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Abstract Background Intimate partner violence (IPV) is common globally, but there is a lack of research on how to intervene early with men who might be using IPV. Building on evidence supporting the benefits of online interventions for women victim/survivors, this study aims to test whether a healthy relationship website (BETTER MAN) is effective at improving men’s help seeking, their recognition of behaviours as IPV and their readiness to change their behaviours. Methods/design In this two-group, pragmatic randomised controlled trial, men aged 18–50 years residing in Australia who have been in an adult intimate relationship (female, male or non-binary partner) in the past 12 months are eligible. Men who report being worried about their behaviour or have had others express concerns about their behaviour towards a partner in the past 12 months will be randomised with a 1:1 allocation ratio to receive the BETTER MAN website or a comparator website (basic healthy relationships information). The BETTER MAN intervention includes self-directed, interactive reflection activities spread across three modules: Better Relationships, Better Values and Better Communication, with a final “action plan” of strategies and resources. Using an intention to treat approach, the primary analysis will estimate between-group difference in the proportion of men who report undertaking help-seeking behaviours for relationship issues in the last 6 months, at 6 months post-baseline. Analysis of secondary outcomes will estimate between-group differences in: (i) mean score of awareness of behaviours in relationships as abusive immediately post-use of website; (ii) mean score on readiness to change immediately post-use of website and 3 months after baseline; and (iii) cost-effectiveness. Discussion This trial will evaluate the effectiveness of an online healthy relationship tool for men who may use IPV. BETTER MAN could be incorporated into practice in community and health settings, providing an evidence-informed website to assist men to seek help to promote healthy relationships and reduce use of IPV. Trial registration ACTRN12622000786796 with the Australian New Zealand Clinical Trials Registry: 2 June 2022. Version: 1 (28 September 2023).

This study aims at explaining the impact of Instagram social media influencers on behavioural intentions (i.e., intentions to interact with them and recommend them, and also purchase the products they endorse or post). It focuses on influencers’ expertise and their role as opinion and taste leaders. Based on opinion leadership theory, a survey was conducted on 210 Instagram users. Main findings reveal that post originality, uniqueness, and quality impact on influencers’ opinion leadership which, in turn, impacts on behavioural intentions. Influencers’ expertise impacts on the intention to recommend the influencers and purchase the products posted, while influencers’ taste leadership only influences the intention to interact with them. Few papers analyse the direct effects of influencers’ expertise and opinion and taste leadership on followers’ behavioural intentions. Consequently, when designing a social media marketing campaign influencers’ selection should be made according to those traits which stimulate specific behaviours such as fostering interaction, increase electronic word of mouth or persuade to purchase the products posted. In case of product endorsements, selecting influencers with acknowledged expertise is recommended as they will cause an impact on the intention to purchase endorsed products. Influencers perceived as opinion leaders have an overall influence on their followers’ behavioural intentions.

This paper presents a complete bibliometric analysis of Aitchison’s 1986 seminal book “The Statistical Analysis of Compositional Data.” We have set three objectives. The first is to analyze the academic structure of Aitchison’s 1986 book. Results reveals that although the work has received citations uninterruptedly since its publication, the number of these has increased very significantly over the past 4 years. This is due to the significant increase in the number of publications on the theme of “Compositional Data Analysis” in fields related to “geoscience” over the last few years. The second objective is to determine which main journals Aitchison’s book has been cited in. The results highlight that the main journals are indexed under the following WoS category: “Geosciences, Multidisciplinary” and “Ecology.” Of these, “Mathematical Geosciences” and “Computers, Geosciences” stand out. The third objective is to determine the main topics analyzed in the principal papers published by authors citing Aitchison’s book. Our results show that the keywords in the main papers to have cited Aitchison’s 1986 book originate from the geoscience field, since many of them are related to concepts directly linked to this field and refer to terms related to “biodiversity,” “geodiversity,” “geoheritage,” and “georesources.” Lastly, the analysis shows how the CoDA methodology is now in a phase of exponential growth, expanding to other fields. This implies that geoscience is becoming consolidated in the scientific literature as one of the branches of modern science that has given rise to a new mathematical theory of great impact.

