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409 results on '"Brandt, Alexander"'

1. Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis

Author

Krämer, Julia, Balloff, Carolin, Weise, Margit, Koska, Valeria, Uthmeier, Yannik, Esderts, Isabell, Nguyen-Minh, Mai, Zimmerhof, Moritz, Hartmann, Alex, Dietrich, Michael, Ingwersen, Jens, Lee, John-Ih, Havla, Joachim, Kümpfel, Tania, Kerschensteiner, Martin, Häußler, Vivien, Heesen, Christoph, Stellmann, Jan-Patrick, Zimmermann, Hanna G., Oertel, Frederike C., Ringelstein, Marius, Brandt, Alexander U., Paul, Friedemann, Aktas, Orhan, Hartung, Hans-Peter, Wiendl, Heinz, Meuth, Sven G., and Albrecht, Philipp

Published
2024
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8. Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria

Author

Banwell, Brenda, Bennett, Jeffrey L, Marignier, Romain, Kim, Ho Jin, Brilot, Fabienne, Flanagan, Eoin P, Ramanathan, Sudarshini, Waters, Patrick, Tenembaum, Silvia, Graves, Jennifer S, Chitnis, Tanuja, Brandt, Alexander U, Hemingway, Cheryl, Neuteboom, Rinze, Pandit, Lekha, Reindl, Markus, Saiz, Albert, Sato, Douglas Kazutoshi, Rostasy, Kevin, Paul, Friedemann, Pittock, Sean J, Fujihara, Kazuo, and Palace, Jacqueline

Published
2023
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9. Haplotype divergence supports long-term asexuality in the oribatid mite Oppiella nova

Author

Brandt, Alexander, Van, Patrick Tran, Bluhm, Christian, Anselmetti, Yoann, Dumas, Zoé, Figuet, Emeric, François, Clémentine M., Galtier, Nicolas, Heimburger, Bastian, Jaron, Kamil S., Labédan, Marjorie, Maraun, Mark, Parker, Darren J., Robinson-Rechavi, Marc, Schaefer, Ina, Simion, Paul, Scheu, Stefan, Schwander, Tanja, and Bast, Jens

Published
2021

11. Brain disconnectome mapping derived from white matter lesions and serum neurofilament light levels in multiple sclerosis: A longitudinal multicenter study

Author

Rise, Henning H., Brune, Synne, Chien, Claudia, Berge, Tone, Bos, Steffan D., Andorrà, Magí, Valdeolivas, Irene Pulido, Beyer, Mona K., Sowa, Piotr, Scheel, Michael, Brandt, Alexander U., Asseyer, Susanna, Blennow, Kaj, Pedersen, Mads L., Zetterberg, Henrik, de Schotten, Michel Thiebaut, Cellerino, Maria, Uccelli, Antonio, Paul, Friedemann, Villoslada, Pablo, Harbo, Hanne F., Westlye, Lars T., and Høgestøl, Einar A.

Published
2022
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17. Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross-sectional Analysis

Author

Müller, Jannis, Sinnecker, Tim, Wendebourg, Maria Janina, Schläger, Regina, Kuhle, Jens, Schädelin, Sabine, Benkert, Pascal, Derfuss, Tobias, Cattin, Philippe, Jud, Christoph, Spiess, Florian, Amann, Michael, Lincke, Therese, Barakovic, Muhamed, Cagol, Alessandro, Tsagkas, Charidimos, Parmar, Katrin, Pröbstel, Anne-Katrin, Reimann, Sophia, Asseyer, Susanna, Duchow, Ankelien, Brandt, Alexander, Ruprecht, Klemens, Hadjikhani, Nouchine, Fukumoto, Shoko, Watanabe, Mitsuru, Masaki, Katsuhisa, Matsushita, Takuya, Isobe, Noriko, Kira, Jun-Ichi, Kappos, Ludwig, Würfel, Jens, Granziera, Cristina, Paul, Friedemann, and Yaldizli, Özgür

Published
2022
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21. Serum GFAP and NfL as disease severity and prognostic biomarkers in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder

Author

Schindler, Patrick, Grittner, Ulrike, Oechtering, Johanna, Leppert, David, Siebert, Nadja, Duchow, Ankelien S., Oertel, Frederike C., Asseyer, Susanna, Kuchling, Joseph, Zimmermann, Hanna G., Brandt, Alexander U., Benkert, Pascal, Reindl, Markus, Jarius, Sven, Paul, Friedemann, Bellmann-Strobl, Judith, Kuhle, Jens, and Ruprecht, Klemens

Published
2021
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24. Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders

Author

Amato, Maria Pia, Banwell, Brenda, Barkhof, Frederik, Bebo, Bruce, Becher, Burkhard, Bethoux, François, Brandt, Alexander, Brownlee, Wallace, Calabresi, Peter, Chatway, Jeremy, Chien, Claudia, Chitnis, Tanuja, Ciccarelli, Olga, Cohen, Jeffrey, Comi, Giancarlo, Correale, Jorge, De Sèze, Jerome, De Stefano, Nicola, Fazekas, Franz, Flanagan, Eoin, Freedman, Mark, Fujihara, Kazuo, Galetta, Steven, Goldman, Myla, Greenberg, Benjamin, Hartung, Hans-Peter, Hemmer, Bernhard, Henning, Anke, Izbudak, Izlem, Kappos, Ludwig, Lassmann, Hans, Laule, Cornelia, Levy, Michael, Lublin, Fred, Lucchinetti, Claudia, Lukas, Carsten, Marrie, Ruth Ann, Miller, Aaron, Miller, David, Montalban, Xavier, Mowry, Ellen, Ourselin, Sebastien, Paul, Friedemann, Pelletier, Daniel, Ranjeva, Jean-Philippe, Reich, Daniel, Reingold, Stephen, Rocca, Maria Assunta, Rovira, Alex, Schlaerger, Regina, Soelberg Sorensen, Per, Sormani, Maria, Stuve, Olaf, Thompson, Alan, Tintoré, Mar, Traboulsee, Anthony, Trapp, Bruce, Trojano, Maria, Uitdehaag, Bernard, Vukusic, Sandra, Waubant, Emmanuelle, Weinshenker, Brian, Wheeler-Kingshott, Claudia Gandini, Xu, Junqian, Cohen, Jeffrey A, Reingold, Stephen C, and Weinshenker, Brian G

Published
2019
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25. Evolution of alternative reproductive systems in Bacillus stick insects.

Author

Lavanchy, Guillaume, Brandt, Alexander, Bastardot, Marc, Dumas, Zoé, Labédan, Marjorie, Massy, Morgane, Toubiana, William, Van, Patrick Tran, Luchetti, Andrea, Scali, Valerio, Mantovani, Barbara, and Schwander, Tanja

Subjects
*PHASMIDA, *GENITALIA, *BACILLUS (Bacteria), *MITOCHONDRIAL DNA, *KARYOTYPES, *HETEROZYGOSITY, *PARTHENOGENESIS, *ISOENZYMES, *EGGS
Abstract

Reproduction is a key feature of all organisms, yet the way in which it is achieved varies greatly across the tree of life. One striking example of this variation is the stick insect genus Bacillus , in which five different reproductive modes have been described: sex, facultative and obligate parthenogenesis, and two highly unusual reproductive modes: hybridogenesis and androgenesis. Under hybridogenesis, the entire genome from the paternal species is eliminated and replaced each generation by mating with the corresponding species. Under androgenesis, an egg is fertilized, but the developing diploid offspring bear two paternal genomes and no maternal genome, as a consequence of unknown mechanisms. Here, we reevaluate the previous descriptions of Bacillus lineages and the proposed F1 hybrid ancestries of the hybridogenetic and obligately parthenogenetic lineages (based on allozymes and karyotypes) from Sicily, where all these reproductive modes are found. We generate a chromosome-level genome assembly for a facultative parthenogenetic species (B. rossius) and combine extensive field sampling with RADseq and mtDNA data. We identify and genetically corroborate all previously described species and confirm the ancestry of hybrid lineages. All hybrid lineages have fully retained their F1 hybrid constitution throughout the genome, indicating that the elimination of the paternal genome in hybridogens is always complete and that obligate parthenogenesis in Bacillus hybrid species is not associated with an erosion of heterozygosity as known in other hybrid asexuals. Our results provide a stepping stone toward understanding the transitions between reproductive modes and the proximate mechanisms of genome elimination. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Retinal Optical Coherence Tomography in Neuromyelitis Optica

