitoring, GLIPIZIDE, EMPAGLIFLOZIN, ATORVASTATIN, ALLOPURINOL, TYPE 2 diabetes, LISINOPRIL, METFORMIN, EXENATIDE, FISH oils
Abstract

The article presents a case study of a 68-year-old Caucasian man with type 2 diabetes. Topics include hyperinsulinemia enhancing the prostate smooth muscle tone and size and altering the transcription of genes involved in sex hormone metabolism; and advised the patient for holding the tamsulosin dose and closely monitoring the blood glucose levels .

Published
2022
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24. The perception of FM sweeps by Chinese and English listeners

Author

Michael Gordon, Huan Luo, David Poeppel, and Anthony Boemio

Subjects
Adult, Male, media_common.quotation_subject, Speech recognition, First language, Phonology, Scale (music), Mandarin Chinese, Speech Acoustics, Sensory Systems, language.human_language, Tone (musical instrument), Variation (linguistics), Acoustic Stimulation, Perception, Auditory Perception, Speech Perception, language, Humans, Female, Natural sounds, Psychology, Language, media_common
Abstract

Frequency-modulated (FM) signals are an integral acoustic component of ecologically natural sounds and are analyzed effectively in the auditory systems of humans and animals. Linearly frequency-modulated tone sweeps were used here to evaluate two questions. First, how rapid a sweep can listeners accurately perceive? Second, is there an effect of native language insofar as the language (phonology) is differentially associated with processing of FM signals? Speakers of English and Mandarin Chinese were tested to evaluate whether being a speaker of a tone language altered the perceptual identification of non-speech tone sweeps. In two psychophysical studies, we demonstrate that Chinese subjects perform better than English subjects in FM direction identification, but not in an FM discrimination task, in which English and Chinese speakers show similar detection thresholds of approximately 20 ms duration. We suggest that the better FM direction identification in Chinese subjects is related to their experience with FM direction analysis in the tone-language environment, even though supra-segmental tonal variation occurs over a longer time scale. Furthermore, the observed common discrimination temporal threshold across two language groups supports the conjecture that processing auditory signals at durations of approximately 20 ms constitutes a fundamental auditory perceptual threshold.

Published
2007
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26. A new vision and order of world.

Author

Boemio, Camilla

Subjects
PHOTOGRAPHY & society, SOCIAL change
Abstract

In a world of change photography is one of most interesting art mediums for analysis, contrast and social metamorphosis. In my research the political view discovered a new order in which was lost a certain idea of Italy, as well as lost innocence; in this article I dwell on the different series of two Italian photographers - Francesco Jodice and GianLuca Perrone - in which I focus on the macro areas of change, and the micro areas in which traditions and a precise idea of this country lost his face for an image of Paolo Sorrentino's masterpiece La grande Bellezza. Before an analysis of the Italians photographic series of works, I explore the general topic of 'evidence' remembering Sascha Weidner; a romantically inclined traveller, restless, as though greeting the world for the first time with the strongest cry. Like an eccentric setting in Joe R. Lansdale's novel, Drive-In, we are the co-stars in a convulsive world where trauma and decadence are not the exception in the collection, a recording or in a display of evidence. [ABSTRACT FROM AUTHOR]

Published
2017
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27. A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Author