We present a rare challenging case of metastatic non-small cell lung cancer with Epstein-Barr virus positivity that was also diagnosed with pulmonary tuberculosis at the same time. Palliative chemotherapy gemcitabine and carboplatin was started after two weeks of anti-tuberculosis treatment with the hopes that this period would be sufficient to keep acid fast bacilli non-viable to minimise risk of tuberculosis re-activation due to chemotherapy induced immunosuppression. She completed four cycles of chemotherapy and six months of anti-tuberculosis treatment with good results and minimal side effects. Two years later, there was disease recurrence in cervical and mediastinal lymph nodes which was treated with local treatment i.e. surgery and palliative radiotherapy. It has been two years since last radiotherapy and overall more than five years since diagnosis with no active disease at present. Given the complexity and rarity of this case, significant multidisciplinary team involvement, including oncologists and radiation oncologists, pulmonologists with special interest in tuberculosis and pathologists was necessary throughout.

Background: The current spread of carbapenemase-producing Enterobacterales (CPE) is a great concern. Methods: We recovered 198 CPE from 162 patients admitted in our Hospital (March 2014-March 2016) during the R-GNOSIS European Project. Microbiological features and plasmid characteristics of CPE recovered from patients co-colonized with multiple CPE were studied. Findings: Thirty patients (18.5%; CI 95%= 12.5%–24.5%) presented co-colonization with multiple CPE producing the same (CPE-SC) (15.4%) or a different carbapenemase (CPE-DC) (4.3%). OXA-48 (83.3%) was the most frequent carbapenemase, followed by VIM-1 (26.7%), NDM-1 (10%) and KPC-3 (3.3%). CPE-DC-patients had longer admissions [63 days (20–107)] than the other patients. Moreover, hospital stay until CPE detection was lower [9 days (5–14)] (p = 0.0052) in CPE-SC-patients than in those with a single colonization; 56% showed co-colonization in the first positive sample, although most of them had previous admissions and had received multiple antibiotic treatments. CPE were more frequently recovered in clinical samples from co-colonized [CPE-DC (28.6%), CPE-SC (24%)] patients than from patients with a single CPE (15.2%). Among CPE-SCOXA-48 [80% (p = 0.11)], K. pneumoniae [88% (p = 0.006)] and E. coli [84% (p

Within the process of progressive digitization of materials and tools for teaching and distance learning of a subject of introduction to Microeconomics (quarterly, in year three of the Degree in Social Work), taught by the authors at the National University of Distance Education (UNED), a virtual assistant in the form of chatbot, or conversational robot, called EconBot, has been designed and made available to students from 2017. This paper presents the reasons that led to its adoption, the process of its development, differentiating two phases, its characteristics and functions, the assessment of its usefulness and the role of teachers in the implementation of this type of technological innovation.

This study presents a comprehensive bibliometric analysis of the paper published by John Aitchison in the Journal of the Royal Statistical Society. Series B (Methodological) in 1982. Having recently reached the milestone of 35 years since its publication, this pioneering paper was the first to illustrate the use of the methodology "Compositional Data Analysis" or "CoDA". By October 2019, this paper had received over 780 citations, making it the most widely cited and influential article among those using said methodology. The bibliometric approach used in this study encompasses a wide range of techniques, including a specific analysis of the main authors and institutions to have cited Aitchison' paper. The VOSviewer software was also used for the purpose of developing network maps for said publication. Specifically, the techniques used were co-citations and bibliographic coupling. The results clearly show the significant impact the paper has had on scientific research, having been cited by authors and institutions that publish all around the world.

Background: Accelerating the diagnosis of bacteremia is one of the biggest challenges in clinical microbiology departments. The fast establishment of a correct treatment is determinant on bacteremic patients’ outcomes. Our objective was to evaluate the impact of antimicrobial therapy and clinical outcomes of a rapid blood culture workflow protocol in positive blood cultures with Gram-negative bacilli (GNB). Methods: A quasi-experimental before–after study was performed with two groups: (i) control group (conventional work-protocol) and (ii) intervention group (rapid workflow-protocol: rapid identification by Matrix-Assisted Laser Desorption/Ionization-Time-Of-Flight (MALDI-TOF) and antimicrobial susceptibility testing (AST) from bacterial pellet without overnight incubation). Patients were divided into different categories according to the type of intervention over treatment. Outcomes were compared between both groups. Results: A total of 313 patients with GNB-bacteremia were included: 125 patients in the control group and 188 in the intervention. The time from positive blood culture to intervention on antibiotic treatment decreased from 2.0 days in the control group to 1.0 in the intervention group (p < 0.001). On the maintenance of correct empirical treatment, the control group reported 2.0 median days until the clinical decision, while in the intervention group was 1.0 (p < 0.001). In the case of treatment de-escalation, a significant difference between both groups (4.0 vs. 2.0, p < 0.001) was found. A decreasing trend on the change from inappropriate treatments to appropriate ones was observed: 3.5 vs. 1.5; p = 0.12. No significant differences were found between both groups on 7-days mortality or on readmissions in the first 30-days. Conclusions: Routine implementation of a rapid workflow protocol anticipates the report of antimicrobial susceptibility testing results in patients with GNB-bacteremia, decreasing the time to effective and optimal antibiotic therapy.