Author

Oertel, Frederike Cosima, Specovius, Svenja, Zimmermann, Hanna G., Chien, Claudia, Motamedi, Seyedamirhosein, Bereuter, Charlotte, Cook, Lawrence, Lana Peixoto, Marco Aurélio, Fontanelle, Mariana Andrade, Kim, Ho Jin, Hyun, Jae-Won, Palace, Jacqueline, Roca-Fernandez, Adriana, Leite, Maria Isabel, Sharma, Srilakshmi, Ashtari, Fereshteh, Kafieh, Rahele, Dehghani, Alireza, Pourazizi, Mohsen, Pandit, Lekha, DʼCunha, Anitha, Aktas, Orhan, Ringelstein, Marius, Albrecht, Philipp, May, Eugene, Tongco, Caryl, Leocani, Letizia, Pisa, Marco, Radaelli, Marta, Martinez-Lapiscina, Elena H., Stiebel-Kalish, Hadas, Siritho, Sasitorn, de Seze, Jérome, Senger, Thomas, Havla, Joachim, Marignier, Romain, Calvo, Alvaro Cobo, Bichuetti, Denis, Tavares, Ivan Maynart, Asgari, Nasrin, Soelberg, Kerstin, Altintas, Ayse, Yildirim, Rengin, Tanriverdi, Uygur, Jacob, Anu, Huda, Saif, Rimler, Zoe, Reid, Allyson, Mao-Draayer, Yang, Soto de Castillo, Ibis, Petzold, Axel, Green, Ari J., Yeaman, Michael R., Smith, Terry, Brandt, Alexander U., and Paul, Friedemann

Published
2021
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34. Multiscale networks in multiple sclerosis.

Author

Kennedy, Keith E., Kerlero de Rosbo, Nicole, Uccelli, Antonio, Cellerino, Maria, Ivaldi, Federico, Contini, Paola, De Palma, Raffaele, Harbo, Hanne F., Berge, Tone, Bos, Steffan D., Høgestøl, Einar A., Brune-Ingebretsen, Synne, de Rodez Benavent, Sigrid A., Paul, Friedemann, Brandt, Alexander U., Bäcker-Koduah, Priscilla, Behrens, Janina, Kuchling, Joseph, Asseyer, Susanna, and Scheel, Michael

Subjects
MULTIPLE sclerosis, PEARSON correlation (Statistics), SYSTEMS biology, WALKING speed, CENTRAL nervous system, RETINAL imaging, BIOLOGICAL networks
Abstract

Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the interplay among these scales. We conducted a multilayer network analysis and deep phenotyping with multi-omics data (genomics, phosphoproteomics and cytomics), brain and retinal imaging, and clinical data, obtained from a multicenter prospective cohort of 328 patients and 90 healthy controls. Multilayer networks were constructed using mutual information for topological analysis, and Boolean simulations were constructed using Pearson correlation to identified paths within and among all layers. The path more commonly found from the Boolean simulations connects protein MK03, with total T cells, the thickness of the retinal nerve fiber layer (RNFL), and the walking speed. This path contains nodes involved in protein phosphorylation, glial cell differentiation, and regulation of stress-activated MAPK cascade, among others. Specific paths identified were subsequently analyzed by flow cytometry at the single-cell level. Combinations of several proteins (GSK3AB, HSBP1 or RS6) and immune cells (Th17, Th1 non-classic, CD8, CD8 Treg, CD56 neg, and B memory) were part of the paths explaining the clinical phenotype. The advantage of the path identified from the Boolean simulations is that it connects information about these known biological pathways with the layers at higher scales (retina damage and disability). Overall, the identified paths provide a means to connect the molecular aspects of MS with the overall phenotype. Author summary: Complex diseases such as Multiple Sclerosis (MS) involve the contribution of a wide range of biological processes. We conducted a systems biology study of MS based on network analysis and deep phenotyping in a prospective cohort of patients with clinical, imaging, genetics, and omics assessments. The genes, proteins and cell paths explained variation in central nervous system damage, and in metrics of disease severity. Such multilayer paths explain the different phenotypes of the disease and can be developed as biomarkers of MS. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Interactions of optic radiation lesions with retinal and brain atrophy in early multiple sclerosis.