Ruggeri, Mirella, Bonetto, Chiara, Lasalvia, Antonio, Girolamo, De, G, Fioritti, A, Rucci, P, Santonastaso, P, Neri, G, Pileggi, F, Ghigi, D, Miceli, M, Scarone, S, Cocchi, A, Torresani, S, Faravelli, C, Zimmermann, Christa, Meneghelli, A, Cremonese, C, Scocco, P, Leuci, E, Mazzi, F, Gennarelli, M, Brambilla, P, Bissoli, S, Bertani, Me, Tosato, Sarah, DE SANTI, Katia, Poli, Sara, Cristofalo, Doriana, Tansella, Michele, Get, Up, Group, Ruggeri, M, Mirella, Me, Bonetto, C, Cristofalo, D, De Santi, K, Lasalvia, A, Lunardi, S, Negretto, V, Poli, S, Tosato, S, Zamboni, Mg, Ballarin, M, Bocchio, Chiavetto, L, Scasselatti, C, Zanardini, R, Bellani, Marcella, Bertoldo, A, Marinelli, Veronica, Perlini, Cinzia, Rambaldelli, Gianluca, Bertani, M, Lazzarotto, L, Bardella, S, Gardellin, F, Lamonaca, D, Lunardon, M, Magnabosco, R, Martucci, M, Nicolau, S, Nifosì, F, Pavanati, M, Rossi, M, Piazza, C, Piccione, G, Sala, A, Sale, A, Stefan, B, Zotos, S, Balbo, M, Boggian, I, Ceccato, E, Dall'Agnola, R, Girotto, B, Goss, Claudia, Leoni, R, Mai, A, Pasqualini, A, Roccato, S, Rossi, A, Strizzolo, S, Urbani, A, Ald, F, Bianchi, B, Cappellari, P, Conti, R, Battisti, De, Lazzarin, E, Merlin, S, Migliorini, G, Pozzan, T, Sarto, L, Visonà, S, Brazzoli, A, Campi, A, Carmagnani, R, Giambelli, S, Gianella, A, Lunardi, L, Madaghiele, D, Maestrelli, P, Paiola, L, Posteri, E, Viola, L, Zamberlan, V, Zenari, M, Zanoni, M, Bonadonna, G, Bonomo, M, Veronese, A, Anderle, P, Angelozz, A, Amalric, I, Baron, G, Candeago, Eb, Castelli, F, Chieco, M, Costanzo, Di, E, Derossi, M, Doriguzzi, M, Galvano, O, Lattanz, M, Lezzi, R, Marcato, M, Marcolin, A, Marini, F, Matranga, M, Scalabrin, D, Zucchetto, M, Zadro, F, Austoni, G, Bianco, M, Bordino, F, Dario, F, Risio, De, A, Gatto, A, Granà, S, Favero, E, Franceschin, A, Friederici, S, Marangon, V, Pascolo, M, Ramon, L, Zambolin, S, Riolo, R, Buffon, A, Bortolo, Di, Fortin, S, Matarrese, F, Mogni, S, Codemo, N, Russi, A, Silvestro, A, Turella, E, Viel, P, 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Guidotti, G, Luoni, A, Macchi, F, Artioli, S, Baldetti, M, Bizzocchi, M, Bolzon, D, Bonello, E, Cacciari, G, Carraresi, C, Caselli, G, Furlato, K, Garlassi, S, Gavarini, A, Macchetti, F, Marteddu, V, Plebiscita, G, Totaro, S, Bebbington, P, Birchwood, M, Dazzan, P, Kuipers, E, Thornicroft, G, Pariante, C, Lawrie, S, Soares, J. C., Ruggeri, M., Bonetto, C., Lasalvia, A., De Girolamo, G., Bertani, M., Rucci, P., Santonastaso, P., Neri, G., Pileggi, F., Ghigi, D., Miceli, M., Scarone, S., Cocchi, A., Torresani, S., Faravelli, C., Zimmermann, C., Meneghelli, A., Cremonese, C., Scocco, P., Leuci, E., Mazzi, F., Gennarelli, Massimo, Brambilla, P., Bissoli, S., Lazzarotto, L., Bardella, S., Gardellin, F., Lamonaca, D., Lunardon, M., Magnabosco, R., Martucci, M., Nicolau, S., Nifosì, F., Bertani, M. E., Tosato, S., De Santi, K., Poli, S., Cristofalo, D., Tansella, Michele, Lunardi, S., Negretto, V., Zamboni, M. G., Ballarin, M., Chiavetto, Luisella