In 1986, a new syndrome was described in Taiwan secondary to hypervirulent K. pneumoniae (hvKP), and its main feature was the ability to cause severe infection in young and immunocompetent hosts. Their virulence is explained by the efficient acquisition of iron and an increase in capsule production, which confer the characteristic hypermucoviscous phenotype. Most of these cases have been described in Asia and subsequently spread to America and Europe, where their prevalence is much lower. We present four cases of bacteremia and liver abscesses secondary to hypervirulent K. pneumoniae, two of them associated with endophthalmitis. K. pneumoniae isolates recovered from two of the patients belonged to capsular serotype K1 (genes wzx_K1 and magA), while the other two were K2 (gene wzy_K2). Both of the K1 isolates were classified into a ST23, and isolates of serotype K2 belonged to the ST375 and ST881 clones.In Europe, hvKP isolates are less frequently recovered, mostly associated with Asian citizens or travelers, which was not the case in our patients. K1 capsular serotype is a major cause of primary liver abscess and secondary septic embolus, and K2 is associated with secondary liver abscess. Although these hypervirulent variants usually affect immunocompetent patients as in our cases, diabetes mellitus is a major risk factor for the most invasive cases, with concomitant poor prognosis. Identification of hypervirulent K. pneumoniae serotypes K1 and K2 should be considered as part of the microbiological diagnosis of community-acquired liver abscess due to their clinical implications. Keywords: Hypermucoviscous Klebsiella pneumoniae, Liver abscess, Community acquired infection, MLST

The aim of the research was to develop a theoretical approach to describe the emotional and techno-ontological logic of mathematics teachers during distance learning during the COVID-19 pandemic and the impact of their emotional state on the learning process. The research approach used in this paper belongs to the qualitative paradigm. The study involved teachers and students from universities in Ecuador, both private and public. The study observed the behavior of teachers and students, analyzed the use of technology in mathematical activities, and analyzed personal opinions about the learning process of the participants of the study. A digital observation guide and open-ended interviews were used to collect data. The qualitative analysis program Atlas. Ti was used to analyze the data. The program created three categories: andragogical heterotopia of mathematics, emotional scar in teacher preparation, and perceptions of the educational process. As the results of the research showed, there was a deficit of digital professional training of teachers in the university teaching of mathematics. As a result of the research work carried out, a theoretical approach is proposed, through which it is possible to avoid the manifestation of techno-ontological logical emotions in mathematics teachers in Ecuadorian universities.

Objetivo: Analizar los artículos sobre usabilidad publicados durante el periodo 1971-2005 desde el punto de vista bibliométrico. Material y Métodos: Para obtener los trabajos se interrogaron las bases de datos del CSIC, Social Science Citation Index, Science Citation Index, PsycInfo, MEDLINE e Inspec mediante estrategias de búsqueda diseñadas ad hoc para cada base de datos. Se calcularon los índices de aporte, aporte específico y solapamiento y los indicadores de evolución de la productividad científica, productividad de las instituciones de trabajo y de las revistas, y distribución de las revistas por área de conocimiento. Resultados: Se ha observado un crecimiento exponencial de los artículos publicados, más acusado en el último quinquenio. Las instituciones más productivas son fundamentalmente universitarias y estadounidenses y las revistas más productivas pertenecen al campo de la informática, ingeniería y psicología. Conclusiones: en la actualidad existe una incógnita sobre la consideración de la usabilidad como ciencia o disciplina científica, ya que no cuenta con un currículo formativo acorde, ni un perfil profesional determinado, ni un área específica de conocimiento en la que se pueda englobar.