Author

Lin, Ting‐Yi, Chien, Claudia, Kuchling, Joseph, Asseyer, Susanna, Motamedi, Seyedamirhosein, Bellmann‐Strobl, Judith, Schmitz‐Hübsch, Tanja, Ruprecht, Klemens, Brandt, Alexander U., Zimmermann, Hanna G., and Paul, Friedemann

Subjects
CEREBRAL atrophy, BRAIN damage, MULTIPLE sclerosis, OPTIC neuritis, OPTICAL coherence tomography, OPTICAL measurements
Abstract

Objective: Retrograde trans‐synaptic neuroaxonal degeneration is considered a key pathological factor of subclinical retinal neuroaxonal damage in multiple sclerosis (MS). We aim to evaluate the longitudinal association of optic radiation (OR) lesion activity with retinal neuroaxonal damage and its role in correlations between retinal and brain atrophy in people with clinically isolated syndrome and early MS (pweMS). Methods: Eighty‐five pweMS were retrospectively screened from a prospective cohort (Berlin CIS cohort). Participants underwent 3T magnetic resonance imaging (MRI) for OR lesion volume and brain atrophy measurements and optical coherence tomography (OCT) for retinal layer thickness measurements. All pweMS were followed with serial OCT and MRI over a median follow‐up of 2.9 (interquartile range: 2.6–3.4) years. Eyes with a history of optic neuritis prior to study enrollment were excluded. Linear mixed models were used to analyze the association of retinal layer thinning with changes in OR lesion volume and brain atrophy. Results: Macular ganglion cell‐inner plexiform layer (GCIPL) thinning was more pronounced in pweMS with OR lesion volume increase during follow‐up compared to those without (Difference: −0.82 μm [95% CI:‐1.49 to −0.15], p = 0.018). Furthermore, GCIPL thinning correlated with both OR lesion volume increase (β [95% CI] = −0.27 [−0.50 to −0.03], p = 0.028) and brain atrophy (β [95% CI] = 0.47 [0.25 to 0.70], p < 0.001). Correlations of GCIPL changes with brain atrophy did not differ between pweMS with or without OR lesion increase (ηp2 = 5.92e−7, p = 0.762). Interpretation: Faster GCIPL thinning rate is associated with increased OR lesion load. Our results support the value of GCIPL as a sensitive biomarker reflecting both posterior visual pathway pathology and global brain neurodegeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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44. A large CRISPR-induced bystander mutation causes immune dysregulation

Author

Simeonov, Dimitre R., Brandt, Alexander J., Chan, Alice Y., Cortez, Jessica T., Li, Zhongmei, Woo, Jonathan M., Lee, Youjin, Carvalho, Claudia M. B., Indart, Alyssa C., Roth, Theodore L., Zou, James, May, Andrew P., Lupski, James R., Anderson, Mark S., Buaas, F. William, Rokhsar, Daniel S., and Marson, Alexander

Published
2019
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45. Visual function resists early neurodegeneration in the visual system in primary progressive multiple sclerosis.

Author

Rosenkranz, Sina C., Gutmann, Lilija, Silemek, Arzu Ceylan Has, Dorr, Michael, Häußler, Vivien, Lüpke, Margareta, Mönch, Andrea, Reinhardt, Stefanie, Kuhle, Jens, Tilsley, Penelope, Heesen, Christoph, Friese, Manuel A., Brandt, Alexander, Paul, Friedemann, Zimmermann, Hanna, and Stellmann, Jan-Patrick

Subjects
VISION, OPTIC neuritis, MULTIPLE sclerosis, ECHO-planar imaging, CONTRAST sensitivity (Vision), PROTON magnetic resonance spectroscopy, NEUROMYELITIS optica, COMPUTER adaptive testing
Published
2023
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