Bocchio, Scasselatti, C., Zanardini, R., Bellani, M., Bertoldo, A., Marinelli, Valentina, Perlini, C., Rambaldelli, G., Pasqualini, A., Pavanati, M., Rossi, M., Piazza, C., Piccione, G., Sala, A., Roccato, S., Rossi-, A., Sale, A., Stefan, B., Strizzolo, S., Zotos, S., Balbo, M., Boggian, I., Ceccato, E., Dall’Agnola, R., Girotto, B., Leoni, R., Mai, A., Urbani, Alessandro, Ald, F., Bianchi, Benedetta, Cappellari, P., Conti, R., De Battisti, L., Lazzarin, E., Merlin, S., Migliorini, G., Pozzan, T., Sarto, L., Visonà, S., Brazzoli, A., Campi, A., Carmagnani, R., Giambelli, S., Gianella, A., Lunardi-, L., Madaghiele, D., Maestrelli, P., Paiola, L., Posteri, E., Viola, L., Zamberlan, V., Zenari, M., Zanoni, M., Bonadonna, G., Bonomo, M., Veronese, A., Anderle, P., Angelozz, A., Amalric, I., Baron, G., Candeago, E. B., Castelli, F., Chieco, M., Di Costanzo, E., Derossi, M., Doriguzzi, M., Galvano, O., Lattanz, M., Lezzi, R., Marcato, M., Marcolin, A., Marini, F., Matranga, M., Scalabrin, D., Zucchetto, M., Zadro, F., Austoni, G., Bianco, M., Bordino, F., Dario, F., DE RISIO, Alfredo, Gatto, A., Granà, S., Favero, E., Franceschin, A., Friederici, S., Marangon, V., Pascolo, M., Ramon, L., Zambolin, S., Riolo, R., Buffon, A., Di Bortolo, E., Fortin, S., Matarrese, F., Mogni, S., Codemo, N., Russi, A., Silvestro, Antonina, Turella, E., Viel, P., Dominoni, A., Andreose, L., Boemio, M., Bressan, L., Cabbia, A., Canesso, E., Cian, R., Dal Piccol, C., Dalla Pasqua, M. M., Di Prisco, A., Mantellato, L., Luison, M., Morgante, S., Santi, M., Sacillotto, M., Scabbio, M., Sponga, P., Sguotto, M. L., Stach, F., Vettorato, M. G., Martinello, G., Dassiè, F., DI MARINO, Simone, Cibiniel, L., Masetto, I., Cabianca, O., Valente, MADDALENA AGNESE, Caberlotto, L., Passoni, A., Flumian, P., Daniel, L., Gion, M., Stanziale, S., Alborino, F., Bortolozzo, V., Bacelle, L., Bicciato, L., Basso, D., Navaglia, F., Manoni, F., Ercolin, M., Giubilini, F., Imbesi, M., Semrov, E., Giovanni, C. S., Taro e Ceno, V., Ovest, P., Anelli, S., Amore, M., Bigi, L., Britta, W., Anna, G. B., Bonatti, U., Borziani, M., Crosato, I., Galluccio, R., Galeotti, M., Gozzi, M., Greco, V., Guagnini, E., Pagani, S., Maccherozzi, M., Marchi, F., Melato, E., Mazzucchi, E., Marzullo, F., Pellegrini, Pietro Carlo, Petrolini, N., Volta, P., Bonara, F., Brusamonti, E., Croci, R., Flamia, I., Fontana, F., Losi, R., Marchioro, R., Raffaini, L., Ruju, L., Saginario, A., Tondelli, M. G., Marrama, D., Bernardelli, L., Bonacini, F., Florindo, A., Merli, M., Nappo, P., Sola, L., Tondelli-, O., Tonna, M., Torre, M. T., Tosatti, M., Venturelli, G., Zampolla, D., Bernardi, A., Cavalli, Chiara, Cigala, L., Ciraudo, C., Di Bari, A., Ferri, L., Gombi, F., Leurini, S., Mandatelli, E., Maccaferri, S., Oroboncoide, M., Pisa, B., Ricci, Carmine, Poggi, E., Zurlini, C., Malpeli, M., Colla, R., Teodori, E., Vecchia, L., D’Andrea, R., Trenti, T., Paolini, P., Carpeggiani, P., Gagliostro, M., Pratelli, M., Lazzaro, S., Antonelli, A., Battistini, Luca, Bellini, Fiorella, Bonini, E., Capelli, C. B., Didomizio, C., Drei, C., Fucci, G., Gualandi, A., Grazia, M. R., Losi-, A. M., Mazzoni, F. M., Marangoni, D., Monna, G., Morselli, M., Oggioni, A., Oprandi, S., Paganelli, W., Passerini, M., Piscitelli, M., Reggiani, G., Rossi-, G., Salvatori, Franco, Trasforini, S., Uslenghi, C., Veggetti, S., Bartolucci, Giuliana, Baruffa, R., Bertelli, R., Borghi, L., Ciavarella, P., Paltrinieri, E., Rizzardi, F., Serra, P., Suzzi, D., Carlo, U., Arienti, P., Aureli, F., Avanzi, R., Callegari, V., Corsino, A., Host, P., Michetti, R., Rizzo, F., Simoncelli, P., Soldati, E., Succi, E., Bertozzi, M., Canetti, E., Cavicchioli, L., Ceccarelli, E., Cenni, S., Marzola, G., Gallina, V., Leoni, C., Olivieri, A., Piccolo, Elisa, Ravagli, S., Russo, R., Tedeschini, D., Verenini, M., Abram, W., Granata, V., Curcio, A., Guerra, G., Granini, S., Natali, L., Montanari, Eleonora, Pasi, F., Ventura, U., Valenti, S., Francesca, M., Farneti, R., Ravagli-, P., Floris, R., Maroncelli, O., Volpones, G., Casali, D., Bencini, A., Cellini, M., De Biase, L., Barbara, L., Charles, L., Pratesi, C., Tanini, A., Loparrino, R., Ulivelli, C., Cussoto, C., Dei, N., Fumanti, E., Pantani, M., Zeloni, G., Bellini-, R., Cellesi, R., Dorigo, N., Gullì, P., Ialeggio, L., Pisanu, M., Rinaldi, G., Konze, A., Modignani, L., Frova, M., Monzani, E., Amadè, E. S., Zanobio, A., Malagoli, M., Pagani-, R., Barbera, S., Morganti, C., Brambilla-, V., Montanari-, A., Caterina, G., LOPEZ CORTES, Carlo, Marocchi, A., Moletta, A., Sberna, M., Cascio, M. T., Manzone, M. L., Barbara-, B., Mari, L., Razzini, E., Bianchi-, Y., Pellizzer, M. R., Verdecchia, A., Sferrazza, M. G., Pismataro, R., D’Eril, G. V., Barassi, A., Pacciolla, R., Faraci, G., Rosmini, B., Carpi, F., Soelva, M., Anderlan, M., De Francesco, M., Duregger, E., Vettori, C., Doimo, S., Kompatscher, E., Forer, M., Kerschbaumer, H., Gampe, A., Nicoletti, M., Acerbi, C., Aquilino, D., Azzali, S., Bensi, L., Cappellari-, D., Casana, E., Campagnola, N., Dal Corso, E., Di Micco, E., Gobbi, E., Mairaghi, L., Malak, S., Mesiano, L., Paterlini, F., Perini, Matteo, Puliti, E. M., Rispoli, R., Rizzo-, E., Sergenti, C., Soave, M., Alpi, A., Bislenghi, L., Bolis, T., Colnaghi, F., Fascendini, S., Grignani, S., Patelli, G., Casale, S., Deledda, G., Goss, C., Mazzi-, M., Rimondini, M., Scassellati, C., Bonvicini, C., Longo, Salvatore, Bocchio Chiavetto, L., Ventriglia, M., Squitti, R., Frisoni, G., Pievani, M., Balestrieri, M., Atzori, M., Beltramello, A., Alessandrini, F., Pizzini, F., Zoccatelli, G., Politi, P., Emanuele, E., Brondino, N., Martino, G., Bergami, A., Zarbo, R., Riva, M. A., Fumagalli, F., Molteni, R., Calabrese, F., Guidotti, Giovanni, Luoni, Alessia, Macchi, F., Artioli, S., Baldetti, M., Bizzocchi, M., Bolzon, D., Bonello, E., Cacciari, G., Carraresi, C., Caselli, G., Furlato, K., Garlassi, S., Gavarini, A., Macchetti, F., Marteddu, V., Plebiscita, G., Totaro, S., Bebbington, P., Birchwood, M., Dazzan, P., Kuipers, E., Thornicroft, G., Pariante, C., Lawrie, S., Soares, J. C., Mirella Ruggeri, Chiara Bonetto, Antonio Lasalvia, Giovanni De Girolamo, Angelo Fioritti, Paola Rucci, Paolo Santonastaso, Giovanni Neri, Francesca Pileggi, Daniela Ghigi, Maurizio Miceli, Silvio Scarone, Angelo Cocchi, Stefano Torresani, Carlo Faravelli, Christa Zimmermann, Anna Meneghelli, Carla Cremonese, Paolo Scocco, Emanuela Leuci, Fausto Mazzi, Massimo Gennarelli, Paolo Brambilla, Sarah Bissoli, Maria Elena Bertani, Sarah Tosato, Katia De Santi, Sara Poli, Doriana Cristofalo, Michele Tansella, and and THE GET UP GROUP