Introducción: El manejo de la infección todavía es un reto en el tratamiento del desnutrido grave porque la inmunosupresión y la anemia concomitante comprometen la respuesta inflamatoria. Objetivo: Comparar la respuesta inflamatoria entre niños con desnutrición aguda grave tipo marasmo y kwashiorkor y niños eutróficos con y sin anemia (grupos control), mediante la medición de los niveles de proteína C reactiva (PCR) y de las citocinas pro-inflamatorias IL-8, IL-1β, IL-6, IL-10, TNFα e IL-12. Metodología: Se realizó un estudio de corte transversal, donde se determinaron los niveles de algunos indicadores de la respuesta inflamatoria como proteína C reactiva (PCR), citocinas pro-inflamatorias como IL-8, IL-1β, IL-6, IL-10, TNF-α e IL-12p70, hemoglobina y ferritina en un grupo de 40 niños: 10 con marasmo, 10 con kwashiorkor, 10 eutróficos con anemia y 10 eutróficos sin anemia. Resultados. La PCR fue significativamente mayor en desnutridos que en eutróficos. Las concentraciones de las citocinas pro-inflamatorias fueron más altas en niños con kwashiorkor seguidos de eutróficos con anemia, marasmáticos y eutróficos sin anemia. La hemoglobina se correlacionó negativamente con los niveles de IL-8 (r=-0,409 p=0,009), IL-6 (r=-0,442 p=0,004) e IL-10 (r=-0,436 p=0,005). Conclusión. Los niños con desnutrición aguda grave producen una respuesta inflamatoria con aumento en los niveles de la PCR y de citocinas pro-inflamatorias que indican infección aun cuando no presenten signos, lo cual apoya la recomendación del protocolo de la OMS de medicarlos con antibioticos. Adicionalmente, estos resultados sugieren que las citocinas pro-inflamatorias podrian participar en la patogenesis de la anemia en pacientes con o sin desnutricion.

El consumo de libros científicos electrónicos es aún muy reducido en el ámbito universitario, debido en parte a la necesidad de realizar una lectura de trabajo durante más tiempo y a problemas de usabilidad y de diseño de las interfaces. En este trabajo se aborda el grado de satisfacción de uso del e-reader, el tipo de lecturas que se realizan en estos dispositivos y el nivel de conocimiento, uso y satisfacción con la colección digital de las bibliotecas universitarias. Para ello se ha realizado una encuesta digital dirigida a estudiantes de las universidades públicas españolas que durante el curso 2012-2013 impartieron docencia en el Grado de Información y Documentación. Los resultados muestran que pese a que el uso del e-reader está muy extendido, el ordenador sigue siendo el dispositivo más empleado para la lectura y consulta del libro científico digital.

Objectives The in vivo selection of E157Q plus R263K has not been reported in patients treated with coformulated bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF). To the best of our knowledge, we hereby report the first case of high-grade INSTI resistance associated with the presence of these aminoacidic substitutions in a treatment-experienced HIV patient treated with BIC/FTC/TAF. Methods Clinical case report and review of the literature. Results A heavily treatment-experienced patient was switched to BIC/FTC/TAF due to drug–drug interactions after being diagnosed with disseminated Mycobacterium avium-intracellulare disease. He had been treated before with raltegravir with poor adherence. No mutations in the integrase gene were detected 1 year after finishing treatment with raltegravir. Months after being switched to BIC/FTC/TAF, and again with poor adherence documented, virological failure (VF) was detected. The polymorphic substitution E157Q and the resistance mutation R263K in the integrase gene were detected, as well as M184V, among other mutations in the reverse transcriptase gene. The patient is currently being treated with dolutegravir q12h plus boosted darunavir along with directly observed treatment, and for the first time in 20 years, plasmatic viral load values are below 100 copies/mL. Conclusions This case illustrates that the combination of E157Q and R263K plus M184V can be selected in vivo in a clinical scenario of poor adherence with BIC/FTC/TAF, although it is a very rare phenomenon. Previous VF with first-generation integrase strand transfer inhibitors (INSTIs) should be kept in mind when switching patients to second-generation INSTIs. [ABSTRACT FROM AUTHOR]

Introduction: Multiple technologies help the development of reconstructive surgical procedures in craniofacial surgery, Surgeon's perception of this type of diagnostic and treatment aids has not been widely studied. Methods and Materials: A workflow is proposed for the management of craniofacial bone defects; the results are showed to the staff in charge for the treatment of these patients. A survey was applied, evaluating the degree of satisfaction and the perception of the staff regarding applicability, usefulness, impact on different process factors of treatment. Descriptive analysis was performed. Results: 30 people were interviewed: specialists, residents of surgical specialties, and general practitioners. The majority did not have experience with CAD/CAM technology (77%), but considered useful (67%), the considered disadvantages were: technical difficulty, administrative procedures to access, costs, lack of information, need for specific training. The benefits were: Improvement in diagnosis and treatment accuracy, specificity, help in planning, innovation, and versatility. Discussion: Tools such as 3D printing, CAD/CAM technology, facilitate the process of anatomical understanding, planning and execution of surgery, the participants agrees with these data, where the impact and utility in the treatment of patients is evident, both for graduate surgeons and those in training. Conclusions: The application of technologies in the practice of medicine may be useful because facilitates the technical execution of the procedure precision, reduces surgical time and costs. Information and studies that evaluate the surgeon's perception regarding the applicability of CAD/CAM technology in the treatment of bone defects are not enough, which represents a novelty of our study. [ABSTRACT FROM AUTHOR]

