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We demonstrate a novel scheme for photonic generation of chirped millimeter-wave (MMW) pulse with ultrahigh time-bandwidth product (TBP). By using a fast wavelength-sweeping laser with a narrow instantaneous linewidth, wideband/high-power photonic transmitter-mixers, and heterodyne-beating technique, continuously tunable chirped MMW waveforms at the W-band are generated and detected through wireless transmission. Compared with the reported optical grating-based wavelength-to-time mapping techniques for chirped pulse generation, our approach eliminates the problem in limited frequency resolution of grating, which seriously limits the continuity, tunability, and TBP of the generated waveform. Furthermore, by changing the alternating current (AC) waveform of the driving signal to the sweeping laser, linearly or nonlinearly continuously chirped MMW pulse can be easily generated and switched. Using our scheme, linearly and nonlinearly chirped pulses with record-high TBPs (89-103 GHz/ 50 μs/7 × 105) are experimentally achieved.

We demonstrate a novel technique for photonic generation of few-cycle millimeter-wave (MMW) pulse using a WR-10 waveguide and near-ballistic unitraveling carrier photodiode (NBUTC-PD)-based photonic-transmitter-mixer (PTM). A 2.5-cycle MMW pulse is generated by simultaneously exciting the PTM optical port with ~100-GHz optical MMW sinusoidal signal and the intermediate-frequency (IF) port with a 25-ps electrical short pulse, respectively. Compared to results using femtosecond optical short pulses to directly excite the PTM (without E-O signal mixing), our approach is capable of providing much less signal distortion, eliminating the ringing oscillation in the tail of response, a much shorter pulse duration, and a higher peak power.

We demonstrate a remotely up-converted and distributed 20-Gbit/s wireless on-off-keying (OOK) data transmission link at the W-band that uses a near-ballistic uni-traveling-carrier photodiode (NBUTC-PD)-based photonic transmitter-mixer. This device consists of an active NBUTC-PD integrated with a planar passive circuit for feeding the intermediate-frequency (IF) modulation input and extracting the up-converted optical-to-electrical (O-E) output signals. An equivalent-circuit model is developed, which allows for the O-E and IF responses to be independently optimized. Accordingly, we can achieve both an ultra-wide O-E bandwidth (67-118 GHz) and IF modulation bandwidth (>;15 GHz) with a very-low coupling loss (

We report generation of high-modulation-depth photonic millimeter-wave (MMW) waveforms by applying line-by-line pulse shaping on a phase-modulated continuous-wave frequency comb. The optimized 20 and 100 GHz optical waveforms are then converted into electrical MMW signals using a near-ballistic uni-traveling-carrier photodiode (NBUTC-PD). A 7.4 dB MMW power enhancement is experimentally achieved by using 2.6 ps optimized pulses at a 100 GHz repetition rate, as compared with excitation by a conventional sinusoidal signal for the NBUTC-PD operated at the same photocurrent. This is in qualitative agreement with a theoretical analysis of spectral power enhancement by optical short pulses comprised of equi-amplitude frequency lines over sinusoidal excitation.

AIM: To investigate the underlying molecular mechanisms of renal cell carcinoma (RCC) by using the microarray expression profiles of normal kidney and RCC tissue for early diagnosis and treatment of RCC. MATERIALS AND METHODS: The gene expression profile of GES781 was downloaded from Gene Expression Omnibus database, including including nine tissue samples of RCC tissues removed from nine patients and eight adjacent normal renal tissue samples. We identified the differentially expressed genes (DEGs) by Multtest package in R software. The screened DEGs were further analyzed by bioinformatics methods. Firstly, the comparison of the DEGs expression degree was performed by cluster analysis. Secondly, DAVID was used to perform functional analysis of up- and down- regulated genes and the protein-protein interaction (PPI) networks were constructed by prePPI. Finally, the pathways of genes in PPI networks were discovered by WebGestalt. RESULTS: Compared with the control, we screened 648 down-regulated and 681 up-regulated DEGs. And the down- and up-regulated DEGs with maximum expression degree were UMOD (uromodulin) and FABP7 (fatty acid binding protein 7), respectively. There was significant difference in the gene expression between the normal kidney and RCC tissue. The up-regulated DEGs in RCC tissue were significantly related to the immune responses and the down-regulated DEGs were significantly related to the oxidation reduction. The most significant pathway in the PPI network of UMOD was cytokine-cytokine receptor interaction. CONCLUSIONS: The screened DEGs have the potential to become candidate target molecules to monitor, diagnose and treat the RCC, and might be beneficial for the early diagnosis and medication control of RCC. [ABSTRACT FROM AUTHOR]