Subjects
Research design, Time Factors, early psychosis, psychosocial interventions, cluster randomized triales, medicine.medical_treatment, Psychological intervention, Medicine (miscellaneous), Assertive community treatment, Severity of Illness Index, law.invention, Study Protocol, Randomized controlled trial, law, Recurrence, Early psychosi, Cluster Analysis, Pharmacology (medical), lcsh:R5-920, Family Relation, Community Mental Health Service, First-episode psychosis, Community Mental Health Center, Community Mental Health Services, Cognitive behavioral therapy, Treatment Outcome, Cognitive Therapy, Italy, Research Design, First-episode psychosisEarly psychosisCognitive behavioral therapyPsychosocial interventionAssertive community treatment, Family Relations, lcsh:Medicine (General), Psychosocial, Human, pragmatic trial, Early psychosis, Family intervention, Psychosocial intervention, Community Mental Health Centers, Humans, Patient Selection, Psychotic Disorders, Sample Size, Case Management, Cognitive Behavioral Therapy, medicine.medical_specialty, psychosocial interventions, Time Factor, cluster randomized triales, Psychotic Disorder, First-episode psychosi, medicine, Psychiatry, Cluster Analysi, business.industry, Mental health, Cognitive therapy, business
Abstract

Background Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in ‘real-world’ services. Methods/Design The Psychosis early Intervention and Assessment of Needs and Outcome (PIANO) trial is part of a larger research program (Genetics, Endophenotypes and Treatment: Understanding early Psychosis - GET UP) which aims to compare, at 9 months, the effectiveness of a multi-component psychosocial intervention versus treatment as usual (TAU) in a large epidemiologically based cohort of patients with FEP and their family members recruited from all public community mental health centers (CMHCs) located in two entire regions of Italy (Veneto and Emilia Romagna), and in the cities of Florence, Milan and Bolzano. The GET UP PIANO trial has a pragmatic cluster randomized controlled design. The randomized units (clusters) are the CMHCs, and the units of observation are the centers’ patients and their family members. Patients in the experimental group will receive TAU plus: 1) cognitive behavioral therapy sessions, 2) psycho-educational sessions for family members, and 3) case management. Patient enrolment will take place over a 1-year period. Several psychopathological, psychological, functioning, and service use variables will be assessed at baseline and follow-up. The primary outcomes are: 1) change from baseline to follow-up in positive and negative symptoms’ severity and subjective appraisal; 2) relapse occurrences between baseline and follow-up, that is, episodes resulting in admission and/or any case-note records of re-emergence of positive psychotic symptoms. The expected number of recruited patients is about 400, and that of relatives about 300. Owing to the implementation of the intervention at the CMHC level, the blinding of patients, clinicians, and raters is not possible, but every effort will be made to preserve the independency of the raters. We expect that this study will generate evidence on the best treatments for FEP, and will identify barriers that may hinder its feasibility in ‘real-world’ clinical settings, patient/family conditions that may render this intervention ineffective or inappropriate, and clinical, psychological, environmental, and service organization predictors of treatment effectiveness, compliance, and service satisfaction. Trial registration ClinicalTrials.gov Identifier NCT01436331