Background: Over the past decades the use of technology in healthcare has increased exponentially, and the recent pandemic further accelerated the dependence on technology, both to access health and care services but also digital resources and information for health care consumers. Carers of people living with dementia from culturally and linguistically diverse (CALD) backgrounds have been disproportionately impacted as in‐language resources are scarce and locating them can be difficult. Thus, there is need to centralize digital resources to improve access for carers of persons living with dementia who speak languages other than English. Responding to this, our project co‐produced the GENIE (Global dEmeNtIa rEsources): a comprehensive, global online gateway to culturally and linguistically appropriate digital dementia resources. Method: Methods comprised an environmental scan (academic literature and systematic online search) and online consultations with key stakeholders to identify resources. Resources were included if developed by healthcare organizations, dementia or aged care peak bodies, dementia advocacy groups, government departments, or academic organizations. The GENIE site was coproduced with CALD carers and providers in Australia. Data analytics are being collected via the website. Result: The environmental scan highlighted the dearth of resources developed for CALD communities, and gaps in availability of digital dementia resources across many languages. Further, dementia resources identified via the literature search were often not available for public access, required payment, or were no longer available. More than 400 resources in 68 languages were identified and included in the gateway, and the site was made publicly available in November 2022. Data analytics show that the uptake of the resource has been good with > 700 new users and >3500 page views in the first two months. Conclusion: The Moving Pictures Genie project has produced one of the most comprehensive gateways to digital dementia resources to support carers and families who speak languages other than English currently available. In addition to the production of the resource, the project provides insights into the gaps in existing resources across languages and geographical regions. These findings will be useful to guide the direction of resource development to avoid duplication and enhance equity and benefit to CALD communities. [ABSTRACT FROM AUTHOR]

Copyright of Question (1669-6581) is the property of Universidad Nacional de La Plata and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of this study was to investigate the effects of route of inoculation and dose on production and avidity of IgY antibodies in chickens. The animals were inoculated with 20 µg of human IgG by intramuscular, intradermal, or subcutaneous routes, or with 2, 20, or 200 µg of human IgG via IM to evaluate the effect of dose. All routes led to significant levels of specific antibodies after the fifth inoculation. There was a significant difference in the levels of antibodies produced with 2 and 200 µg of antigen after the third and seventh inoculation. It was observed that there is no influence of route of inoculation or dose on the avidity of the antibodies produced. Furthermore, the index of avidity is influenced directly by the number of inoculations. These results are important to help future studies where antibody production of IgY from laying hens is necessary. [ABSTRACT FROM AUTHOR]

MicroRNAs (miRNAs) are small single stranded RNA sequences involved in posttranscriptional regulation of different biological and physiological processes. Paracoccidioidomycosis (PCM) is an infection caused by Paracoccidioides brasiliensis, and it is a major cause of mortality due to systemic mycoses in Brazil. To date, there have been few reports on the role of miRNAs in the immune response against fungi, especially PCM. The objective of this study was to evaluate the differential expression of miRNAs related to the inflammatory response associated with pulmonary infection by P. brasiliensis. For this purpose, lungs from BALB/c mice, intravenously infected with P. brasiliensis (2.7× 107 yeast cells/ml, n = 12) and noninfected BALB/c mice (n = 8), were collected at the 28 and 56 day after infection. The lung parenchyma presented a great number of yeast cells, granulomas, and edema at 28 days and a framework of resolution of the inflammatory process after 56 days. The mRNAs gata-3, ror-γ t, foxp3, and IL-6 were positively regulated at the moment at the 56 day, while the TGF-β1 mRNA was positively regulated at both moments. The miRNAs 126a-5p, 340-5p, 30b-5p, 19b-3p, 221-3p, 20a-5p, 130a-3p, and 301a-3p, 466k presented the greatest increase in expression levels 28 days after infection, and the miRNAs let-7f-5p, let-7a-5p, 5p-26b, let-7e-5p and 369-3p, 466k presented a greater increase in levels of expression 56 days after infection. This study shows a set of differentially expressed miRNAs possibly involved in the immune response in mice during pulmonary infection by P. brasiliensis. [ABSTRACT FROM AUTHOR]

