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3. A Multicenter Study on the Clinical Characteristics and Outcomes Among Children With Moderate to Severe Abusive Head Trauma

Author

Lee, Jan Hau, Liu, Jun, Chor, Yek Kee, Gan, Chin Seng, Ong, Jacqueline, Anantasit, Nattachai, Samransamruajkit, Rujipat, Kurosawa, Hiroshi, Ming, Mei Xiu, Dang, Hongxing, Abbas, Qalab, Lee, Pei-Chuen, Liu, Chunfeng, Kazzaz, Yasser M., González-Dambrauskas, Sebastián, Roa G, Juan D., Fernández-Sarmiento, Jaime, Gómez Arriola, Natalia Elizabeth, Ardila Gómez, Ivan Jose, Jaramillo Bustamante, Juan Camilo, Caporal, Paula, Aparicio, Gabriela, Pantoja Chamorro, Freddy Israel, Terán Miranda, Thelma Elvira, Flores, Marisol Fonseca, Torre Gómez, Rosa Elena de la, Pilar Orive, Francisco Javier, Lasso Palomino, Rubén Eduardo, Watzlawik, Natalia Zita, Yock-Corrales, Adriana, Guier-Bonilla, Luisana, Turina, Deborah M., Rodríguez, María Miñambres, Domínguez Rojas, Jesús Ángel, Domínguez-Rojas, Jesús Ángel, Roa, Juan D., Fernandez-Sarmiento, Jaime, Zhu, Yanan, Kazzaz, Yasser, Dewi, Dianna Sri, and Chong, Shu-Ling

Published
2024
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4. Challenges in institutional ethical review process and approval for international multicenter clinical studies in lower and middle-income countries: the case of PARITY study.

Author

Lopez-Baron, Eliana, Abbas, Qalab, Caporal, Paula, Agulnik, Asya, Attebery, Jonah E., Holloway, Adrian, Kissoon, Niranjan "Tex", Mulgado-Aguas, Celia Isabel, Amegan-Aho, Kokou, Majdalani, Marianne, Ocampo, Carmen, Pascal, Havugarurema, Miller, Erika, Kanyamuhunga, Aimable, Tekleab, Atnafu Mekonnen, Bacha, Tigist, González-Dambrauskas, Sebastian, Bhutta, Adnan T., Kortz, Teresa B., and Murthy, Srinivas

Published
2024
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6. A Multicenter Study on the Clinical Characteristics and Outcomes Among Children With Moderate to Severe Abusive Head Trauma.

Author

Yock-Corrales, Adriana, Lee, Jan Hau, Domínguez-Rojas, Jesús Ángel, Caporal, Paula, Roa, Juan D., Fernandez-Sarmiento, Jaime, González-Dambrauskas, Sebastián, Zhu, Yanan, Abbas, Qalab, Kazzaz, Yasser, Dewi, Dianna Sri, and Chong, Shu-Ling

Abstract

We aimed to identify clinical characteristics, risk factors for diagnosis, and describe outcomes among children with AHT. We performed an observational cohort study in tertiary care hospitals from 14 countries across Asia and Ibero-America. We included patients <5 years old who were admitted to participating pediatric intensive care units (PICUs) with moderate to severe traumatic brain injury (TBI). We performed descriptive analysis and multivariable logistic regression for risk factors of AHT. 47 (12%) out of 392 patients were diagnosed with AHT. Compared to those with accidental injuries, children with AHT were more frequently < 2 years old (42, 89.4% vs 133, 38.6%, p < 0.001), more likely to arrive by private transportation (25, 53.2%, vs 88, 25.7%, p < 0.001), but less likely to have multiple injuries (14, 29.8% vs 158, 45.8%, p = 0.038). The AHT group was more likely to suffer subdural hemorrhage (SDH) (39, 83.0% vs 89, 25.8%, p < 0.001), require antiepileptic medications (41, 87.2% vs 209, 60.6%, p < 0.001), and neurosurgical interventions (27, 57.40% vs 143, 41.40%, p = 0.038). Mortality, PICU length of stay, and functional outcomes at 3 months were similar in both groups. In the multivariable logistic regression, age <2 years old (aOR 8.44, 95%CI 3.07-23.2), presence of seizures (aOR 3.43, 95%CI 1.60-7.36), and presence of SDH (aOR 9.58, 95%CI 4.10-22.39) were independently associated with AHT. AHT diagnosis represented 12% of our TBI cohort. Overall, children with AHT required more neurosurgical interventions and the use of anti-epileptic medications. Children younger than 2 years and with SDH were independently associated with a diagnosis of AHT. Observational cohort study. III. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Uncovering Causes of Childhood Death Using the Minimally Invasive Autopsy at the Community Level in an Urban Vulnerable Setting of Argentina: A Population-Based Study.