Published
2012

28. THE TM6SF2 E167K VARIANT IS AN INDEPENDENT PREDICTOR OF SEVERE LIVER STEATOSIS IN CHRONIC HEPATITIS C

Author

Mariantonietta Pisaturo, E. Miraglia del Giudice, Le Adinolfi, Rosa Zampino, Margherita Macera, Grazia Cirillo, Aldo Marrone, Anna Grandone, Adriana Boemio, Maria Stanzione, Evangelista Sagnelli, and Nicola Coppola

Subjects
medicine.medical_specialty, Pediatrics, Hepatology, Liver steatosis, Chronic hepatitis, business.industry, Internal medicine, Gastroenterology, medicine, Independent predictor, business, TM6SF2
Abstract

N. Coppola1, R. Zampino2, G. Cirillo3, M. Stanzione4, M. Macera1, A. Boemio2, A. Grandone3, M. Pisaturo1, A. Marrone2, L.E. Adinolfi2, E. Sagnelli 1, E. Miraglia del Giudice3 1 Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Naples, ITALY 2 Internal Medicine and Hepatology, Second University of Naples, Naples, ITALY 3 Department of Pediatrics, Second University of Naples, Naples, ITALY 4 Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, ITALY

Published
2015
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29. P731 CANNABINOID RECEPTOR 2-63 QQ VARIANT IS ASSOCIATED WITH PERSISTENTLY NORMAL AMINOTRANSFERASE SERUM LEVELS IN CHRONIC HEPATITIS C

Author

Nicola Coppola, Carmine Minichini, Maria Stanzione, Adriana Boemio, Rosa Zampino, Le Adinolfi, E. Miraglia del Giudice, Aldo Marrone, Evangelista Sagnelli, Nicolina Capoluongo, G. Bellini, Caterina Sagnelli, Sabatino Maione, and F. Rossi

Subjects
Hepatology, Chronic hepatitis, business.industry, Immunology, Cannabinoid receptor type 2, Medicine, business, Virology
Published
2014
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31. TM6 SF2 E167K variant is associated with severe steatosis in chronic hepatitis C, regardless of PNPLA3 polymorphism.

Author

Coppola, Nicola, Rosa, Zampino, Cirillo, Grazia, Stanzione, Maria, Macera, Margherita, Boemio, Adriana, Grandone, Anna, Pisaturo, Mariantonietta, Marrone, Aldo, Adinolfi, Luigi E., Sagnelli, Evangelista, and Miraglia del Giudice, Emanuele

Subjects
FATTY degeneration, GENETIC polymorphisms, CHRONIC hepatitis C, HEPATIC fibrosis, DYSLIPIDEMIA, TRIGLYCERIDES, GENETICS
Abstract

Background & Aims A common non-synonymous polymorphism, E167K, in transmembrane six superfamily member 2 ( TM6 SF2) gene has been recently associated with an increased hepatic triglyceride content, dyslipidemia and liver fibrosis in NAFLD patients. We investigated possible associations between the TM6 SF2 variants and liver lesions in chronic hepatitis C. Patients and Methods 148 consecutive patients with biopsy proven anti- HCV/ HCV- RNA-positive chronic hepatitis, naive for antiviral therapy, were genotyped for TM6 SF2 E167K and PNPLA3 I148M variants. Results The score of liver steatosis was higher in the 18 patients with TM6 SF2 E167K variant (mean 1.9 ± 1.3) than in the 130 homozygotes for TM6 SF2 167E allele (1.1 ± 1.1, P = 0.02), and the prevalence of a steatosis score ≥ 3 was 33.3% vs. 12.3% respectively ( P = 0.02). No difference in necroinflammatory or fibrosis scores was found between the two groups. A general linear model identified as independent predictors of steatosis TM6 SF2 E167K and PNPLA3 M148M variants and waist circumference ( P = 0.0376, P = 0.0069 and P = 0.0273 respectively). Conclusions This is the first demonstration that TM6 SF2 E167K variant is an independent predictor of liver steatosis in chronic hepatitis C. [ABSTRACT FROM AUTHOR]