Copyright of Adicciones is the property of Sociedad Cientifica Espanola de Estudios sobre el Alcohol and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Los ecosistemas emprendedores enfrentan diversos desafíos relacionados con acceso a financiamiento, capacitación, redes de contacto y, primordialmente, normativa y políticas públicas que los regulan. El objetivo del estudio es analizar las variables que pueden potenciar la iniciativa emprendedora y contribuir a un ecosistema emprendedor más activo e integrador en Ecuador. El diseño metodológico del estudio se centró en un enfoque apoyado con técnicas de regresión múltiple, las cuales revelan las dinámicas intrínsecas del emprendimiento ecuatoriano y su relación con las políticas públicas, identificando variables claves que influyen en su éxito a través de algoritmos de softwares como Python y R Studio, que aseguran la precisión y reproducibilidad de los resultados. El estudio revela que variables como el apoyo y las políticas gubernamentales, la educación empresarial en la escuela básica y la transferencia de investigación y desarrollo (I+D) están positivamente correlacionadas con la financiación para emprendedores. Se concluye en la necesidad de implementar políticas que promuevan la transferencia de conocimiento científico y tecnológico para impulsar el desarrollo empresarial, así como, la necesidad de investigaciones futuras que exploren otros posibles determinantes además de la financiación para emprendedores, como la infraestructura financiera y la cultura empresarial.

Resumen: Introducción: el síndrome de Sjögren (SS) se caracteriza por un amplio espectro de manifestaciones clínicas, clásicamente cursa con síndrome seco. Sin embargo, menos del 10% de los casos puede iniciar con manifestaciones extraglandulares. Caso clínico: se presenta el caso de una paciente de 36 años con cuadro de coloración violácea en 2 dedos de la mano. Durante la anamnesis y los estudios complementarios, se encontró un perfil autoinmune indicativo de SS y vasculitis crioglobulinémica. Además, la biopsia de glándula salival fue positiva para SS. Conclusión: el caso presentado representa un reto diagnóstico debido a las manifestaciones iniciales atípicas. Por ello, solo conociendo las diferentes manifestaciones de esta enfermedad se puede sospechar de la misma y realizar un diagnóstico oportuno. Abstract: Introduction: Sjögren's syndrome is characterized by a broad spectrum of clinical manifestations; classically it presents with dry syndrome, However, less than 10% of these patients may present with extra glandular manifestations. Case report: We present the case of a 36-year-old female patient with a purplish discoloration in two fingers of her hand. During anamnesis and complementary studies, she exhibited an autoimmune profile indicative of SS and cryoglobulinemic vasculitis. Additionally, a salivary gland biopsy was positive for Sjögren's syndrome. Conclusion: The case presented represents a diagnostic challenge due to the atypical initial manifestations. Therefore, only by being aware of the different manifestations that this disease can present can one suspect it and make a timely diagnosis.

Spinal cord compression syndrome is one of the most frequent oncologic emergencies, in which early diagnosis and treatment are key factors to prevent severe and irreversible neurological damage. It is estimated to have a prevalence of 3.4% in oncologic patients and is a source of significant morbidity in cancer patients. Spinal cord infiltration with hematogenous dissemination is the most common cause of spinal cord compression. In the present case, we present a clinical case of spinal cord compression syndrome secondary to a phyllodes tumour of the breast who was admitted to the emergency for lumbar pain with red flags and who suffered a spinal cord infarction with irreversible sequelae and poor prognosis.

This article aims to disseminate information about Brazilian Zouk and contribute to the historical understanding of Brazilian dances through critical reflection. To this end, we researched various bibliographic sources, such as articles, theses, dissertations, videos, and reports, in addition to personal notes. The analysis showed disputes concerning the following aspects: 1) the rise of the musical rhythm and dance; 2) the use of basic and competitive movements; 3) the process of commodification; and 4) contemporary issues related to the body. It is important to emphasize that this work is motivated by the necessity to broaden the debate on dance historiography in the country.

O artigo objetiva difundir informações a respeito do Zouk Brasileiro, buscando contribuir com a historicização de danças brasileiras por meio de uma reflexão crítica. Para isso, foram consultadas fontes bibliográficas (artigos, teses, dissertações, vídeos e reportagens) e registros de diários de campo. As análises evidenciam disputas a respeito dos pontos: 1) surgimento do ritmo musical e da dança; 2) utilização de movimentos básicos e competitivos; 3) processo de mercantilização; e 4) questões contemporâneas do corpo. Destaca-se que o trabalho se justifica pela necessidade de ampliação dos debates acerca das historiografias de dança no país.