Author

Caballero, Mauricio T, Grigaites, Sebastian Diaz, Niveyro, Paola X De la Iglesia, Esperante, Sebastian, Bianchi, Alejandra M, Nuño, Alejandra, Valle, Sandra, Afarian, Gabriela, Ferretti, Adrian J P, Baglivo, Sofia Jares, Luca, Julian De, Zea, Cristian M, Caporal, Paula, Labanca, Maria Jose, Diamanti, Adriana, Alvarez-Paggi, Damian, Bassat, Quique, Polack, Fernando P, and Network, Community Mortality

Subjects
CAUSES of death, MIDDLE-income countries, CONFIDENCE intervals, AUTOPSY, ENDOSCOPIC surgery, COMMUNITY health services, AT-risk people, LOW-income countries, DESCRIPTIVE statistics, DEATH, METROPOLITAN areas, DATA analysis software
Abstract

Background Precise determination of the causal chain that leads to community deaths in children in low- and middle-income countries is critical to estimating all causes of mortality accurately and to planning preemptive strategies for targeted allocation of resources to reduce this scourge. Methods An active surveillance population-based study that combined minimally invasive tissue sampling (MITS) and verbal autopsies (VA) among children under 5 was conducted in Buenos Aires, Argentina, from September 2018 to December 2020 to define the burden of all causes of community deaths. Results Among 90 cases enrolled (86% of parental acceptance), 81 had complete MITS, 15.6% were neonates, 65.6% were post-neonatal infants, and 18.9% were children aged 1–5 years. Lung infections were the most common cause of death (CoD) in all age groups (57.8%). Among all cases of lung infections, acute bronchiolitis was the most common CoD in infants aged <12 months (23 of 36, 63.9%), and bacterial pneumonia was the most common cause in children aged >12 months (8 of 11, 72.7%). The most common comorbid condition in all age groups was undernutrition in 18 of 90 (20%). It was possible to find an immediate CoD in 78 of 81 subjects where MITS could be done. With this combined approach, we were able to determine that sudden infant death syndrome was overestimated in state reports. Conclusions CoD determination by a combination of MITS and VA provides an accurate estimation of the chain of events that leads to death, emphasizing possible interventions to prevent mortality in children. [ABSTRACT FROM AUTHOR]

Published
2021
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14. 643: ESTIMATING THE GLOBAL PREVALENCE OF PEDIATRIC ACUTE CRITICAL ILLNESS IN RESOURCE-LIMITED SETTINGS.

Author

Sakaan, Firas, Holloway, Adrian, Abbas, Qalab, Appiah, John, Attebery, Jonah, Caporal, Paula, Fink, Ericka, Kissoon, Niranjan, Lee, Jan Hau, López-Barón, Eliana, Murthy, Srinivas, Muttalib, Fiona, Remy, Kenneth, de Sá Rodrigues, Karla Emília, Rodrigues, Adriana Teixeira, Andre-VonArnim, Amelie Von Saint, Wiens, Matthew, Agulnik, Asya, Bhutta, Adnan, and Kortz, Teresa

Published
2023
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15. 258: CHALLENGES IN INSTITUTIONAL APPROVAL PROCESS FOR A MULTINATIONAL STUDY: THE GLOBAL PARITY.

Author

López-Barón, Eliana, Agulnik, Asya, Abbas, Qalab, Holloway, Adrian, Appiah, John A., Kissoon, Niranjan, Kortz, Teresa, Lee, Jan Hau, Bhutta, Adnan, Remy, Kenneth, Caporal, Paula, Fink, Ericka, Muttalib, Fiona, Sakaan, Firas, Rodrigues, Adriana Teixeira, de Sá Rodrigues, Karla Emília, Andre-VonArnim, Amelie Von Saint, Attebery, Jonah, Wiens, Matthew, and Murthy, Srinivas

Published
2023
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