Published
2015
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34. Cannabinoid Receptor 2-63 QQ Variant Is Associated with Persistently Normal Aminotransferase Serum Levels in Chronic Hepatitis C.

Author

Coppola, Nicola, Zampino, Rosa, Sagnelli, Caterina, Bellini, Giulia, Marrone, Aldo, Stanzione, Maria, Capoluongo, Nicolina, Boemio, Adriana, Minichini, Carmine, Adinolfi, Luigi Elio, Maione, Sabatino, Giudice, Emanuele Miraglia Del, Sagnelli, Evangelista, and Rossi, Francesca

Subjects
HEPATITIS C treatment, CANNABINOID receptors, AMINOTRANSFERASES, SERUM, ANTIVIRAL agents, GENETIC polymorphisms
Abstract

Background and Aim: To evaluate in anti-HCV-positive patients the clinical impact of the rs35761398 variant of the CNR2 gene leading to the substitution of Gln (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with Arg (R). Patients and Methods: 253 consecutive anti-HCV-/HCV-RNA-positive patients were enrolled, of whom 53 were HCV carriers with persistently normal ALT (PNALT group) and 200 had a history of steadily abnormal serum ALT values (abnormal ALT group). All patients were naive for antiviral therapy and were screened for the CNR2 rs35761398 polymorphism by a TaqMan assay. Results: Subjects in the PNALT group, compared with those in the abnormal ALT group were older (58.5±12 vs. 50.7±12.4 years, p = 0.001), more frequently female (66% vs. 42%, p = 0.003), with lower body massindex (BMI) (24.5±3.1 vs. 26.6±4.6, p = 0.003), and more frequently with HCV genotype 2 (43.1% vs 17.7%, p = 0.0002) and CB2-63 QQ variant (34% vs. 11%, p = 0.0001). Considering all 253 patients, no difference in the demographic, biochemical, or virological data was observed between patients in the different CB2-63 variants. The logistic regression analysis identified CB2-63 QQ, HCV genotype 2, older age and lower BMI as independent predictors of PNALT (p<0.00001). Discussion: The CB2-63 QQ variant in HCV patients was independently associated with the PNALT status. [ABSTRACT FROM AUTHOR]

Published
2014
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35. Observer reproducibility of results from a low-dose I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure.

Author

Pellegrino, Teresa, Petretta, Mario, Luca, Serena, Paolillo, Stefania, Boemio, Antonio, Carotenuto, Raffaella, Petretta, Maria, Nuzzo, Carmine, Perrone-Filardi, Pasquale, and Cuocolo, Alberto

Subjects
CARDIAC imaging, HEART failure, GUANIDINES, RADIOTHERAPY treatment planning, SINGLE-photon emission computed tomography, THERAPEUTICS
Abstract