In this work, we employed a novel microwave-assisted synthesis method to produce nitrogen and boron co-doped carbon dots (B–N co-doped CDs). To achieve optimal synthesis, we conducted a comprehensive parameter modulation approach, combining various synthesis temperatures, times, and precursor concentrations, while keeping the power constant at 150 W and pH 5. Using maximum fluorescence emission as our response variable, the best conditions were identified as 120 °C, 3 min, and a precursor concentration of 1 mg/mL. Characterization using field emission scanning electron microscopy revealed these CDs to have a spherical morphology with an average size of 10.9 ± 3.38 nm. Further high-resolution transmission electron microscopy showed an interplanar distance of 0.23 nm, which is in line with prior findings of CDs that present a 0.21 nm distance corresponding to the (100) plane of graphite. Optical properties were ascertained through UV–vis absorption, identifying distinct π–π* and n–π* transitions. Fluorescence spectroscopy highlighted an emission peak at 375 nm when excited at 295 nm, achieving a quantum yield of 56.7%. Fourier-transform infrared spectroscopy and Raman spectroscopy analyses confirmed the boronic acid and amine groups’ presence, underscoring the graphitic nature of the core and the co-doping of boron and nitrogen. These empirical observations were compared with theoretical investigations through simulated Raman spectra, proposing a potential structure for the CDs. X-ray photoelectron spectroscopy further endorsed the co-doping of nitrogen and boron, along with the detection of the specified functional groups. All these characteristics could lend this nanomaterial to different types of applications such as fluorescent probes for a broad range of analytes and for fluorescent cell imaging.

Objectives Methods Results Conclusions Clinical implications Dementia care scholarship focuses on care challenges and less on positive aspects of care, especially among culturally and linguistically diverse (CALD) carers outside the United States. This article investigates positive aspects of dementia care across eight CALD groups in Australia.We analyzed interviews of 112 family carers using a four-domain framework covering: a sense of personal growth, feelings of mutuality, increases in family cohesion, and a sense of personal accomplishment.Positive associations with care are derived from past relationships, feelings of mutual obligation, valuing changed relationships and enjoying spending time with the person with dementia. Positive aspects of care were not associated with increased family cohesion except in Vietnamese and Arab families; neither was use of ethno-specific residential aged care, except for Greek and Italian families. Religion and spirituality as a coping and comforting mechanism was inconsistently expressed.The study reveals the multi-dimensional nature of care, what resonates, and diverges across CALD populations. Knowing which parts of the framework apply and which do not is useful for interventions seeking to enhance positive aspects of care.Migrant populations are varied and dynamic, and practitioners should be mindful of differences within and between ethnic minority groups. [ABSTRACT FROM AUTHOR]

In this report, we present a rare case of solid silicone implant displacement to the contralateral side after aesthetic gluteal augmentation, a phenomenon that has never been reported before in the literature. A 29-year-old woman with a history of gluteal augmentation 9 months previously and soft tissue infection presented for a consultation due to 3 days of sudden progressive pain in the right gluteus with erythema and edema, without a history of trauma. Displacement of the left gluteal implant to the right gluteal pocket was shown by magnetic resonance imaging. Because the patient refused implant removal, the decision was made to perform capsulotomy, to reconstruct the gluteal pockets, and to preserve the implants. The patient showed a satisfactory early and late postoperative course. Possible causes of this complication include poor surgical technique, with insufficient tissue preservation to keep the pockets apart, and the presence of seroma or hematoma that favored an infectious process, thereby leading to deterioration of the dissected soft tissues with dehiscence of the wound favoring the displacement of the implant.

The aim of this study was to investigate the effects of route of inoculation and dose on production and avidity of IgY antibodies in chickens. The animals were inoculated with 20 µg of human IgG by intramuscular, intradermal, or subcutaneous routes, or with 2, 20, or 200 µg of human IgG via IM to evaluate the effect of dose. All routes led to significant levels of specific antibodies after the fifth inoculation. There was a significant difference in the levels of antibodies produced with 2 and 200 µg of antigen after the third and seventh inoculation. It was observed that there is no influence of route of inoculation or dose on the avidity of the antibodies produced. Furthermore, the index of avidity is influenced directly by the number of inoculations. These results are important to help future studies where antibody production of IgY from laying hens is necessary.

Proponemos este Dossier porque la cuestión animal es un emergente que nos concierne. Aun a aquellos que lo sienten ajeno, lejano e, incluso, burdo. La convivencia con otras especies y lo que nace fruto de ella nos atraviesa como humanidad, en todo el sentido que alcanza esta palabra. Creímos oportuno invitar a investigadoras e investigadores reconocidos en sus respectivos campos de saber, que están trabajando el tema desde diversos puntos de Latinoamérica. Y, de esta manera, presentar, desde diversas aristas, qué es lo que se está planteando, discutiendo, revisando y reconstruyendo en torno a los animales no humanos.

In this paper, there is a reflection about the relationship between gender, women and history. First, we consider the way in which social history understood the feminist movement and the gender theory. Second, we characterize what was known as women’s history, feminist history and gender history, although, as will be seen, the boundaries of these categories are blurred. Finally, we establish a dialogue between Joan Scott and Simone de Beauvoir, about their own ways to see the history of women and gender, and about the ideas of method used by them.

En este ensayo se reflexiona sobre la relación género, mujeres e historia. Para ello, en primer lugar, consideramos la manera en que la historia social interpretó al movimiento feminista y la teoría de género. En la segunda parte caracterizamos lo que se dio a conocer como historia de las mujeres, historia feminista e historia de género, aunque –como veremos– los límites de estas categorías son difusos. En la última parte establecemos un diálogo entre dos de las más notables representantes de este debate: Joan Scott y Simone de Beauvoir, sobre sus respectivas maneras de abordar la historia de las mujeres y del género, y sobre las ideas de método de las que cada una hace uso.

Este artículo presenta la metodología de trabajo de investigación que se implementa en la Cátedra I Prácticas de la Enseñanza que consiste en la Sistematización de Experiencias. Esta metodología, desde una perspectiva latinoamericana, apunta a reconocer la riqueza de conocimientos generados en la práctica, recuperar aquellos que han sido valiosos y pertinentes en diversos contextos y hacerlos comunicables para que otros puedan valerse de estas prácticas. Se parte de hacer un recorrido por esta metodología de trabajo y compartir la implementación que se hace desde Prácticas de la Enseñanza para enriquecer la trayectoria formativa de los estudiantes del Profesorado en Comunicación Social de la FPyCS de la UNLP.

Esta investigación representa el doceavo informe del Grupo de Memoria Histórica de la Comisión Nacional de Reparación y Reconciliación (CNRR), que hasta la fecha ha publicado diecinueve investigaciones. El proyecto surgió con la Ley de Justicia y Paz, del año 2005, con el propósito de "presentar informes sobre el origen y evolución de los grupos armados ilegales" (artículo 51). En este informe, el historiador y abogado Mario Aguilera Pena presenta una investigación que, como su titulo lo advierte, tiene por objeto reconstruir la historia de un orden social desarmado, como programa y proceso liderado por la Asociación de Trabajadores y Campesinos del Carare (ATCC), creada en 1987, en el corregimiento de La India, Santander.

En este artículo se trabajaran las categorías especismo/antiespecismo, hasta el momento analizadas casi exclusivamente por la Filosofia, desde el campo de la Comunicación en clave de identidad: en un primer momento problematizándolas desde el esencialismo/no esencialismo para luego reflexionar sobre su posible desplazamiento hacia la perspectiva de identidad/es.

El presente trabajo expone el informe final de nuestro Proyecto de Extensión "Educar para la salud: jóvenes y sexualidad", el cual se estructura en talleres de salud sexual y reproductiva orientada a jóvenes, trabajando a partir de sus percepciones sobre el tema, de manera de lograr que el aprendizaje en los talleres fuera significativo para ellos. Como producto de esta experiencia elaboramos una producción audiovisual que será distribuida en Hospitales Públicos, Centros de Atención Primaria de la Salud y Escuelas Secundarias Públicas de la ciudad de La Plata. Palabras clave: talleres – aprendizaje – salud sexual y reproductiva – comunicación

Este es un informe de avance del proyecto “Sembrando Valores: campañas participativas de concientización, profilaxis y terapéutica de las zoonosis en barrios marginales, destinadas a fomentar el cuidado de la salud y el respeto por la vida”, ejecutado desde la Facultad de Veterinaria, con el apoyo de la Facultad de Periodismo y Comunicación Social y la Facultad de Bellas Artes. Compartimos aquí la experiencia de trabajar en los barrios con el objetivo que nos propusimos de promover la salud y bienestar tanto animal como humana de comunidades vulnerables, impulsando una relación humanitaria y responsable entre ellos; facilitando la prevención de enfermedades infectocontagiosas y zoonóticas a través de experiencias directas (atención veterinaria y esterilización) realizadas por profesionales y voluntarios idóneos, motivando la responsabilidad a través de talleres de concientización y primeros auxilios y fomentando el respeto por la vida a través del reconocimiento de actitudes positivas. Palabras clave: animales – concientización – profilaxis – zoonosis – maltrato