Purpose: Imaging of the cardiac autonomic system with I-metaiodobenzylguanidine (MIBG) is useful in the evaluation of patients with a variety of cardiac conditions, including heart failure (HF), but few data are available about the reproducibility of this technique. We assessed the observer reproducibility of the results from a low-dose I-MIBG cardiac imaging protocol in patients with HF. Methods: A total of 74 patients (62 men, age 67 ± 10 years) with HF and left ventricular systolic dysfunction (ejection fraction 31 ± 7 %) underwent low-dose (111 MBq) planar and single-photon emission computed tomography (SPECT) I-MIBG cardiac sympathetic imaging. The intraclass coefficient of correlation (ICC), Lin's concordance correlation coefficient, and Bland-Altman analysis were used to evaluate the intraobserver and interobserver reproducibility of early and late heart-to-mediastinum (H/M) ratios and of defect scores on SPECT images. The κ statistic was used to evaluate the concordance rates for the identification of patients with a low H/M ratio (<1.60) on late planar imaging. Results: The differences between measurements obtained twice by the same examiner and by two examiners were negligible for both early and late H/M ratios and for SPECT defect scores. These findings were confirmed by the results of Bland-Altman analysis, and ICC and Lin's coefficient values were excellent (>0.90) for all measurements. For the identification of patients with a low H/M ratio, the κ values were 0.90 for intraobserver concordance and 0.83 for interobserver concordance. Conclusion: The present study showed a high observer reproducibility of planar H/M ratios and SPECT defect scores using a low-dose I-MIBG cardiac imaging protocol in patients with HF. [ABSTRACT FROM AUTHOR]

Published
2013
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36. Clinical description of a patient carrying the smallest reported deletion involving 10p14 region.

Author

Melis, Daniela, Genesio, Rita, Boemio, Pasquale, Del Giudice, Ennio, Cappuccio, Gerarda, Mormile, Angela, Ronga, Valentina, Conti, Anna, Imperati, Floriana, Nitsch, Lucio, and Andria, Generoso

Abstract

Haploinsufficiency of a region located distal to 10p14 designated HDR1, is responsible for hypoparathyroidism, sensorineural deafness, and renal anomalies (HDR syndrome). Haploinsufficiency of a more proximal region, located on 10p13-10p14, designated as DGCR2 is associated with congenital heart defects and thymus hypoplasia/aplasia or T cell defect. We describe a patient showing facial dysmorphisms, delayed psychomotor development and bilateral sensorineural hearing loss and carrying a 10p14 deletion, the smallest deletion found in the literature so far. Our patient, carrying a partial deletion of the DGCR2 region and of the HDR1 region, including the GATA3 gene, showed, unexpectedly, only few of the clinical features of DiGeorge 2 syndrome (psychomotor retardation, palpebral ptosis, epicanthic folds, anteverted nares, cryptorchidism, hand/foot abnormalities) and did not show other typical signs, such as cardiac defect, cleft palate, and abnormal T cell levels. Of the three characteristic features of the HDR syndrome, our patient had only sensorineural deafness. On the basis of the revision of the other cases reported in the literature with a deletion including the 10p14 region, we suggest that GATA3 haploinsufficiency, although not recorded for each patient, is responsible for deafness. The present case shows that even this small 10p deletion is responsible for a specific phenotype. We also underline the importance of CGH-array, in order to obtain a more precise physical mapping of the 10p deletions and an accurate genotype-phenotype correlation. © 2012 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2012
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37. Hierarchical and asymmetric temporal sensitivity in human auditory cortices.

Author

Boemio, Anthony, Fromm, Stephen, Braun, Allen, and Poeppel, David

Subjects
*AUDITORY cortex, *TEMPORAL lobe, *CEREBRAL dominance, *CEREBRAL hemispheres, *BRAIN, *NEUROSCIENCES, *MEDICAL sciences
Abstract

Lateralization of function in auditory cortex has remained a persistent puzzle. Previous studies using signals with differing spectrotemporal characteristics support a model in which the left hemisphere is more sensitive to temporal and the right more sensitive to spectral stimulus attributes. Here we use single-trial sparse-acquisition fMRI and a stimulus with parametrically varying segmental structure affecting primarily temporal properties. We show that both left and right auditory cortices are remarkably sensitive to temporal structure. Crucially, beyond bilateral sensitivity to timing information, we uncover two functionally significant interactions. First, local spectrotemporal signal structure is differentially processed in the superior temporal gyrus. Second, lateralized responses emerge in the higher-order superior temporal sulcus, where more slowly modulated signals preferentially drive the right hemisphere. The data support a model in which sounds are analyzed on two distinct timescales, 25-50 ms and 200-300 ms. [ABSTRACT FROM AUTHOR]

Published
2005
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